JP2008515994A5 - - Google Patents
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- Publication number
- JP2008515994A5 JP2008515994A5 JP2007536899A JP2007536899A JP2008515994A5 JP 2008515994 A5 JP2008515994 A5 JP 2008515994A5 JP 2007536899 A JP2007536899 A JP 2007536899A JP 2007536899 A JP2007536899 A JP 2007536899A JP 2008515994 A5 JP2008515994 A5 JP 2008515994A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- group
- alkenyl
- alkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 46
- 125000003342 alkenyl group Chemical group 0.000 claims 27
- 125000001072 heteroaryl group Chemical group 0.000 claims 25
- 125000003118 aryl group Chemical group 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 150000002431 hydrogen Chemical class 0.000 claims 18
- 108020002202 Adenosylhomocysteinase Proteins 0.000 claims 16
- 102000005234 Adenosylhomocysteinase Human genes 0.000 claims 13
- 241000124008 Mammalia Species 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000000547 substituted alkyl group Chemical group 0.000 claims 13
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 10
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 8
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 239000001301 oxygen Substances 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 239000011593 sulfur Substances 0.000 claims 8
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 8
- 229920002554 vinyl polymer Polymers 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 239000013037 reversible inhibitor Substances 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- -1 —NH 2 Substances 0.000 claims 5
- 102000004157 Hydrolases Human genes 0.000 claims 4
- 108090000604 Hydrolases Proteins 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- 102100037850 Interferon gamma Human genes 0.000 claims 4
- 108010074328 Interferon-gamma Proteins 0.000 claims 4
- 108010002350 Interleukin-2 Proteins 0.000 claims 4
- 206010029240 Neuritis Diseases 0.000 claims 4
- 206010053613 Type IV hypersensitivity reaction Diseases 0.000 claims 4
- 230000001363 autoimmune Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 201000006417 multiple sclerosis Diseases 0.000 claims 4
- 230000005951 type IV hypersensitivity Effects 0.000 claims 4
- 208000027930 type IV hypersensitivity disease Diseases 0.000 claims 4
- 102100020925 Adenosylhomocysteinase Human genes 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- NWPWVFAEENVVJM-UHFFFAOYSA-N Deoxyeritadenine Chemical compound NC1=NC=NC2=C1N=CN2CCC(O)C(O)=O NWPWVFAEENVVJM-UHFFFAOYSA-N 0.000 claims 3
- 208000036142 Viral infection Diseases 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 230000009385 viral infection Effects 0.000 claims 3
- ZJUKTBDSGOFHSH-WFMPWKQPSA-N S-Adenosylhomocysteine Chemical compound O[C@@H]1[C@H](O)[C@@H](CSCC[C@H](N)C(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZJUKTBDSGOFHSH-WFMPWKQPSA-N 0.000 claims 2
- 230000002364 anti-haemorrhagic effect Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229940034982 antineoplastic agent Drugs 0.000 claims 2
- 230000002008 hemorrhagic effect Effects 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 229940125721 immunosuppressive agent Drugs 0.000 claims 2
- 230000006965 reversible inhibition Effects 0.000 claims 2
- 238000005094 computer simulation Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000031261 interleukin-10 production Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 0 *c1nc2c(*)nc(*)cc2[n]1**=* Chemical compound *c1nc2c(*)nc(*)cc2[n]1**=* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/964,236 US7517887B2 (en) | 2003-04-09 | 2004-10-13 | Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof |
| US10/964,236 | 2004-10-13 | ||
| PCT/US2005/036890 WO2006044573A2 (en) | 2004-10-13 | 2005-10-13 | Reversible inhibitors of s-adenosyl-l-homocysteine hydrolase and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012153898A Division JP2012197314A (ja) | 2004-10-13 | 2012-07-09 | Ｓ−アデノシル−ｌ−ホモシステイン加水分解酵素の可逆的阻害剤およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008515994A JP2008515994A (ja) | 2008-05-15 |
| JP2008515994A5 true JP2008515994A5 (https=) | 2008-11-27 |
| JP5270163B2 JP5270163B2 (ja) | 2013-08-21 |
Family
ID=36203526
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007536899A Expired - Fee Related JP5270163B2 (ja) | 2004-10-13 | 2005-10-13 | Ｓ−アデノシル−ｌ−ホモシステイン加水分解酵素の可逆的阻害剤およびその使用 |
| JP2012153898A Withdrawn JP2012197314A (ja) | 2004-10-13 | 2012-07-09 | Ｓ−アデノシル−ｌ−ホモシステイン加水分解酵素の可逆的阻害剤およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012153898A Withdrawn JP2012197314A (ja) | 2004-10-13 | 2012-07-09 | Ｓ−アデノシル−ｌ−ホモシステイン加水分解酵素の可逆的阻害剤およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7517887B2 (https=) |
| EP (1) | EP1799682B1 (https=) |
| JP (2) | JP5270163B2 (https=) |
| AU (1) | AU2005295704A1 (https=) |
| CA (1) | CA2584209A1 (https=) |
| WO (1) | WO2006044573A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7196093B2 (en) * | 2003-04-09 | 2007-03-27 | General Atomics | Reversible inhibitors of SAH hydrolase and uses thereof |
| US7517887B2 (en) | 2003-04-09 | 2009-04-14 | General Atomics | Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof |
| US7868011B2 (en) * | 2003-04-09 | 2011-01-11 | General Atomics | Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus |
| AR045134A1 (es) * | 2003-07-29 | 2005-10-19 | Smithkline Beecham Plc | Compuesto de 1h - imidazo [4,5-c] piridin-ilo, composicion farmaceutica que lo comprende, proceso para prepararla, su uso para preparar dicha composicion farmaceutica, combinacion farmaceutica, uso de la combinacion farmaceutica para la preparacion de un medicamento, procedimientos para preparar dic |
| JP4584335B2 (ja) * | 2005-09-02 | 2010-11-17 | ファイザー・インク | ヒドロキシ置換１ｈ−イミダゾピリジンおよび方法 |
| US7625890B2 (en) | 2005-11-10 | 2009-12-01 | Smithkline Beecham Corp. | Substituted imidazo[4,5-c]pyridine compounds as Akt inhibitors |
| UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
| WO2008145159A1 (de) * | 2007-05-30 | 2008-12-04 | Sarstedt Aktiengesellschaft & Co. | Eine blutentnahmevorrichtung umfassend komponenten zur stabilisierung des homocysteinspiegels und/oder zur hemmung der fortlaufenden bildung von homocystein in blutproben, serumproben oder blutplasmaproben |
| CN101456860B (zh) * | 2007-12-10 | 2011-02-16 | 中国科学院上海药物研究所 | 4-[9-(6-氨基嘌呤基)]-2(s)-羟基丁酸甲酯的制备方法 |
| TWI386204B (zh) * | 2008-04-10 | 2013-02-21 | Mitsubishi Tanabe Pharma Corp | 高半胱胺酸合成酶抑制劑 |
| CN102405047B (zh) * | 2009-01-30 | 2014-07-09 | 葛兰素史密斯克莱有限责任公司 | 结晶型的n-{(1s)-2-氨基-1-[(3-氟苯基)甲基]乙基}-5-氯-4-(4-氯-1-甲基-1h-吡唑-5-基)-2-噻吩甲酰胺盐酸盐 |
| WO2011043480A1 (ja) * | 2009-10-09 | 2011-04-14 | 田辺三菱製薬株式会社 | ホモシステイン合成酵素阻害薬 |
| US9139592B2 (en) | 2010-06-14 | 2015-09-22 | Trt Pharma Inc. | Modulators of Nrf2 and uses thereof |
| CN117045661B (zh) * | 2023-10-11 | 2024-01-30 | 广东医科大学附属医院 | Sahh可逆型抑制剂的应用、药物组合物及其应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE756914A (fr) * | 1969-10-25 | 1971-03-30 | Fujisawa Pharmaceutical Co | Nouveaux derives de l'adenine et leurs sels |
| SE8404768L (sv) * | 1983-09-27 | 1985-03-28 | Ceskoslovenska Akademie Ved | 9-(aminoalkyl)-8-hydroxiadeniner och sett for deras framstellning |
| SE463851B (sv) * | 1988-09-02 | 1991-02-04 | Amsu Ltd | Komposition foer behandling av erektil dysfunktion via uretra |
| JPH0374330A (ja) * | 1989-08-11 | 1991-03-28 | Snow Brand Milk Prod Co Ltd | 脱髄疾患治療剤 |
| DE4221256C2 (de) * | 1992-06-26 | 1997-07-10 | Lancaster Group Ag | Galenische Zusammensetzung für die topische Anwendung |
| US5804584A (en) * | 1992-11-16 | 1998-09-08 | Cell Therapeutics, Inc. | Therapeutic compounds containing a monocyclic five- to six- membered ring structure having one to two nitrogen atoms |
| US5869305A (en) * | 1992-12-04 | 1999-02-09 | The University Of Pittsburgh | Recombinant viral vector system |
| US5629327A (en) * | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| US5641783A (en) * | 1993-11-12 | 1997-06-24 | Cell Therapeutics, Inc. | Substituted amino alcohol compounds |
| US6020337A (en) * | 1993-04-05 | 2000-02-01 | Cell Therapeutics, Inc. | Electronegative-substituted long chain xanthine compounds |
| DK0705263T3 (da) | 1993-06-21 | 1997-05-05 | Merrell Pharma Inc | Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner |
| US5756466A (en) * | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5741511A (en) * | 1995-04-12 | 1998-04-21 | Sam Yang Co., Ltd. | Transdermal drug delivery device for treating erectile dysfunction |
| US5888767A (en) * | 1996-11-27 | 1999-03-30 | The Johns Hopkins University School Of Medicine | Method of using a conditionally replicating viral vector to express a gene |
| WO1997023256A1 (en) * | 1995-12-22 | 1997-07-03 | Localmed, Inc. | Localized intravascular delivery of growth factors for promotion of angiogenesis |
| US5668173A (en) * | 1996-02-23 | 1997-09-16 | The Board Of Trustees Of The University Of Illinois Corp. | Method of increasing the conversion of homocysteine to methionine and uses thereof |
| US5736154A (en) * | 1996-03-11 | 1998-04-07 | Fuisz Technologies Ltd. | Transdermal delivery system |
| US6429212B1 (en) * | 1996-08-16 | 2002-08-06 | Ishihara Sangyo Kaisha Ltd. | Medicinal composition |
| AU731838B2 (en) * | 1997-03-14 | 2001-04-05 | Otsuka Pharmaceutical Co., Ltd. | Novel pyrimidine derivative |
| ATE275834T1 (de) * | 1997-03-20 | 2004-10-15 | Coventry Group Ltd | Nährungsergänzungsmittel für kardiovasküläre gesundheit |
| US5854023A (en) * | 1997-07-17 | 1998-12-29 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding human S-adenosyl-5-homocysteine hydrolase derived from bladder |
| US6066467A (en) * | 1997-07-24 | 2000-05-23 | Anticancer, Inc. | High specificity homocysteine assays for biological samples |
| SE9703226D0 (sv) * | 1997-09-08 | 1997-09-08 | Astra Ab | New pharmaceutical composition |
| ATE293603T1 (de) * | 1997-10-14 | 2005-05-15 | Mitsubishi Pharma Corp | Piperazin-verbindungen und ihre medizinische verwendung |
| GB9724838D0 (en) * | 1997-11-26 | 1998-01-21 | Franks Christopher R | Compositions |
| US6197801B1 (en) * | 1998-01-14 | 2001-03-06 | Usa Doctors Products, Inc. | Injectable pharmaceutical composition for treatment and reversal of erectile dysfunction |
| US5962274A (en) * | 1998-03-13 | 1999-10-05 | Wake Forest University | Viral vector directed to predetermined target cells |
| CN1305846C (zh) * | 1998-03-26 | 2007-03-21 | 参天制药株式会社 | 脲衍生物 |
| EP1076649A4 (en) * | 1998-04-28 | 2010-06-02 | Trega Biosciences Inc | ISOQUINOLINE-BASED COMPOUNDS IN PLACE OF MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USE |
| US6353003B1 (en) * | 1998-06-17 | 2002-03-05 | Eli Lilly And Company | Method for reducing levels of homocysteine and C-reactive protein |
| US6323188B1 (en) * | 1998-07-01 | 2001-11-27 | Donald L. Weissman | Treatment and prevention of cardiovascular diseases, heart attack, and stroke, primary and subsequent, with help of aspirin and certain vitamins |
| US6210686B1 (en) * | 1998-12-18 | 2001-04-03 | Beth Israel Deaconess Medical Center | Dietary supplement and method for lowering risk of heart disease |
| US6274170B1 (en) * | 1999-02-18 | 2001-08-14 | Richard Heibel | Compounds for cardiovascular treatment comprising multi-vitamin and anti-platelet aggregating agents and methods for making and using the same |
| AU4684000A (en) | 1999-04-27 | 2000-11-10 | Antibody Systems, Inc. | Compositions containing tetracyclines for treating hemorrhagic virus infections and other disorders |
| US6811788B2 (en) | 2000-01-19 | 2004-11-02 | Baofa Yu | Combinations and methods for treating neoplasms |
| US6361800B1 (en) * | 2000-04-13 | 2002-03-26 | Cooper Concepts, Inc. | Multi-vitamin and mineral supplement |
| US6337317B1 (en) * | 2000-06-27 | 2002-01-08 | The University Of British Columbia | Antimicrobial peptides and methods of use thereof |
| JP2005538057A (ja) * | 2002-06-07 | 2005-12-15 | スリーエム イノベイティブ プロパティズ カンパニー | エーテル置換イミダゾピリジン |
| US7868011B2 (en) * | 2003-04-09 | 2011-01-11 | General Atomics | Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus |
| US7517887B2 (en) | 2003-04-09 | 2009-04-14 | General Atomics | Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof |
| US7196093B2 (en) * | 2003-04-09 | 2007-03-27 | General Atomics | Reversible inhibitors of SAH hydrolase and uses thereof |
-
2004
- 2004-10-13 US US10/964,236 patent/US7517887B2/en not_active Expired - Lifetime
-
2005
- 2005-10-13 CA CA002584209A patent/CA2584209A1/en not_active Abandoned
- 2005-10-13 AU AU2005295704A patent/AU2005295704A1/en not_active Abandoned
- 2005-10-13 WO PCT/US2005/036890 patent/WO2006044573A2/en not_active Ceased
- 2005-10-13 EP EP05814804A patent/EP1799682B1/en not_active Expired - Lifetime
- 2005-10-13 JP JP2007536899A patent/JP5270163B2/ja not_active Expired - Fee Related
-
2012
- 2012-07-09 JP JP2012153898A patent/JP2012197314A/ja not_active Withdrawn
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