JP2006517093A5 - - Google Patents

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Publication number
JP2006517093A5
JP2006517093A5 JP2004559278A JP2004559278A JP2006517093A5 JP 2006517093 A5 JP2006517093 A5 JP 2006517093A5 JP 2004559278 A JP2004559278 A JP 2004559278A JP 2004559278 A JP2004559278 A JP 2004559278A JP 2006517093 A5 JP2006517093 A5 JP 2006517093A5
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Japan
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tumor
marker
expression level
predictive marker
predictive
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JP2004559278A
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English (en)
Japanese (ja)
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JP5717937B2 (ja
JP2006517093A (ja
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Priority claimed from PCT/US2003/038539 external-priority patent/WO2004053066A2/en
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Publication of JP2006517093A5 publication Critical patent/JP2006517093A5/ja
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Publication of JP5717937B2 publication Critical patent/JP5717937B2/ja
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JP2004559278A 2002-12-06 2003-12-04 プロテアソーム阻害療法を用いた患者の同定、判定および治療方法 Expired - Lifetime JP5717937B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43151402P 2002-12-06 2002-12-06
US60/431,514 2002-12-06
PCT/US2003/038539 WO2004053066A2 (en) 2002-12-06 2003-12-04 Methods for the identification, assessment, and treatment of patients with proteasome inhibition therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010092346A Division JP5896593B2 (ja) 2002-12-06 2010-04-13 プロテアソーム阻害療法を用いた患者の同定、判定および治療方法

Publications (3)

Publication Number Publication Date
JP2006517093A JP2006517093A (ja) 2006-07-20
JP2006517093A5 true JP2006517093A5 (enExample) 2007-01-25
JP5717937B2 JP5717937B2 (ja) 2015-05-13

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JP2004559278A Expired - Lifetime JP5717937B2 (ja) 2002-12-06 2003-12-04 プロテアソーム阻害療法を用いた患者の同定、判定および治療方法
JP2010092346A Expired - Fee Related JP5896593B2 (ja) 2002-12-06 2010-04-13 プロテアソーム阻害療法を用いた患者の同定、判定および治療方法

Family Applications After (1)

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JP2010092346A Expired - Fee Related JP5896593B2 (ja) 2002-12-06 2010-04-13 プロテアソーム阻害療法を用いた患者の同定、判定および治療方法

Country Status (8)

Country Link
US (3) US20040156854A1 (enExample)
EP (1) EP1581629B1 (enExample)
JP (2) JP5717937B2 (enExample)
AU (1) AU2003298873B2 (enExample)
CA (1) CA2508348C (enExample)
ES (1) ES2542328T3 (enExample)
MX (1) MXPA05005923A (enExample)
WO (1) WO2004053066A2 (enExample)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080050836A1 (en) * 1998-05-01 2008-02-28 Isabelle Guyon Biomarkers for screening, predicting, and monitoring benign prostate hyperplasia
US20030114410A1 (en) * 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
US20090215024A1 (en) * 2001-01-24 2009-08-27 Health Discovery Corporation Biomarkers upregulated in prostate cancer
US20090226915A1 (en) * 2001-01-24 2009-09-10 Health Discovery Corporation Methods for Screening, Predicting and Monitoring Prostate Cancer
US20090215058A1 (en) * 2001-01-24 2009-08-27 Health Discovery Corporation Methods for screening, predicting and monitoring prostate cancer
AU2003300899A1 (en) * 2002-12-12 2004-06-30 Oncotech, Inc. Genes related to sensitivity and resistance to chemotherapeutic drug treatment
JP2007529426A (ja) * 2004-03-12 2007-10-25 エントレメッド インコーポレイテッド 抗血管新生薬
CA3002661C (en) 2004-05-21 2022-03-15 The Board Of Trustees Of The University Of Arkansas Use of gene expression profiling to predict survival in cancer patient
EP1828917A4 (en) * 2004-11-12 2012-04-25 Health Discovery Corp BIOMARKERS FOR DETECTING, PREDICTING AND MONITORING PROSTATE DISEASE
WO2006101535A1 (en) * 2005-03-23 2006-09-28 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Inhibition of proteasome function to potentiate the proapoptotic and antitumor activity of cytokines
WO2006112400A1 (ja) * 2005-04-18 2006-10-26 National University Corporation Hamamatsu University School Of Medicine 癌の転移性及び浸潤能の検査方法
JP5904569B2 (ja) * 2005-06-08 2016-04-13 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 癌治療を受けている患者の同定、判定および処置のための方法
EP1912664A2 (en) * 2005-07-06 2008-04-23 Biodevelops Pharma Entwicklung GmbH Use of a compound for enhancing the expression of membrane proteins on the cell surface
WO2007022041A2 (en) * 2005-08-11 2007-02-22 Novartis Ag Mutations and polymorphisms of hdac3
US20070071762A1 (en) * 2005-09-21 2007-03-29 Ccc Diagnostics, Llc Comprehensive diagnostic testing procedures for personalized anticancer chemotherapy (pac)
US20070197473A1 (en) * 2005-11-04 2007-08-23 Frankel Stanley R Methods of using SAHA and Bortezomib for treating cancer
CA2632188A1 (en) * 2005-11-10 2007-05-24 Rosetta Inpharmatics Llc Discover biological features using composite images
WO2007059111A2 (en) * 2005-11-14 2007-05-24 Entremed, Inc. Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
CN100372568C (zh) * 2005-12-09 2008-03-05 中国科学院广州生物医药与健康研究院 化合物mg-132在制备治疗白血病药物中的应用
US7875274B2 (en) * 2005-12-16 2011-01-25 The Board Of Trustees Of The Leland Stanford Junior University Protein modulators of resistance to alkylating agents
US20070292869A1 (en) * 2006-03-02 2007-12-20 Ppd Biomarker Discovery Sciences, Llc Compositions and Methods for Analyzing Renal Cancer
CA2646065C (en) * 2006-03-20 2014-01-14 Entremed, Inc. Disease modifying anti-arthritic activity of 2-methoxyestradiol
EP2021502A4 (en) * 2006-05-09 2010-08-25 Mas Metabolic Analytical Servi GENES AND ATYPICAL MARKERS IN TYPE 2 DIABETES AND OBESITY
EP2484688B1 (en) 2006-06-19 2016-06-08 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
EP2046973A4 (en) * 2006-08-10 2010-04-07 Millennium Pharm Inc METHODS OF IDENTIFYING, EVALUATING, AND TREATING PATIENTS SUBJECTED TO ANTICANCER THERAPY
US20100113392A1 (en) * 2006-11-03 2010-05-06 Badros Ashraf Z Methods of using saha and bortezomib for treating multiple myeloma
JP5413818B2 (ja) * 2007-03-29 2014-02-12 国立大学法人佐賀大学 蛍光多重染色による蛋白定量法
CA2683643C (en) * 2007-04-10 2015-11-24 Martin G. Pomper Imaging and therapy of virus-associated tumors
US20080317768A1 (en) * 2007-06-21 2008-12-25 Boeing Company Bioconjugated nanoparticles
CN110372795A (zh) 2007-08-02 2019-10-25 吉利德生物制剂公司 Lox和loxl2抑制剂及其应用
WO2009026579A1 (en) * 2007-08-23 2009-02-26 Cornell Research Foundation, Inc. Proteasome inhibitors and their use in treating pathogen infection and cancer
EP2227693B1 (en) 2007-11-30 2015-08-19 Clarient Diagnostic Services, Inc. Tle3 as a marker for chemotherapy
WO2009076551A2 (en) * 2007-12-12 2009-06-18 The Regents Of The University Of California Systems and methods for predicting response of biological samples
WO2009148528A2 (en) * 2008-05-30 2009-12-10 Millennium Pharmaceuticals, Inc. Assessment of chromosomal alterations to predict clinical outcome of bortezomib treatment
US8321144B2 (en) * 2008-10-23 2012-11-27 Microsoft Corporation Non-contiguous regions processing
US20110263442A1 (en) * 2008-10-29 2011-10-27 Jan Akervall Method of using biomarkers
US20120015906A1 (en) * 2009-01-02 2012-01-19 Shaughnessy Jr John D Uses of bortezomib in predicting survival in multiple myeloma patients
WO2010080769A2 (en) 2009-01-06 2010-07-15 Arresto Biosciences, Inc. Chemotherapeutic methods and compositions
BR112012008080A2 (pt) * 2009-08-21 2017-07-04 Gilead Biologics Inc ensaios de rastreamento in vivo.
RU2012110585A (ru) * 2009-08-21 2013-09-27 Джилид Байолоджикс, Инк. Каталичические домены лизилоксидазы и loxl2
AU2010284001A1 (en) * 2009-08-21 2012-03-22 Gilead Biologics, Inc. Therapeutic methods and compositions
US20110044907A1 (en) * 2009-08-21 2011-02-24 Derek Marshall In vivo screening assays
CA2771774A1 (en) * 2009-08-21 2011-02-24 Gilead Biologics, Inc. In vitro screening assays
US8853147B2 (en) * 2009-11-13 2014-10-07 Onyx Therapeutics, Inc. Use of peptide epoxyketones for metastasis suppression
WO2011085216A2 (en) 2010-01-08 2011-07-14 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating parkinson's disease and restless legs syndrome
WO2011094806A1 (en) * 2010-02-03 2011-08-11 Monash University Diagnostic and prognostic assay for breast cancer
RU2015108348A (ru) 2010-02-04 2015-07-20 Джилид Байолоджикс, Инк. Антитела, связывающиеся с лизилоксидазоподобным ферментом-2 (loxl2), и способы их применения
US20130224151A1 (en) 2010-03-31 2013-08-29 United States Of America Use of FAAH Inhibitors for Treating Abdominal, Visceral and Pelvic Pain
JP5740880B2 (ja) 2010-09-15 2015-07-01 株式会社リコー 画像形成装置、及びプログラム
SI2742356T1 (sl) * 2011-08-11 2016-06-30 Janssen Pharmaceutica N.V. Prediktorji pri zdravljenju raka
US20150184246A1 (en) * 2011-11-11 2015-07-02 Millennium Pharmaceuticals, Inc. Biomarkers of response to proteasome inhibitors
WO2013148147A1 (en) 2012-03-26 2013-10-03 The U.S.A., As Represented By The Secretary Dept. Of Health And Human Services Dna methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms
WO2014078571A1 (en) * 2012-11-14 2014-05-22 The Board Of Trustees Of The University Of Arkansas Methods of detecting 14q32 translocations
EP3305916B1 (en) 2013-05-20 2019-06-26 BioVentures, LLC Gep5 model for multiple myeloma
ES2923942T3 (es) 2013-11-06 2022-10-03 Us Health Procedimiento para el subtipado de tipos de linfoma por medio de perfiles de expresión
US20170166974A1 (en) * 2014-05-20 2017-06-15 Erasmus University Medical Center Rotterdam Method for the treatment of multiple myeloma
US10607152B2 (en) * 2015-05-26 2020-03-31 Textio, Inc. Using machine learning to predict outcomes for documents
US20170159130A1 (en) * 2015-12-03 2017-06-08 Amit Kumar Mitra Transcriptional classification and prediction of drug response (t-cap dr)
USRE50076E1 (en) 2015-12-30 2024-08-13 Hyundai Heavy Industries Co., Ltd. Liquefied gas carrier
WO2017184861A1 (en) 2016-04-20 2017-10-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Evaluation of mantle cell lymphoma and methods related thereto
CN106928370B (zh) * 2016-09-26 2021-02-02 华东师范大学 一种REGγ-20S蛋白酶体抑制剂的筛选系统及其应用
US11804298B2 (en) 2017-07-17 2023-10-31 Joon Kim Cancer diagnostic apparatus and cancer diagnostic system using the same
KR102007664B1 (ko) * 2017-07-17 2019-08-07 김준 암 진단기 및 이를 이용한 암 진단시스템
US11899022B2 (en) 2017-08-23 2024-02-13 The General Hospital Corporation Multiplexed proteomics and predictive drug candidate assessment
EP3502279A1 (en) * 2017-12-20 2019-06-26 Koninklijke Philips N.V. Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression
US12433488B2 (en) * 2018-01-17 2025-10-07 14336186 Canada Corp. (Exclaro) System and methods for real time raman spectroscopy for cancer detection
CN110499287B (zh) * 2019-08-30 2021-07-23 博雅干细胞科技有限公司 简易制备胎盘间充质干细胞外泌体的方法
US20230340604A1 (en) * 2022-04-20 2023-10-26 Morehouse School Of Medicine Methods of treatment and diagnosis of multiple myeloma progression

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
WO1987002671A1 (en) 1985-11-01 1987-05-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2077665A1 (en) 1990-03-05 1991-09-06 Robert Siman Chymotrypsin-like proteases and their inhibitors
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
CA2087413A1 (en) 1992-01-17 1993-07-18 Joseph R. Lakowicz Fluorescent energy transfer immunoassay
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5693617A (en) 1994-03-15 1997-12-02 Proscript, Inc. Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
US6660268B1 (en) 1994-03-18 2003-12-09 The President And Fellows Of Harvard College Proteasome regulation of NF-KB activity
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US6335358B1 (en) 1995-04-12 2002-01-01 President And Fellows Of Harvard College Lactacystin analogs
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
GB9704444D0 (en) * 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US6355623B2 (en) * 1998-09-24 2002-03-12 Hopital-Sainte-Justine Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage
WO2001002567A1 (en) * 1999-07-02 2001-01-11 Millennium Pharmaceuticals, Inc. 16405 receptor, a g-protein coupled receptor
WO2001064837A2 (en) * 2000-02-29 2001-09-07 The General Hospital Corporation β NETRIN AND USES THEREOF
US20040006205A1 (en) * 2001-04-03 2004-01-08 Li Li Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20030185815A1 (en) * 2001-04-03 2003-10-02 Muralidhara Padigaru Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use
CA2446806A1 (en) * 2001-05-11 2002-11-21 Board Of Regents, The University Of Texas System Anti-cd26 monoclonal antibodies as therapy for diseases associated with cells expressing cd26
JP5904569B2 (ja) * 2005-06-08 2016-04-13 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 癌治療を受けている患者の同定、判定および処置のための方法
US8067152B2 (en) * 2006-02-27 2011-11-29 The Fred Hutchinson Cancer Research Center Liver cancer biomarkers

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