|
EP1389209B1
(en)
*
|
2001-04-24 |
2009-04-08 |
Purdue Research Foundation |
Folate mimetics and folate-receptor binding conjugates thereof
|
|
WO2003097647A1
(en)
*
|
2002-05-15 |
2003-11-27 |
Endocyte, Inc. |
Vitamin-mitomycin conjugates
|
|
AU2003266233A1
(en)
*
|
2002-07-09 |
2004-01-23 |
Morphochem Aktiengesellschaft Fur Kombinatorische Chemie |
Novel tubulysin analogues
|
|
DK1592457T3
(da)
|
2003-01-27 |
2012-10-22 |
Endocyte Inc |
Folat-vinblastin-konjugat som lægemiddel
|
|
JP5149620B2
(ja)
|
2004-07-23 |
2013-02-20 |
エンドサイト，インコーポレイテッド |
２価リンカーおよびその結合体
|
|
EP1863816B1
(en)
*
|
2005-03-16 |
2014-06-25 |
Endocyte, Inc. |
Synthesis and purification of pteroic acid and conjugates thereof
|
|
EP2382995A3
(en)
*
|
2005-08-19 |
2013-09-25 |
Endocyte, Inc. |
Ligand conjugates of Vinca alkaloids, analogs and derivatives
|
|
AU2006279304A1
(en)
*
|
2005-08-19 |
2007-02-22 |
Endocyte, Inc. |
Multi-drug ligand conjugates
|
|
WO2008101231A2
(en)
|
2007-02-16 |
2008-08-21 |
Endocyte, Inc. |
Methods and compositions for treating and diagnosing kidney disease
|
|
CN104127878A
(zh)
|
2007-03-14 |
2014-11-05 |
恩多塞特公司 |
结合配体连接的微管溶素递药缀合物
|
|
US8980833B2
(en)
*
|
2007-05-10 |
2015-03-17 |
R&D-Biopharmaceuticals Gmbh |
Tubulysine derivatives
|
|
BRPI0812970A2
(pt)
|
2007-06-25 |
2019-09-24 |
Endocyte Inc |
conjugados contendo espaçadores hidrofílicos
|
|
US9877965B2
(en)
|
2007-06-25 |
2018-01-30 |
Endocyte, Inc. |
Vitamin receptor drug delivery conjugates for treating inflammation
|
|
US8476451B2
(en)
*
|
2007-07-20 |
2013-07-02 |
The Regents Of The University Of California |
Tubulysin D analogues
|
|
EP2181101A2
(en)
*
|
2007-07-20 |
2010-05-05 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
Tubulysin d analogues
|
|
US9187521B2
(en)
|
2007-10-25 |
2015-11-17 |
Endocyte, Inc. |
Tubulysins and processes for preparing
|
|
EP2174947A1
(en)
*
|
2008-09-25 |
2010-04-14 |
Universität des Saarlandes |
Bioactive pre-tubulysins and use thereof
|
|
IT1394860B1
(it)
|
2009-07-22 |
2012-07-20 |
Kemotech S R L |
Composti farmaceutici
|
|
US8394922B2
(en)
|
2009-08-03 |
2013-03-12 |
Medarex, Inc. |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
|
|
EP2409983A1
(en)
|
2010-07-19 |
2012-01-25 |
Leibniz-Institut für Pflanzenbiochemie (IPB) |
Tubulysin analogues
|
|
AU2011285532B2
(en)
|
2010-08-06 |
2015-09-10 |
Endocyte, Inc. |
Processes for preparing tubulysins
|
|
WO2012171020A1
(en)
|
2011-06-10 |
2012-12-13 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
CN104244718A
(zh)
*
|
2011-12-05 |
2014-12-24 |
伊格尼卡生物治疗公司 |
抗体-药物缀合物以及相关化合物、组合物和方法
|
|
US10080805B2
(en)
|
2012-02-24 |
2018-09-25 |
Purdue Research Foundation |
Cholecystokinin B receptor targeting for imaging and therapy
|
|
US20140080175A1
(en)
|
2012-03-29 |
2014-03-20 |
Endocyte, Inc. |
Processes for preparing tubulysin derivatives and conjugates thereof
|
|
US9981046B2
(en)
|
2012-05-15 |
2018-05-29 |
Concortis Biosystems, Corp., a wholly owned Subsidiary of Sorrento Therapeutics, Inc. |
Drug-conjugates, conjugation methods, and uses thereof
|
|
US11873281B2
(en)
|
2012-07-12 |
2024-01-16 |
Hangzhou Dac Biotech Co., Ltd. |
Conjugates of cell binding molecules with cytotoxic agents
|
|
PL2872157T3
(pl)
|
2012-07-12 |
2020-07-13 |
Hangzhou Dac Biotech Co., Ltd |
Koniugaty wiążących komórkę cząsteczek ze środkami cytotoksycznymi
|
|
EP2708243A1
(en)
|
2012-09-17 |
2014-03-19 |
OntoChem GmbH |
Receptor ligand linked cytotoxic molecules
|
|
EP2908818A4
(en)
|
2012-10-16 |
2016-07-13 |
Endocyte Inc |
CONJUGATES OF DRUG DELIVERY CONTAINING ARTIFICIAL AMINO ACIDS AND METHODS OF USE
|
|
BR112015011118B1
(pt)
|
2012-11-15 |
2022-12-13 |
Endocyte, Inc |
Conjugado; composição farmacêutica; e uso de um conjugado
|
|
US10131682B2
(en)
|
2012-11-24 |
2018-11-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
|
|
CA2892863C
(en)
|
2012-12-10 |
2022-03-15 |
Mersana Therapeutics, Inc. |
Polymeric scaffold based on phf for targeted drug delivery
|
|
WO2014093640A1
(en)
|
2012-12-12 |
2014-06-19 |
Mersana Therapeutics,Inc. |
Hydroxy-polmer-drug-protein conjugates
|
|
RS56169B1
(sr)
|
2013-02-14 |
2017-11-30 |
Bristol Myers Squibb Co |
Jedinjenja tubulisina, metode pripreme i primena
|
|
US20140249315A1
(en)
|
2013-03-01 |
2014-09-04 |
Endocyte, Inc. |
Processes for preparing tubulysins
|
|
US10781259B2
(en)
|
2013-06-06 |
2020-09-22 |
Magenta Therapeutics, Inc. |
Modified antibodies and related compounds, compositions, and methods of use
|
|
WO2015057876A1
(en)
|
2013-10-15 |
2015-04-23 |
Sorrento Therapeutics Inc. |
Drug-conjugates with a targeting molecule and two different drugs
|
|
ES2826398T3
(es)
|
2013-10-15 |
2021-05-18 |
Seagen Inc |
Enlazadores-fármacos pegilados para una mejor farmacocinética de los conjugados ligando-fármaco
|
|
WO2015113760A1
(en)
*
|
2014-01-28 |
2015-08-06 |
Tube Pharmaceuticals Gmbh |
Cytotoxic tubulysin compounds for conjugation
|
|
CA2938919C
(en)
|
2014-02-28 |
2020-12-29 |
Hangzhou Dac Biotech Co., Ltd |
Charged linkers and their uses for conjugation
|
|
MX2016012830A
(es)
|
2014-04-11 |
2017-01-05 |
Medimmune Llc |
Anticuerpos contra el receptor 2 del factor de crecimiento epidermico humano (her2) biespecificos.
|
|
US10077287B2
(en)
|
2014-11-10 |
2018-09-18 |
Bristol-Myers Squibb Company |
Tubulysin analogs and methods of making and use
|
|
CN105641707B
(zh)
*
|
2014-11-11 |
2020-11-24 |
杭州多禧生物科技有限公司 |
细胞毒素分子同细胞结合受体分子的共轭体
|
|
EP3250238B1
(en)
|
2015-01-28 |
2022-06-01 |
Sorrento Therapeutics, Inc. |
Antibody drug conjugates
|
|
FI3319936T3
(fi)
|
2015-07-12 |
2026-03-12 |
Hangzhou Dac Biotech Co Ltd |
Silloituslinkkereitä soluun sitoutuvien molekyylien konjugoimiseksi
|
|
US9839687B2
(en)
|
2015-07-15 |
2017-12-12 |
Suzhou M-Conj Biotech Co., Ltd. |
Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
|
|
SMT202000285T1
(it)
|
2015-11-10 |
2020-07-08 |
Medimmune Llc |
Molecole di legame specifiche per asct2 e loro usi
|
|
CN108367043A
(zh)
|
2015-12-04 |
2018-08-03 |
西雅图基因公司 |
季铵化的微管溶素化合物的缀合物
|
|
US11793880B2
(en)
|
2015-12-04 |
2023-10-24 |
Seagen Inc. |
Conjugates of quaternized tubulysin compounds
|
|
KR20180134351A
(ko)
|
2016-03-25 |
2018-12-18 |
시애틀 지네틱스, 인크. |
페길화된 약물-링커 및 그의 중간체의 제조를 위한 공정
|
|
CA3042442C
(en)
|
2016-11-14 |
2024-01-02 |
Hangzhou Dac Biotech Co., Ltd |
Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses of such conjugates with the linkers
|
|
AU2018237683A1
(en)
|
2017-03-24 |
2019-10-31 |
Seagen Inc. |
Process for the preparation of glucuronide drug-linkers and intermediates thereof
|
|
US10988546B2
(en)
|
2017-08-01 |
2021-04-27 |
Medimmune, Llc |
BCMA monoclonal antibody-drug conjugate
|
|
JP2022540395A
(ja)
|
2019-06-29 |
2022-09-15 |
ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． |
細胞結合性分子－チューブリシン誘導体共役体及びその調製方法
|
|
US20220241377A1
(en)
|
2019-07-24 |
2022-08-04 |
Molgenie GmbH |
Receptor-targeting peptide-drug conjugates
|
|
CR20230146A
(es)
|
2020-09-11 |
2023-06-07 |
Medimmune Ltd |
Moléculas de unión a b7-h4 terapéuticas
|
|
CN117980327A
(zh)
|
2021-11-03 |
2024-05-03 |
杭州多禧生物科技有限公司 |
抗体的特异性偶联
|
|
GB202117928D0
(en)
|
2021-12-11 |
2022-01-26 |
Cancer Research Tech Ltd |
Immunotherapy for cancer
|
|
KR20240159839A
(ko)
|
2022-03-09 |
2024-11-06 |
아스트라제네카 아베 |
FRα에 대한 결합 분자
|
|
TW202448517A
(zh)
|
2023-02-16 |
2024-12-16 |
瑞典商阿斯特捷利康公司 |
用治療性結合分子治療癌症的組合療法
|