JP2006516409A5 - - Google Patents
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- Publication number
- JP2006516409A5 JP2006516409A5 JP2006503245A JP2006503245A JP2006516409A5 JP 2006516409 A5 JP2006516409 A5 JP 2006516409A5 JP 2006503245 A JP2006503245 A JP 2006503245A JP 2006503245 A JP2006503245 A JP 2006503245A JP 2006516409 A5 JP2006516409 A5 JP 2006516409A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- chain variable
- variable region
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 26
- 239000000523 sample Substances 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 230000001404 mediated effect Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 230000014759 maintenance of location Effects 0.000 claims 4
- 239000013068 control sample Substances 0.000 claims 3
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 208000024780 Urticaria Diseases 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 101100227726 Arabidopsis thaliana FRL3 gene Proteins 0.000 claims 1
- 101100120609 Caenorhabditis elegans frh-1 gene Proteins 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012434 Dermatitis allergic Diseases 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 101150023991 FMNL1 gene Proteins 0.000 claims 1
- 101150005226 FRL1 gene Proteins 0.000 claims 1
- 101150065691 FRL2 gene Proteins 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010016946 Food allergy Diseases 0.000 claims 1
- 102100028930 Formin-like protein 1 Human genes 0.000 claims 1
- 102100032789 Formin-like protein 3 Human genes 0.000 claims 1
- 201000010435 allergic urticaria Diseases 0.000 claims 1
- 208000010216 atopic IgE responsiveness Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 101150029401 fmnl3 gene Proteins 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44422903P | 2003-02-01 | 2003-02-01 | |
| US60/444,229 | 2003-02-01 | ||
| PCT/US2004/002894 WO2004070011A2 (en) | 2003-02-01 | 2004-02-02 | HIGH AFFINITY ANTI-HUMAN IgE ANTIBODIES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011098737A Division JP5296138B2 (ja) | 2003-02-01 | 2011-04-26 | 高親和性抗ヒトＩｇＥ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006516409A JP2006516409A (ja) | 2006-07-06 |
| JP2006516409A5 true JP2006516409A5 (https=) | 2009-10-22 |
| JP4764334B2 JP4764334B2 (ja) | 2011-08-31 |
Family
ID=32850839
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503243A Pending JP2006516408A (ja) | 2003-02-01 | 2004-02-02 | 高親和性抗体の生成方法 |
| JP2006503245A Expired - Lifetime JP4764334B2 (ja) | 2003-02-01 | 2004-02-02 | 高親和性抗ヒトＩｇＥ抗体 |
| JP2010202452A Pending JP2011042654A (ja) | 2003-02-01 | 2010-09-09 | 新規のＩｇＥエピトープの同定 |
| JP2011098737A Expired - Lifetime JP5296138B2 (ja) | 2003-02-01 | 2011-04-26 | 高親和性抗ヒトＩｇＥ抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503243A Pending JP2006516408A (ja) | 2003-02-01 | 2004-02-02 | 高親和性抗体の生成方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010202452A Pending JP2011042654A (ja) | 2003-02-01 | 2010-09-09 | 新規のＩｇＥエピトープの同定 |
| JP2011098737A Expired - Lifetime JP5296138B2 (ja) | 2003-02-01 | 2011-04-26 | 高親和性抗ヒトＩｇＥ抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7531169B2 (https=) |
| EP (4) | EP2000481B1 (https=) |
| JP (4) | JP2006516408A (https=) |
| CN (3) | CN1829806A (https=) |
| AU (3) | AU2004209637A1 (https=) |
| CA (2) | CA2514840C (https=) |
| CY (2) | CY1118063T1 (https=) |
| DK (2) | DK2407485T3 (https=) |
| ES (2) | ES2575547T3 (https=) |
| HU (2) | HUE028407T2 (https=) |
| IL (1) | IL176940A (https=) |
| MX (1) | MX338940B (https=) |
| PT (1) | PT2000481E (https=) |
| SI (2) | SI2000481T1 (https=) |
| WO (2) | WO2004070011A2 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| WO2004070011A2 (en) * | 2003-02-01 | 2004-08-19 | Tanox, Inc. | HIGH AFFINITY ANTI-HUMAN IgE ANTIBODIES |
| US20060234296A1 (en) * | 2003-02-01 | 2006-10-19 | Sanjaya Singh | Method for generating high affinity antibodies |
| PL3718564T3 (pl) | 2003-12-23 | 2024-03-18 | Genentech, Inc. | Nowe przeciwciała anty-IL 13 i ich zastosowania |
| CN102702359A (zh) * | 2004-02-02 | 2012-10-03 | 泰勒公司 | 新的IgE表位的鉴别 |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| WO2006055704A2 (en) * | 2004-11-17 | 2006-05-26 | Curagen Corporation | Antibodies directed to ten-m proteins and uses thereof |
| EP1941275B1 (en) * | 2005-09-29 | 2013-07-24 | Medimmune, Inc. | Method of identifying membrane lg specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| AR065368A1 (es) | 2007-02-15 | 2009-06-03 | Astrazeneca Ab | Anticuerpos para moleculas de ige |
| SI2132230T1 (sl) | 2007-03-22 | 2014-07-31 | Genentech, Inc. | Apoptotska protitelesa, ki veĹľejo membransko-vezan IgE |
| DE102007052281A1 (de) * | 2007-11-02 | 2009-05-07 | Zenteris Gmbh | Einschritt-Multiplex-Immuntest |
| US20100248971A1 (en) | 2007-12-03 | 2010-09-30 | Takashi Inagaki | Process for antibody production |
| US8633139B2 (en) | 2007-12-21 | 2014-01-21 | Abbvie Biotherapeutics Inc. | Methods of screening complex protein libraries to identify altered properties |
| CN101230103B (zh) * | 2008-03-25 | 2011-09-07 | 中国医药集团总公司四川抗菌素工业研究所 | 一全人源重组抗-IgE抗体 |
| BRPI0918670B8 (pt) | 2008-09-17 | 2021-05-25 | Xencor Inc | anticorpo |
| EP2427497B1 (fr) | 2009-05-07 | 2016-12-07 | Stallergenes | Utilisation d'immunoglobulines igg1 et/ou de ligands du récepteur cd32 pour le traitement de maladies et manifestations inflammatoires par voie mucosale |
| KR101832510B1 (ko) | 2009-10-26 | 2018-02-26 | 제넨테크, 인크. | 치료 항-ｉｇｅ 항체에 대해 특이적인 항체를 검출하기 위한 검정 및 아나필락시스에서의 이의 용도 |
| KR20130010123A (ko) * | 2010-04-07 | 2013-01-25 | 아비에 인코포레이티드 | ＴＮＦ-α 결합 단백질 |
| AR089434A1 (es) | 2011-12-23 | 2014-08-20 | Genentech Inc | Procedimiento para preparar formulaciones con alta concentracion de proteinas |
| KR20140119777A (ko) | 2012-01-31 | 2014-10-10 | 제넨테크, 인크. | 항-ig-e m1'' 항체 및 그의 사용 방법 |
| EP2849723B1 (en) | 2012-05-18 | 2018-05-02 | Genentech, Inc. | High-concentration monoclonal antibody formulations |
| US9574004B2 (en) | 2012-08-21 | 2017-02-21 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an IL-4R antagonist |
| PT3889181T (pt) | 2012-09-07 | 2024-05-29 | Regeneron Pharma | Um anticorpo antagonista de il-4r para utilização no tratamento da dermatite atópica por administração |
| TWI633891B (zh) | 2013-06-04 | 2018-09-01 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑以治療過敏及增強過敏原－特異之免疫療法的方法 |
| TWI682781B (zh) | 2013-07-11 | 2020-01-21 | 美商再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| US10196458B2 (en) | 2013-07-26 | 2019-02-05 | The Regents Of The University Of California | Anti-immunoglobulin E antibodies and methods of using thereof |
| EP3100048B1 (en) | 2014-01-29 | 2021-05-05 | Cytiva Sweden AB | Method and system for interaction analysis |
| WO2015130975A1 (en) | 2014-02-28 | 2015-09-03 | Regeneron Pharmaceuticals, Inc. | Methods for treating skin infection by administering an il-4r antagonist |
| DK3157951T3 (da) * | 2014-06-17 | 2020-08-17 | Academia Sinica | Humaniserede anti-ige-antistoffer, der tværbinder cd23 på b-lymfocytter, men ikke sensibiliserer mastceller |
| ES2857553T3 (es) * | 2014-10-24 | 2021-09-29 | Hoffmann La Roche | Humanización de anticuerpos basada en ángulo interdominio VH-VL |
| AU2015346150B2 (en) | 2014-11-14 | 2021-08-19 | Regeneron Pharmaceuticals, Inc. | Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist |
| HUE067888T2 (hu) | 2016-09-01 | 2024-11-28 | Regeneron Pharma | Módszerek az allergia megelõzésére vagy kezelésére egy IL-4R antagonista adagolásával |
| WO2018057776A1 (en) | 2016-09-22 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an il-4r inhibitor |
| TWI784988B (zh) | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| AU2017382281B2 (en) | 2016-12-22 | 2024-07-11 | Genentech, Inc. | Methods and formulations for reducing reconstitution time of lyophilized polypeptides |
| AU2018205484B2 (en) * | 2017-01-06 | 2024-11-21 | Sixal, Inc. | Therapeutic anti-lgE antibodies and methods and compositions thereof |
| US11053309B2 (en) | 2017-08-04 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating active eosinophilic esophagitis |
| CA3079946A1 (en) | 2017-10-30 | 2019-05-09 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| KR20220098056A (ko) | 2018-02-09 | 2022-07-08 | 제넨테크, 인크. | 비만 세포 매개 염증성 질환에 대한 치료 및 진단 방법 |
| US20210115155A1 (en) * | 2018-03-26 | 2021-04-22 | Novartis Ag | Methods of treating chronic spontaneous urticaria using ligelizumab |
| US11292847B2 (en) | 2018-05-13 | 2022-04-05 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an IL-4R inhibitor |
| CN109651510B (zh) * | 2018-12-04 | 2023-03-24 | 上海长征医院 | 抗Eno1抗体及其用途 |
| CA3132587A1 (en) | 2019-03-21 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
| GB2589049C (en) | 2019-04-11 | 2024-02-21 | argenx BV | Anti-IgE antibodies |
| BR112022000740A2 (pt) | 2019-07-16 | 2022-07-05 | Sanofi Biotechnology | Métodos para tratamento ou prevenção de asma por administração de um antagonista de il-4r |
| WO2021026205A1 (en) | 2019-08-05 | 2021-02-11 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| US11504426B2 (en) | 2019-08-05 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist |
| JP2021141861A (ja) * | 2020-03-13 | 2021-09-24 | 富士フイルム和光純薬株式会社 | 抗原に対する親和力が向上した抗体のスクリーニング方法および製造方法 |
| WO2021255621A1 (en) | 2020-06-15 | 2021-12-23 | Novartis Ag | Treatment of food allergy using anti-ige antibodies |
| EP4305190A4 (en) | 2021-03-11 | 2025-03-26 | Iggenix, Inc. | METHODS AND SYSTEMS FOR PREDICTING AN ALLERGIC REACTION |
| CN117460531A (zh) | 2021-06-14 | 2024-01-26 | 诺华股份有限公司 | 含有抗IgE抗体的药物配制品 |
| EP4431528A1 (en) * | 2021-10-29 | 2024-09-18 | Longbio Pharma (Suzhou) Co., Ltd. | Isolated antigen binding protein and use thereof |
| KR20240116810A (ko) | 2021-12-14 | 2024-07-30 | 노파르티스 아게 | 항-ige 항체를 사용한 알레르기 반응의 치료 |
| CN116143932B (zh) * | 2022-12-07 | 2025-02-11 | 南开大学 | 一种针对IgE的抗体或其抗原结合片段以及Fc变体 |
| CN116359516A (zh) * | 2023-04-04 | 2023-06-30 | 郑州安图生物工程股份有限公司 | 检测血清总IgE含量的试剂盒及应用 |
| CN119490594B (zh) * | 2023-08-15 | 2025-09-16 | 东莞市朋志生物科技有限公司 | 一种抗免疫球蛋白e的抗体及其应用 |
| CN119745868B (zh) * | 2024-11-21 | 2026-04-07 | 广州创瑞健康科技有限公司 | 一种人免疫球蛋白e拮抗剂、筛选方法以及应用 |
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-
2004
- 2004-02-02 WO PCT/US2004/002894 patent/WO2004070011A2/en not_active Ceased
- 2004-02-02 SI SI200432324A patent/SI2000481T1/sl unknown
- 2004-02-02 EP EP08104978.5A patent/EP2000481B1/en not_active Expired - Lifetime
- 2004-02-02 ES ES08104978.5T patent/ES2575547T3/es not_active Expired - Lifetime
- 2004-02-02 EP EP04707368A patent/EP1592776A4/en not_active Withdrawn
- 2004-02-02 PT PT08104978T patent/PT2000481E/pt unknown
- 2004-02-02 US US10/544,056 patent/US7531169B2/en not_active Expired - Lifetime
- 2004-02-02 CN CNA2004800082701A patent/CN1829806A/zh active Pending
- 2004-02-02 EP EP11170255.1A patent/EP2407485B1/en not_active Expired - Lifetime
- 2004-02-02 HU HUE08104978A patent/HUE028407T2/hu unknown
- 2004-02-02 JP JP2006503243A patent/JP2006516408A/ja active Pending
- 2004-02-02 CN CN201210316908.4A patent/CN102993306B/zh not_active Expired - Lifetime
- 2004-02-02 HU HUE11170255A patent/HUE028458T2/en unknown
- 2004-02-02 CA CA2514840A patent/CA2514840C/en not_active Expired - Lifetime
- 2004-02-02 JP JP2006503245A patent/JP4764334B2/ja not_active Expired - Lifetime
- 2004-02-02 AU AU2004209637A patent/AU2004209637A1/en not_active Abandoned
- 2004-02-02 WO PCT/US2004/002892 patent/WO2004070010A2/en not_active Ceased
- 2004-02-02 ES ES11170255.1T patent/ES2566778T3/es not_active Expired - Lifetime
- 2004-02-02 CA CA002514839A patent/CA2514839A1/en not_active Abandoned
- 2004-02-02 EP EP04707380A patent/EP1592777A4/en not_active Withdrawn
- 2004-02-02 CN CN2004800070117A patent/CN1771338B/zh not_active Expired - Lifetime
- 2004-02-02 DK DK11170255.1T patent/DK2407485T3/en active
- 2004-02-02 AU AU2004209638A patent/AU2004209638B2/en not_active Expired
- 2004-02-02 SI SI200432311A patent/SI2407485T1/sl unknown
- 2004-02-02 DK DK08104978.5T patent/DK2000481T3/en active
- 2004-07-29 MX MX2011007343A patent/MX338940B/es unknown
-
2006
- 2006-07-18 IL IL176940A patent/IL176940A/en active IP Right Grant
-
2009
- 2009-03-27 US US12/413,014 patent/US8252284B2/en not_active Expired - Fee Related
-
2010
- 2010-09-09 JP JP2010202452A patent/JP2011042654A/ja active Pending
-
2011
- 2011-04-26 JP JP2011098737A patent/JP5296138B2/ja not_active Expired - Lifetime
- 2011-05-03 AU AU2011202021A patent/AU2011202021B2/en not_active Expired
-
2012
- 2012-07-27 US US13/559,938 patent/US8604171B2/en not_active Expired - Fee Related
-
2013
- 2013-11-07 US US14/074,309 patent/US9156908B2/en not_active Expired - Lifetime
-
2016
- 2016-04-04 CY CY20161100269T patent/CY1118063T1/el unknown
- 2016-06-09 CY CY20161100504T patent/CY1117617T1/el unknown
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