JP2022544656A5 - - Google Patents

Info

Publication number
JP2022544656A5
JP2022544656A5 JP2022508853A JP2022508853A JP2022544656A5 JP 2022544656 A5 JP2022544656 A5 JP 2022544656A5 JP 2022508853 A JP2022508853 A JP 2022508853A JP 2022508853 A JP2022508853 A JP 2022508853A JP 2022544656 A5 JP2022544656 A5 JP 2022544656A5
Authority
JP
Japan
Prior art keywords
alkyl
optionally substituted
cancer
alkenyl
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022508853A
Other languages
English (en)
Japanese (ja)
Other versions
JP7649289B2 (ja
JP2022544656A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/046425 external-priority patent/WO2021030711A1/en
Publication of JP2022544656A publication Critical patent/JP2022544656A/ja
Publication of JP2022544656A5 publication Critical patent/JP2022544656A5/ja
Priority to JP2025036468A priority Critical patent/JP7807589B2/ja
Application granted granted Critical
Publication of JP7649289B2 publication Critical patent/JP7649289B2/ja
Priority to JP2026005252A priority patent/JP2026063185A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022508853A 2019-08-15 2020-08-14 アルキニルキナゾリン化合物 Active JP7649289B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2025036468A JP7807589B2 (ja) 2019-08-15 2025-03-07 アルキニルキナゾリン化合物
JP2026005252A JP2026063185A (ja) 2019-08-15 2026-01-15 アルキニルキナゾリン化合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962887392P 2019-08-15 2019-08-15
US62/887,392 2019-08-15
US202063065028P 2020-08-13 2020-08-13
US63/065,028 2020-08-13
PCT/US2020/046425 WO2021030711A1 (en) 2019-08-15 2020-08-14 Alkynyl quinazoline compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025036468A Division JP7807589B2 (ja) 2019-08-15 2025-03-07 アルキニルキナゾリン化合物

Publications (3)

Publication Number Publication Date
JP2022544656A JP2022544656A (ja) 2022-10-20
JP2022544656A5 true JP2022544656A5 (enExample) 2023-08-22
JP7649289B2 JP7649289B2 (ja) 2025-03-19

Family

ID=72291115

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2022508853A Active JP7649289B2 (ja) 2019-08-15 2020-08-14 アルキニルキナゾリン化合物
JP2025036468A Active JP7807589B2 (ja) 2019-08-15 2025-03-07 アルキニルキナゾリン化合物
JP2026005252A Pending JP2026063185A (ja) 2019-08-15 2026-01-15 アルキニルキナゾリン化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2025036468A Active JP7807589B2 (ja) 2019-08-15 2025-03-07 アルキニルキナゾリン化合物
JP2026005252A Pending JP2026063185A (ja) 2019-08-15 2026-01-15 アルキニルキナゾリン化合物

Country Status (13)

Country Link
US (2) US12435046B2 (enExample)
EP (2) EP4013749B1 (enExample)
JP (3) JP7649289B2 (enExample)
KR (2) KR20260013506A (enExample)
CN (3) CN114787150A (enExample)
AU (2) AU2020328598B2 (enExample)
BR (1) BR112022002518A2 (enExample)
CA (1) CA3150701A1 (enExample)
DK (1) DK4013749T3 (enExample)
FI (1) FI4013749T3 (enExample)
IL (1) IL290561A (enExample)
MX (2) MX2022001952A (enExample)
WO (1) WO2021030711A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020328598B2 (en) 2019-08-15 2026-07-02 Black Diamond Therapeutics, Inc. Alkynyl quinazoline compounds
KR102887500B1 (ko) * 2020-08-10 2025-11-17 아비스코 테라퓨틱스 컴퍼니 리미티드 Egfr 억제제 및 이의 제조방법 및 응용
MX2023004998A (es) * 2020-11-02 2023-05-12 Black Diamond Therapeutics Inc Metodo para tratar canceres con derivados de quinazolina sustituida con alquino.
CN116710096A (zh) * 2020-11-02 2023-09-05 黑钻治疗公司 用炔取代的喹唑啉衍生物治疗癌症的方法
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
WO2023049168A1 (en) * 2021-09-21 2023-03-30 Black Diamond Therapeutics, Inc. Polymorphs as erbb inhibitors
WO2025038731A1 (en) * 2023-08-15 2025-02-20 Black Diamond Therapeutics, Inc. Method of treating cancers with alkyne substituted quinazoline derivatives
AU2024345242A1 (en) * 2023-09-22 2026-04-09 Hanmi Pharm. Co. Ltd. Novel skeletal derivative effective for her2 mutation, and pharmaceutical composition comprising same
WO2025128831A1 (en) * 2023-12-13 2025-06-19 Black Diamond Therapeutics, Inc. Combinations comprising alkyne substituted quinazoline derivatives and their use in the treatment of cancer
WO2025137285A1 (en) * 2023-12-20 2025-06-26 Black Diamond Therapeutics, Inc. Alkyne substituted quinazoline derivatives and uses thereof
CN122580302A (zh) * 2023-12-21 2026-08-14 黑钻治疗公司 Erbb抑制剂的固体形式
WO2025137421A1 (en) * 2023-12-21 2025-06-26 Black Diamond Therapeutics, Inc. Compositions comprising alkyne substituted quinazoline derivatives and related uses
CN118084767B (zh) * 2024-04-02 2025-06-17 康龙化成手性医药技术(宁波)有限公司 一种外型-6-氟甲基-3-氮杂双环[3,1,0]己烷盐酸盐及其衍生物的合成方法
CN118724779B (zh) * 2024-06-05 2025-09-23 浙江瑞博制药有限公司 一种醛基化合物的制备方法
WO2026064728A1 (en) * 2024-09-23 2026-03-26 Black Diamond Therapeutics, Inc. Method of treating cancers with alkyne substituted quinazoline derivatives

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041077B2 (ja) 1976-09-06 1985-09-13 喜徳 喜谷 1,2‐ジアミノシクロヘキサン異性体のシス白金(2)錯体
US4261989A (en) 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
US5266573A (en) 1989-08-07 1993-11-30 Elf Sanofi Trifluoromethylphenyltetrahydropyridines for the treatment and/or prophylaxis of intestinal motility disorders
EP0647450A1 (en) 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Improved prodrugs for enzyme mediated activation
ATE446955T1 (de) 1995-03-30 2009-11-15 Pfizer Prod Inc Chinazolinone derivate
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
CN100503580C (zh) 1996-04-12 2009-06-24 沃尼尔·朗伯公司 酪氨酸激酶的不可逆抑制剂
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
TW436485B (en) 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
JP3270834B2 (ja) 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
UA71945C2 (en) 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
EE05345B1 (et) 1999-02-10 2010-10-15 Astrazeneca Ab Kinasoliini derivaadid angiogeneesi inhibiitoritena
NZ516633A (en) 1999-06-21 2004-09-24 Boehringer Ingelheim Pharma Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds
DE50111799D1 (de) 2000-04-08 2007-02-15 Boehringer Ingelheim Pharma Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
DE10042061A1 (de) 2000-08-26 2002-03-07 Boehringer Ingelheim Pharma Bicyclische Heterocyclen,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
KR100600550B1 (ko) 2000-10-20 2006-07-13 에자이 가부시키가이샤 질소 함유 방향환 유도체
DE10063435A1 (de) 2000-12-20 2002-07-04 Boehringer Ingelheim Pharma Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
JP4285996B2 (ja) * 2001-02-21 2009-06-24 田辺三菱製薬株式会社 キナゾリン誘導体
ES2263743T3 (es) 2001-04-13 2006-12-16 Pfizer Products Inc. Derivados de 4-aminopiridopirimidina sustituidos con un grupo biciclico.
DE60223279T2 (de) 2001-11-30 2008-05-29 Osi Pharmaceuticals, Inc. Verfahren für die herstellung substituierter bicyclischer derivate zur behandlung von anomalem zellwachstum
EP1478648B1 (en) 2002-02-01 2014-04-30 ARIAD Pharmaceuticals, Inc. Phosphorus-containing compounds and uses thereof
RU2312861C2 (ru) 2002-03-05 2007-12-20 Мерк Фросст Кэнада Лтд. Ингибиторы катепсин-цистеинпротеазы
DE10217689A1 (de) 2002-04-19 2003-11-13 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung
TWI275390B (en) 2002-04-30 2007-03-11 Wyeth Corp Process for the preparation of 7-substituted-3- quinolinecarbonitriles
PE20040945A1 (es) 2003-02-05 2004-12-14 Warner Lambert Co Preparacion de quinazolinas substituidas
US7399865B2 (en) 2003-09-15 2008-07-15 Wyeth Protein tyrosine kinase enzyme inhibitors
BRPI0414488A (pt) 2003-09-16 2006-11-14 Astrazeneca Ab derivado de quinazolina, composição farmacêutica, uso de um derivado de quinazolina, métodos para produzir um efeito anti - proliferativo em um animal de sangue quente, para prevenção ou tratamento de tumores em um aminal de sangue quente, para fornecer um efeito inibidor da tirosina quinase de egfr seletivo em um animal de sangue quente e para tratar um cáncer em um animal de sangue quente e, processo para a preparação de um derivado de quinazolina
HRP20110958T1 (hr) 2004-05-06 2012-01-31 Warner-Lambert Company Llc 4-fenilaminokinazolin-6-ilamidi
JPWO2006025490A1 (ja) * 2004-09-01 2008-05-08 田辺三菱製薬株式会社 分子シャペロン機能調節剤
WO2006028958A2 (en) 2004-09-02 2006-03-16 Genentech, Inc. Pyridyl inhibitors of hedgehog signalling
NZ556673A (en) 2005-02-03 2010-03-26 Gen Hospital Corp Method for treating gefitinib and/or erlotinib resistant cancer with an EGFR inhibitor
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
PE20070207A1 (es) 2005-07-22 2007-03-09 Genentech Inc Tratamiento combinado de los tumores que expresan el her
WO2007055513A1 (en) 2005-11-08 2007-05-18 Hanmi Pharm. Co., Ltd. Quinazoline derivatives as a signal transduction inhibitor and method for the preparation thereof
KR100832593B1 (ko) 2005-11-08 2008-05-27 한미약품 주식회사 신호전달 저해제로서의 퀴나졸린 유도체 및 이의 제조방법
KR20080015594A (ko) 2006-08-16 2008-02-20 주식회사종근당 포스포디에스테라제 저해제로서 유용한 퀴나졸린 유도체 및그 제조방법
CA2662617C (en) 2006-09-11 2014-11-18 Changgeng Qian Quinazoline based egfr inhibitors containing a zinc binding moiety
TWI377944B (en) 2007-06-05 2012-12-01 Hanmi Holdings Co Ltd Novel amide derivative for inhibiting the growth of cancer cells
WO2008157500A1 (en) 2007-06-17 2008-12-24 Kalypsys, Inc. Aminoquinazoline cannabinoid receptor modulators for treatment of disease
BRPI0816769A2 (pt) 2007-09-12 2016-11-29 Hoffmann La Roche combinações de compostos inibidores de fosfoinositida 3-cinase e agentes quimioterapêuticos, e métodos de uso
WO2009055730A1 (en) 2007-10-25 2009-04-30 Genentech, Inc. Process for making thienopyrimidine compounds
US8168784B2 (en) 2008-06-20 2012-05-01 Abbott Laboratories Processes to make apoptosis promoters
US9006252B2 (en) 2008-09-26 2015-04-14 National Health Research Institutes Fused multicyclic compounds as protein kinase inhibitors
CA2804190A1 (en) 2009-07-02 2011-01-06 Newgen Therapeutics, Inc. Phosphorus containing quinazoline compounds and methods of use
US8735409B2 (en) 2009-12-21 2014-05-27 Qiang Zhang Quinazoline derivatives
CN102382106A (zh) 2010-08-30 2012-03-21 黄振华 苯胺取代的喹唑啉衍生物
CN102382065B (zh) 2010-08-30 2014-05-28 山东轩竹医药科技有限公司 苯胺取代的喹唑啉衍生物
CN102452989B (zh) 2010-10-19 2014-10-22 山东轩竹医药科技有限公司 苯胺取代的喹唑啉衍生物
EP2680850B1 (en) * 2011-03-04 2018-05-23 Newgen Therapeutics, Inc. Alkyne substituted quinazoline compound and methods of use
CN102731485B (zh) 2011-04-02 2016-06-15 齐鲁制药有限公司 4-(取代苯氨基)喹唑啉衍生物及其制备方法、药物组合物和用途
CN102918029B (zh) 2011-05-17 2015-06-17 江苏康缘药业股份有限公司 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
TWI577693B (zh) 2011-05-31 2017-04-11 江蘇康緣藥業股份有限公司 聚(adp-核糖)聚合酶之三環抑制劑
CA2841932A1 (en) 2011-07-13 2013-01-17 Novartis Ag 4 - piperidinyl compounds for use as tankyrase inhibitors
CN102898386B (zh) 2011-07-27 2015-07-29 上海医药集团股份有限公司 喹唑啉衍生物、其制备方法、中间体、组合物及其应用
CN102516232A (zh) 2011-12-14 2012-06-27 无锡美克赛医药科技有限公司 一种ErbB2的小分子选择性抑制剂及其应用
CN103987700B (zh) 2012-03-09 2016-08-31 江苏豪森药业集团有限公司 4-喹唑啉胺类衍生物及其用途
WO2013173254A1 (en) 2012-05-14 2013-11-21 Dawei Zhang Bicyclic compounds as kinases inhibitors
CA2876689C (en) * 2012-06-13 2022-04-26 Incyte Corporation Substituted tricyclic compounds as fgfr inhibitors
CN102942561A (zh) 2012-11-06 2013-02-27 深圳海王药业有限公司 4-氨基喹唑啉杂环化合物及其用途
CN103965120B (zh) 2013-01-25 2016-08-17 上海医药集团股份有限公司 喹啉及喹唑啉衍生物、制备方法、中间体、组合物及应用
CN104119350B (zh) 2013-04-28 2017-04-12 广东东阳光药业有限公司 氨基喹唑啉类衍生物及其盐和使用方法
CN104513229A (zh) 2013-09-28 2015-04-15 正大天晴药业集团股份有限公司 喹唑啉衍生物及其制备方法
MX380928B (es) 2013-10-10 2025-03-12 Araxes Pharma Llc Inhibidores de kras g12c.
EP2947460A1 (en) 2014-05-22 2015-11-25 Medizinische Universität Wien Personalized therapy of inflammation-associated cancer using methods of assessing the susceptibility of a subject to the treatment with EGFR inhibitors/antagonists
WO2016023217A1 (zh) 2014-08-15 2016-02-18 安润医药科技(苏州)有限公司 喹唑啉衍生物、其制备方法、药物组合物和应用
WO2016055982A1 (en) 2014-10-10 2016-04-14 Acerta Pharma B.V. Quinoline and quinazoline compounds
HRP20230305T1 (hr) 2014-12-24 2023-05-26 Principia Biopharma Inc. Pripravci za ileo-jejunalnu dostavu lijeka
WO2016203406A1 (en) 2015-06-19 2016-12-22 Novartis Ag Compounds and compositions for inhibiting the activity of shp2
US9890187B2 (en) 2015-06-26 2018-02-13 Epos-Iasis Research And Development, Ltd. Prototype systems of theranostic biomarkers for in vivo molecular management of cancer
GB201517216D0 (en) 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
WO2017112777A1 (en) 2015-12-22 2017-06-29 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
CN105348271A (zh) 2015-12-23 2016-02-24 常州润诺生物科技有限公司 喹唑啉类衍生物药用用途及其制备方法
EP3856349A1 (en) 2018-09-25 2021-08-04 Black Diamond Therapeutics, Inc. Tyrosine kinase inhibitor compositions, methods of making and methods of use
WO2020068867A1 (en) 2018-09-25 2020-04-02 Black Diamond Therapeutics, Inc. Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use
CN109265449B (zh) 2018-11-07 2021-11-23 沈阳工业大学 Egfr和her2双靶点酪氨酸激酶抑制剂及制备方法和用途
WO2020139748A1 (en) 2018-12-28 2020-07-02 Cedars-Sinai Medical Center Methods of treating inflammatory bowel diseases that target ripk2
AU2020328598B2 (en) 2019-08-15 2026-07-02 Black Diamond Therapeutics, Inc. Alkynyl quinazoline compounds
EP4097083A1 (en) 2020-01-29 2022-12-07 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and methods of using same
WO2021195206A1 (en) 2020-03-24 2021-09-30 Black Diamond Therapeutics, Inc. Polymorphic forms and related uses
US11608343B2 (en) 2020-04-24 2023-03-21 Boehringer Ingelheim International Gmbh Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors
WO2022040377A1 (en) 2020-08-20 2022-02-24 Black Diamond Therapeutics, Inc. Methods for preparing quinazoline derivatives
WO2022076671A1 (en) 2020-10-08 2022-04-14 Black Diamond Therapeutics, Inc. Method of treating cancers using quinazoline derivatives
MX2023004998A (es) 2020-11-02 2023-05-12 Black Diamond Therapeutics Inc Metodo para tratar canceres con derivados de quinazolina sustituida con alquino.
WO2023049168A1 (en) 2021-09-21 2023-03-30 Black Diamond Therapeutics, Inc. Polymorphs as erbb inhibitors
WO2025038731A1 (en) 2023-08-15 2025-02-20 Black Diamond Therapeutics, Inc. Method of treating cancers with alkyne substituted quinazoline derivatives

Similar Documents

Publication Publication Date Title
TWI855000B (zh) Sting促效化合物
JP2021526133A5 (enExample)
JP2019525962A (ja) ケモカイン受容体調節剤及びそれの使用
US11433036B2 (en) Oxprenolol compositions for treating cancer
JP2022071077A5 (enExample)
ES2877712T3 (es) Terapias combinadas para su uso en el tratamiento del cáncer de mama
JP2011509309A5 (enExample)
EP3703755B1 (en) Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from bcl2 inhibitors, bcl2/bclxl inhibitors, and bclxl inhibitors for use in the treatment of cancer
JP2011507896A5 (enExample)
CN1531435A (zh) 抑制血管生成的方法
JP2006501201A5 (enExample)
JP2015503596A5 (enExample)
JP2024525740A5 (enExample)
JP2012522841A5 (enExample)
JP2004523478A5 (enExample)
JP2014518544A5 (enExample)
JP2025528115A (ja) 腫瘍治療のための、放射線治療と組み合わせたピペラジン化合物の使用
RU2435587C2 (ru) Средство, потенцирующее радиационную терапию
JP2009503110A5 (enExample)
US20240325382A1 (en) Compositions and methods for treating anemia associated with a ribosomal disorder
EP2902028A1 (en) Drug composition for treating tumors and application thereof
CN113527693B (zh) 一种侧链可修饰的聚缩硫酮及其类似物的制备方法和医药新用途
JPH05504345A (ja) 新規ジヒドロピリジン
RU2013110377A (ru) Новые производные 6,7-двузамещенного изохинолина и их применение
CN111278465A (zh) mIDH1抑制剂和DNA低甲基化剂(HMA)的组合