JP2006528205A - 改良放射性金属錯体組成物 - Google Patents

改良放射性金属錯体組成物 Download PDF

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Publication number
JP2006528205A
JP2006528205A JP2006525001A JP2006525001A JP2006528205A JP 2006528205 A JP2006528205 A JP 2006528205A JP 2006525001 A JP2006525001 A JP 2006525001A JP 2006525001 A JP2006525001 A JP 2006525001A JP 2006528205 A JP2006528205 A JP 2006528205A
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JP
Japan
Prior art keywords
metal complex
tropane
formula
conjugate
biocompatible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006525001A
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English (en)
Japanese (ja)
Other versions
JP2006528205A5 (enExample
Inventor
マックギル，デイビッド
ヘンリクセン，イングリッド
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GE Healthcare Ltd
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GE Healthcare Ltd
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Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of JP2006528205A publication Critical patent/JP2006528205A/ja
Publication of JP2006528205A5 publication Critical patent/JP2006528205A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2006525001A 2003-02-07 2004-02-09 改良放射性金属錯体組成物 Pending JP2006528205A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03002809A EP1444990A1 (en) 2003-02-07 2003-02-07 Improved Radiometal Complex Compositions
PCT/GB2004/000443 WO2004069285A1 (en) 2003-02-07 2004-02-09 Improved radiometal complex compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011071532A Division JP2011132258A (ja) 2003-02-07 2011-03-29 改良放射性金属錯体組成物

Publications (2)

Publication Number Publication Date
JP2006528205A true JP2006528205A (ja) 2006-12-14
JP2006528205A5 JP2006528205A5 (enExample) 2007-03-29

Family

ID=32605351

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006525001A Pending JP2006528205A (ja) 2003-02-07 2004-02-09 改良放射性金属錯体組成物
JP2011071532A Pending JP2011132258A (ja) 2003-02-07 2011-03-29 改良放射性金属錯体組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011071532A Pending JP2011132258A (ja) 2003-02-07 2011-03-29 改良放射性金属錯体組成物

Country Status (16)

Country Link
US (1) US20070020177A1 (enExample)
EP (2) EP1444990A1 (enExample)
JP (2) JP2006528205A (enExample)
KR (1) KR20050103221A (enExample)
CN (1) CN100548387C (enExample)
AT (1) ATE487498T1 (enExample)
AU (1) AU2004210191B2 (enExample)
BR (1) BRPI0407056A (enExample)
CA (1) CA2514307A1 (enExample)
DE (1) DE602004029983D1 (enExample)
ES (1) ES2355100T3 (enExample)
MX (1) MXPA05008356A (enExample)
NO (1) NO20053754L (enExample)
RU (1) RU2005123799A (enExample)
WO (1) WO2004069285A1 (enExample)
ZA (1) ZA200506728B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011132258A (ja) * 2003-02-07 2011-07-07 Ge Healthcare Ltd 改良放射性金属錯体組成物

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8741261B2 (en) 2003-12-18 2014-06-03 Ge Healthcare Limited Methods for carbon isotope labeling synthesis by transition metal-promoted carbonylation via isocyanate using azides and carbon-isotope monoxide
WO2006134424A2 (en) * 2004-12-03 2006-12-21 Ge Healthcare Limited Method for the use of [11c] carbon monoxide in labeling synthesis of 11c-labelled acids by photo-induced free radical carbonylation
GB0428020D0 (en) 2004-12-22 2005-01-26 Amersham Health As Stabilisation of radiopharmaceutical precursors
WO2006082497A1 (en) * 2005-02-01 2006-08-10 Ge Healthcare Limited Method for the use of [11c] carbon monoxide in labeling synthesis of 11c-labelled compounds by thermally induced free radical carbonylation
US20060217537A1 (en) * 2005-03-22 2006-09-28 Bengt Langstrom Methods for carbon isotope labeling synthesis by transition metal-promoted carbonylation via ketene using diazo compounds and carbon-isotope monoxide
CA2610252A1 (en) * 2005-06-14 2006-12-21 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
WO2007026216A1 (en) * 2005-08-31 2007-03-08 Ge Healthcare Limited Method for the use of [11c] carbon monoxide in labeling synthesis of 11c-labelled ketones by photo-induced free radical carbonylation
EP2080526A4 (en) * 2006-11-09 2012-11-07 Nihon Mediphysics Co Ltd RADIOACTIVE DIAGNOSTIC IMAGING DAY
RU2366434C1 (ru) * 2007-12-07 2009-09-10 Институт неорганической химии им. А.В. Николаева Сибирского отделения Российской Академии наук Гексаядерные кластерные комплексы рения на основе радиоактивных изотопов, обладающие противоопухолевыми свойствами
GB0922023D0 (en) * 2009-12-17 2010-02-03 Ge Healthcare Ltd Preparation of n-monofluoroalkyl compounds
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
JP6244203B2 (ja) * 2010-07-27 2017-12-06 ジーイー・ヘルスケア・リミテッド 放射性医薬組成物
US9636413B2 (en) * 2012-11-15 2017-05-02 Endocyte, Inc. Conjugates for treating diseases caused by PSMA expressing cells
JP2016510342A (ja) * 2013-02-15 2016-04-07 トーマス・ジェファーソン・ユニバーシティＴｈｏｍａｓ Ｊｅｆｆｅｒｓｏｎ Ｕｎｉｖｅｒｓｉｔｙ 腫瘍画像化のためのキット
AU2014336638C1 (en) 2013-10-18 2020-09-17 Novartis Ag Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
EP4541378A3 (en) 2013-11-14 2025-07-30 Endocyte, Inc. Compounds for positron emission tomography
US20150375901A1 (en) * 2014-06-30 2015-12-31 Karen J. Orlich Reusable, eco-friendly container for storing and dispensing food and beverage
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging
RU2624237C1 (ru) * 2016-10-26 2017-07-03 Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный медицинский биофизический центр имени А.И. Бурназяна" Радиофармацевтическая композиция для радиосиновэктомии и способ ее получения
USD905136S1 (en) 2018-03-05 2020-12-15 Bliss Industries, Llc Hammermill hammer
US10610870B2 (en) 2017-08-21 2020-04-07 Bliss Industries, Llc Hot and cold forming hammer and method of assembly
US10207274B1 (en) 2017-08-21 2019-02-19 Roger Young Non-forged hammermill hammer
US10486160B2 (en) 2017-08-21 2019-11-26 Bliss Industries, Llc Method of replacing hammers and spacers
US10478824B2 (en) 2017-08-21 2019-11-19 Bliss Industries, Llc System and method for installing hammers
US12138630B2 (en) 2017-08-21 2024-11-12 Bliss Industries, Llc Hammermill hammer
USD840447S1 (en) 2017-12-06 2019-02-12 Roger Young Swing hammer
USD839934S1 (en) 2017-12-06 2019-02-05 Roger Young Swing hammer
USD861048S1 (en) 2017-12-06 2019-09-24 Roger Young Swing hammer
CN112368024A (zh) 2018-04-17 2021-02-12 恩多塞特公司 治疗癌症的方法
JP7604397B2 (ja) 2019-05-20 2024-12-23 エンドサイト・インコーポレイテッド Ｐｓｍａコンジュゲートの調製方法
WO2022156908A1 (en) * 2021-01-25 2022-07-28 Vrije Universiteit Brussel Method for preparing a lyophilized composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5513258A (en) * 1978-03-31 1980-01-30 Procter & Gamble Stable scanning agent for radioactive ray photograph
JPH11515029A (ja) * 1995-11-03 1999-12-21 プレジデント アンド フェローズ オブ ハーバード カレッジ ドーパミン輸送体造影剤
JP2002516612A (ja) * 1997-06-03 2002-06-04 コールター ファーマシューティカル，インコーポレイティド 放射性同位体によって標識されたペプチドのための放射線保護剤
WO2002053192A1 (en) * 2000-12-28 2002-07-11 Amersham Plc Stabilised radiopharmaceutical compositions

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US4364920A (en) * 1975-04-30 1982-12-21 Medi-Physics, Inc. Stable diagnostic reagents
US4497744A (en) * 1978-03-31 1985-02-05 Mallinckrodt, Inc. Gentisic acid salts as radiographic scanning agent stabilizers
EP0078642B1 (en) * 1981-10-30 1986-12-10 AMERSHAM INTERNATIONAL plc Radiopharmaceutical composition based on technetium-99m and reagent for making it
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
US7105678B2 (en) * 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
WO2001040239A2 (en) * 1999-12-03 2001-06-07 Yale University Transition metal-cyclopentadienyl-tropane conjugates
FR2833952B1 (fr) 2001-12-26 2004-03-26 Schering Ag Derive du tropane, produit de chelation comprenant ce derive de tropane et un metal ou un complexe de metal et radiopharmaceutique
EP1444990A1 (en) * 2003-02-07 2004-08-11 Amersham plc Improved Radiometal Complex Compositions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5513258A (en) * 1978-03-31 1980-01-30 Procter & Gamble Stable scanning agent for radioactive ray photograph
JPS61210042A (ja) * 1978-03-31 1986-09-18 マリンクロツト　インコーポレーテツド 安定な放射線写真用スキヤニング剤の調製用組成物
JPH11515029A (ja) * 1995-11-03 1999-12-21 プレジデント アンド フェローズ オブ ハーバード カレッジ ドーパミン輸送体造影剤
JP2002516612A (ja) * 1997-06-03 2002-06-04 コールター ファーマシューティカル，インコーポレイティド 放射性同位体によって標識されたペプチドのための放射線保護剤
WO2002053192A1 (en) * 2000-12-28 2002-07-11 Amersham Plc Stabilised radiopharmaceutical compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011132258A (ja) * 2003-02-07 2011-07-07 Ge Healthcare Ltd 改良放射性金属錯体組成物

Also Published As

Publication number Publication date
WO2004069285A1 (en) 2004-08-19
EP1444990A1 (en) 2004-08-11
CN100548387C (zh) 2009-10-14
ES2355100T3 (es) 2011-03-22
NO20053754L (no) 2005-10-05
AU2004210191A1 (en) 2004-08-19
MXPA05008356A (es) 2006-03-13
BRPI0407056A (pt) 2006-01-17
ATE487498T1 (de) 2010-11-15
NO20053754D0 (no) 2005-08-05
CA2514307A1 (en) 2004-08-19
ZA200506728B (en) 2006-10-25
AU2004210191B2 (en) 2007-08-23
DE602004029983D1 (de) 2010-12-23
RU2005123799A (ru) 2006-03-27
EP1590007A1 (en) 2005-11-02
KR20050103221A (ko) 2005-10-27
US20070020177A1 (en) 2007-01-25
JP2011132258A (ja) 2011-07-07
EP1590007B1 (en) 2010-11-10
CN1767859A (zh) 2006-05-03

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