ES2282858T3 - Derivados de la 4-fenil-4-(1h-imidazol-2-il)-piperidina y su uso como agonistas opioides delta no peptidicos con actividad antidepresiva y ansiolitica. - Google Patents
Derivados de la 4-fenil-4-(1h-imidazol-2-il)-piperidina y su uso como agonistas opioides delta no peptidicos con actividad antidepresiva y ansiolitica. Download PDFInfo
- Publication number
- ES2282858T3 ES2282858T3 ES04726520T ES04726520T ES2282858T3 ES 2282858 T3 ES2282858 T3 ES 2282858T3 ES 04726520 T ES04726520 T ES 04726520T ES 04726520 T ES04726520 T ES 04726520T ES 2282858 T3 ES2282858 T3 ES 2282858T3
- Authority
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- Spain
- Prior art keywords
- het
- alkyl
- phenyl
- imidazol
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| WOPCT/EP03/03879 | 2003-04-11 | ||
| EP0303879 | 2003-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2282858T3 true ES2282858T3 (es) | 2007-10-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04726520T Expired - Lifetime ES2282858T3 (es) | 2003-04-11 | 2004-04-08 | Derivados de la 4-fenil-4-(1h-imidazol-2-il)-piperidina y su uso como agonistas opioides delta no peptidicos con actividad antidepresiva y ansiolitica. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20060287345A1 (enExample) |
| EP (1) | EP1615644B1 (enExample) |
| JP (1) | JP2006522775A (enExample) |
| AR (1) | AR044010A1 (enExample) |
| AT (1) | ATE353649T1 (enExample) |
| AU (1) | AU2004228960A1 (enExample) |
| CA (1) | CA2521186A1 (enExample) |
| CL (1) | CL2004000754A1 (enExample) |
| DE (1) | DE602004004771T2 (enExample) |
| ES (1) | ES2282858T3 (enExample) |
| TW (1) | TW200509913A (enExample) |
| WO (1) | WO2004089372A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2149370A1 (en) | 2008-07-31 | 2010-02-03 | Neuroscienze Pharmaness S.C. A R.L. | Diazabicyclic compounds and microemulsions thereof |
| IT1390848B1 (it) | 2008-07-31 | 2011-10-19 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| JP2011030565A (ja) * | 2009-07-06 | 2011-02-17 | Yokohama City Univ | 社会的隔離モデル動物 |
| IT1396951B1 (it) | 2009-12-18 | 2012-12-20 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| JP2016519161A (ja) * | 2013-05-24 | 2016-06-30 | アルカームス ファーマ アイルランド リミテッド | モルファン及びモルフィナン類似物及び使用の方法 |
| EP3974430A1 (en) | 2015-03-17 | 2022-03-30 | Nippon Chemiphar Co., Ltd. | Morphinan derivative |
| JPWO2018030382A1 (ja) | 2016-08-09 | 2019-06-13 | 日本ケミファ株式会社 | モルヒナン誘導体 |
| ES2981564T3 (es) | 2016-09-16 | 2024-10-09 | Nippon Chemiphar Co | Derivados de morfinano para el tratamiento de enfermedades relacionadas con agonistas de receptores delta opioides |
| MY205690A (en) * | 2018-05-01 | 2024-11-06 | Merck Sharp & Dohme Llc | Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors |
| CA3158860A1 (en) | 2019-11-22 | 2021-05-27 | The Kitasato Institute | Pyrazolomorphinan derivative |
| TW202302096A (zh) | 2021-02-26 | 2023-01-16 | 學校法人東京理科大學 | 壓力關連障礙之治療或預防用醫藥組成物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5354863A (en) * | 1992-01-21 | 1994-10-11 | G. D. Searle & Co. | Opioid agonist compounds |
| DE19805370A1 (de) * | 1997-03-14 | 1998-09-17 | Gruenenthal Gmbh | Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen |
| HN1999000149A (es) * | 1998-09-09 | 2000-01-12 | Pfizer Prod Inc | Derivados de 4,4-biarilpiperidina |
| EP1038872A1 (en) * | 1999-02-22 | 2000-09-27 | Pfizer Products Inc. | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands |
| DE19939044A1 (de) * | 1999-08-18 | 2001-03-15 | Gruenenthal Gmbh | Verwendung von Morphinanderivaten als Arzneimittel |
| SE0101767D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| WO2003039440A2 (en) * | 2001-10-15 | 2003-05-15 | Janssen Pharmaceutica N.V. | Substituted 4-phenyl-4-(1h-imidazol-2-yl)-piperidine derivatives for reducing ischaemic damage |
| PT1438304E (pt) * | 2001-10-15 | 2007-03-30 | Janssen Pharmaceutica Nv | Novos derivados 4-fenil-4-[1h-imidazolo-2-il] piperidina substituídos e sua utilização como agonistas selectivos não peptídicos de delta opióides |
-
2004
- 2004-04-07 AR ARP040101193A patent/AR044010A1/es not_active Application Discontinuation
- 2004-04-07 CL CL200400754A patent/CL2004000754A1/es unknown
- 2004-04-08 DE DE602004004771T patent/DE602004004771T2/de not_active Expired - Fee Related
- 2004-04-08 US US10/552,527 patent/US20060287345A1/en not_active Abandoned
- 2004-04-08 EP EP04726520A patent/EP1615644B1/en not_active Expired - Lifetime
- 2004-04-08 AU AU2004228960A patent/AU2004228960A1/en not_active Abandoned
- 2004-04-08 JP JP2006505540A patent/JP2006522775A/ja not_active Withdrawn
- 2004-04-08 AT AT04726520T patent/ATE353649T1/de not_active IP Right Cessation
- 2004-04-08 WO PCT/EP2004/050492 patent/WO2004089372A1/en not_active Ceased
- 2004-04-08 ES ES04726520T patent/ES2282858T3/es not_active Expired - Lifetime
- 2004-04-08 CA CA002521186A patent/CA2521186A1/en not_active Abandoned
- 2004-04-09 TW TW093109827A patent/TW200509913A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2521186A1 (en) | 2004-10-21 |
| WO2004089372A1 (en) | 2004-10-21 |
| EP1615644A1 (en) | 2006-01-18 |
| JP2006522775A (ja) | 2006-10-05 |
| DE602004004771T2 (de) | 2007-12-06 |
| US20060287345A1 (en) | 2006-12-21 |
| CL2004000754A1 (es) | 2005-02-25 |
| TW200509913A (en) | 2005-03-16 |
| EP1615644B1 (en) | 2007-02-14 |
| AU2004228960A1 (en) | 2004-10-21 |
| ATE353649T1 (de) | 2007-03-15 |
| AR044010A1 (es) | 2005-08-24 |
| DE602004004771D1 (de) | 2007-03-29 |
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