JP2006522775A - 置換された４−フェニル−４−’１ｈ−イミダゾール−２−イル！−ピペリジン誘導体および抗抑鬱および不安緩解活性を有する選択性非ペプチドデルタオピオイドアゴニストとしてのそれらの使用 - Google Patents
置換された４−フェニル−４−’１ｈ−イミダゾール−２−イル！−ピペリジン誘導体および抗抑鬱および不安緩解活性を有する選択性非ペプチドデルタオピオイドアゴニストとしてのそれらの使用 Download PDFInfo
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- JP2006522775A JP2006522775A JP2006505540A JP2006505540A JP2006522775A JP 2006522775 A JP2006522775 A JP 2006522775A JP 2006505540 A JP2006505540 A JP 2006505540A JP 2006505540 A JP2006505540 A JP 2006505540A JP 2006522775 A JP2006522775 A JP 2006522775A
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- Prior art keywords
- het
- alkyl
- group
- phenyl
- imidazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0303879 | 2003-04-11 | ||
| PCT/EP2004/050492 WO2004089372A1 (en) | 2003-04-11 | 2004-04-08 | Substituted 4-phenyl-4-`1h-imidazol-2-yl !-piperidine derivatives and their use as selective non-peptide delta opioid agonists with antidepressant and anxiolytic activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006522775A true JP2006522775A (ja) | 2006-10-05 |
| JP2006522775A5 JP2006522775A5 (enExample) | 2007-06-07 |
Family
ID=33154992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006505540A Withdrawn JP2006522775A (ja) | 2003-04-11 | 2004-04-08 | 置換された４−フェニル−４−’１ｈ−イミダゾール−２−イル！−ピペリジン誘導体および抗抑鬱および不安緩解活性を有する選択性非ペプチドデルタオピオイドアゴニストとしてのそれらの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20060287345A1 (enExample) |
| EP (1) | EP1615644B1 (enExample) |
| JP (1) | JP2006522775A (enExample) |
| AR (1) | AR044010A1 (enExample) |
| AT (1) | ATE353649T1 (enExample) |
| AU (1) | AU2004228960A1 (enExample) |
| CA (1) | CA2521186A1 (enExample) |
| CL (1) | CL2004000754A1 (enExample) |
| DE (1) | DE602004004771T2 (enExample) |
| ES (1) | ES2282858T3 (enExample) |
| TW (1) | TW200509913A (enExample) |
| WO (1) | WO2004089372A1 (enExample) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011030565A (ja) * | 2009-07-06 | 2011-02-17 | Yokohama City Univ | 社会的隔離モデル動物 |
| JP2016519161A (ja) * | 2013-05-24 | 2016-06-30 | アルカームス ファーマ アイルランド リミテッド | モルファン及びモルフィナン類似物及び使用の方法 |
| KR20180002616A (ko) | 2015-03-17 | 2018-01-08 | 고쿠리쯔 다이가쿠 호징 츠쿠바 다이가쿠 | 모르피난 유도체 |
| WO2018030382A1 (ja) | 2016-08-09 | 2018-02-15 | 国立大学法人 筑波大学 | モルヒナン誘導体 |
| WO2018052114A1 (ja) | 2016-09-16 | 2018-03-22 | 国立大学法人 筑波大学 | モルヒナン誘導体のオピオイドδ受容体アゴニスト関連疾患の治療のための使用 |
| WO2021100878A1 (ja) | 2019-11-22 | 2021-05-27 | 学校法人北里研究所 | ピラゾロモルヒナン誘導体 |
| JP2021523102A (ja) * | 2018-05-01 | 2021-09-02 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | スピロピペリジン系ニコチン性アセチルコリン受容体アロステリック調節剤 |
| KR20230152039A (ko) | 2021-02-26 | 2023-11-02 | 갓코호우징 도쿄리카다이가쿠 | 스트레스 관련 장애의 치료 또는 예방용 의약 조성물 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1390848B1 (it) | 2008-07-31 | 2011-10-19 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| EP2149370A1 (en) | 2008-07-31 | 2010-02-03 | Neuroscienze Pharmaness S.C. A R.L. | Diazabicyclic compounds and microemulsions thereof |
| IT1396951B1 (it) | 2009-12-18 | 2012-12-20 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5354863A (en) * | 1992-01-21 | 1994-10-11 | G. D. Searle & Co. | Opioid agonist compounds |
| DE19805370A1 (de) * | 1997-03-14 | 1998-09-17 | Gruenenthal Gmbh | Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen |
| HN1999000149A (es) * | 1998-09-09 | 2000-01-12 | Pfizer Prod Inc | Derivados de 4,4-biarilpiperidina |
| EP1038872A1 (en) * | 1999-02-22 | 2000-09-27 | Pfizer Products Inc. | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands |
| DE19939044A1 (de) * | 1999-08-18 | 2001-03-15 | Gruenenthal Gmbh | Verwendung von Morphinanderivaten als Arzneimittel |
| SE0101767D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| NZ531679A (en) * | 2001-10-15 | 2005-02-25 | Janssen Pharmaceutica Nv | Novel substituted 4-phenyl-4-[1H-imidazol-2-YL]-piperidine derivatives and their use as selective non-peptide delta opioid agonists |
| CA2462374C (en) * | 2001-10-15 | 2011-01-18 | Janssen Pharmaceutica N.V. | Substituted 4-phenyl-4-(1h-imidazol-2-yl)-piperidine derivatives for reducing ischaemic damage |
-
2004
- 2004-04-07 CL CL200400754A patent/CL2004000754A1/es unknown
- 2004-04-07 AR ARP040101193A patent/AR044010A1/es not_active Application Discontinuation
- 2004-04-08 JP JP2006505540A patent/JP2006522775A/ja not_active Withdrawn
- 2004-04-08 US US10/552,527 patent/US20060287345A1/en not_active Abandoned
- 2004-04-08 CA CA002521186A patent/CA2521186A1/en not_active Abandoned
- 2004-04-08 DE DE602004004771T patent/DE602004004771T2/de not_active Expired - Fee Related
- 2004-04-08 AT AT04726520T patent/ATE353649T1/de not_active IP Right Cessation
- 2004-04-08 AU AU2004228960A patent/AU2004228960A1/en not_active Abandoned
- 2004-04-08 WO PCT/EP2004/050492 patent/WO2004089372A1/en not_active Ceased
- 2004-04-08 EP EP04726520A patent/EP1615644B1/en not_active Expired - Lifetime
- 2004-04-08 ES ES04726520T patent/ES2282858T3/es not_active Expired - Lifetime
- 2004-04-09 TW TW093109827A patent/TW200509913A/zh unknown
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011030565A (ja) * | 2009-07-06 | 2011-02-17 | Yokohama City Univ | 社会的隔離モデル動物 |
| JP2016519161A (ja) * | 2013-05-24 | 2016-06-30 | アルカームス ファーマ アイルランド リミテッド | モルファン及びモルフィナン類似物及び使用の方法 |
| EP3974430A1 (en) | 2015-03-17 | 2022-03-30 | Nippon Chemiphar Co., Ltd. | Morphinan derivative |
| US11643411B2 (en) | 2015-03-17 | 2023-05-09 | Nippon Chemiphar Co., Ltd. | Morphinan derivative |
| KR20230104767A (ko) | 2015-03-17 | 2023-07-10 | 닛뽕 케미파 가부시키가이샤 | 모르피난 유도체 |
| US10442802B2 (en) | 2015-03-17 | 2019-10-15 | Nippon Chemiphar Co., Ltd. | Morphinan derivative |
| KR20180002616A (ko) | 2015-03-17 | 2018-01-08 | 고쿠리쯔 다이가쿠 호징 츠쿠바 다이가쿠 | 모르피난 유도체 |
| US10995092B2 (en) | 2015-03-17 | 2021-05-04 | Nippon Chemiphar Co., Ltd. | Morphinan derivative |
| WO2018030382A1 (ja) | 2016-08-09 | 2018-02-15 | 国立大学法人 筑波大学 | モルヒナン誘導体 |
| KR20200024120A (ko) | 2016-09-16 | 2020-03-06 | 닛뽕 케미파 가부시키가이샤 | 모르피난 유도체의 오피오이드 δ 수용체 아고니스트 관련 질환의 치료를 위한 사용 |
| US11633392B2 (en) | 2016-09-16 | 2023-04-25 | Nippon Chemiphar Co., Ltd. | Use of morphinan derivative for therapeutic treatment of opioid delta receptor agonist-related disease |
| WO2018052114A1 (ja) | 2016-09-16 | 2018-03-22 | 国立大学法人 筑波大学 | モルヒナン誘導体のオピオイドδ受容体アゴニスト関連疾患の治療のための使用 |
| EP4414037A2 (en) | 2016-09-16 | 2024-08-14 | Nippon Chemiphar Co., Ltd. | Morphinan derivatives for the treatment of opioid delta receptor agonist-related diseases |
| US12109209B2 (en) | 2016-09-16 | 2024-10-08 | Nippon Chemiphar Co., Ltd. | Use of morphinan derivatives for treatment of opioid delta receptor agonist-related disease |
| JP2021523102A (ja) * | 2018-05-01 | 2021-09-02 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | スピロピペリジン系ニコチン性アセチルコリン受容体アロステリック調節剤 |
| US11332463B2 (en) | 2018-05-01 | 2022-05-17 | Merck Sharp & Dohme Corp. | Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors |
| JP7073533B2 (ja) | 2018-05-01 | 2022-05-23 | メルク・シャープ・アンド・ドーム・コーポレーション | スピロピペリジン系ニコチン性アセチルコリン受容体アロステリック調節剤 |
| WO2021100878A1 (ja) | 2019-11-22 | 2021-05-27 | 学校法人北里研究所 | ピラゾロモルヒナン誘導体 |
| EP4062972A1 (en) | 2019-11-22 | 2022-09-28 | The Kitasato Institute | Pyrazolomorphinan derivative |
| KR20230152039A (ko) | 2021-02-26 | 2023-11-02 | 갓코호우징 도쿄리카다이가쿠 | 스트레스 관련 장애의 치료 또는 예방용 의약 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004004771D1 (de) | 2007-03-29 |
| AU2004228960A1 (en) | 2004-10-21 |
| AR044010A1 (es) | 2005-08-24 |
| TW200509913A (en) | 2005-03-16 |
| EP1615644B1 (en) | 2007-02-14 |
| ATE353649T1 (de) | 2007-03-15 |
| DE602004004771T2 (de) | 2007-12-06 |
| EP1615644A1 (en) | 2006-01-18 |
| ES2282858T3 (es) | 2007-10-16 |
| WO2004089372A1 (en) | 2004-10-21 |
| CL2004000754A1 (es) | 2005-02-25 |
| CA2521186A1 (en) | 2004-10-21 |
| US20060287345A1 (en) | 2006-12-21 |
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