JP2006514099A - 組織化前の三環系インテグラーゼインヒビター化合物 - Google Patents

組織化前の三環系インテグラーゼインヒビター化合物 Download PDF

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Publication number
JP2006514099A
JP2006514099A JP2005501423A JP2005501423A JP2006514099A JP 2006514099 A JP2006514099 A JP 2006514099A JP 2005501423 A JP2005501423 A JP 2005501423A JP 2005501423 A JP2005501423 A JP 2005501423A JP 2006514099 A JP2006514099 A JP 2006514099A
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Prior art keywords
compound
substituted
phosphonate
alkyl
aryl
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Pending
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JP2005501423A
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Japanese (ja)
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JP2006514099A5 (https=
Inventor
ジェイムズ エム． チェン，
シャオウー チェン，
マリア ファディス，
ハオルン ジン，
チョング ユー． キム，
ローラ エヌ． シャチェラー，
Original Assignee
ギリアード サイエンシーズ， インコーポレイテッド
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Publication of JP2006514099A publication Critical patent/JP2006514099A/ja
Publication of JP2006514099A5 publication Critical patent/JP2006514099A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2005501423A 2002-10-16 2003-10-16 組織化前の三環系インテグラーゼインヒビター化合物 Pending JP2006514099A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41896302P 2002-10-16 2002-10-16
US47878303P 2003-06-16 2003-06-16
PCT/US2003/032666 WO2004035576A2 (en) 2002-10-16 2003-10-16 Pre-organized tricyclic integrase inhibitor compounds

Publications (2)

Publication Number Publication Date
JP2006514099A true JP2006514099A (ja) 2006-04-27
JP2006514099A5 JP2006514099A5 (https=) 2007-01-25

Family

ID=32110203

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005501423A Pending JP2006514099A (ja) 2002-10-16 2003-10-16 組織化前の三環系インテグラーゼインヒビター化合物

Country Status (19)

Country Link
US (3) US20040157804A1 (https=)
EP (1) EP1558613A2 (https=)
JP (1) JP2006514099A (https=)
KR (1) KR20050087787A (https=)
CN (1) CN100374438C (https=)
AP (1) AP1858A (https=)
AU (2) AU2003301439A1 (https=)
BR (1) BR0315405A (https=)
CA (1) CA2501881A1 (https=)
EA (1) EA011399B1 (https=)
HR (1) HRP20050431A2 (https=)
IS (1) IS7845A (https=)
MX (1) MXPA05003950A (https=)
NO (1) NO20052378L (https=)
NZ (1) NZ539264A (https=)
OA (1) OA13079A (https=)
PL (1) PL377966A1 (https=)
UA (1) UA79830C2 (https=)
WO (2) WO2004035577A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
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JP2007532665A (ja) * 2004-04-14 2007-11-15 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖインテグラーゼ阻害剤化合物のホスホネート類似物
JP2009537546A (ja) * 2006-05-16 2009-10-29 ギリアード サイエンシーズ， インコーポレイテッド インテグラーゼ阻害剤
JP2015510927A (ja) * 2012-03-28 2015-04-13 キュン ドン ファーマ． カンパニー． リミテッド． ソリフェナシン又はその塩の製造方法及びここに用いられる新規な中間体

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US7538112B2 (en) * 2004-05-07 2009-05-26 Merck & Co., Inc. HIV integrase inhibitors
US7476666B2 (en) 2004-06-09 2009-01-13 Merck & Co., Inc. HIV integrase inhibitors
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EP1812439B2 (en) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinase inhibitors
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WO2006122403A1 (en) 2005-05-19 2006-11-23 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists
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US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
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EP1976517A1 (en) 2005-12-30 2008-10-08 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
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US20090291921A1 (en) * 2007-11-20 2009-11-26 Gilead Sciences, Inc. Integrase inhibitors
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WO2010011814A1 (en) 2008-07-25 2010-01-28 Smithkline Beecham Corporation Chemical compounds
RU2530899C2 (ru) * 2008-07-28 2014-10-20 Селлсьютикс Корпорейшн Противомалярийные соединения
CN102245572B (zh) 2008-12-11 2015-03-25 盐野义制药株式会社 氨甲酰基吡啶酮hiv整合酶抑制剂的方法和中间体
KR101733625B1 (ko) 2008-12-11 2017-05-10 시오노기세야쿠 가부시키가이샤 카르바모일피리돈 ｈｉｖ 인테그라제 억제제 및 중간체의 합성
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ES2446720T3 (es) 2009-10-13 2014-03-10 Elanco Animal Health Ireland Limited Inhibidores de la integrasa macrocíclica
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JP5745869B2 (ja) * 2010-01-22 2015-07-08 富山化学工業株式会社 アルアルキル基を有する複素環化合物
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US10260089B2 (en) 2012-10-29 2019-04-16 The Research Foundation Of The State University Of New York Compositions and methods for recognition of RNA using triple helical peptide nucleic acids
JP7381190B2 (ja) 2014-12-26 2023-11-15 エモリー・ユニバーシテイ Ｎ４－ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途
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CN109305990B (zh) * 2017-07-28 2021-02-26 四川海思科制药有限公司 一种磷酸衍生物及制备方法和用途
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007532665A (ja) * 2004-04-14 2007-11-15 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖインテグラーゼ阻害剤化合物のホスホネート類似物
JP2009537546A (ja) * 2006-05-16 2009-10-29 ギリアード サイエンシーズ， インコーポレイテッド インテグラーゼ阻害剤
JP2015510927A (ja) * 2012-03-28 2015-04-13 キュン ドン ファーマ． カンパニー． リミテッド． ソリフェナシン又はその塩の製造方法及びここに用いられる新規な中間体

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NO20052378L (no) 2005-07-18
AU2003301306A1 (en) 2004-05-04
US7253180B2 (en) 2007-08-07
EP1558613A2 (en) 2005-08-03
US20040157804A1 (en) 2004-08-12
AU2003301439A1 (en) 2004-05-04
MXPA05003950A (es) 2005-06-17
AP1858A (en) 2008-06-30
AU2003301439A8 (en) 2004-05-04
US20040167124A1 (en) 2004-08-26
CN100374438C (zh) 2008-03-12
CA2501881A1 (en) 2004-04-29
WO2004035577A3 (en) 2004-07-29
CN1726212A (zh) 2006-01-25
EA011399B1 (ru) 2009-02-27
HRP20050431A2 (en) 2005-10-31
IS7845A (is) 2005-05-13
UA79830C2 (en) 2007-07-25
KR20050087787A (ko) 2005-08-31
WO2004035576A2 (en) 2004-04-29
AP2005003279A0 (en) 2005-06-30
EA200500660A1 (ru) 2005-10-27
PL377966A1 (pl) 2006-02-20
NZ539264A (en) 2007-08-31
OA13079A (en) 2006-11-10
US20090029939A1 (en) 2009-01-29
WO2004035576A3 (en) 2004-06-24
WO2004035577A2 (en) 2004-04-29
BR0315405A (pt) 2005-08-09
NO20052378D0 (no) 2005-05-13

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