JP2006526643A5 - - Google Patents
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- Publication number
- JP2006526643A5 JP2006526643A5 JP2006515004A JP2006515004A JP2006526643A5 JP 2006526643 A5 JP2006526643 A5 JP 2006526643A5 JP 2006515004 A JP2006515004 A JP 2006515004A JP 2006515004 A JP2006515004 A JP 2006515004A JP 2006526643 A5 JP2006526643 A5 JP 2006526643A5
- Authority
- JP
- Japan
- Prior art keywords
- molecular weight
- ferric
- complex
- group
- sucrose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 20
- -1 iron saccharide Chemical class 0.000 claims 13
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 12
- 229910052742 iron Inorganic materials 0.000 claims 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 235000000346 sugar Nutrition 0.000 claims 7
- 229930006000 Sucrose Natural products 0.000 claims 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000005720 sucrose Substances 0.000 claims 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 4
- 238000001035 drying Methods 0.000 claims 4
- 239000011541 reaction mixture Substances 0.000 claims 4
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims 3
- 229960004887 ferric hydroxide Drugs 0.000 claims 3
- RUTXIHLAWFEWGM-UHFFFAOYSA-H iron(3+) sulfate Chemical compound [Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O RUTXIHLAWFEWGM-UHFFFAOYSA-H 0.000 claims 3
- IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 claims 3
- 229910000360 iron(III) sulfate Inorganic materials 0.000 claims 3
- 239000000176 sodium gluconate Substances 0.000 claims 3
- 229940005574 sodium gluconate Drugs 0.000 claims 3
- 235000012207 sodium gluconate Nutrition 0.000 claims 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims 2
- 229910021578 Iron(III) chloride Inorganic materials 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000002585 base Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000000502 dialysis Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims 2
- VCJMYUPGQJHHFU-UHFFFAOYSA-N iron(3+);trinitrate Chemical compound [Fe+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O VCJMYUPGQJHHFU-UHFFFAOYSA-N 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical class OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims 1
- CIWBSHSKHKDKBQ-DUZGATOHSA-N D-isoascorbic acid Chemical class OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- GZCGUPFRVQAUEE-VANKVMQKSA-N aldehydo-L-glucose Chemical group OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)C=O GZCGUPFRVQAUEE-VANKVMQKSA-N 0.000 claims 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims 1
- 150000008041 alkali metal carbonates Chemical class 0.000 claims 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 239000012431 aqueous reaction media Substances 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 235000010350 erythorbic acid Nutrition 0.000 claims 1
- 229960002413 ferric citrate Drugs 0.000 claims 1
- 229910001447 ferric ion Inorganic materials 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 239000000174 gluconic acid Substances 0.000 claims 1
- 235000012208 gluconic acid Nutrition 0.000 claims 1
- 150000002303 glucose derivatives Chemical class 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- PVFSDGKDKFSOTB-UHFFFAOYSA-K iron(3+);triacetate Chemical compound [Fe+3].CC([O-])=O.CC([O-])=O.CC([O-])=O PVFSDGKDKFSOTB-UHFFFAOYSA-K 0.000 claims 1
- YPJCVYYCWSFGRM-UHFFFAOYSA-H iron(3+);tricarbonate Chemical compound [Fe+3].[Fe+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O YPJCVYYCWSFGRM-UHFFFAOYSA-H 0.000 claims 1
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 claims 1
- 229940026239 isoascorbic acid Drugs 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229940062350 sodium ferric gluconate complex Drugs 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 230000003068 static effect Effects 0.000 claims 1
- 150000003445 sucroses Chemical class 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47465203P | 2003-05-30 | 2003-05-30 | |
| US60/474,652 | 2003-05-30 | ||
| PCT/US2004/016866 WO2005000210A2 (en) | 2003-05-30 | 2004-05-28 | Synthesis of high molecular weight iron-saccharidic complexes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011244615A Division JP2012082199A (ja) | 2003-05-30 | 2011-11-08 | 高分子量鉄サッカリド複合体の合成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006526643A JP2006526643A (ja) | 2006-11-24 |
| JP2006526643A5 true JP2006526643A5 (enExample) | 2007-07-12 |
| JP4945240B2 JP4945240B2 (ja) | 2012-06-06 |
Family
ID=33551502
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006515004A Expired - Fee Related JP4945240B2 (ja) | 2003-05-30 | 2004-05-28 | 高分子量鉄サッカリド複合体の合成 |
| JP2011244615A Pending JP2012082199A (ja) | 2003-05-30 | 2011-11-08 | 高分子量鉄サッカリド複合体の合成 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011244615A Pending JP2012082199A (ja) | 2003-05-30 | 2011-11-08 | 高分子量鉄サッカリド複合体の合成 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7964568B2 (enExample) |
| EP (1) | EP1628986B1 (enExample) |
| JP (2) | JP4945240B2 (enExample) |
| CN (1) | CN1798754A (enExample) |
| AU (1) | AU2004251625B2 (enExample) |
| BR (1) | BRPI0410830A (enExample) |
| CA (1) | CA2526771C (enExample) |
| IL (1) | IL172225A (enExample) |
| WO (1) | WO2005000210A2 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6929954B2 (en) | 2000-11-02 | 2005-08-16 | Chromaceutical Advanced Technologies, Inc. | Method for producing purified hematinic iron-saccharidic complex and product produced |
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| US7662294B1 (en) | 2004-02-02 | 2010-02-16 | Cox Jr Henry Wilmore | Method for reducing organic contamination |
| WO2005094203A2 (en) | 2004-03-16 | 2005-10-13 | Navinta, Llc | Sodium ferric gluconate complexes and method of manufacture thereof |
| EP1733058B8 (en) * | 2004-03-16 | 2012-10-24 | Navinta LLC | Iron sucrose complexes and method of manufacture thereof |
| EP1756130A1 (de) * | 2004-05-17 | 2007-02-28 | Cilag AG | Verfahren zur herstellung von eisen (iii) gluconatkomlex |
| WO2005116046A1 (de) * | 2004-05-24 | 2005-12-08 | Cilag Ag | Verfahren zur herstellung von eisensaccharosekomplex |
| US8030480B2 (en) | 2004-12-06 | 2011-10-04 | Emcure Pharmaceuticals Limited | Cost-effective process for preparation of manufacture of iron sucrose |
| GB0428020D0 (en) * | 2004-12-22 | 2005-01-26 | Amersham Health As | Stabilisation of radiopharmaceutical precursors |
| CN100528237C (zh) | 2005-04-26 | 2009-08-19 | 重庆医药工业研究院有限责任公司 | 多核的氢氧化铁-糖复合物的制备方法 |
| US7776842B2 (en) * | 2005-08-23 | 2010-08-17 | Albion Laboratories, Inc. | Amino sugar chelates |
| CN1895260B (zh) * | 2006-06-23 | 2011-01-12 | 杭州平和安康医药科技有限公司 | 蔗糖铁无菌粉针及制备方法 |
| US8609926B1 (en) | 2006-11-21 | 2013-12-17 | Henry Wilmore Cox, Jr. | Methods for managing sulfide in wastewater systems |
| US20080132465A1 (en) * | 2006-12-05 | 2008-06-05 | Vincent Windisch | Apparatus and method for isolating iron components from serum |
| EP1947120A1 (de) * | 2007-01-19 | 2008-07-23 | Vifor (International) Ag | Eisen-Kohlenhydrat-Komplex-Verbindungen |
| BRPI0807212B1 (pt) | 2007-02-06 | 2022-01-11 | United Kingdom Research And Innovation | Processos para produzir um material sólido de íon metálico de poli oxo-hidróxi modificado por ligante, composições para uso em terapia que compreende o material sólido de íon metálico de poli oxohidróxi modificado por ligante e uso das composições e uso de uma composição compreendendo um material sólido de íon metálico de poli oxo-hidróxi modificado por ligante |
| EP1997833A1 (de) * | 2007-05-29 | 2008-12-03 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydratderivat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| WO2009078037A2 (en) * | 2007-12-17 | 2009-06-25 | Gland Pharma Limited | Novel process for the preparation of iron sucrose complex |
| EP2296998A1 (en) * | 2008-05-23 | 2011-03-23 | Hospira, Inc. | Packaged iron sucrose products |
| BRPI0823117B8 (pt) * | 2008-09-29 | 2021-06-22 | Vifor Int Ag | receptáculo e método para armazenar e suprir um líquido e uma preparação médica líquida |
| MX2011009936A (es) * | 2009-03-25 | 2011-10-06 | Pharmacosmos Holding As | Un compuesto de oligosacarido de hierro estable. |
| WO2010111132A2 (en) | 2009-03-27 | 2010-09-30 | Bend Research, Inc. | Spray-drying process |
| KR101141410B1 (ko) * | 2009-10-23 | 2012-05-04 | 국립암센터 | 광감각제 - 금속나노입자 전하 복합체 및 이를 함유하는 광역학 치료 또는 진단을 위한 조성물 |
| US8536106B2 (en) | 2010-04-14 | 2013-09-17 | Ecolab Usa Inc. | Ferric hydroxycarboxylate as a builder |
| IT1405688B1 (it) * | 2010-06-09 | 2014-01-24 | Biofer Spa | Nuovi complessi a basso peso molecolare tra ferro ed acido maltobionico, uso di questi per la somministrazione intramuscolare o sottocutanea nella terapia di stati anemici, e nuove composizioni farmaceutiche adatte a questi usi. |
| EP2611529B1 (en) | 2010-09-03 | 2019-01-23 | Bend Research, Inc. | Spray-drying method |
| PT2611530T (pt) | 2010-09-03 | 2019-05-09 | Bend Res Inc | Aparelho de secagem por pulverização e métodos de utilização do mesmo |
| EP2618924A1 (en) | 2010-09-24 | 2013-07-31 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
| CN102451185A (zh) * | 2010-10-19 | 2012-05-16 | 长春纳米生技公司 | 金属离子纳米簇组合物 |
| CA2849926C (en) | 2011-10-13 | 2020-07-21 | Vidasym, Inc. | Iron-fiber composition, preparation and uses thereof |
| CN103059072B (zh) * | 2013-01-18 | 2015-08-26 | 常州工程职业技术学院 | 一种绿色环保的蔗糖铁原料药的制备方法 |
| CN109497565B (zh) | 2013-03-08 | 2021-10-26 | 上海礼邦医药科技有限公司 | 金属离子-功能性纤维组分络合物组合物、其制备及用途 |
| US9370202B2 (en) * | 2013-03-15 | 2016-06-21 | LG Bionano, LLC | Encapsulated metal ion nanoclusters |
| CN104177505B (zh) * | 2013-05-24 | 2016-10-19 | 重庆圣华曦药业股份有限公司 | 一种分离和纯化多糖铁复合物的方法 |
| KR102465025B1 (ko) * | 2013-07-18 | 2022-11-09 | 맨카인드 코포레이션 | 열-안정성 건조 분말 약제학적 조성물 및 방법 |
| EP3212169B1 (en) | 2014-10-31 | 2021-01-13 | Bend Research, Inc. | Process for forming active domains dispersed in a matrix |
| CN104892782A (zh) * | 2015-05-05 | 2015-09-09 | 农业部规划设计研究院 | 低聚糖醛酸钙及其制备方法和在植物营养剂中的应用 |
| EP3302504A4 (en) * | 2015-05-29 | 2019-01-23 | Sun Pharmaceutical Industries Limited | IRON SUCROSE COMPOSITION AND PROCESS FOR PREPARING THE SAME |
| GB201517893D0 (en) | 2015-10-09 | 2015-11-25 | Medical Res Council | Methods for producing carboxylate ligand modified ferric iron hydroxide colloids |
| WO2018198135A1 (en) * | 2017-04-26 | 2018-11-01 | Mylan Laboratories Ltd. | Improved process for the preparation of iron complex |
| CN108498539A (zh) * | 2018-05-03 | 2018-09-07 | 东营天东制药有限公司 | 一种水溶性铁剂复合体原料药的制备方法 |
| US12331066B2 (en) | 2019-02-12 | 2025-06-17 | Biophore India Pharmaceuticals Pvt. Ltd | Process for the preparation of sucroferric oxyhydroxide |
| CN113004429B (zh) * | 2019-12-20 | 2023-02-03 | 金陵药业股份有限公司 | 一种羧基麦芽糖铁的精制方法 |
| WO2023028252A1 (en) | 2021-08-27 | 2023-03-02 | American Regent, Inc. | Iron compositions and methods of making and using them |
| CN114249844B (zh) * | 2021-10-13 | 2022-11-18 | 重庆医药高等专科学校 | 一种分子量可控的多聚糖铁及其制备方法 |
| CA3280511A1 (en) | 2024-07-18 | 2026-03-01 | Malian Biologicals Gmbh | Iron supplementation in affective disorders and/or post-traumatic stress disorder (ptsd) and/or serotonin-dependent diseases and iron supplementation in neurodevelopmental or psychiatric disorder |
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| US2885393A (en) * | 1956-02-24 | 1959-05-05 | R K Laros Company | Dextran-iron complex and process for making same |
| GB879441A (en) | 1959-05-25 | 1961-10-11 | Crookes Lab Ltd | Improved injectable iron preparations |
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| IT1251702B (it) * | 1991-10-16 | 1995-05-19 | Mediolanum Farmaceutici Srl | Complessi del ferro con la conalbumina e i suoi derivati |
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| EP1330226A4 (en) * | 2000-11-02 | 2005-11-23 | Chromaceutical Advanced Tech | METHOD FOR PRODUCING A CLEANED HEMATIN IRON SACCHARIDE COMPLEX AND PRODUCT MANUFACTURED |
| PE20021017A1 (es) * | 2001-04-03 | 2002-11-24 | Pharmacia Corp | Composicion parenteral reconstituible |
| US6693211B2 (en) | 2002-05-15 | 2004-02-17 | Geneva Pharmaceuticals, Inc. | Chemical process |
-
2004
- 2004-05-26 US US10/853,951 patent/US7964568B2/en not_active Expired - Fee Related
- 2004-05-28 WO PCT/US2004/016866 patent/WO2005000210A2/en not_active Ceased
- 2004-05-28 AU AU2004251625A patent/AU2004251625B2/en not_active Ceased
- 2004-05-28 CA CA2526771A patent/CA2526771C/en not_active Expired - Fee Related
- 2004-05-28 CN CNA2004800149881A patent/CN1798754A/zh active Pending
- 2004-05-28 EP EP04776157.2A patent/EP1628986B1/en not_active Expired - Lifetime
- 2004-05-28 BR BRPI0410830-2A patent/BRPI0410830A/pt not_active IP Right Cessation
- 2004-05-28 JP JP2006515004A patent/JP4945240B2/ja not_active Expired - Fee Related
-
2005
- 2005-11-28 IL IL172225A patent/IL172225A/en not_active IP Right Cessation
-
2011
- 2011-05-16 US US13/108,392 patent/US8691776B2/en not_active Expired - Fee Related
- 2011-11-08 JP JP2011244615A patent/JP2012082199A/ja active Pending
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