CA2521186A1 - Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists with antidepressant and anxiolytic activity - Google Patents
Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists with antidepressant and anxiolytic activity Download PDFInfo
- Publication number
- CA2521186A1 CA2521186A1 CA002521186A CA2521186A CA2521186A1 CA 2521186 A1 CA2521186 A1 CA 2521186A1 CA 002521186 A CA002521186 A CA 002521186A CA 2521186 A CA2521186 A CA 2521186A CA 2521186 A1 CA2521186 A1 CA 2521186A1
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- CA
- Canada
- Prior art keywords
- alkyl
- phenyl
- imidazol
- het
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0303879 | 2003-04-11 | ||
| EPPCT/EP03/03879 | 2003-04-11 | ||
| PCT/EP2004/050492 WO2004089372A1 (en) | 2003-04-11 | 2004-04-08 | Substituted 4-phenyl-4-`1h-imidazol-2-yl !-piperidine derivatives and their use as selective non-peptide delta opioid agonists with antidepressant and anxiolytic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2521186A1 true CA2521186A1 (en) | 2004-10-21 |
Family
ID=33154992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002521186A Abandoned CA2521186A1 (en) | 2003-04-11 | 2004-04-08 | Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists with antidepressant and anxiolytic activity |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20060287345A1 (enExample) |
| EP (1) | EP1615644B1 (enExample) |
| JP (1) | JP2006522775A (enExample) |
| AR (1) | AR044010A1 (enExample) |
| AT (1) | ATE353649T1 (enExample) |
| AU (1) | AU2004228960A1 (enExample) |
| CA (1) | CA2521186A1 (enExample) |
| CL (1) | CL2004000754A1 (enExample) |
| DE (1) | DE602004004771T2 (enExample) |
| ES (1) | ES2282858T3 (enExample) |
| TW (1) | TW200509913A (enExample) |
| WO (1) | WO2004089372A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2149370A1 (en) | 2008-07-31 | 2010-02-03 | Neuroscienze Pharmaness S.C. A R.L. | Diazabicyclic compounds and microemulsions thereof |
| IT1390848B1 (it) | 2008-07-31 | 2011-10-19 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| JP2011030565A (ja) * | 2009-07-06 | 2011-02-17 | Yokohama City Univ | 社会的隔離モデル動物 |
| IT1396951B1 (it) | 2009-12-18 | 2012-12-20 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| WO2014190270A1 (en) * | 2013-05-24 | 2014-11-27 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
| CN113292558A (zh) | 2015-03-17 | 2021-08-24 | 日本化学药品株式会社 | 吗啡喃衍生物 |
| JPWO2018030382A1 (ja) | 2016-08-09 | 2019-06-13 | 日本ケミファ株式会社 | モルヒナン誘導体 |
| ES2981564T3 (es) | 2016-09-16 | 2024-10-09 | Nippon Chemiphar Co | Derivados de morfinano para el tratamiento de enfermedades relacionadas con agonistas de receptores delta opioides |
| PL3788043T3 (pl) | 2018-05-01 | 2025-03-10 | Merck Sharp & Dohme Llc | Spiropiperydynowe allosteryczne modulatory receptorów nikotynowych acetylocholiny |
| AU2020385852A1 (en) | 2019-11-22 | 2022-06-02 | Nippon Chemiphar Co., Ltd. | Pyrazolomorphinan derivative |
| CA3211977A1 (en) | 2021-02-26 | 2022-09-01 | Tokyo University Of Science Foundation | Pharmaceutical composition for treatment or prevention of stress-related disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5354863A (en) * | 1992-01-21 | 1994-10-11 | G. D. Searle & Co. | Opioid agonist compounds |
| DE19805370A1 (de) * | 1997-03-14 | 1998-09-17 | Gruenenthal Gmbh | Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen |
| HN1999000149A (es) * | 1998-09-09 | 2000-01-12 | Pfizer Prod Inc | Derivados de 4,4-biarilpiperidina |
| EP1038872A1 (en) * | 1999-02-22 | 2000-09-27 | Pfizer Products Inc. | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands |
| DE19939044A1 (de) * | 1999-08-18 | 2001-03-15 | Gruenenthal Gmbh | Verwendung von Morphinanderivaten als Arzneimittel |
| SE0101767D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| AU2002346994B2 (en) * | 2001-10-15 | 2007-09-06 | Janssen Pharmaceutica N.V. | Novel substituted 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists |
| JP4418676B2 (ja) * | 2001-10-15 | 2010-02-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 虚血性損傷を減らすための置換された４−フェニル−４−（１ｈ−イミダゾール−２−イル）−ピペリジン誘導体 |
-
2004
- 2004-04-07 AR ARP040101193A patent/AR044010A1/es not_active Application Discontinuation
- 2004-04-07 CL CL200400754A patent/CL2004000754A1/es unknown
- 2004-04-08 AT AT04726520T patent/ATE353649T1/de not_active IP Right Cessation
- 2004-04-08 CA CA002521186A patent/CA2521186A1/en not_active Abandoned
- 2004-04-08 WO PCT/EP2004/050492 patent/WO2004089372A1/en not_active Ceased
- 2004-04-08 JP JP2006505540A patent/JP2006522775A/ja not_active Withdrawn
- 2004-04-08 US US10/552,527 patent/US20060287345A1/en not_active Abandoned
- 2004-04-08 EP EP04726520A patent/EP1615644B1/en not_active Expired - Lifetime
- 2004-04-08 AU AU2004228960A patent/AU2004228960A1/en not_active Abandoned
- 2004-04-08 ES ES04726520T patent/ES2282858T3/es not_active Expired - Lifetime
- 2004-04-08 DE DE602004004771T patent/DE602004004771T2/de not_active Expired - Fee Related
- 2004-04-09 TW TW093109827A patent/TW200509913A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1615644A1 (en) | 2006-01-18 |
| ES2282858T3 (es) | 2007-10-16 |
| JP2006522775A (ja) | 2006-10-05 |
| AR044010A1 (es) | 2005-08-24 |
| US20060287345A1 (en) | 2006-12-21 |
| ATE353649T1 (de) | 2007-03-15 |
| EP1615644B1 (en) | 2007-02-14 |
| DE602004004771T2 (de) | 2007-12-06 |
| CL2004000754A1 (es) | 2005-02-25 |
| AU2004228960A1 (en) | 2004-10-21 |
| TW200509913A (en) | 2005-03-16 |
| DE602004004771D1 (de) | 2007-03-29 |
| WO2004089372A1 (en) | 2004-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |