JP2006518359A - 経皮または経粘膜投与用の医薬組成物 - Google Patents
経皮または経粘膜投与用の医薬組成物 Download PDFInfo
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- JP2006518359A JP2006518359A JP2006502159A JP2006502159A JP2006518359A JP 2006518359 A JP2006518359 A JP 2006518359A JP 2006502159 A JP2006502159 A JP 2006502159A JP 2006502159 A JP2006502159 A JP 2006502159A JP 2006518359 A JP2006518359 A JP 2006518359A
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Classifications
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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Abstract
Description
−リン酸緩衝剤(例えば、リン酸二または一ナトリウム)、クエン酸緩衝剤(例えば、クエン酸ナトリウムまたはクエン酸カリウム)、炭酸ナトリウム、重炭酸ナトリウムなどの塩基性化または塩基性緩衝剤(炭酸ナトリウムと重炭酸ナトリウムの混合物が好ましい)、または
−トリス緩衝剤などの中性緩衝剤(好ましくはリン酸緩衝剤)
からなる群から選択される。
表Iに示した組成を有する第1群のゲルについて、安定性試験を行う。
−95°エタノール26000gを、800ミリバールの減圧下に、コルマ(Koruma)ミキサー槽に導入する。
−95°エタノール19500gを、800ミリバールの減圧下に、コルマ(Koruma)ミキサー槽に入れる。
Claims (21)
- 少なくとも1種類の活性物質の経皮または経粘膜投与用の医薬組成物であって、
皮膚吸収促進剤としての少なくとも1種類の脂肪酸、少なくとも1種類のアルコール系媒体、および当該医薬組成物中の前記脂肪酸を安定化させることができる少なくとも1種類の安定剤を含むことを特徴とする医薬組成物。 - 前記脂肪酸が、カプリン酸、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸、パルミトレイン酸、リノール酸およびリノレン酸からなる群から選択される請求項1に記載の医薬組成物。
- 脂肪酸の含有量が0.1%〜20%、好ましくは0.2%〜10%、さらに好ましくは0.5%〜5%であり、これらのパーセントが医薬組成物100gに対して重量基準で表されたものである請求項1に記載の医薬組成物。
- 前記安定剤が、緩衝剤および/または前記脂肪酸のエステルからなる群から選択される請求項1に記載の医薬組成物。
- pHが4〜10、好ましくは5〜9、さらに好ましくは6〜8である請求項1に記載の医薬組成物。
- 前記緩衝剤が、
−リン酸緩衝剤(例えば、リン酸二または一ナトリウム)、クエン酸緩衝剤(例えば、クエン酸ナトリウムまたはクエン酸カリウム)、炭酸ナトリウム、重炭酸ナトリウムなどの塩基性化または塩基性緩衝剤(好ましくは炭酸ナトリウムと重炭酸ナトリウムの混合物)、あるいは
−トリス緩衝剤などの中性緩衝剤(好ましくはリン酸緩衝剤)
からなる群から選択される請求項4に記載の医薬組成物。 - 緩衝剤の含有量が1%〜80%、好ましくは5%〜70%、さらに好ましくは10%〜50%であり、これらのパーセントが医薬組成物100gに対して重量基準で表されたものである請求項6に記載の医薬組成物。
- 前記脂肪酸エステルが、オレイン酸エチル、オレイン酸イソプロピル、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、オクタン酸エチル、ドデカン酸エチル、リノール酸エチルおよびリノレン酸エチルからなる群から選択される請求項2に記載の医薬組成物。
- 脂肪酸エステルの含有量が0.1%〜10%、好ましくは0.2%〜5%、さらに好ましくは0.5%〜2.5%であり、これらのパーセントが医薬組成物100gに対して重量基準で表されたものである請求項8に記載の医薬組成物。
- 前記アルコール系媒体が、エタノールおよび/またはイソプロパノールからなる群から選択され、好ましくはエタノールである請求項1に記載の医薬組成物。
- アルコール系媒体の含有量が10%〜90%、好ましくは20%〜80%、さらに好ましくは40%〜70%であり、これらのパーセントが医薬組成物100gに対して重量基準で表されたものである請求項10に記載の医薬組成物。
- 好ましくはグリセリン、プロピレングリコールおよびポリエチレングリコール、ならびにそれらの混合物からなる群から選択される共溶媒をさらに含む請求項1に記載の医薬組成物。
- 共溶媒の含有量が0.5%〜20%、好ましくは1%〜10%であり、これらのパーセントが医薬組成物100gに対して重量基準で表されたものである請求項12に記載の医薬組成物。
- ゲル、液剤、クリーム、ローション、乳剤、軟膏剤、エーロゾル剤または貼付剤の形態、好ましくはゲルまたは液剤の形態である請求項1に記載の医薬組成物。
- ゲルの形態であり、
ゲル化剤の含有量が0.2%〜30%、好ましくは0.5%〜10%、さらに好ましくは0.3%〜5%であり、これらのパーセントが製剤100gに対して重量基準で表されたものである請求項1に記載の医薬組成物。 - 前記ゲル化剤が、カルボマー類、非前中和アクリルポリマー類、セルロース誘導体、ポロキサマー類、ポロキサミン類、キトサン、デキストラン、ペクチン類、天然ゴム類およびそれらの混合物からなる群から選択され、好ましくはカルボマー類および/またはセルロース誘導体、さらに好ましくはカルボポール(登録商標)980および/またはヒドロキシプロピルセルロースからなる群から選択される請求項15に記載の医薬組成物。
- さらに中和剤を含む請求項15に記載の医薬組成物。
- 前記中和剤が、トリエタノールアミン、水酸化ナトリウム、水酸化アンモニウム、水酸化カリウム、アルギニン、アミノメチルプロパノールおよびトロメタミン、ならびにそれらの混合物からなる群から選択され、好ましくはトリエタノールアミンおよび/またはトロメタミンである請求項17に記載の医薬組成物。
- 前記中和剤/ゲル化剤の比が、10/1〜0.1/1、好ましくは7/1〜0.5/1、さらに好ましくは4/1〜1/1である請求項17に記載の医薬組成物。
- 前記活性物質が、エストロゲン類、プロゲスチン類、アンドロゲン類、抗エストロゲン類および抗アンドロゲン類、ならびにそれらの混合物からなる群から選択される請求項1に記載の医薬組成物。
- 活性物質の含有量が0.01%〜5%であり、これらのパーセントが医薬組成物100gに対して重量基準で表されたものである請求項20に記載の医薬組成物。
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FR03/02083 | 2003-02-20 | ||
FR0302083A FR2851470B1 (fr) | 2003-02-20 | 2003-02-20 | Composition pharmaceutique pour administration transdermique ou transmuqueuse |
US10/436,380 | 2003-05-12 | ||
US10/436,380 US7611727B2 (en) | 2003-02-20 | 2003-05-12 | Pharmaceutical composition for transdermal or transmucous administration |
PCT/FR2004/000393 WO2004075822A2 (fr) | 2003-02-20 | 2004-02-19 | Composition pharmaceutique pour administration transdermique ou transmuqueuse |
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JP2006518359A true JP2006518359A (ja) | 2006-08-10 |
JP2006518359A5 JP2006518359A5 (ja) | 2007-04-05 |
JP4925103B2 JP4925103B2 (ja) | 2012-04-25 |
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US (3) | US7611727B2 (ja) |
EP (1) | EP1990061A3 (ja) |
JP (1) | JP4925103B2 (ja) |
DE (1) | DE602004017700D1 (ja) |
FR (1) | FR2851470B1 (ja) |
HK (1) | HK1084590A1 (ja) |
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JP2013508444A (ja) * | 2009-10-27 | 2013-03-07 | ブザン ヘルスケア ルクセンブルグ エスアーエールエル | 活性剤を含む経皮医薬組成物 |
JP2014528457A (ja) * | 2011-10-07 | 2014-10-27 | フロリダ ステイト ユニバーシティ リサーチ ファウンデーション | 脳震盪に関連する良好な転帰へのプロゲステロンの予防的使用および急性後使用 |
KR20160127014A (ko) * | 2014-02-04 | 2016-11-02 | 지아코 파마 리미티드 | 국소 투여용 약학 조성물 |
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Cited By (4)
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---|---|---|---|---|
JP2013508444A (ja) * | 2009-10-27 | 2013-03-07 | ブザン ヘルスケア ルクセンブルグ エスアーエールエル | 活性剤を含む経皮医薬組成物 |
JP2014528457A (ja) * | 2011-10-07 | 2014-10-27 | フロリダ ステイト ユニバーシティ リサーチ ファウンデーション | 脳震盪に関連する良好な転帰へのプロゲステロンの予防的使用および急性後使用 |
KR20160127014A (ko) * | 2014-02-04 | 2016-11-02 | 지아코 파마 리미티드 | 국소 투여용 약학 조성물 |
KR102415152B1 (ko) | 2014-02-04 | 2022-06-29 | 지아코 파마 리미티드 | 국소 투여용 약학 조성물 |
Also Published As
Publication number | Publication date |
---|---|
US20120122829A1 (en) | 2012-05-17 |
US20040175416A1 (en) | 2004-09-09 |
FR2851470A1 (fr) | 2004-08-27 |
EP1990061A2 (fr) | 2008-11-12 |
FR2851470B1 (fr) | 2007-11-16 |
DE602004017700D1 (de) | 2008-12-24 |
EP1990061A3 (fr) | 2011-09-07 |
HK1084590A1 (en) | 2006-08-04 |
JP4925103B2 (ja) | 2012-04-25 |
US20100048526A1 (en) | 2010-02-25 |
US7611727B2 (en) | 2009-11-03 |
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