ES2355100T3 - Composiciones mejoradas de complejos de radiometal. - Google Patents

Composiciones mejoradas de complejos de radiometal. Download PDF

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Publication number
ES2355100T3
ES2355100T3 ES04709267T ES04709267T ES2355100T3 ES 2355100 T3 ES2355100 T3 ES 2355100T3 ES 04709267 T ES04709267 T ES 04709267T ES 04709267 T ES04709267 T ES 04709267T ES 2355100 T3 ES2355100 T3 ES 2355100T3
Authority
ES
Spain
Prior art keywords
radioprotector
tropane
biocompatible
conjugate
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04709267T
Other languages
English (en)
Spanish (es)
Inventor
DavidAmersham plc MCGILL
Ingrid Henriksen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Application granted granted Critical
Publication of ES2355100T3 publication Critical patent/ES2355100T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0497Organic compounds conjugates with a carrier being an organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
ES04709267T 2003-02-07 2004-02-09 Composiciones mejoradas de complejos de radiometal. Expired - Lifetime ES2355100T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03002809 2003-02-07
EP03002809A EP1444990A1 (en) 2003-02-07 2003-02-07 Improved Radiometal Complex Compositions

Publications (1)

Publication Number Publication Date
ES2355100T3 true ES2355100T3 (es) 2011-03-22

Family

ID=32605351

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04709267T Expired - Lifetime ES2355100T3 (es) 2003-02-07 2004-02-09 Composiciones mejoradas de complejos de radiometal.

Country Status (16)

Country Link
US (1) US20070020177A1 (enExample)
EP (2) EP1444990A1 (enExample)
JP (2) JP2006528205A (enExample)
KR (1) KR20050103221A (enExample)
CN (1) CN100548387C (enExample)
AT (1) ATE487498T1 (enExample)
AU (1) AU2004210191B2 (enExample)
BR (1) BRPI0407056A (enExample)
CA (1) CA2514307A1 (enExample)
DE (1) DE602004029983D1 (enExample)
ES (1) ES2355100T3 (enExample)
MX (1) MXPA05008356A (enExample)
NO (1) NO20053754L (enExample)
RU (1) RU2005123799A (enExample)
WO (1) WO2004069285A1 (enExample)
ZA (1) ZA200506728B (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1444990A1 (en) * 2003-02-07 2004-08-11 Amersham plc Improved Radiometal Complex Compositions
US8741261B2 (en) 2003-12-18 2014-06-03 Ge Healthcare Limited Methods for carbon isotope labeling synthesis by transition metal-promoted carbonylation via isocyanate using azides and carbon-isotope monoxide
WO2006134424A2 (en) * 2004-12-03 2006-12-21 Ge Healthcare Limited Method for the use of [11c] carbon monoxide in labeling synthesis of 11c-labelled acids by photo-induced free radical carbonylation
GB0428020D0 (en) 2004-12-22 2005-01-26 Amersham Health As Stabilisation of radiopharmaceutical precursors
WO2006082497A1 (en) * 2005-02-01 2006-08-10 Ge Healthcare Limited Method for the use of [11c] carbon monoxide in labeling synthesis of 11c-labelled compounds by thermally induced free radical carbonylation
US20060217537A1 (en) * 2005-03-22 2006-09-28 Bengt Langstrom Methods for carbon isotope labeling synthesis by transition metal-promoted carbonylation via ketene using diazo compounds and carbon-isotope monoxide
WO2006134822A1 (ja) * 2005-06-14 2006-12-21 Nihon Medi-Physics Co., Ltd. 放射性画像診断剤
US8273861B2 (en) 2005-08-31 2012-09-25 Ge Healthcare Limited Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled ketones by photo-induced free radical carbonylation
EP2080526A4 (en) * 2006-11-09 2012-11-07 Nihon Mediphysics Co Ltd RADIOACTIVE DIAGNOSTIC IMAGING DAY
RU2366434C1 (ru) * 2007-12-07 2009-09-10 Институт неорганической химии им. А.В. Николаева Сибирского отделения Российской Академии наук Гексаядерные кластерные комплексы рения на основе радиоактивных изотопов, обладающие противоопухолевыми свойствами
GB0922023D0 (en) * 2009-12-17 2010-02-03 Ge Healthcare Ltd Preparation of n-monofluoroalkyl compounds
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
HUE050033T2 (hu) 2010-07-27 2020-11-30 Serac Healthcare Ltd Radioaktív gyógyszerkészítmények
KR102575825B1 (ko) * 2012-11-15 2023-09-06 엔도사이트, 인코포레이티드 Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트
WO2014126902A1 (en) * 2013-02-15 2014-08-21 Thomas Jefferson University Kit for tumor imaging
SG11201602249RA (en) 2013-10-18 2016-05-30 Deutsches Krebsforsch Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
EA035171B1 (ru) 2013-11-14 2020-05-08 Эндосайт, Инк. Конъюгаты на основе связывающихся с psma лигандов или ингибиторов psma для позитронно-эмиссионной томографии
US20150375901A1 (en) * 2014-06-30 2015-12-31 Karen J. Orlich Reusable, eco-friendly container for storing and dispensing food and beverage
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging
RU2624237C1 (ru) * 2016-10-26 2017-07-03 Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный медицинский биофизический центр имени А.И. Бурназяна" Радиофармацевтическая композиция для радиосиновэктомии и способ ее получения
US10610870B2 (en) 2017-08-21 2020-04-07 Bliss Industries, Llc Hot and cold forming hammer and method of assembly
US10486160B2 (en) 2017-08-21 2019-11-26 Bliss Industries, Llc Method of replacing hammers and spacers
US10207274B1 (en) 2017-08-21 2019-02-19 Roger Young Non-forged hammermill hammer
US12138630B2 (en) 2017-08-21 2024-11-12 Bliss Industries, Llc Hammermill hammer
USD905136S1 (en) 2018-03-05 2020-12-15 Bliss Industries, Llc Hammermill hammer
US10478824B2 (en) 2017-08-21 2019-11-19 Bliss Industries, Llc System and method for installing hammers
USD861048S1 (en) 2017-12-06 2019-09-24 Roger Young Swing hammer
USD839934S1 (en) 2017-12-06 2019-02-05 Roger Young Swing hammer
USD840447S1 (en) 2017-12-06 2019-02-12 Roger Young Swing hammer
BR112020020961A2 (pt) 2018-04-17 2021-01-19 Endocyte, Inc. Métodos de tratamento de câncer
CN120097929A (zh) 2019-05-20 2025-06-06 因多塞特股份有限公司 制备psma缀合物的方法
WO2022156908A1 (en) * 2021-01-25 2022-07-28 Vrije Universiteit Brussel Method for preparing a lyophilized composition

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364920A (en) * 1975-04-30 1982-12-21 Medi-Physics, Inc. Stable diagnostic reagents
US4497744A (en) * 1978-03-31 1985-02-05 Mallinckrodt, Inc. Gentisic acid salts as radiographic scanning agent stabilizers
US4233284A (en) * 1978-03-31 1980-11-11 The Procter & Gamble Company Stabilized radiographic scanning agents
DE78642T1 (de) * 1981-10-30 1983-10-27 Amersham International Plc, Amersham, Buckinghamshire Radiopharmazeutische zubereitung auf grund von technetium-99m und reagenz zur herstellung derselben.
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
US6171576B1 (en) 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
US7105678B2 (en) * 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
US5961955A (en) * 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
AU4308001A (en) * 1999-12-03 2001-06-12 Yale University Transition metal-cyclopentadienyl-tropane conjugates
GB0031592D0 (en) * 2000-12-28 2001-02-07 Nycomed Amersham Plc Stabilised radiopharmaceutical compositions
FR2833952B1 (fr) 2001-12-26 2004-03-26 Schering Ag Derive du tropane, produit de chelation comprenant ce derive de tropane et un metal ou un complexe de metal et radiopharmaceutique
EP1444990A1 (en) * 2003-02-07 2004-08-11 Amersham plc Improved Radiometal Complex Compositions

Also Published As

Publication number Publication date
KR20050103221A (ko) 2005-10-27
NO20053754L (no) 2005-10-05
WO2004069285A1 (en) 2004-08-19
ZA200506728B (en) 2006-10-25
AU2004210191B2 (en) 2007-08-23
JP2006528205A (ja) 2006-12-14
DE602004029983D1 (de) 2010-12-23
ATE487498T1 (de) 2010-11-15
MXPA05008356A (es) 2006-03-13
CN1767859A (zh) 2006-05-03
AU2004210191A1 (en) 2004-08-19
RU2005123799A (ru) 2006-03-27
EP1590007B1 (en) 2010-11-10
BRPI0407056A (pt) 2006-01-17
EP1590007A1 (en) 2005-11-02
JP2011132258A (ja) 2011-07-07
EP1444990A1 (en) 2004-08-11
CN100548387C (zh) 2009-10-14
CA2514307A1 (en) 2004-08-19
NO20053754D0 (no) 2005-08-05
US20070020177A1 (en) 2007-01-25

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