JP2016510342A - 腫瘍画像化のためのキット - Google Patents
腫瘍画像化のためのキット Download PDFInfo
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
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- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
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- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
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- A—HUMAN NECESSITIES
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Abstract
Description
本出願は、2013年2月15日付の米国仮出願第61/765,312号の優先権の利益を主張し、その内容はその全体が参照により本明細書に組み込まれる。
の構造を有する化合物を含む凍結乾燥組成物で構成される。
いくつかの態様において、キットは4℃で保存される。他の態様において、キットは−20℃で保存される。さらなる態様において、キットは、20〜250μgの当該化合物、50〜500μgのグルコヘプトナート、および任意に64Cu、68Ga、89Zrまたは99mTcを含む。当該キットを調製するための方法もまた提供される。
Cu−64−TP3805が、ヒト乳癌患者における原発腫瘍を画像化することができることが今示された。分析された20の腫瘍のうち、全ての病原が悪性であった。加えて、全身陽電子放出断層撮影(PET)/コンピューター制御断層撮影(CT)画像化において、4つはセンチネンタルリンパ節(1人の患者において2つ、他の2人の患者において1つずつ)に関与し、明確に線引きされた。この研究において、注目すべき他の2つの観察がなされた。第1は、Cu−64−TP3805の取り込みが速い、すなわち、注射後15分であった。したがって、68分の半寿命であり、発生器により生成されるGa−68も用いることができる。Ga−68の陽電子放出は、Cu−64のそれよりも4倍以上大きい88%である。これは、画像品質を損なうこと、また、被験者への放射線負荷をかなり低下させる、150MBq未満(〜4mCi)のGa−688の投与を可能にする。いずれの場合においても、画像は、患者の空腹または血糖レベルの監視を必要とせず、注射後15分で得ることができる。
の構造を有する画像化化合物の混合物から構成される組成物を含む。
TP3805合成およびキット調製。簡単に説明すると、ABI 341Aペプチド合成剤を用いて、Wang樹脂(Applied Biosystems, Foster City, CA)上に、C末端ジアミノジチオール(N2S2)キレート剤を有するPACAPアナログを合成した(Thakur (2009) supra; Thakur, et al. (2010) supra; Zhang, et al. (2008) supra; Anderson, et al. (2001) J. Nucl. Med. 42(2):213-221; Lewis, et al. (2001) Proc. Natl. Acad. Sci. 98(3):1206-1211)。まずFmoc−Lys(ivDde)をペプチドのC末端に、次いで4−アミノ酪酸(γ−Aba)を導入した。そして27アミノ酸長のPACAP配列を、t−Bocで保護されたHis(Trt)誘導体である最終的なヒスチジル残基との標準的なFmocカップリングによって構築した。キャップングt−Boc機能は、C末端リジンのγアミノ基に実行される後続の脱保護およびカップリングサイクルの間に、N末端アミノ基が保護されたままであることを確実にするために必要であった。そして、C末端のivDde基は、2%ヒドラジンで選択的に除去され、ジ−Fmoc−L−ジアミノプロピオン酸、およびS−ベンゾイルチオグリコール酸の連続添加が続く。結果として得られる保護されたジアミンジチオール(NS−ベンゾイル)2−含有PACAPペプチドを、トリフルオロ酢酸(TFA)水:フェノール:チオアニソール/エタン(82.5:5:5:5:2.5)を用いて樹脂から切断し、ジエチルエーテルで沈殿させた。
Cu−64−TP3805、放射化学的純度および滅菌状態。全てのCu−64−TP3805調製物に関して、放射化学的純度をHPLCによって判断し、97±2%が平均であった。さらなる放射化学精製は行わなかった。調製物の比活性は、平均44.4GBq(1.2Ci)/μmolであった。全ての調製物は滅菌であった。シリンジおよび静脈ラインに残存する全放射能は、5.5MBq(150μCi)未満であった。
試薬。脱酸素および滅菌H2Oを、400ml−脱イオン化H2Oを500mlビーカーに入れ、0.2−ミクロンろ過した窒素で5分間フラッシュすることにより調製した。水を続けて清潔な滅菌500mlガラスボトルに移し、封をして、オートクレーブにかけた。水を室温まで冷却し、4℃で保存した。
無菌操作を用いて、200μlの滅菌、発熱物質を含まない、デオキシ水(防腐剤を含まない)を64Cu溶液に注入した。溶液を混合し、ペプチドを含有するバイアルに移した。バイアルを振盪し、粉体の完全な溶解を確実にした。そして溶液を50℃90分間インキュベートし、続けて、使用前に室温に放置した。特定の態様において溶液は室温から90℃の範囲の温度でインキュベートすることができる。
Claims (12)
- グルコヘプトナート、グリシン緩衝液、およびHis−Ser−Asp−Gly−Ile−Phe−Thr−Asp−Ser−Tyr−Ser−Arg−Tyr−Arg−Lys−Gln−Met−Ala−Val−Lys−Lys−Tyr−Leu−Ala−Ala−Val−Leu−γAba−Lys(R) (配列番号:1)、ここで、Rはリジン残基のγアミノ基に結合されたキレート剤であり、前記キレート剤は
- キットが4℃で保存される、請求項1に記載のキット。
- キットが−20℃で保存される、請求項1に記載のキット。
- キットが20μg〜250μgの化合物を含む、請求項1に記載のキット。
- キットが50〜500μgのグルコヘプトナートを含む、請求項1に記載のキット。
- 64Cu、68Ga、89Zrまたは99mTcをさらに含む、請求項1に記載のキット。
- 腫瘍画像化のためのキットを調製する方法であって、
(a)容器内において、グルコヘプトナート、グリシン緩衝液およびHis−Ser−Asp−Gly−Ile−Phe−Thr−Asp−Ser−Tyr−Ser−Arg−Tyr−Arg−Lys−Gln−Met−Ala−Val−Lys−Lys−Tyr−Leu−Ala−Ala−Val−Leu−γAba−Lys(R)(配列番号:1)、ここで、Rはリジン残基のγアミノ基に結合されたキレート剤であり、前記キレート剤は
(b) (a)の組み合わせを凍結すること、
(c) 凍結した組み合わせを凍結乾燥すること、
(d) 容器に滅菌窒素ガスを導入すること、
(e) 容器に封をすること、
を含む、前記方法。 - 容器を4℃で保管する、請求項7に記載の方法。
- 容器を−20℃で保管する、請求項7に記載の方法。
- (a)の組み合わせが、20μg〜250μgの化合物を含む、請求項7に記載の方法。
- 容器が50〜500μgのグルコヘプトナートを含む、請求項7に記載の方法。
- His−Ser−Asp−Gly−Ile−Phe−Thr−Asp−Ser−Tyr−Ser−Arg−Tyr−Arg−Lys−Gln−Met−Ala−Val−Lys−Lys−Tyr−Leu−Ala−Ala−Val−Leu−γAba−Lys(R) (配列番号:1)、ここで、Rはリジン残基のγアミノ基に結合されたキレート剤であり、前記キレート剤は、
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WO2016086036A2 (en) | 2014-11-25 | 2016-06-02 | Bristol-Myers Squibb Company | Methods and compositions for 18f-radiolabeling of biologics |
US10729600B2 (en) | 2015-06-30 | 2020-08-04 | The Procter & Gamble Company | Absorbent structure |
EP3463486A1 (en) | 2016-06-01 | 2019-04-10 | Bristol-Myers Squibb Company | Pet imaging with pd-l1 binding polypeptides |
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Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04505022A (ja) * | 1989-12-29 | 1992-09-03 | ネオークス コポレイション | 診断または治療に使用する放射性同位元素で標識した蛋白質 |
JP2002510500A (ja) * | 1998-04-03 | 2002-04-09 | ミレニアム ファーマシューティカルズ インク. | 神経精神障害を診断および治療するための方法および組成物 |
JP2002516612A (ja) * | 1997-06-03 | 2002-06-04 | コールター ファーマシューティカル,インコーポレイティド | 放射性同位体によって標識されたペプチドのための放射線保護剤 |
JP2003534013A (ja) * | 2000-05-24 | 2003-11-18 | シェーリング コーポレイション | 哺乳動物レセプタータンパク質;関連試薬および方法 |
JP2004529884A (ja) * | 2001-02-26 | 2004-09-30 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | 金属放射性医薬のためのアスコルビン酸類似体 |
JP2005514335A (ja) * | 2001-10-19 | 2005-05-19 | トマス ジェファソン ユニバーシティ | 腫瘍イメージング及び治療のためのpacap組成物及び方法 |
JP2007515924A (ja) * | 2003-12-15 | 2007-06-21 | アウレリウム バイオファーマ インク. | ビメンチン指向性診断法、および、多剤耐性を示す腫瘍性疾患の治療法 |
JP2010099076A (ja) * | 1997-08-01 | 2010-05-06 | Schering Corp | 哺乳動物細胞膜タンパク質;関連試薬 |
JP2011132258A (ja) * | 2003-02-07 | 2011-07-07 | Ge Healthcare Ltd | 改良放射性金属錯体組成物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5985240A (en) * | 1989-08-09 | 1999-11-16 | Rhomed Incorporated | Peptide radiopharmaceutical applications |
AU3826899A (en) * | 1998-07-20 | 2000-02-14 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Peptide analogues of pacap |
GB0116815D0 (en) * | 2001-07-10 | 2001-08-29 | Nycomed Amersham Plc | Improved chelator conjugates |
CN101293103A (zh) * | 2008-06-02 | 2008-10-29 | 北京师范大学 | 99mTc标记冻干品药盒及其制备方法 |
CN101422623B (zh) * | 2008-12-05 | 2010-10-13 | 北京协核吉成科技有限公司 | 一种99mTc-Trodat-1标记冻干品药盒及其制备方法 |
-
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Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04505022A (ja) * | 1989-12-29 | 1992-09-03 | ネオークス コポレイション | 診断または治療に使用する放射性同位元素で標識した蛋白質 |
JP2002516612A (ja) * | 1997-06-03 | 2002-06-04 | コールター ファーマシューティカル,インコーポレイティド | 放射性同位体によって標識されたペプチドのための放射線保護剤 |
JP2010099076A (ja) * | 1997-08-01 | 2010-05-06 | Schering Corp | 哺乳動物細胞膜タンパク質;関連試薬 |
JP2002510500A (ja) * | 1998-04-03 | 2002-04-09 | ミレニアム ファーマシューティカルズ インク. | 神経精神障害を診断および治療するための方法および組成物 |
JP2003534013A (ja) * | 2000-05-24 | 2003-11-18 | シェーリング コーポレイション | 哺乳動物レセプタータンパク質;関連試薬および方法 |
JP2004529884A (ja) * | 2001-02-26 | 2004-09-30 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | 金属放射性医薬のためのアスコルビン酸類似体 |
JP2005514335A (ja) * | 2001-10-19 | 2005-05-19 | トマス ジェファソン ユニバーシティ | 腫瘍イメージング及び治療のためのpacap組成物及び方法 |
JP2011132258A (ja) * | 2003-02-07 | 2011-07-07 | Ge Healthcare Ltd | 改良放射性金属錯体組成物 |
JP2007515924A (ja) * | 2003-12-15 | 2007-06-21 | アウレリウム バイオファーマ インク. | ビメンチン指向性診断法、および、多剤耐性を示す腫瘍性疾患の治療法 |
Non-Patent Citations (8)
Title |
---|
BIOCONJUGATE CHEMISTRY, vol. 13, JPN6016033413, 2002, pages 679 - 684, ISSN: 0003389777 * |
BIOCONJUGATE CHEMISTRY, vol. 22, JPN6016033406, 2011, pages 1650 - 1662, ISSN: 0003389779 * |
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, JPN6016033404, 2010, pages 7338 - 7347, ISSN: 0003389778 * |
INORGANIC CHEMISTRY, vol. 20, no. 6, JPN6016033415, 1981, pages 1629 - 1632, ISSN: 0003389781 * |
PET IMAGING OF ONCOGENE OVEREXPRESSION, vol. 45, no. 8, JPN6016033411, 2004, pages 1381 - 1389, ISSN: 0003389776 * |
PLOS ONE, vol. Vol.6, Issue 12, JPN6016033408, 2011, pages 1 - 7, ISSN: 0003389780 * |
REGULATORY PEPTIDES, vol. 144, JPN6016033409, 2007, pages 91 - 100, ISSN: 0003389775 * |
THE JOURNAL OF NUCLEAR MEDICINE, vol. 51, no. 1, JPN6016033402, 2010, pages 106 - 111, ISSN: 0003389774 * |
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SG11201506407VA (en) | 2015-09-29 |
WO2014126902A1 (en) | 2014-08-21 |
CA2901231C (en) | 2020-06-23 |
AU2014216515A1 (en) | 2015-10-08 |
KR20150140650A (ko) | 2015-12-16 |
EP2956157A1 (en) | 2015-12-23 |
CA2901231A1 (en) | 2014-08-21 |
EP2956157A4 (en) | 2017-03-01 |
CN105377287A (zh) | 2016-03-02 |
US20150374861A1 (en) | 2015-12-31 |
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