JP2010528994A5 - - Google Patents
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- Publication number
- JP2010528994A5 JP2010528994A5 JP2010509700A JP2010509700A JP2010528994A5 JP 2010528994 A5 JP2010528994 A5 JP 2010528994A5 JP 2010509700 A JP2010509700 A JP 2010509700A JP 2010509700 A JP2010509700 A JP 2010509700A JP 2010528994 A5 JP2010528994 A5 JP 2010528994A5
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- JP
- Japan
- Prior art keywords
- het
- atoms
- group
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims description 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 210000003128 head Anatomy 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- -1 1,3-dihydrobenzimidazolyl Chemical group 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000002152 alkylating effect Effects 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 238000004517 catalytic hydrocracking Methods 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001070 dihydroindolyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000004324 lymphatic system Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007025717.3 | 2007-06-01 | ||
| DE102007025717A DE102007025717A1 (de) | 2007-06-01 | 2007-06-01 | Arylether-pyridazinonderivate |
| PCT/EP2008/003549 WO2008145242A1 (de) | 2007-06-01 | 2008-05-02 | Arylether-pyridazinonderivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010528994A JP2010528994A (ja) | 2010-08-26 |
| JP2010528994A5 true JP2010528994A5 (enExample) | 2011-06-23 |
| JP5385262B2 JP5385262B2 (ja) | 2014-01-08 |
Family
ID=39669858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509700A Expired - Fee Related JP5385262B2 (ja) | 2007-06-01 | 2008-05-02 | アリールエーテルピリダジノン誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8445489B2 (enExample) |
| EP (1) | EP2152370B1 (enExample) |
| JP (1) | JP5385262B2 (enExample) |
| KR (1) | KR20100027182A (enExample) |
| CN (1) | CN101678214B (enExample) |
| AR (1) | AR066769A1 (enExample) |
| AT (1) | ATE515289T1 (enExample) |
| AU (1) | AU2008255327B2 (enExample) |
| BR (1) | BRPI0812295A2 (enExample) |
| CA (1) | CA2688517C (enExample) |
| DE (1) | DE102007025717A1 (enExample) |
| DK (1) | DK2152370T3 (enExample) |
| EA (1) | EA200901603A1 (enExample) |
| ES (1) | ES2367152T3 (enExample) |
| IL (1) | IL202373A (enExample) |
| MX (1) | MX2009012709A (enExample) |
| PL (1) | PL2152370T3 (enExample) |
| PT (1) | PT2152370E (enExample) |
| WO (1) | WO2008145242A1 (enExample) |
| ZA (1) | ZA200909055B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ574873A (en) * | 2006-07-25 | 2012-03-30 | Cephalon Inc | Pyridazinone derivatives as h3 inhibitors |
| DE102008062826A1 (de) * | 2008-12-23 | 2010-07-01 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102009003954A1 (de) * | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Pyridazinonderivate |
| WO2012003338A1 (en) | 2010-07-01 | 2012-01-05 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| US8703953B2 (en) * | 2012-03-09 | 2014-04-22 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| EP2858982A4 (en) | 2012-06-12 | 2015-11-11 | Abbvie Inc | PYRIDINONE AND PYRIDAZINONE DERIVATIVES |
| EP2922543B1 (en) * | 2012-11-20 | 2017-05-24 | Merck Sharp & Dohme Corp. | Substituted pyridone derivatives as pde10 inhibitors |
| ES2634627T3 (es) * | 2013-02-07 | 2017-09-28 | Merck Patent Gmbh | Derivados de amidas piridazinona |
| WO2014159776A1 (en) * | 2013-03-14 | 2014-10-02 | Cephalon, Inc. | Solid state forms of 6-[4-[3-(r)-2-methylpyrrolidine-1-yl)-propoxy]phenyl]2h-pyridazine-3-one hydrochloride |
| EP3229836B1 (en) | 2014-12-09 | 2019-11-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Human monoclonal antibodies against axl |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| US10208024B2 (en) | 2015-10-23 | 2019-02-19 | Array Biopharma Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases |
| WO2018081381A1 (en) * | 2016-10-26 | 2018-05-03 | Proteostasis Therapeutics, Inc | Pyridazine derivatives, compositions and methods for modulating cftr |
| AU2019374812B2 (en) * | 2018-11-06 | 2025-03-06 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| EP3877376B1 (en) | 2018-11-06 | 2023-08-23 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| CA3118908A1 (en) | 2018-11-06 | 2020-05-14 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| EP3898615A1 (en) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
| CN113490666A (zh) | 2018-12-19 | 2021-10-08 | 奥瑞生物药品公司 | 作为fgfr酪氨酸激酶的抑制剂的取代的吡唑并[1,5-a]吡啶化合物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5795964A (en) | 1980-12-04 | 1982-06-15 | Morishita Seiyaku Kk | Preparation of 2-substituted-3(2h)-pyridazinone derivative |
| US4397854A (en) | 1981-05-14 | 1983-08-09 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| CN1038249C (zh) * | 1991-08-28 | 1998-05-06 | 罗姆和哈斯公司 | 含有二氢哒嗪酮及其相关化合物的杀菌组合物 |
| IL115889A0 (en) | 1994-11-14 | 1996-01-31 | Rohm & Haas | Pyridazinones and their use as fungicides |
| US5635494A (en) | 1995-04-21 | 1997-06-03 | Rohm And Haas Company | Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| BR9707495A (pt) | 1996-02-13 | 1999-07-27 | Zeneca Ltd | Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente |
| JP4464466B2 (ja) | 1996-03-05 | 2010-05-19 | アストラゼネカ・ユーケイ・リミテッド | ４―アニリノキナゾリン誘導体 |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| KR100626605B1 (ko) | 1997-11-19 | 2006-09-22 | 코와 가부시키가이샤 | 신규 피리다진 유도체 및 이를 유효성분으로 하는 의약 |
| TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
| EP1124804B1 (en) * | 1998-10-27 | 2005-08-24 | Abbott Laboratories | Prostaglandin endoperoxide h synthase biosynthesis inhibitors |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| IL152682A0 (en) | 2000-05-31 | 2003-06-24 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| JP2004502766A (ja) | 2000-07-07 | 2004-01-29 | アンギオジェン・ファーマシューティカルズ・リミテッド | 血管損傷剤としてのコルヒノール誘導体 |
| CA2410562A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
| EP1463509A1 (en) | 2001-10-31 | 2004-10-06 | MERCK PATENT GmbH | Type 4 phosphodiesterase inhibitors and uses thereof |
| DE10349587A1 (de) | 2003-10-24 | 2005-05-25 | Merck Patent Gmbh | Benzimidazolylderivate |
| DE102005057924A1 (de) * | 2005-12-05 | 2007-06-06 | Merck Patent Gmbh | Pyridazinonderivate |
| NZ574873A (en) * | 2006-07-25 | 2012-03-30 | Cephalon Inc | Pyridazinone derivatives as h3 inhibitors |
| DE102006037478A1 (de) | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | 2-(Heterocyclylbenzyl)-pyridazinonderivate |
-
2007
- 2007-06-01 DE DE102007025717A patent/DE102007025717A1/de not_active Withdrawn
-
2008
- 2008-05-02 WO PCT/EP2008/003549 patent/WO2008145242A1/de not_active Ceased
- 2008-05-02 PL PL08749296T patent/PL2152370T3/pl unknown
- 2008-05-02 EA EA200901603A patent/EA200901603A1/ru unknown
- 2008-05-02 AU AU2008255327A patent/AU2008255327B2/en not_active Ceased
- 2008-05-02 US US12/602,284 patent/US8445489B2/en not_active Expired - Fee Related
- 2008-05-02 ES ES08749296T patent/ES2367152T3/es active Active
- 2008-05-02 CN CN200880018485XA patent/CN101678214B/zh not_active Expired - Fee Related
- 2008-05-02 MX MX2009012709A patent/MX2009012709A/es active IP Right Grant
- 2008-05-02 JP JP2010509700A patent/JP5385262B2/ja not_active Expired - Fee Related
- 2008-05-02 AT AT08749296T patent/ATE515289T1/de active
- 2008-05-02 KR KR1020097027511A patent/KR20100027182A/ko not_active Withdrawn
- 2008-05-02 PT PT08749296T patent/PT2152370E/pt unknown
- 2008-05-02 CA CA2688517A patent/CA2688517C/en active Active
- 2008-05-02 EP EP08749296A patent/EP2152370B1/de not_active Not-in-force
- 2008-05-02 BR BRPI0812295-4A2A patent/BRPI0812295A2/pt not_active IP Right Cessation
- 2008-05-02 DK DK08749296.3T patent/DK2152370T3/da active
- 2008-05-30 AR ARP080102270A patent/AR066769A1/es unknown
-
2009
- 2009-11-26 IL IL202373A patent/IL202373A/en active IP Right Grant
- 2009-12-18 ZA ZA200909055A patent/ZA200909055B/xx unknown
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