JP2006514614A5 - - Google Patents
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- JP2006514614A5 JP2006514614A5 JP2004546183A JP2004546183A JP2006514614A5 JP 2006514614 A5 JP2006514614 A5 JP 2006514614A5 JP 2004546183 A JP2004546183 A JP 2004546183A JP 2004546183 A JP2004546183 A JP 2004546183A JP 2006514614 A5 JP2006514614 A5 JP 2006514614A5
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| US43663502P | 2002-12-30 | 2002-12-30 | |
| PCT/GB2003/004590 WO2004037251A1 (en) | 2002-10-24 | 2003-10-23 | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 and type 2 |
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| JP2006514614A JP2006514614A (ja) | 2006-05-11 |
| JP2006514614A5 true JP2006514614A5 (de) | 2006-10-12 |
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| CA (1) | CA2501228A1 (de) |
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| NO (1) | NO20052469L (de) |
| PL (1) | PL376301A1 (de) |
| WO (1) | WO2004037251A1 (de) |
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| SE0302572D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302570D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| GB0408771D0 (en) * | 2004-04-20 | 2004-05-26 | Sterix Ltd | Compound |
| US20100222316A1 (en) | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US7880001B2 (en) | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| DE102004047272A1 (de) * | 2004-09-24 | 2006-04-06 | Schering Ag | Inhibitoren der löslichen Adenylatzyklase |
| CN102816081A (zh) | 2005-01-05 | 2012-12-12 | 雅培制药有限公司 | 11-β-羟甾类脱氢酶1型酶的抑制剂 |
| US8198331B2 (en) | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US7511175B2 (en) | 2005-01-05 | 2009-03-31 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| WO2006097337A2 (en) * | 2005-03-18 | 2006-09-21 | Onepharm Gmbh | 11β-HYDROXYSTEROID DEHYDROGENASES |
| WO2006105127A2 (en) * | 2005-03-31 | 2006-10-05 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
| US7786137B2 (en) * | 2005-05-10 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of ion channels |
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| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP5736098B2 (ja) | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
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| US20100022572A1 (en) | 2008-07-18 | 2010-01-28 | Kowa Company, Ltd. | Novel spiro compound and medicine comprising the same |
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| MX2011004258A (es) | 2008-10-22 | 2011-06-01 | Merck Sharp & Dohme | Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos. |
| US8252781B2 (en) | 2008-10-29 | 2012-08-28 | Kowa Company, Ltd. | 1,2-diazetidin-3-one derivatives and drugs containing same |
| JP5557845B2 (ja) | 2008-10-31 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体 |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
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| ES2619557T3 (es) * | 2009-05-04 | 2017-06-26 | Agios Pharmaceuticals, Inc. | Activadores de PKM2 para uso en el tratamiento del cáncer |
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| DK2448581T3 (en) | 2009-06-29 | 2017-03-13 | Agios Pharmaceuticals Inc | Therapeutic compositions and methods for their applications |
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| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
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| EP3243385B1 (de) | 2011-02-25 | 2021-01-13 | Merck Sharp & Dohme Corp. | Neue cyclische azabenzimidazolderivate als antidiabetika |
| US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
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| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
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| EP3309166A3 (de) * | 2013-01-23 | 2018-08-22 | Sphaera Pharma Pvt. Ltd. | 11-beta-hydroxy-steroiden zur verwendung bei einer mitochondrien-biogenese und krankheiten im zusammenhang mit mitochondriendysfunktion oder -abreicherung |
| EP2958562A4 (de) | 2013-02-22 | 2016-08-10 | Merck Sharp & Dohme | Antidiabetische bicyclische verbindungen |
| US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
| WO2014139144A1 (en) | 2013-03-15 | 2014-09-18 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| EP3171855B1 (de) | 2014-07-23 | 2020-08-26 | Sphaera Pharma Pvt. Ltd. | 11.beta.-hydroxysteroid-4-aza-verbindungen, zusammensetzungen und verwendungen davon |
| MX2017016041A (es) | 2015-06-11 | 2018-04-24 | Agios Pharmaceuticals Inc | Metodos para usar activadores de piruvato cinasa. |
| EP3551176A4 (de) | 2016-12-06 | 2020-06-24 | Merck Sharp & Dohme Corp. | Antidiabetische heterocyclische verbindungen |
| US10968232B2 (en) | 2016-12-20 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| CN111479805A (zh) | 2017-08-29 | 2020-07-31 | 罗格斯新泽西州立大学 | 治疗性吲唑 |
| WO2020120576A1 (en) * | 2018-12-11 | 2020-06-18 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | p38α AUTOPHOSPHORYLATION INHIBITORS |
| KR102433502B1 (ko) * | 2020-01-17 | 2022-08-18 | 재단법인 대구경북첨단의료산업진흥재단 | 신규 화합물, 이의 제조방법 및 이의 용도 |
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| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
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| GB9020338D0 (en) * | 1990-09-18 | 1990-10-31 | Lilly Industries Ltd | Pharmaceutical compounds |
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| TWI242011B (en) * | 1997-03-31 | 2005-10-21 | Eisai Co Ltd | 1,4-substituted cyclic amine derivatives |
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| US6849622B2 (en) * | 2000-10-06 | 2005-02-01 | Tanabe Seiyaku Co., Ltd. | Aliphatic nitrogenous five-membered ring compounds |
| JP5145624B2 (ja) * | 2000-12-22 | 2013-02-20 | コニカミノルタホールディングス株式会社 | シラノール基含有記録媒体用インク、ポリマー粒子の水分散体及びインクジェット記録用水系インク |
-
2003
- 2003-10-23 KR KR1020057007048A patent/KR20050059294A/ko not_active Application Discontinuation
- 2003-10-23 EP EP03758357A patent/EP1556040A1/de not_active Withdrawn
- 2003-10-23 PL PL03376301A patent/PL376301A1/xx not_active Application Discontinuation
- 2003-10-23 MX MXPA05004434A patent/MXPA05004434A/es unknown
- 2003-10-23 JP JP2004546183A patent/JP2006514614A/ja active Pending
- 2003-10-23 CA CA002501228A patent/CA2501228A1/en not_active Abandoned
- 2003-10-23 AU AU2003274373A patent/AU2003274373A1/en not_active Abandoned
- 2003-10-23 WO PCT/GB2003/004590 patent/WO2004037251A1/en active Application Filing
- 2003-10-23 BR BR0315605-2A patent/BR0315605A/pt not_active IP Right Cessation
-
2005
- 2005-05-23 NO NO20052469A patent/NO20052469L/no not_active Application Discontinuation
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