JP2006516021A5 - - Google Patents
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- Publication number
- JP2006516021A5 JP2006516021A5 JP2004538262A JP2004538262A JP2006516021A5 JP 2006516021 A5 JP2006516021 A5 JP 2006516021A5 JP 2004538262 A JP2004538262 A JP 2004538262A JP 2004538262 A JP2004538262 A JP 2004538262A JP 2006516021 A5 JP2006516021 A5 JP 2006516021A5
- Authority
- JP
- Japan
- Prior art keywords
- sepharose
- anx4
- dea
- group
- aex resin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012614 Q-Sepharose Substances 0.000 claims 2
- 101700025520 ANX4 Proteins 0.000 claims 1
- 102100007804 ANXA4 Human genes 0.000 claims 1
- 101700019970 ANXA4 Proteins 0.000 claims 1
- 239000012564 Q sepharose fast flow resin Substances 0.000 claims 1
- 229920002684 Sepharose Polymers 0.000 claims 1
- 239000003957 anion exchange resin Substances 0.000 claims 1
Claims (1)
- 前記ＡＥＸ樹脂が、ＡＮＸ４、ＤＥＡＥ、Ｑ−セファロース、Ｑ−セファロースＦＦ、ＱセファロースＨＰ、及びＱ−セファロースＸＬからなる群から選択される、請求項２に記載の方法。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41222702P | 2002-09-20 | 2002-09-20 | |
| US10/646,798 US20040048315A1 (en) | 2002-08-28 | 2003-08-25 | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
| US66288403A | 2003-09-16 | 2003-09-16 | |
| PCT/US2003/029546 WO2004026251A2 (en) | 2002-09-20 | 2003-09-22 | Process for decreasing aggregate levels of pegylated protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006516021A JP2006516021A (ja) | 2006-06-15 |
| JP2006516021A5 true JP2006516021A5 (ja) | 2006-07-27 |
| JP4633463B2 JP4633463B2 (ja) | 2011-02-16 |
Family
ID=32034217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004538262A Expired - Lifetime JP4633463B2 (ja) | 2002-09-20 | 2003-09-22 | Ｐｅｇ化タンパク質の凝集レベルを低下させるための方法 |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1545428B1 (ja) |
| JP (1) | JP4633463B2 (ja) |
| KR (1) | KR101120130B1 (ja) |
| AT (1) | ATE453662T1 (ja) |
| AU (1) | AU2003272585B2 (ja) |
| BR (1) | BRPI0314120B8 (ja) |
| CA (1) | CA2498886C (ja) |
| DE (1) | DE60330787D1 (ja) |
| DK (1) | DK1545428T3 (ja) |
| ES (1) | ES2337041T3 (ja) |
| HK (1) | HK1079798B (ja) |
| IL (1) | IL167538A (ja) |
| MX (1) | MXPA05003121A (ja) |
| PL (1) | PL212726B1 (ja) |
| PT (1) | PT1545428E (ja) |
| SI (1) | SI1545428T1 (ja) |
| WO (1) | WO2004026251A2 (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06007848A (es) * | 2004-02-09 | 2006-09-04 | Pharmacia Corp | Conjugados de antagonistas del receptor de hormona del crecimiento humana modificados quimicamente. |
| KR20070100299A (ko) * | 2004-12-22 | 2007-10-10 | 암브룩스, 인코포레이티드 | 재조합 인간 성장 호르몬의 발현 및 정제 방법 |
| WO2011018515A1 (en) * | 2009-08-14 | 2011-02-17 | Novo Nordisk Health Care Ag | Method of purifying pegylated proteins |
| US9562252B2 (en) * | 2011-05-13 | 2017-02-07 | Biogen Ma Inc. | Methods of preventing and removing trisulfide bonds |
| KR20140062044A (ko) | 2011-08-25 | 2014-05-22 | 에프. 호프만-라 로슈 아게 | 양이온 및 음이온 교환 크로마토그래피 방법 |
| PL3731872T3 (pl) * | 2017-12-29 | 2022-03-21 | F. Hoffmann-La Roche Ag | Sposób dostarczania kompozycji pegylowanego białka |
| CN112107880B (zh) * | 2020-09-16 | 2022-08-09 | 珠海中科先进技术研究院有限公司 | 一种低共熔混合物及利用其萃取鲟鱼鱼籽蛋白质的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3641115A1 (de) * | 1986-12-02 | 1988-06-16 | Lentia Gmbh | Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins |
| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| US5153265A (en) * | 1988-01-20 | 1992-10-06 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| US5969109A (en) * | 1990-02-28 | 1999-10-19 | Bona; Constantin | Chimeric antibodies comprising antigen binding sites and B and T cell epitopes |
| DK44593D0 (da) * | 1993-04-20 | 1993-04-20 | Novo Nordisk As | Fremgangsmaade til fremstilling af et polypeptid |
| ZA955789B (en) * | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
| WO1996040731A1 (en) * | 1995-06-07 | 1996-12-19 | Mount Sinai School Of Medicine Of The City University Of New York | Pegylated modified proteins |
| DE122006000003I2 (de) * | 1995-09-21 | 2011-01-13 | Genentech Inc | Varianten des menschlichen wachstumshormons |
| SE9802454D0 (sv) * | 1998-07-08 | 1998-07-08 | Pharmacia & Upjohn Ab | Production of peptides |
| SE9904502D0 (sv) * | 1999-12-09 | 1999-12-09 | Pharmacia & Upjohn Ab | Production of peptides |
-
2003
- 2003-09-22 CA CA2498886A patent/CA2498886C/en not_active Expired - Fee Related
- 2003-09-22 DK DK03754774.2T patent/DK1545428T3/da active
- 2003-09-22 BR BRPI0314120A patent/BRPI0314120B8/pt not_active IP Right Cessation
- 2003-09-22 PL PL375443A patent/PL212726B1/pl unknown
- 2003-09-22 SI SI200331730T patent/SI1545428T1/sl unknown
- 2003-09-22 AT AT03754774T patent/ATE453662T1/de active
- 2003-09-22 KR KR1020057004785A patent/KR101120130B1/ko active IP Right Grant
- 2003-09-22 ES ES03754774T patent/ES2337041T3/es not_active Expired - Lifetime
- 2003-09-22 WO PCT/US2003/029546 patent/WO2004026251A2/en active Application Filing
- 2003-09-22 DE DE60330787T patent/DE60330787D1/de not_active Expired - Lifetime
- 2003-09-22 EP EP03754774A patent/EP1545428B1/en not_active Expired - Lifetime
- 2003-09-22 PT PT03754774T patent/PT1545428E/pt unknown
- 2003-09-22 AU AU2003272585A patent/AU2003272585B2/en not_active Expired
- 2003-09-22 JP JP2004538262A patent/JP4633463B2/ja not_active Expired - Lifetime
- 2003-09-22 MX MXPA05003121A patent/MXPA05003121A/es active IP Right Grant
-
2005
- 2005-03-20 IL IL167538A patent/IL167538A/en not_active IP Right Cessation
- 2005-12-29 HK HK05112085.6A patent/HK1079798B/zh not_active IP Right Cessation
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