CN100548387C - 改进的放射性金属配合物组合物 - Google Patents

改进的放射性金属配合物组合物 Download PDF

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Publication number
CN100548387C
CN100548387C CNB2004800091645A CN200480009164A CN100548387C CN 100548387 C CN100548387 C CN 100548387C CN B2004800091645 A CNB2004800091645 A CN B2004800091645A CN 200480009164 A CN200480009164 A CN 200480009164A CN 100548387 C CN100548387 C CN 100548387C
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CN
China
Prior art keywords
compositions
tropane
stabilisation
conjugate
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CNB2004800091645A
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English (en)
Chinese (zh)
Other versions
CN1767859A (zh
Inventor
D·麦吉尔
I·亨里克森
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication of CN1767859A publication Critical patent/CN1767859A/zh
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Publication of CN100548387C publication Critical patent/CN100548387C/zh
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Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB2004800091645A 2003-02-07 2004-02-09 改进的放射性金属配合物组合物 Expired - Lifetime CN100548387C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03002809.6 2003-02-07
EP03002809A EP1444990A1 (en) 2003-02-07 2003-02-07 Improved Radiometal Complex Compositions

Publications (2)

Publication Number Publication Date
CN1767859A CN1767859A (zh) 2006-05-03
CN100548387C true CN100548387C (zh) 2009-10-14

Family

ID=32605351

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800091645A Expired - Lifetime CN100548387C (zh) 2003-02-07 2004-02-09 改进的放射性金属配合物组合物

Country Status (16)

Country Link
US (1) US20070020177A1 (enExample)
EP (2) EP1444990A1 (enExample)
JP (2) JP2006528205A (enExample)
KR (1) KR20050103221A (enExample)
CN (1) CN100548387C (enExample)
AT (1) ATE487498T1 (enExample)
AU (1) AU2004210191B2 (enExample)
BR (1) BRPI0407056A (enExample)
CA (1) CA2514307A1 (enExample)
DE (1) DE602004029983D1 (enExample)
ES (1) ES2355100T3 (enExample)
MX (1) MXPA05008356A (enExample)
NO (1) NO20053754L (enExample)
RU (1) RU2005123799A (enExample)
WO (1) WO2004069285A1 (enExample)
ZA (1) ZA200506728B (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1444990A1 (en) * 2003-02-07 2004-08-11 Amersham plc Improved Radiometal Complex Compositions
US8741261B2 (en) * 2003-12-18 2014-06-03 Ge Healthcare Limited Methods for carbon isotope labeling synthesis by transition metal-promoted carbonylation via isocyanate using azides and carbon-isotope monoxide
EP1831133A2 (en) * 2004-12-03 2007-09-12 GE Healthcare UK Limited Method for the use of ý11c¨carbon monoxide in labeling synthesis of 11c-labelled acids by photo-induced free radical carbonylation
GB0428020D0 (en) 2004-12-22 2005-01-26 Amersham Health As Stabilisation of radiopharmaceutical precursors
US20060171882A1 (en) * 2005-02-01 2006-08-03 Bengt Langstrom Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled compounds by thermally induced free radical carbonylation
US20060217537A1 (en) * 2005-03-22 2006-09-28 Bengt Langstrom Methods for carbon isotope labeling synthesis by transition metal-promoted carbonylation via ketene using diazo compounds and carbon-isotope monoxide
KR20080022108A (ko) * 2005-06-14 2008-03-10 니혼 메디피직스 가부시키가이샤 방사성 화상 진단제
EP1934160B1 (en) * 2005-08-31 2014-07-23 GE Healthcare Limited Method for the use of [11c]carbon monoxide in labeling synthesis of 11c-labelled ketones by photo-induced free radical carbonylation
WO2008056481A1 (en) * 2006-11-09 2008-05-15 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
RU2366434C1 (ru) * 2007-12-07 2009-09-10 Институт неорганической химии им. А.В. Николаева Сибирского отделения Российской Академии наук Гексаядерные кластерные комплексы рения на основе радиоактивных изотопов, обладающие противоопухолевыми свойствами
GB0922023D0 (en) * 2009-12-17 2010-02-03 Ge Healthcare Ltd Preparation of n-monofluoroalkyl compounds
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
EP2598175B1 (en) * 2010-07-27 2020-05-20 Serac Healthcare Limited Radiopharmaceutical compositions
KR102575825B1 (ko) * 2012-11-15 2023-09-06 엔도사이트, 인코포레이티드 Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트
SG11201506407VA (en) * 2013-02-15 2015-09-29 Univ Jefferson Kit for tumor imaging
MY194484A (en) 2013-10-18 2022-11-30 Deutsches Krebsforsch Labeled Inhibitors of Prostate Specific Membrane Antigen (PSMA), Their use as Imaging Agents and Pharmaceutical Agents for the Treatment of Prostate Cancer
MX2016006219A (es) 2013-11-14 2016-10-28 Endocyte Inc Compuestos para tomografia por emision de positrones.
US20150375901A1 (en) * 2014-06-30 2015-12-31 Karen J. Orlich Reusable, eco-friendly container for storing and dispensing food and beverage
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging
RU2624237C1 (ru) * 2016-10-26 2017-07-03 Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный медицинский биофизический центр имени А.И. Бурназяна" Радиофармацевтическая композиция для радиосиновэктомии и способ ее получения
US10207274B1 (en) 2017-08-21 2019-02-19 Roger Young Non-forged hammermill hammer
USD905136S1 (en) 2018-03-05 2020-12-15 Bliss Industries, Llc Hammermill hammer
US12138630B2 (en) 2017-08-21 2024-11-12 Bliss Industries, Llc Hammermill hammer
US10486160B2 (en) 2017-08-21 2019-11-26 Bliss Industries, Llc Method of replacing hammers and spacers
US10478824B2 (en) 2017-08-21 2019-11-19 Bliss Industries, Llc System and method for installing hammers
US10610870B2 (en) 2017-08-21 2020-04-07 Bliss Industries, Llc Hot and cold forming hammer and method of assembly
USD861048S1 (en) 2017-12-06 2019-09-24 Roger Young Swing hammer
USD839934S1 (en) 2017-12-06 2019-02-05 Roger Young Swing hammer
USD840447S1 (en) 2017-12-06 2019-02-12 Roger Young Swing hammer
KR20210003135A (ko) 2018-04-17 2021-01-11 엔도사이트, 인코포레이티드 암의 치료 방법
WO2020236808A1 (en) 2019-05-20 2020-11-26 Endocyte, Inc. Methods for preparing psma conjugates
WO2022156908A1 (en) * 2021-01-25 2022-07-28 Vrije Universiteit Brussel Method for preparing a lyophilized composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1489330A (en) * 1975-04-30 1977-10-19 Hoffmann La Roche Stable diagnostic reagents
WO1997016210A1 (en) * 1995-11-03 1997-05-09 President And Fellows Of Harvard College Dopamine transporter imaging agent
WO1998055154A1 (en) * 1997-06-03 1998-12-10 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
WO2002053192A1 (en) * 2000-12-28 2002-07-11 Amersham Plc Stabilised radiopharmaceutical compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
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US4497744A (en) * 1978-03-31 1985-02-05 Mallinckrodt, Inc. Gentisic acid salts as radiographic scanning agent stabilizers
US4233284A (en) * 1978-03-31 1980-11-11 The Procter & Gamble Company Stabilized radiographic scanning agents
EP0078642B1 (en) * 1981-10-30 1986-12-10 AMERSHAM INTERNATIONAL plc Radiopharmaceutical composition based on technetium-99m and reagent for making it
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
US7105678B2 (en) * 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
EP1233968A2 (en) * 1999-12-03 2002-08-28 Yale University Transition metal-cyclopentadienyl-tropane conjugates
FR2833952B1 (fr) 2001-12-26 2004-03-26 Schering Ag Derive du tropane, produit de chelation comprenant ce derive de tropane et un metal ou un complexe de metal et radiopharmaceutique
EP1444990A1 (en) * 2003-02-07 2004-08-11 Amersham plc Improved Radiometal Complex Compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1489330A (en) * 1975-04-30 1977-10-19 Hoffmann La Roche Stable diagnostic reagents
WO1997016210A1 (en) * 1995-11-03 1997-05-09 President And Fellows Of Harvard College Dopamine transporter imaging agent
WO1998055154A1 (en) * 1997-06-03 1998-12-10 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
WO2002053192A1 (en) * 2000-12-28 2002-07-11 Amersham Plc Stabilised radiopharmaceutical compositions

Also Published As

Publication number Publication date
NO20053754D0 (no) 2005-08-05
DE602004029983D1 (de) 2010-12-23
NO20053754L (no) 2005-10-05
RU2005123799A (ru) 2006-03-27
EP1590007A1 (en) 2005-11-02
ES2355100T3 (es) 2011-03-22
KR20050103221A (ko) 2005-10-27
JP2011132258A (ja) 2011-07-07
MXPA05008356A (es) 2006-03-13
WO2004069285A1 (en) 2004-08-19
EP1444990A1 (en) 2004-08-11
EP1590007B1 (en) 2010-11-10
ZA200506728B (en) 2006-10-25
CN1767859A (zh) 2006-05-03
CA2514307A1 (en) 2004-08-19
JP2006528205A (ja) 2006-12-14
AU2004210191B2 (en) 2007-08-23
AU2004210191A1 (en) 2004-08-19
ATE487498T1 (de) 2010-11-15
US20070020177A1 (en) 2007-01-25
BRPI0407056A (pt) 2006-01-17

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Granted publication date: 20091014