JP2006516643A - 過敏性大腸症候群及び神経性胃炎の治療用組成物及び方法 - Google Patents

過敏性大腸症候群及び神経性胃炎の治療用組成物及び方法 Download PDF

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Publication number
JP2006516643A
JP2006516643A JP2006503254A JP2006503254A JP2006516643A JP 2006516643 A JP2006516643 A JP 2006516643A JP 2006503254 A JP2006503254 A JP 2006503254A JP 2006503254 A JP2006503254 A JP 2006503254A JP 2006516643 A JP2006516643 A JP 2006516643A
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Prior art keywords
compound
formula
patient
tianeptine
group
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Japanese (ja)
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JP2006516643A5 (enExample
Inventor
エフ．クチャリック ロバート
ダブリュー．ハリス ハーバート
Original Assignee
ヴェラ ファーマスーティカルズ インコーポレイテッド
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Publication of JP2006516643A publication Critical patent/JP2006516643A/ja
Publication of JP2006516643A5 publication Critical patent/JP2006516643A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
JP2006503254A 2003-02-04 2004-02-02 過敏性大腸症候群及び神経性胃炎の治療用組成物及び方法 Pending JP2006516643A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/358,034 US6683072B1 (en) 2003-02-04 2003-02-04 Compositions and methods for treatment of irritable bowel syndrome and nonulcer dyspepsia
PCT/US2004/002931 WO2004069188A2 (en) 2003-02-04 2004-02-02 Methods for treatment of ibs and nud

Publications (2)

Publication Number Publication Date
JP2006516643A true JP2006516643A (ja) 2006-07-06
JP2006516643A5 JP2006516643A5 (enExample) 2007-03-15

Family

ID=30115458

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006503254A Pending JP2006516643A (ja) 2003-02-04 2004-02-02 過敏性大腸症候群及び神経性胃炎の治療用組成物及び方法

Country Status (7)

Country Link
US (1) US6683072B1 (enExample)
EP (1) EP1594509B1 (enExample)
JP (1) JP2006516643A (enExample)
AT (1) ATE476982T1 (enExample)
CA (1) CA2515048A1 (enExample)
DE (1) DE602004028574D1 (enExample)
WO (1) WO2004069188A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010520298A (ja) * 2007-03-05 2010-06-10 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド ７−［（３−クロロ−６，１１−ジヒドロ−６−メチルジベンゾ［ｃ，ｆ］［１，２］チアゼピン−１１−イル）アミノ］ヘプタン酸Ｓ，Ｓ−ジオキシドの多形相ならびにそれらの製造及び使用方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003293405A1 (en) * 2002-12-03 2004-06-23 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
FR2881350B1 (fr) * 2005-02-02 2007-04-06 Merck Generiques Soc En Comman Nouvelle forme galenique orale de la tianeptine
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers
EP1752143A1 (en) * 2005-08-08 2007-02-14 NewThera Novel uses for drugs targeting glutamine synthetase
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
JP5546451B2 (ja) 2007-06-04 2014-07-09 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US8198268B2 (en) * 2008-10-31 2012-06-12 Janssen Biotech, Inc. Tianeptine sulfate salt forms and methods of making and using the same
CN102977053B (zh) * 2012-11-30 2015-04-15 山东诚创医药技术开发有限公司 一种噻奈普汀钠杂质d的制备方法
HK1220696A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 鸟苷酸环化酶激动剂及其用途
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
GB201517133D0 (en) * 2015-09-28 2015-11-11 Numedicus Ltd New pharmaceutical use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3758528A (en) * 1970-03-13 1973-09-11 Science Union & Cie Tricyclic compounds
EP0004516A2 (fr) * 1978-03-28 1979-10-03 SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE Nouvelles compositions pharmaceutiques agissant sur la motricité gastro-intestinale
JP2001316380A (ja) * 2000-03-31 2001-11-13 Adir １１−アミノ−３−クロロ−６，１１−ジヒドロ−５，５−ジオキソ−６−メチル−ジベンゾ〔ｃ，ｆ〕〔１，２〕チアゼピンの製造方法及びチアネピンの合成への応用
JP2002528386A (ja) * 1998-08-05 2002-09-03 ジョージタウン・ユニバーシティ 新規な二および三環式アザ化合物およびその使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL138423C (enExample) 1966-07-14
GB1269551A (en) 1969-03-27 1972-04-06 Science Union & Cie New tricyclic derivatives and process for their manufacture
US3821249A (en) 1970-03-13 1974-06-28 En Nom Collectif Science Union Dibenzothiazefin derivatives
FR2480283A1 (fr) 1980-04-10 1981-10-16 Science Union & Cie Nouveaux derives tricycliques, leurs procedes de preparation et leur utilisation comme medicament
FR2594827B1 (fr) 1986-02-21 1988-05-20 Adir Nouveau derive tricyclique denomme acide ((chloro-3 methyl-6 dioxo-5,5 dihydro-6, 11 dibenzo (c,f) thiazepine (1,2) yl-11 amino)-5 pentazoique, son procede de preparation et les compositions pharmaceutiques qui le contiennent
FR2747921B1 (fr) 1996-04-24 1998-10-30 Adir Comprime matriciel permettant la liberation prolongee du sel de sodium de tianeptine apres administration par voie orale

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3758528A (en) * 1970-03-13 1973-09-11 Science Union & Cie Tricyclic compounds
EP0004516A2 (fr) * 1978-03-28 1979-10-03 SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE Nouvelles compositions pharmaceutiques agissant sur la motricité gastro-intestinale
JP2002528386A (ja) * 1998-08-05 2002-09-03 ジョージタウン・ユニバーシティ 新規な二および三環式アザ化合物およびその使用
JP2001316380A (ja) * 2000-03-31 2001-11-13 Adir １１−アミノ−３−クロロ−６，１１−ジヒドロ−５，５−ジオキソ−６−メチル−ジベンゾ〔ｃ，ｆ〕〔１，２〕チアゼピンの製造方法及びチアネピンの合成への応用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010520298A (ja) * 2007-03-05 2010-06-10 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド ７−［（３−クロロ−６，１１−ジヒドロ−６−メチルジベンゾ［ｃ，ｆ］［１，２］チアゼピン−１１−イル）アミノ］ヘプタン酸Ｓ，Ｓ−ジオキシドの多形相ならびにそれらの製造及び使用方法

Also Published As

Publication number Publication date
EP1594509A2 (en) 2005-11-16
EP1594509A4 (en) 2009-06-03
ATE476982T1 (de) 2010-08-15
EP1594509B1 (en) 2010-08-11
WO2004069188A2 (en) 2004-08-19
US6683072B1 (en) 2004-01-27
WO2004069188A3 (en) 2005-03-17
CA2515048A1 (en) 2004-08-19
DE602004028574D1 (de) 2010-09-23

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