JP2006516641A - アデノシン受容体の完全アゴニストおよび部分アゴニスト - Google Patents
アデノシン受容体の完全アゴニストおよび部分アゴニスト Download PDFInfo
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- JP2006516641A JP2006516641A JP2006503239A JP2006503239A JP2006516641A JP 2006516641 A JP2006516641 A JP 2006516641A JP 2006503239 A JP2006503239 A JP 2006503239A JP 2006503239 A JP2006503239 A JP 2006503239A JP 2006516641 A JP2006516641 A JP 2006516641A
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- JP
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- Prior art keywords
- amino
- oxolan
- hydroxymethyl
- purin
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000009346 Adenosine receptors Human genes 0.000 title description 3
- 108050000203 Adenosine receptors Proteins 0.000 title description 3
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- 208000010125 myocardial infarction Diseases 0.000 claims abstract description 3
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- 125000000217 alkyl group Chemical group 0.000 claims description 55
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- 125000001424 substituent group Chemical group 0.000 claims description 49
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- 229960005305 adenosine Drugs 0.000 claims description 26
- 229910052736 halogen Inorganic materials 0.000 claims description 26
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- 125000004093 cyano group Chemical group *C#N 0.000 claims description 25
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 239000001257 hydrogen Substances 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 24
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 23
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 21
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- SHSCEZIUPOISRQ-JNIYBQFBSA-N 1-[(3r)-3-[[2-chloro-9-[(2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]pyrrolidin-1-yl]ethanone Chemical compound C1N(C(=O)C)CC[C@H]1NC1=NC(Cl)=NC2=C1N=CN2[C@H]1[C@H](O)C[C@@H](CO)O1 SHSCEZIUPOISRQ-JNIYBQFBSA-N 0.000 claims description 2
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- 201000004332 intermediate coronary syndrome Diseases 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- VIQDUCBDZPYNNX-UHFFFAOYSA-N phenyl(pyrrolidin-1-yl)methanone Chemical compound C=1C=CC=CC=1C(=O)N1CCCC1 VIQDUCBDZPYNNX-UHFFFAOYSA-N 0.000 claims description 2
- KKNKYIHFOMMLCJ-LZGVZRDRSA-N (2r,3r,5s)-2-[2-chloro-6-[[(1r)-2-hydroxycyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol Chemical compound O1[C@H](CO)C[C@@H](O)[C@@H]1N1C2=NC(Cl)=NC(N[C@H]3C(CCC3)O)=C2N=C1 KKNKYIHFOMMLCJ-LZGVZRDRSA-N 0.000 claims 1
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- YAUUECFHRSHLAF-UHFFFAOYSA-N (4-fluorophenyl)-pyrrolidin-1-ylmethanone Chemical compound C1=CC(F)=CC=C1C(=O)N1CCCC1 YAUUECFHRSHLAF-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44452603P | 2003-02-03 | 2003-02-03 | |
| PCT/US2004/002868 WO2004069185A2 (en) | 2003-02-03 | 2004-02-02 | Partial and full agonists of a1 adenosine receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006516641A true JP2006516641A (ja) | 2006-07-06 |
| JP2006516641A5 JP2006516641A5 (enExample) | 2007-03-22 |
Family
ID=32850877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503239A Pending JP2006516641A (ja) | 2003-02-03 | 2004-02-02 | アデノシン受容体の完全アゴニストおよび部分アゴニスト |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7163928B2 (enExample) |
| EP (1) | EP1590359A2 (enExample) |
| JP (1) | JP2006516641A (enExample) |
| KR (1) | KR20050097971A (enExample) |
| AU (1) | AU2004209986C1 (enExample) |
| CA (1) | CA2515068A1 (enExample) |
| NZ (1) | NZ541651A (enExample) |
| WO (1) | WO2004069185A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7371737B2 (en) | 2004-09-09 | 2008-05-13 | Solvay Pharmaceuticals, B.V. | 2-substituted-6-trifluoromethyl purine derivatives with adenosine-A3 antagonistic activity |
| US7338964B2 (en) | 2004-09-09 | 2008-03-04 | Solvay Pharmaceuticals, B.V. | 2-substituted-1-deaza purine derivatives with adenosine receptor modulating activity |
| AR050630A1 (es) * | 2004-09-09 | 2006-11-08 | Solvay Pharm Bv | DERIVADOS DE 6- TRIFLUOROMETIL PURINA 2- SUSTITUIDA CON ACTIVIDAD ANTAGONISTA DE ADENOSINA-A3. PROCESOS DE OBTENCIoN Y COMPOSICIONES FARMACÉUTICAS. |
| US7488720B2 (en) | 2005-10-13 | 2009-02-10 | Cv Therapeutics, Inc. | A1 adenosine receptor agonists |
| BRPI0619261A2 (pt) * | 2005-11-30 | 2011-09-27 | Inotek Pharmaceuticals Corp | derivados de purina e métodos de uso desses |
| KR101204213B1 (ko) | 2007-12-21 | 2012-11-26 | 에프. 호프만-라 로슈 아게 | 오렉신 수용체 길항제로서의 헤테로아릴 유도체 |
| ATE535515T1 (de) | 2008-01-11 | 2011-12-15 | Hoffmann La Roche | Modulatoren für amyloid beta |
| KR101247840B1 (ko) | 2008-02-22 | 2013-03-26 | 에프. 호프만-라 로슈 아게 | 아밀로이드 베타 조절제 |
| JP5502089B2 (ja) | 2008-10-09 | 2014-05-28 | エフ．ホフマン−ラ ロシュ アーゲー | アミロイドβのモジュレーター |
| CN102209537A (zh) | 2008-11-10 | 2011-10-05 | 弗·哈夫曼-拉罗切有限公司 | 杂环γ分泌酶调节剂 |
| EP2448953A1 (en) | 2009-06-30 | 2012-05-09 | Forest Laboratories Holdings Limited | Alkoxy-carbonyl-amino-alkynyl-adenosine compounds and derivatives thatreof as a2ar agonists |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| AR131380A1 (es) | 2022-12-16 | 2025-03-12 | Astrazeneca Ab | Purinas 2,6,9-trisustituidas |
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- 2004-02-02 US US10/770,542 patent/US7163928B2/en not_active Expired - Lifetime
- 2004-02-02 NZ NZ541651A patent/NZ541651A/en unknown
- 2004-02-02 CA CA002515068A patent/CA2515068A1/en not_active Abandoned
- 2004-02-02 EP EP04707373A patent/EP1590359A2/en not_active Withdrawn
- 2004-02-02 KR KR1020057014259A patent/KR20050097971A/ko not_active Ceased
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| JPS55160796A (en) * | 1979-06-01 | 1980-12-13 | Yamasa Shoyu Co Ltd | Preparation of n6-alkyl cordycepin |
| JPS55160794A (en) * | 1979-06-01 | 1980-12-13 | Yamasa Shoyu Co Ltd | N6-substituted cordycepin and its preparation |
| JPH07500586A (ja) * | 1991-10-24 | 1995-01-19 | ノボ ノルディスク アクティーゼルスカブ | 新規２，６−ジ置換プリン誘導体 |
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| WO1999020284A1 (en) * | 1997-10-23 | 1999-04-29 | Trustees Of The University Of Pennsylvania | Methods for reducing ischemic injury of the heart via the sequential administration of monophosphoryl lipid a and adenosine receptor agents |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1590359A2 (en) | 2005-11-02 |
| AU2004209986A1 (en) | 2004-08-19 |
| US20040198691A1 (en) | 2004-10-07 |
| US7163928B2 (en) | 2007-01-16 |
| AU2004209986B2 (en) | 2009-01-22 |
| KR20050097971A (ko) | 2005-10-10 |
| NZ541651A (en) | 2009-01-31 |
| WO2004069185A3 (en) | 2004-09-23 |
| CA2515068A1 (en) | 2004-08-19 |
| WO2004069185A2 (en) | 2004-08-19 |
| AU2004209986C1 (en) | 2009-08-13 |
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