JP2006516271A - ナトリウム／カルシウム交換系の阻害に有用なピリジン誘導体 - Google Patents

ナトリウム／カルシウム交換系の阻害に有用なピリジン誘導体 Download PDF

Info

Publication number
JP2006516271A
JP2006516271A JP2006500151A JP2006500151A JP2006516271A JP 2006516271 A JP2006516271 A JP 2006516271A JP 2006500151 A JP2006500151 A JP 2006500151A JP 2006500151 A JP2006500151 A JP 2006500151A JP 2006516271 A JP2006516271 A JP 2006516271A
Authority
JP
Japan
Prior art keywords
yloxy
chroman
pyridin
phenylchroman
acetamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006500151A
Other languages
English (en)
Japanese (ja)
Inventor
オトソマー、レーナ
コスケライネン、ツーラ
カルヤライネン、アルト
ラスク、シルパ
ポッレセッロ、ピエロ
レビヨキ、ヨウコ
Original Assignee
オリオン コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8565286&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2006516271(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by オリオン コーポレーション filed Critical オリオン コーポレーション
Publication of JP2006516271A publication Critical patent/JP2006516271A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2006500151A 2003-01-09 2004-01-09 ナトリウム／カルシウム交換系の阻害に有用なピリジン誘導体 Pending JP2006516271A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20030030A FI20030030A0 (fi) 2003-01-09 2003-01-09 Uusia yhdisteitä
PCT/FI2004/000011 WO2004063191A1 (en) 2003-01-09 2004-01-09 Pyridine derivatives useful for inhibiting sodium/calcium exchange system

Publications (1)

Publication Number Publication Date
JP2006516271A true JP2006516271A (ja) 2006-06-29

Family

ID=8565286

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006500151A Pending JP2006516271A (ja) 2003-01-09 2004-01-09 ナトリウム／カルシウム交換系の阻害に有用なピリジン誘導体

Country Status (22)

Country Link
US (1) US7482340B2 (uk)
EP (1) EP1583759A1 (uk)
JP (1) JP2006516271A (uk)
KR (1) KR20050095601A (uk)
CN (1) CN100457752C (uk)
AR (1) AR042733A1 (uk)
AU (1) AU2004203943B2 (uk)
BR (1) BRPI0406669A (uk)
CA (1) CA2512184A1 (uk)
EA (1) EA008539B1 (uk)
FI (1) FI20030030A0 (uk)
HR (1) HRP20050703A2 (uk)
IL (1) IL169435A0 (uk)
IS (1) IS7969A (uk)
MX (1) MXPA05007435A (uk)
NO (1) NO20053730L (uk)
NZ (1) NZ541087A (uk)
PL (1) PL378326A1 (uk)
RS (1) RS20050528A (uk)
UA (1) UA81941C2 (uk)
WO (1) WO2004063191A1 (uk)
ZA (1) ZA200505461B (uk)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013060371A (ja) * 2011-09-12 2013-04-04 Sanofi 置換２−（クロマン−６−イルオキシ）−チアゾール及び医薬としてのその使用
JP2014531429A (ja) * 2011-09-12 2014-11-27 サノフイ 置換２−（クロマン−６−イルオキシ）−チアゾール及び医薬としてのその使用
JP2016511266A (ja) * 2013-03-08 2016-04-14 サノフイ 置換クロマン−６−イルオキシ−シクロアルカンおよび医薬品としてのそれらの使用
WO2017030169A1 (ja) * 2015-08-19 2017-02-23 日産化学工業株式会社 液晶配向剤などに用いられる新規なイミド系重合体

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20011507A0 (fi) * 2001-07-10 2001-07-10 Orion Corp Uusia yhdisteitä
KR101233223B1 (ko) * 2004-12-21 2013-02-14 제이엔씨 석유 화학 주식회사 크로만환을 가지는 액정 화합물, 액정 조성물 및 이 액정조성물을 함유하는 액정 표시소자
UA109896C2 (xx) 2007-02-22 2015-10-26 Похідні імінопіридину та їх застосування як мікробіоцидів
JP5913357B2 (ja) * 2010-12-06 2016-04-27 アウトイフオンイ トヘラペウトイクス リミテッド Ｋｖ３阻害剤として有用なヒダントイン誘導体
EP2524908A1 (en) 2011-05-20 2012-11-21 LEK Pharmaceuticals d.d. Process for the preparation of alfa-substituted ketones and their application in synthesis of pharmaceutically active compounds
US8912224B2 (en) 2011-09-12 2014-12-16 Sanofi Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals
KR101817925B1 (ko) 2011-09-12 2018-01-12 사노피 치환된 ２-（크로만-６-일옥시）-티아졸 및 약제로서의 이의 용도
WO2013144191A1 (de) * 2012-03-29 2013-10-03 Bayer Intellectual Property Gmbh Substituierte 2 -amino - 3 - cyanopyridine als inhibitoren des natrium calcium austausches und ihre verwendung bei kardiovaskulären erkrankungen
GB201416186D0 (en) 2014-09-12 2014-10-29 Redx Pharma Ltd Compounds
KR102594441B1 (ko) 2015-03-06 2023-10-25 파마케아, 인크. 플루오르화된 리실 옥시다아제-유사 2 억제제 및 이의 용도
EP3265445B1 (en) 2015-03-06 2021-05-05 Pharmakea, Inc. Lysyl oxidase-like 2 inhibitors and uses thereof
CN109983006B (zh) 2016-09-07 2022-02-25 法玛克亚公司 赖氨酰氧化酶样2抑制剂的结晶形式及其制备方法
CN117180280A (zh) 2016-09-07 2023-12-08 法玛克亚公司 赖氨酰氧化酶样2抑制剂的用途
WO2019175464A1 (en) 2018-03-14 2019-09-19 Orion Corporation Compounds useful as inhibitors of sodium-calcium exchanger (ncx)
CA3187514A1 (en) 2020-07-28 2022-02-03 Andrew BELFIELD Fused bicyclic raf inhibitors and methods for use thereof
CN115850258B (zh) * 2022-12-27 2024-09-24 东北林业大学 一种马赛替尼的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04113839A (ja) * 1990-09-05 1992-04-15 Mitsubishi Petrochem Co Ltd ポリカーボネート樹脂積層物
JPH1149752A (ja) * 1997-08-05 1999-02-23 Taisho Pharmaceut Co Ltd フェノキシピリジン誘導体

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2820817A (en) 1954-02-04 1958-01-21 Mcneilab Inc Oxygenated indan compounds and method of making the same
US3862232A (en) 1963-07-03 1975-01-21 Upjohn Co 1-(p-hydroxyphenyl)-2-phenyl-6-(2-diethylaminoethoxy)-3,4-dihydronaphthalene and the salts thereof
BE650081A (uk) 1963-07-03
GB1154119A (en) 1968-05-20 1969-06-04 Merck Ag E 3-Alkyl-Flavanones
FR2733685B1 (fr) 1995-05-05 1997-05-30 Adir Utilisation des derives du benzopyrane pour l'obtention de compositions pharmaceutiques destinees au traitement des pathologies liees a l'echangeur c1-/hc03-, na+ independant
JPH0967336A (ja) 1995-09-04 1997-03-11 Kanebo Ltd 新規なイソチオウレア誘導体
US6156801A (en) 1997-03-27 2000-12-05 Taisho Pharmaceutical Co., Ltd. 2-phenoxyaniline derivatives
DE19742508A1 (de) * 1997-09-26 1999-04-01 Hoechst Marion Roussel De Gmbh Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
KR20010031212A (ko) 1997-10-20 2001-04-16 우에하라 아끼라 2-페녹시아닐린 유도체
JPH11302235A (ja) 1998-04-15 1999-11-02 Taisho Pharmaceut Co Ltd フェノキシアルキルアミン誘導体
AU4360200A (en) 1999-04-23 2000-11-10 Bristol-Myers Squibb Company Bicyclic acyl guanidine sodium/proton exchange inhibitors and method
SK3292002A3 (en) 1999-09-17 2003-04-01 Nissan Chemical Ind Ltd Benzopyran derivative
FI20011507A0 (fi) * 2001-07-10 2001-07-10 Orion Corp Uusia yhdisteitä

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04113839A (ja) * 1990-09-05 1992-04-15 Mitsubishi Petrochem Co Ltd ポリカーボネート樹脂積層物
JPH1149752A (ja) * 1997-08-05 1999-02-23 Taisho Pharmaceut Co Ltd フェノキシピリジン誘導体

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013060371A (ja) * 2011-09-12 2013-04-04 Sanofi 置換２−（クロマン−６−イルオキシ）−チアゾール及び医薬としてのその使用
JP2014531429A (ja) * 2011-09-12 2014-11-27 サノフイ 置換２−（クロマン−６−イルオキシ）−チアゾール及び医薬としてのその使用
JP2016511266A (ja) * 2013-03-08 2016-04-14 サノフイ 置換クロマン−６−イルオキシ−シクロアルカンおよび医薬品としてのそれらの使用
WO2017030169A1 (ja) * 2015-08-19 2017-02-23 日産化学工業株式会社 液晶配向剤などに用いられる新規なイミド系重合体

Also Published As

Publication number Publication date
ZA200505461B (en) 2006-03-29
US20060241147A1 (en) 2006-10-26
BRPI0406669A (pt) 2005-12-20
AU2004203943A1 (en) 2004-07-29
WO2004063191A1 (en) 2004-07-29
IS7969A (is) 2005-08-02
CN100457752C (zh) 2009-02-04
US7482340B2 (en) 2009-01-27
NO20053730D0 (no) 2005-08-03
EP1583759A1 (en) 2005-10-12
IL169435A0 (en) 2007-07-04
EA008539B1 (ru) 2007-06-29
CA2512184A1 (en) 2004-07-29
AU2004203943B2 (en) 2009-09-17
HRP20050703A2 (en) 2005-10-31
NO20053730L (no) 2005-10-07
AR042733A1 (es) 2005-06-29
CN1745078A (zh) 2006-03-08
UA81941C2 (uk) 2008-02-25
RS20050528A (en) 2007-06-04
PL378326A1 (pl) 2006-03-20
FI20030030A0 (fi) 2003-01-09
NZ541087A (en) 2008-04-30
MXPA05007435A (es) 2005-09-12
EA200501104A1 (ru) 2005-12-29
KR20050095601A (ko) 2005-09-29

Similar Documents

Publication Publication Date Title
JP2006516271A (ja) ナトリウム／カルシウム交換系の阻害に有用なピリジン誘導体
US6777414B1 (en) Nitrogen-containing heterocyclic compounds and benamide compounds and drugs containing the same
JP5254228B2 (ja) バニロイド受容体アンタゴニストとしての、新規化合物、その異性体またはその薬学的に許容される塩；並びにそれを含む医薬組成物
AU2014355887B2 (en) Urea derivative or pharmacologically acceptable salt thereof
JP4782342B2 (ja) フェノキシプロパノールアミン類、それらの製造方法およびそれらを含む医薬組成物
AU2007323193A1 (en) Acetylene derivatives as Stearoyl CoA Desaturase inhibitors
JP2003523998A (ja) 新規化合物
CN111183130B (zh) 苯并杂环衍生物及包含其的医药组合物
CA2684037A1 (en) Compounds with anti-cancer activity
JP2004532227A (ja) ベータ−３アデノレセプタ作動薬として有用な２，６−置換クロマン誘導体
EP0558094A1 (en) Pyridine compounds for treating amnesia
EA006580B1 (ru) Новые соединения, являющиеся сильнодействующими ингибиторами механизма обмена ионов na+/ca2+ при лечении аритмии
ES2251827T3 (es) Derivado de piridina y producto farmaceutico que lo contiene.
JP2009179562A (ja) グリシントランスポーター阻害剤
JPH10152460A (ja) ２−アミノ−１−（４−ヒドロキシ−２−メチルフェニル）プロパノール誘導体
KR20060067738A (ko) 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 신규한 ｎ-아릴아마이드 유도체 및 이를함유하는 약제학적 조성물
JPH1077271A (ja) ３−ピリジルアミノ化合物またはその塩を含有する循環器官用剤
FR2706894A1 (en) N-Phenyl-N-(piperidinoalkyl)arylamide derivatives, their preparation and their application in therapeutics
JPH1192454A (ja) フェノキシピリジン誘導体
KR20010013009A (ko) 혈관형성을 저해하는 5-치환된-1,2,4-티아디아졸릴 유도체

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20061124

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100323

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20100527

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100621

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100723

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110201