JP2006519846A5 - - Google Patents
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- JP2006519846A5 JP2006519846A5 JP2006507031A JP2006507031A JP2006519846A5 JP 2006519846 A5 JP2006519846 A5 JP 2006519846A5 JP 2006507031 A JP2006507031 A JP 2006507031A JP 2006507031 A JP2006507031 A JP 2006507031A JP 2006519846 A5 JP2006519846 A5 JP 2006519846A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- heterocyclyl
- heteroaryl
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims description 249
- 125000000623 heterocyclic group Chemical group 0.000 claims description 192
- 150000001875 compounds Chemical class 0.000 claims description 171
- 125000001072 heteroaryl group Chemical group 0.000 claims description 154
- 125000003118 aryl group Chemical group 0.000 claims description 107
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 103
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 83
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 81
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 80
- 239000000203 mixture Substances 0.000 claims description 71
- -1 R 5 O-alkyl Chemical group 0.000 claims description 65
- 125000003545 alkoxy group Chemical group 0.000 claims description 60
- 125000000304 alkynyl group Chemical group 0.000 claims description 49
- 125000005018 aryl alkenyl group Chemical group 0.000 claims description 45
- 125000005015 aryl alkynyl group Chemical group 0.000 claims description 41
- 125000004104 aryloxy group Chemical group 0.000 claims description 41
- 125000004447 heteroarylalkenyl group Chemical group 0.000 claims description 41
- 125000005312 heteroarylalkynyl group Chemical group 0.000 claims description 41
- 238000000034 method Methods 0.000 claims description 41
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 36
- 125000003342 alkenyl group Chemical group 0.000 claims description 25
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 22
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- 125000004414 alkyl thio group Chemical group 0.000 claims description 20
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 20
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 20
- 229910052717 sulfur Inorganic materials 0.000 claims description 18
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 17
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 16
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- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims description 10
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 8
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- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 4
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 4
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 3
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| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| JP4568361B2 (ja) | 2005-04-22 | 2010-10-27 | アラントス・ファーマシューティカルズ・ホールディング・インコーポレーテッド | ジペプチジルペプチダーゼ−ｉｖ阻害剤 |
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| US8796293B2 (en) | 2006-04-25 | 2014-08-05 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
| US7511063B2 (en) * | 2006-08-16 | 2009-03-31 | Schering Corporation | High affinity quinoline-based kinase ligands |
| JP2010510202A (ja) | 2006-11-17 | 2010-04-02 | ファイザー株式会社 | 置換ビシクロカルボキシアミド化合物 |
| MX2009005509A (es) | 2006-12-07 | 2009-06-03 | Hoffmann La Roche | 2-aminoquinolina como los antagonistas de los receptores 5-hidroxitriptamina 5a (5-ht5a). |
| ATE545417T1 (de) | 2007-03-14 | 2012-03-15 | Ranbaxy Lab Ltd | Pyrazoloä3,4-büpyridin-derivate als phosphodiesterasehemmer |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| US8030495B2 (en) * | 2007-05-23 | 2011-10-04 | Coleman Paul J | Cyclopropyl pyrrolidine orexin receptor antagonists |
| US8614326B2 (en) | 2007-08-22 | 2013-12-24 | Allergan, Inc. | Therapeutic quinoline and naphthalene derivatives |
| MX2010003001A (es) | 2007-09-27 | 2010-04-01 | Hoffmann La Roche | Derivados de quinolina como antagonistas del receptor de la 5-hidroxitriptamina 5a. |
| ES2522365T3 (es) | 2007-10-11 | 2014-11-14 | Astrazeneca Ab | Derivados de pirrolo [2,3-D] pirimidina como inhibidores de proteína quinasas B |
| WO2009051112A1 (ja) | 2007-10-15 | 2009-04-23 | Takeda Pharmaceutical Company Limited | アミド化合物およびその用途 |
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| WO2009095752A1 (en) * | 2008-01-29 | 2009-08-06 | Glenmark Pharmaceuticals, S.A. | Fused pyrazole derivatives as cannabinoid receptor modulators |
| KR20100119825A (ko) * | 2008-03-05 | 2010-11-10 | 에프. 호프만-라 로슈 아게 | 2-아미노퀴놀린 |
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| GB0812969D0 (en) | 2008-07-15 | 2008-08-20 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| CN102395576A (zh) | 2009-02-27 | 2012-03-28 | 埃姆比特生物科学公司 | 调控jak激酶的喹唑啉衍生物和其使用方法 |
| CA2754058A1 (en) * | 2009-03-02 | 2010-09-10 | Sirtris Pharmaceuticals, Inc. | 8-substituted quinolines and related analogs as sirtuin modulators |
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- 2004-03-10 WO PCT/US2004/007286 patent/WO2004080463A1/en not_active Ceased
- 2004-03-10 CA CA002518398A patent/CA2518398A1/en not_active Abandoned
- 2004-03-10 EP EP04719237A patent/EP1601357A4/en not_active Withdrawn
- 2004-03-10 MX MXPA05009722A patent/MXPA05009722A/es not_active Application Discontinuation
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