JP2006523722A5 - - Google Patents
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- Publication number
- JP2006523722A5 JP2006523722A5 JP2006513115A JP2006513115A JP2006523722A5 JP 2006523722 A5 JP2006523722 A5 JP 2006523722A5 JP 2006513115 A JP2006513115 A JP 2006513115A JP 2006513115 A JP2006513115 A JP 2006513115A JP 2006523722 A5 JP2006523722 A5 JP 2006523722A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally
- optionally substituted
- substituted
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 298
- 125000001424 substituent group Chemical group 0.000 claims 127
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 61
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 31
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 28
- 125000001475 halogen functional group Chemical group 0.000 claims 19
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 14
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 13
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 9
- 125000002883 imidazolyl group Chemical group 0.000 claims 8
- 125000003226 pyrazolyl group Chemical group 0.000 claims 7
- 125000000168 pyrrolyl group Chemical group 0.000 claims 7
- -1 In some cases Chemical compound 0.000 claims 6
- 125000001041 indolyl group Chemical group 0.000 claims 6
- KPPVNWGJXFMGAM-UUILKARUSA-N (e)-2-methyl-1-(6-methyl-3,4-dihydro-2h-quinolin-1-yl)but-2-en-1-one Chemical compound CC1=CC=C2N(C(=O)C(/C)=C/C)CCCC2=C1 KPPVNWGJXFMGAM-UUILKARUSA-N 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 5
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000003394 haemopoietic effect Effects 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 125000005640 glucopyranosyl group Chemical group 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000026037 malignant tumor of neck Diseases 0.000 claims 1
- LOTBYPQQWICYBB-UHFFFAOYSA-N methyl n-hexyl-n-[2-(hexylamino)ethyl]carbamate Chemical compound CCCCCCNCCN(C(=O)OC)CCCCCC LOTBYPQQWICYBB-UHFFFAOYSA-N 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 201000001514 prostate carcinoma Diseases 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000001635 urinary tract Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46347903P | 2003-04-17 | 2003-04-17 | |
| US48405303P | 2003-06-30 | 2003-06-30 | |
| PCT/US2004/011990 WO2004094376A1 (en) | 2003-04-17 | 2004-04-16 | Hydroxamic acids useful in the treatment of hyper-proliferative disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006523722A JP2006523722A (ja) | 2006-10-19 |
| JP2006523722A5 true JP2006523722A5 (enExample) | 2007-06-07 |
Family
ID=33313443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006513115A Pending JP2006523722A (ja) | 2003-04-17 | 2004-04-16 | 過剰増殖性障害の処置に有用なヒドロキサム酸 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20060063760A1 (enExample) |
| EP (1) | EP1620397A1 (enExample) |
| JP (1) | JP2006523722A (enExample) |
| KR (1) | KR20060004943A (enExample) |
| AR (1) | AR043850A1 (enExample) |
| AU (1) | AU2004232987A1 (enExample) |
| BR (1) | BRPI0409586A (enExample) |
| CA (1) | CA2522565A1 (enExample) |
| CL (1) | CL2004000810A1 (enExample) |
| CO (1) | CO5630022A2 (enExample) |
| EC (1) | ECSP056174A (enExample) |
| MA (1) | MA27834A1 (enExample) |
| MX (1) | MXPA05010800A (enExample) |
| NO (1) | NO20055399L (enExample) |
| PE (1) | PE20050139A1 (enExample) |
| RU (1) | RU2005135486A (enExample) |
| TW (1) | TW200508196A (enExample) |
| WO (1) | WO2004094376A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1937650T3 (da) * | 2005-09-08 | 2011-10-03 | S Bio Pte Ltd | Heterocykliske forbindelser |
| JP2007077085A (ja) * | 2005-09-15 | 2007-03-29 | Univ Of Tokyo | Ｈｄａｃ阻害活性を有する新規置換ヒドロキサム酸誘導体 |
| CN101417967A (zh) * | 2007-10-26 | 2009-04-29 | 浙江海正药业股份有限公司 | 组蛋白去乙酰酶抑制剂、其组合物及其应用 |
| KR20140144696A (ko) * | 2012-04-16 | 2014-12-19 | 도아 에이요 가부시키가이샤 | ２환성 화합물 |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| GB201905721D0 (en) | 2019-04-24 | 2019-06-05 | Univ Dundee | Compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0301861B1 (en) * | 1987-07-29 | 1992-04-01 | Takeda Chemical Industries, Ltd. | Cell proliferation inhibitors |
| US5929097A (en) * | 1996-10-16 | 1999-07-27 | American Cyanamid Company | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| JPH10182583A (ja) * | 1996-12-25 | 1998-07-07 | Mitsui Chem Inc | 新規ヒドロキサム酸誘導体 |
| AU2207001A (en) * | 1999-12-24 | 2001-07-09 | Smithkline Beecham Plc | Novel compounds and process |
| NZ544689A (en) * | 2001-11-06 | 2007-08-31 | Novartis Ag | Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination |
| AU2003219595A1 (en) * | 2002-04-11 | 2003-10-27 | In2Gen Co., Ltd. | Alpha,Beta-UNSATURATED HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS |
| WO2004012663A2 (en) * | 2002-08-01 | 2004-02-12 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme |
-
2004
- 2004-04-12 AR ARP040101216A patent/AR043850A1/es unknown
- 2004-04-15 CL CL200400810A patent/CL2004000810A1/es unknown
- 2004-04-16 TW TW093110582A patent/TW200508196A/zh unknown
- 2004-04-16 CA CA002522565A patent/CA2522565A1/en not_active Abandoned
- 2004-04-16 EP EP04759991A patent/EP1620397A1/en not_active Withdrawn
- 2004-04-16 AU AU2004232987A patent/AU2004232987A1/en not_active Abandoned
- 2004-04-16 KR KR1020057019640A patent/KR20060004943A/ko not_active Withdrawn
- 2004-04-16 MX MXPA05010800A patent/MXPA05010800A/es unknown
- 2004-04-16 US US10/554,390 patent/US20060063760A1/en not_active Abandoned
- 2004-04-16 BR BRPI0409586-3A patent/BRPI0409586A/pt not_active IP Right Cessation
- 2004-04-16 PE PE2004000380A patent/PE20050139A1/es not_active Application Discontinuation
- 2004-04-16 JP JP2006513115A patent/JP2006523722A/ja active Pending
- 2004-04-16 RU RU2005135486/04A patent/RU2005135486A/ru not_active Application Discontinuation
- 2004-04-16 WO PCT/US2004/011990 patent/WO2004094376A1/en not_active Ceased
-
2005
- 2005-10-28 MA MA28573A patent/MA27834A1/fr unknown
- 2005-11-10 CO CO05114719A patent/CO5630022A2/es not_active Application Discontinuation
- 2005-11-15 NO NO20055399A patent/NO20055399L/no not_active Application Discontinuation
- 2005-11-17 EC EC2005006174A patent/ECSP056174A/es unknown
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