JP2006516652A5 - - Google Patents
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- JP2006516652A5 JP2006516652A5 JP2006503317A JP2006503317A JP2006516652A5 JP 2006516652 A5 JP2006516652 A5 JP 2006516652A5 JP 2006503317 A JP2006503317 A JP 2006503317A JP 2006503317 A JP2006503317 A JP 2006503317A JP 2006516652 A5 JP2006516652 A5 JP 2006516652A5
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- JP
- Japan
- Prior art keywords
- composition
- peptide
- amino acids
- minimum
- net positive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 36
- 150000001413 amino acids Chemical class 0.000 claims 14
- 241000124008 Mammalia Species 0.000 claims 11
- 230000002438 mitochondrial effect Effects 0.000 claims 9
- 230000037050 permeability transition Effects 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 6
- 230000004770 neurodegeneration Effects 0.000 claims 5
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 230000000903 blocking effect Effects 0.000 claims 4
- 208000028867 ischemia Diseases 0.000 claims 4
- 210000003205 muscle Anatomy 0.000 claims 4
- 210000003470 mitochondria Anatomy 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- SFVLTCAESLKEHH-WKAQUBQDSA-N (2s)-6-amino-2-[[(2s)-2-[[(2r)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-n-[(2s)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide Chemical compound CC1=CC(O)=CC(C)=C1C[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N)=O)CC1=CC=CC=C1 SFVLTCAESLKEHH-WKAQUBQDSA-N 0.000 claims 2
- 206010021143 Hypoxia Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 108010033284 arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide Proteins 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 125000002091 cationic group Chemical group 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000007954 hypoxia Effects 0.000 claims 2
- 239000002756 mu opiate receptor agonist Substances 0.000 claims 2
- 229940126487 mu opioid receptor agonist Drugs 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- LSNDLIKCFHLFKO-JTQLQIEISA-N (2s)-2-azaniumyl-3-(4-hydroxy-2,6-dimethylphenyl)propanoate Chemical group CC1=CC(O)=CC(C)=C1C[C@H](N)C(O)=O LSNDLIKCFHLFKO-JTQLQIEISA-N 0.000 claims 1
- UEVAHGMTRWGMTB-JBXUNAHCSA-N (2s)-6-amino-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]hexanamide Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 UEVAHGMTRWGMTB-JBXUNAHCSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 150000008574 D-amino acids Chemical class 0.000 claims 1
- 125000002038 D-arginyl group Chemical group N[C@@H](C(=O)*)CCCNC(=N)N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010022680 Intestinal ischaemia Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 108010048898 phenylalanyl-arginyl-phenylalanyllysinamide Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000010410 reperfusion Effects 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 108010094098 tyrosyl-arginyl-phenylalanyl-lysinamide Proteins 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44477703P | 2003-02-04 | 2003-02-04 | |
| US60/444,777 | 2003-02-04 | ||
| US53569004P | 2004-01-08 | 2004-01-08 | |
| US60/535,690 | 2004-01-08 | ||
| PCT/US2004/003193 WO2004070054A2 (en) | 2003-02-04 | 2004-02-03 | Methods for preventing mitochondrial permeability transition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010241738A Division JP5775285B2 (ja) | 2003-02-04 | 2010-10-28 | ミトコンドリア透過性転移の阻止方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006516652A JP2006516652A (ja) | 2006-07-06 |
| JP2006516652A5 true JP2006516652A5 (cg-RX-API-DMAC7.html) | 2007-10-18 |
| JP4838114B2 JP4838114B2 (ja) | 2011-12-14 |
Family
ID=32853391
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503317A Expired - Lifetime JP4838114B2 (ja) | 2003-02-04 | 2004-02-03 | ミトコンドリア透過性転移の阻止方法 |
| JP2010241738A Expired - Lifetime JP5775285B2 (ja) | 2003-02-04 | 2010-10-28 | ミトコンドリア透過性転移の阻止方法 |
| JP2013182343A Expired - Lifetime JP5837542B2 (ja) | 2003-02-04 | 2013-09-03 | ミトコンドリア透過性転移の阻止方法 |
| JP2014202889A Expired - Lifetime JP6126059B2 (ja) | 2003-02-04 | 2014-10-01 | ミトコンドリア透過性転移の阻止方法 |
| JP2015135207A Expired - Lifetime JP6166312B2 (ja) | 2003-02-04 | 2015-07-06 | ミトコンドリア透過性転移の阻止方法 |
| JP2017025764A Pending JP2017095519A (ja) | 2003-02-04 | 2017-02-15 | ミトコンドリア透過性転移の阻止方法 |
| JP2019001256A Pending JP2019089773A (ja) | 2003-02-04 | 2019-01-08 | ミトコンドリア透過性転移の阻止方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010241738A Expired - Lifetime JP5775285B2 (ja) | 2003-02-04 | 2010-10-28 | ミトコンドリア透過性転移の阻止方法 |
| JP2013182343A Expired - Lifetime JP5837542B2 (ja) | 2003-02-04 | 2013-09-03 | ミトコンドリア透過性転移の阻止方法 |
| JP2014202889A Expired - Lifetime JP6126059B2 (ja) | 2003-02-04 | 2014-10-01 | ミトコンドリア透過性転移の阻止方法 |
| JP2015135207A Expired - Lifetime JP6166312B2 (ja) | 2003-02-04 | 2015-07-06 | ミトコンドリア透過性転移の阻止方法 |
| JP2017025764A Pending JP2017095519A (ja) | 2003-02-04 | 2017-02-15 | ミトコンドリア透過性転移の阻止方法 |
| JP2019001256A Pending JP2019089773A (ja) | 2003-02-04 | 2019-01-08 | ミトコンドリア透過性転移の阻止方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (8) | US7576061B2 (cg-RX-API-DMAC7.html) |
| EP (9) | EP1599216B9 (cg-RX-API-DMAC7.html) |
| JP (7) | JP4838114B2 (cg-RX-API-DMAC7.html) |
| CN (3) | CN102784383B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004209663B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2515080C (cg-RX-API-DMAC7.html) |
| CY (2) | CY1114959T1 (cg-RX-API-DMAC7.html) |
| DK (3) | DK2656854T3 (cg-RX-API-DMAC7.html) |
| ES (3) | ES2436011T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE027110T2 (cg-RX-API-DMAC7.html) |
| PT (2) | PT1599216E (cg-RX-API-DMAC7.html) |
| SI (1) | SI2656854T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004070054A2 (cg-RX-API-DMAC7.html) |
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| CA2971931C (en) | 2004-01-23 | 2019-01-08 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
| AU2014203126B2 (en) * | 2005-09-16 | 2016-03-10 | Cornell Research Foundation, Inc. | Methods for reducing cd36 expression |
| EP3725324A1 (en) * | 2005-09-16 | 2020-10-21 | Cornell Research Foundation, Inc. | Aromatic-cationic peptide for use in a method for reducing cd36 expression |
| DK2252312T3 (da) | 2008-02-07 | 2014-06-16 | Univ Cornell | Fremgangsmåder til forebyggelse eller behandling af insulinresistens |
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| DE102008061044A1 (de) | 2008-12-11 | 2010-06-17 | Henkel Ag & Co. Kgaa | Zusammensetzung mit antioxidativ wirksamen Peptiden |
| CN102573881A (zh) * | 2009-03-20 | 2012-07-11 | 通用医疗公司以马萨诸塞州通用医疗公司名义经营 | 预防和治疗烧伤损伤和继发性并发症的方法 |
| JP5909182B2 (ja) * | 2009-08-12 | 2016-04-26 | コーネル ユニヴァーシティー | 代謝性症候群を予防し又は治療するための方法 |
| EP3338788A1 (en) | 2009-08-24 | 2018-06-27 | Stealth Peptides International, Inc. | Methods and copositions for preventing or treating opthalmic conditions |
| CN102711785A (zh) * | 2009-10-05 | 2012-10-03 | 康奈尔大学 | 预防或治疗心力衰竭的方法 |
| US20130190244A1 (en) * | 2009-12-31 | 2013-07-25 | Stealth Peptides International, Inc. | Methods for performing a coronary artery bypass graft procedure |
| EP3090754A1 (en) * | 2009-12-31 | 2016-11-09 | Stealth Peptides International, Inc. | Methods for the prevention or treatment of vessel occlusion injury |
| CN104725472A (zh) * | 2010-01-25 | 2015-06-24 | 康奈尔大学 | 芳香族阳离子肽及其用途 |
| US20130040901A1 (en) * | 2010-02-26 | 2013-02-14 | University Of Florida Research Foundation Inc. | Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy |
| EP3040080A1 (en) | 2010-03-15 | 2016-07-06 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
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| WO2012129427A2 (en) * | 2011-03-24 | 2012-09-27 | Cornell University | Aromatic-cationic peptides and uses of same |
| US9434753B2 (en) | 2011-09-19 | 2016-09-06 | Gencia Corporation | Modified creatine compounds |
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| CN104114181B (zh) * | 2011-10-17 | 2017-06-09 | 康奈尔大学 | 芳香族阳离子肽及其用途 |
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| CN110193077A (zh) * | 2012-10-22 | 2019-09-03 | 康德生物医疗技术公司 | 降低与心脏衰竭相关的风险和与其相关的因素的方法 |
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| CA2920020C (en) | 2013-08-02 | 2023-03-14 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention and treatment of friedreich's ataxia |
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| PT1599216E (pt) * | 2003-02-04 | 2013-12-17 | Cornell Res Foundation Inc | Métodos de prevenção da transição de permeabilidade mitocondrial |
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2004
- 2004-02-03 PT PT47078092T patent/PT1599216E/pt unknown
- 2004-02-03 ES ES04707809T patent/ES2436011T3/es not_active Expired - Lifetime
- 2004-02-03 DK DK13178043.9T patent/DK2656854T3/en active
- 2004-02-03 EP EP04707809.2A patent/EP1599216B9/en not_active Expired - Lifetime
- 2004-02-03 EP EP20210900.5A patent/EP3842055A1/en active Pending
- 2004-02-03 EP EP19207802.0A patent/EP3659618A1/en not_active Withdrawn
- 2004-02-03 ES ES13178043.9T patent/ES2540897T3/es not_active Expired - Lifetime
- 2004-02-03 EP EP11009660.9A patent/EP2491943B1/en not_active Expired - Lifetime
- 2004-02-03 AU AU2004209663A patent/AU2004209663B2/en not_active Expired
- 2004-02-03 PT PT131780439T patent/PT2656854E/pt unknown
- 2004-02-03 US US10/771,232 patent/US7576061B2/en active Active
- 2004-02-03 SI SI200432258T patent/SI2656854T1/sl unknown
- 2004-02-03 CN CN201210177633.0A patent/CN102784383B/zh not_active Expired - Lifetime
- 2004-02-03 EP EP17192437.6A patent/EP3305313A1/en not_active Withdrawn
- 2004-02-03 EP EP14186875.2A patent/EP2865385B1/en not_active Expired - Lifetime
- 2004-02-03 ES ES14186875.2T patent/ES2605504T3/es not_active Expired - Lifetime
- 2004-02-03 EP EP20130178043 patent/EP2656854B1/en not_active Expired - Lifetime
- 2004-02-03 CN CN2012100218642A patent/CN102617706A/zh active Pending
- 2004-02-03 DK DK14186875.2T patent/DK2865385T3/en active
- 2004-02-03 HU HUE13178043A patent/HUE027110T2/en unknown
- 2004-02-03 EP EP18199147.2A patent/EP3479838A1/en not_active Withdrawn
- 2004-02-03 CN CN201410412683.1A patent/CN104225574B/zh not_active Expired - Lifetime
- 2004-02-03 DK DK04707809.2T patent/DK1599216T3/da active
- 2004-02-03 WO PCT/US2004/003193 patent/WO2004070054A2/en not_active Ceased
- 2004-02-03 CA CA2515080A patent/CA2515080C/en not_active Expired - Lifetime
- 2004-02-03 JP JP2006503317A patent/JP4838114B2/ja not_active Expired - Lifetime
- 2004-02-03 EP EP16192437.8A patent/EP3144009A1/en not_active Withdrawn
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2006
- 2006-06-30 US US11/427,804 patent/US7718620B2/en active Active
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2010
- 2010-04-02 US US12/753,403 patent/US20100190718A1/en not_active Abandoned
- 2010-10-28 JP JP2010241738A patent/JP5775285B2/ja not_active Expired - Lifetime
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2011
- 2011-09-28 US US13/247,648 patent/US8404646B2/en not_active Expired - Fee Related
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2013
- 2013-02-27 US US13/778,994 patent/US8957030B2/en not_active Expired - Lifetime
- 2013-09-03 JP JP2013182343A patent/JP5837542B2/ja not_active Expired - Lifetime
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2014
- 2014-01-24 CY CY20141100064T patent/CY1114959T1/el unknown
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2015
- 2015-01-13 US US14/595,946 patent/US20150359838A1/en not_active Abandoned
- 2015-07-06 JP JP2015135207A patent/JP6166312B2/ja not_active Expired - Lifetime
- 2015-08-03 CY CY20151100675T patent/CY1116575T1/el unknown
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2017
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2019
- 2019-01-08 JP JP2019001256A patent/JP2019089773A/ja active Pending
- 2019-09-12 US US16/569,573 patent/US20200038472A1/en not_active Abandoned
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2022
- 2022-02-10 US US17/668,744 patent/US20230293624A1/en not_active Abandoned
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