AU2004228960A1 - Substituted 4-phenyl-4-`1H-imidazol-2-yl !-piperidine derivatives and their use as selective non-peptide delta opioid agonists with antidepressant and anxiolytic activity - Google Patents
Substituted 4-phenyl-4-`1H-imidazol-2-yl !-piperidine derivatives and their use as selective non-peptide delta opioid agonists with antidepressant and anxiolytic activity Download PDFInfo
- Publication number
- AU2004228960A1 AU2004228960A1 AU2004228960A AU2004228960A AU2004228960A1 AU 2004228960 A1 AU2004228960 A1 AU 2004228960A1 AU 2004228960 A AU2004228960 A AU 2004228960A AU 2004228960 A AU2004228960 A AU 2004228960A AU 2004228960 A1 AU2004228960 A1 AU 2004228960A1
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- Australia
- Prior art keywords
- het
- alkyl
- phenyl
- imidazol
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0303879 | 2003-04-11 | ||
| EPPCT/EP03/03879 | 2003-04-11 | ||
| PCT/EP2004/050492 WO2004089372A1 (en) | 2003-04-11 | 2004-04-08 | Substituted 4-phenyl-4-`1h-imidazol-2-yl !-piperidine derivatives and their use as selective non-peptide delta opioid agonists with antidepressant and anxiolytic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2004228960A1 true AU2004228960A1 (en) | 2004-10-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2004228960A Abandoned AU2004228960A1 (en) | 2003-04-11 | 2004-04-08 | Substituted 4-phenyl-4-`1H-imidazol-2-yl !-piperidine derivatives and their use as selective non-peptide delta opioid agonists with antidepressant and anxiolytic activity |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20060287345A1 (enExample) |
| EP (1) | EP1615644B1 (enExample) |
| JP (1) | JP2006522775A (enExample) |
| AR (1) | AR044010A1 (enExample) |
| AT (1) | ATE353649T1 (enExample) |
| AU (1) | AU2004228960A1 (enExample) |
| CA (1) | CA2521186A1 (enExample) |
| CL (1) | CL2004000754A1 (enExample) |
| DE (1) | DE602004004771T2 (enExample) |
| ES (1) | ES2282858T3 (enExample) |
| TW (1) | TW200509913A (enExample) |
| WO (1) | WO2004089372A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1390848B1 (it) | 2008-07-31 | 2011-10-19 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| EP2149370A1 (en) | 2008-07-31 | 2010-02-03 | Neuroscienze Pharmaness S.C. A R.L. | Diazabicyclic compounds and microemulsions thereof |
| JP2011030565A (ja) * | 2009-07-06 | 2011-02-17 | Yokohama City Univ | 社会的隔離モデル動物 |
| IT1396951B1 (it) | 2009-12-18 | 2012-12-20 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| NZ631018A (en) * | 2013-05-24 | 2017-12-22 | Alkermes Pharma Ireland Ltd | Morphan and morphinan analogues, and methods of use |
| SG10201907667RA (en) | 2015-03-17 | 2019-09-27 | Nippon Chemiphar Co Ltd | Morphinan derivative |
| WO2018030382A1 (ja) | 2016-08-09 | 2018-02-15 | 国立大学法人 筑波大学 | モルヒナン誘導体 |
| US11633392B2 (en) | 2016-09-16 | 2023-04-25 | Nippon Chemiphar Co., Ltd. | Use of morphinan derivative for therapeutic treatment of opioid delta receptor agonist-related disease |
| KR102587811B1 (ko) | 2018-05-01 | 2023-10-11 | 머크 샤프 앤드 돔 엘엘씨 | 니코틴성 아세틸콜린 수용체의 스피로피페리딘 알로스테릭 조정제 |
| EP4062972A4 (en) | 2019-11-22 | 2023-11-22 | The Kitasato Institute | PYRAZOLOMORPHINAND DERIVATIVES |
| US20240156796A1 (en) | 2021-02-26 | 2024-05-16 | Tokyo University Of Science Foundation | Pharmaceutical composition for treatment or prevention of stress-related disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5354863A (en) * | 1992-01-21 | 1994-10-11 | G. D. Searle & Co. | Opioid agonist compounds |
| DE19805370A1 (de) * | 1997-03-14 | 1998-09-17 | Gruenenthal Gmbh | Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen |
| HN1999000149A (es) * | 1998-09-09 | 2000-01-12 | Pfizer Prod Inc | Derivados de 4,4-biarilpiperidina |
| EP1038872A1 (en) * | 1999-02-22 | 2000-09-27 | Pfizer Products Inc. | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands |
| DE19939044A1 (de) * | 1999-08-18 | 2001-03-15 | Gruenenthal Gmbh | Verwendung von Morphinanderivaten als Arzneimittel |
| SE0101767D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| NZ531679A (en) * | 2001-10-15 | 2005-02-25 | Janssen Pharmaceutica Nv | Novel substituted 4-phenyl-4-[1H-imidazol-2-YL]-piperidine derivatives and their use as selective non-peptide delta opioid agonists |
| CA2462374C (en) * | 2001-10-15 | 2011-01-18 | Janssen Pharmaceutica N.V. | Substituted 4-phenyl-4-(1h-imidazol-2-yl)-piperidine derivatives for reducing ischaemic damage |
-
2004
- 2004-04-07 CL CL200400754A patent/CL2004000754A1/es unknown
- 2004-04-07 AR ARP040101193A patent/AR044010A1/es not_active Application Discontinuation
- 2004-04-08 JP JP2006505540A patent/JP2006522775A/ja not_active Withdrawn
- 2004-04-08 US US10/552,527 patent/US20060287345A1/en not_active Abandoned
- 2004-04-08 CA CA002521186A patent/CA2521186A1/en not_active Abandoned
- 2004-04-08 DE DE602004004771T patent/DE602004004771T2/de not_active Expired - Fee Related
- 2004-04-08 AT AT04726520T patent/ATE353649T1/de not_active IP Right Cessation
- 2004-04-08 AU AU2004228960A patent/AU2004228960A1/en not_active Abandoned
- 2004-04-08 WO PCT/EP2004/050492 patent/WO2004089372A1/en not_active Ceased
- 2004-04-08 EP EP04726520A patent/EP1615644B1/en not_active Expired - Lifetime
- 2004-04-08 ES ES04726520T patent/ES2282858T3/es not_active Expired - Lifetime
- 2004-04-09 TW TW093109827A patent/TW200509913A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004004771D1 (de) | 2007-03-29 |
| AR044010A1 (es) | 2005-08-24 |
| TW200509913A (en) | 2005-03-16 |
| EP1615644B1 (en) | 2007-02-14 |
| ATE353649T1 (de) | 2007-03-15 |
| DE602004004771T2 (de) | 2007-12-06 |
| EP1615644A1 (en) | 2006-01-18 |
| ES2282858T3 (es) | 2007-10-16 |
| WO2004089372A1 (en) | 2004-10-21 |
| CL2004000754A1 (es) | 2005-02-25 |
| CA2521186A1 (en) | 2004-10-21 |
| JP2006522775A (ja) | 2006-10-05 |
| US20060287345A1 (en) | 2006-12-21 |
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