JP2006518704A5 - - Google Patents

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Publication number
JP2006518704A5
JP2006518704A5 JP2004552485A JP2004552485A JP2006518704A5 JP 2006518704 A5 JP2006518704 A5 JP 2006518704A5 JP 2004552485 A JP2004552485 A JP 2004552485A JP 2004552485 A JP2004552485 A JP 2004552485A JP 2006518704 A5 JP2006518704 A5 JP 2006518704A5
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JP
Japan
Prior art keywords
alkyl
alkenyl
aryl
metal ion
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004552485A
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English (en)
Japanese (ja)
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JP2006518704A (ja
JP4620467B2 (ja
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Publication date
Priority claimed from DE10254439A external-priority patent/DE10254439A1/de
Application filed filed Critical
Publication of JP2006518704A publication Critical patent/JP2006518704A/ja
Publication of JP2006518704A5 publication Critical patent/JP2006518704A5/ja
Application granted granted Critical
Publication of JP4620467B2 publication Critical patent/JP4620467B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2004552485A 2002-11-21 2003-10-20 チューブライシン、その製造方法、及び、チューブライシン製剤 Expired - Lifetime JP4620467B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10254439A DE10254439A1 (de) 2002-11-21 2002-11-21 Tubulysine, Herstellungsverfahren und Tubulysin-Mittel
PCT/EP2003/011603 WO2004046170A2 (de) 2002-11-21 2003-10-20 Tubulysine, herstellungsverfahren und tubulysin-mittel

Publications (3)

Publication Number Publication Date
JP2006518704A JP2006518704A (ja) 2006-08-17
JP2006518704A5 true JP2006518704A5 (https=) 2007-03-15
JP4620467B2 JP4620467B2 (ja) 2011-01-26

Family

ID=32240267

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004552485A Expired - Lifetime JP4620467B2 (ja) 2002-11-21 2003-10-20 チューブライシン、その製造方法、及び、チューブライシン製剤

Country Status (7)

Country Link
US (1) US7754885B2 (https=)
EP (2) EP2028185A1 (https=)
JP (1) JP4620467B2 (https=)
AT (1) ATE412659T1 (https=)
AU (1) AU2003283282A1 (https=)
DE (2) DE10254439A1 (https=)
WO (1) WO2004046170A2 (https=)

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BR112015008365A2 (pt) 2012-10-16 2017-07-04 Endocyte Inc composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente
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CN114040778A (zh) 2019-06-29 2022-02-11 杭州多禧生物科技有限公司 一种细胞结合分子-Tubulysin衍生物偶联物及其制备方法
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CN120936382A (zh) 2023-02-16 2025-11-11 阿斯利康(瑞典)有限公司 采用治疗性结合分子治疗癌症的组合疗法

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DE19638870B4 (de) * 1996-09-23 2009-05-14 Helmholtz-Zentrum für Infektionsforschung GmbH Tubulysine, Verfahren zu ihrer Gewinnung und sie enthaltende Mittel
DE10008089A1 (de) * 2000-02-22 2001-10-31 Biotechnolog Forschung Gmbh Syntheseverfahren zur Herstellung von Tubulysinen
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US20100047841A1 (en) * 2007-02-27 2010-02-25 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Synthesis of desacetoxytubulysin h and analogs thereof

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