PL377966A1 - Wstępnie zorganizowane tricykliczne związki, będące inhibitorami integrazy - Google Patents
Wstępnie zorganizowane tricykliczne związki, będące inhibitorami integrazyInfo
- Publication number
- PL377966A1 PL377966A1 PL377966A PL37796603A PL377966A1 PL 377966 A1 PL377966 A1 PL 377966A1 PL 377966 A PL377966 A PL 377966A PL 37796603 A PL37796603 A PL 37796603A PL 377966 A1 PL377966 A1 PL 377966A1
- Authority
- PL
- Poland
- Prior art keywords
- inhibitor compounds
- integrase inhibitor
- organized
- tricyclic integrase
- organized tricyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41896302P | 2002-10-16 | 2002-10-16 | |
US47878303P | 2003-06-16 | 2003-06-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL377966A1 true PL377966A1 (pl) | 2006-02-20 |
Family
ID=32110203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL377966A PL377966A1 (pl) | 2002-10-16 | 2003-10-16 | Wstępnie zorganizowane tricykliczne związki, będące inhibitorami integrazy |
Country Status (19)
Country | Link |
---|---|
US (3) | US20040157804A1 (pl) |
EP (1) | EP1558613A2 (pl) |
JP (1) | JP2006514099A (pl) |
KR (1) | KR20050087787A (pl) |
CN (1) | CN100374438C (pl) |
AP (1) | AP1858A (pl) |
AU (2) | AU2003301439A1 (pl) |
BR (1) | BR0315405A (pl) |
CA (1) | CA2501881A1 (pl) |
EA (1) | EA011399B1 (pl) |
HR (1) | HRP20050431A2 (pl) |
IS (1) | IS7845A (pl) |
MX (1) | MXPA05003950A (pl) |
NO (1) | NO20052378L (pl) |
NZ (1) | NZ539264A (pl) |
OA (1) | OA13079A (pl) |
PL (1) | PL377966A1 (pl) |
UA (1) | UA79830C2 (pl) |
WO (2) | WO2004035577A2 (pl) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2369746A1 (en) * | 1999-05-19 | 2000-11-30 | Neurosearch A/S | Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders |
KR20060006047A (ko) * | 2003-04-28 | 2006-01-18 | 티보텍 파마슈티칼즈 리미티드 | Hiv 인테그레이즈 저해제 |
US20070185007A1 (en) | 2003-09-19 | 2007-08-09 | Haolun Jin | Aza-quinolinol phosphonate integrase inhibitor compounds |
CA2547418A1 (en) * | 2003-12-08 | 2005-06-23 | The Research Foundation Of State University Of New York | Site selectively tagged and templated molecularly imprinted polymers for sensor applications |
JP2007514759A (ja) | 2003-12-19 | 2007-06-07 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
WO2005068980A1 (en) * | 2004-01-07 | 2005-07-28 | The Research Foundation Of State University Of New York | Protein imprinted polymers with integrated emission sites |
DK1742642T3 (da) * | 2004-04-14 | 2009-02-16 | Gilead Sciences Inc | Phosphonatanaloge af HIV-integraseinhibitorforbindelser |
WO2005110415A1 (en) * | 2004-05-07 | 2005-11-24 | Merck & Co., Inc. | Hiv integrase inhibitors |
CN101146540A (zh) * | 2004-06-09 | 2008-03-19 | 默克公司 | Hiv整合酶抑制剂 |
US7745459B2 (en) | 2004-09-21 | 2010-06-29 | Japan Tobacco Inc. | Quinolizinone compound and use thereof as HIV integrase inhibitor |
US7713973B2 (en) | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
AR057023A1 (es) * | 2005-05-16 | 2007-11-14 | Gilead Sciences Inc | Compuestos heterociclicos con propiedades inhibidoras de hiv-integrasa |
WO2006122403A1 (en) | 2005-05-19 | 2006-11-23 | Merck Frosst Canada Ltd. | Quinoline derivatives as ep4 antagonists |
CA2616314A1 (en) * | 2005-07-27 | 2007-02-01 | Gilead Sciences, Inc. | Antiviral phosphonate conjugates for inhibition of hiv |
US20080234231A1 (en) * | 2005-08-04 | 2008-09-25 | Johns Brian A | Hiv Integrase Inhibitors |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
WO2007076005A2 (en) * | 2005-12-21 | 2007-07-05 | Gilead Sciences, Inc. | Processes and intermediates useful for preparing integrase inhibitor compounds |
JP4676536B2 (ja) | 2005-12-30 | 2011-04-27 | ギリアド サイエンシズ, インコーポレイテッド | Hivインテグラーゼ阻害剤の薬物動態の改善方法 |
US20090233964A1 (en) * | 2005-12-30 | 2009-09-17 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
CA2651579A1 (en) | 2006-05-16 | 2007-11-29 | Gilead Sciences, Inc. | Integrase inhibitors |
GEP20135728B (en) | 2006-10-09 | 2013-01-25 | Takeda Pharmaceuticals Co | Kinase inhibitors |
WO2009067541A2 (en) * | 2007-11-20 | 2009-05-28 | Gilead Sciences, Inc. | Integrase inhibitors |
US8993542B2 (en) | 2008-01-25 | 2015-03-31 | Chimerix Inc. | Methods of treating viral infections |
EP2320909B8 (en) | 2008-07-25 | 2016-03-30 | VIIV Healthcare Company | Chemical compounds |
EP2321275A4 (en) * | 2008-07-28 | 2012-05-09 | Polymedix Inc | CONNECTIONS AGAINST MALARIA |
ES2763540T3 (es) | 2008-12-11 | 2020-05-29 | Viiv Healthcare Co | Intermedios para inhibidores de la integrasa del VIH de carbamoilpiridona |
BRPI0923217A2 (pt) | 2008-12-11 | 2017-05-23 | Glaxosmithkline Llc | processos para a preparação de um composto de piridona, e para a preparação de uma forma cristalina, composto, sal ou um hidrato deste, forma cristalina de um sal de sódio ou um hidrato deste, e, composição farmacêutica. |
TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
EP2270021A1 (en) * | 2009-06-18 | 2011-01-05 | Centre National de la Recherche Scientifique | Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability |
WO2011011483A1 (en) * | 2009-07-22 | 2011-01-27 | Glaxosmithkline Llc | Chemical compounds |
EP2488521B1 (en) | 2009-10-13 | 2013-12-18 | Elanco Animal Health Ireland Limited | Macrocyclic integrase inhibitors |
JP5745869B2 (ja) * | 2010-01-22 | 2015-07-08 | 富山化学工業株式会社 | アルアルキル基を有する複素環化合物 |
US8283366B2 (en) | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
EP2534150B1 (en) | 2010-02-12 | 2017-04-05 | Chimerix, Inc. | Methods of treating viral infection |
TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
TWI503323B (zh) | 2010-03-29 | 2015-10-11 | Oncotherapy Science Inc | 三環化合物以及含此化合物之pbk抑制劑 |
US8716293B2 (en) | 2010-04-02 | 2014-05-06 | Janssen R&D Ireland | Macrocyclic integrase inhibitors |
WO2012131539A1 (en) | 2011-03-31 | 2012-10-04 | Pfizer Inc. | Novel bicyclic pyridinones |
WO2013082476A1 (en) | 2011-11-30 | 2013-06-06 | Emory University | Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections |
KR101365849B1 (ko) * | 2012-03-28 | 2014-02-24 | 경동제약 주식회사 | 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체 |
UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
US10260089B2 (en) | 2012-10-29 | 2019-04-16 | The Research Foundation Of The State University Of New York | Compositions and methods for recognition of RNA using triple helical peptide nucleic acids |
HRP20211456T1 (hr) | 2014-12-26 | 2021-12-24 | Emory University | Protuvirusni derivati n4-hidroksicitidina |
AU2016214102B2 (en) | 2015-02-03 | 2018-09-27 | Pfizer Inc. | Novel cyclopropabenzofuranyl pyridopyrazinediones |
CN104803905B (zh) * | 2015-04-17 | 2017-10-10 | 复旦大学 | 一种合成异吲哚啉‑1‑酮衍生物的方法 |
WO2017133517A1 (zh) * | 2016-02-03 | 2017-08-10 | 四川海思科制药有限公司 | 一种磷酰胺衍生物及制备方法和用途 |
CN109305990B (zh) * | 2017-07-28 | 2021-02-26 | 四川海思科制药有限公司 | 一种磷酸衍生物及制备方法和用途 |
CN109305989B (zh) * | 2017-07-28 | 2021-02-26 | 四川海思科制药有限公司 | 一种磷酰胺衍生物及制备方法和用途 |
US11331331B2 (en) | 2017-12-07 | 2022-05-17 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
Family Cites Families (32)
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CH385846A (de) | 1960-03-31 | 1964-12-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen 7-Acyl-8-hydroxy-chinolinen und ihre Verwendung als Fungizide und Bakterizide im Pflanzen- und Materialschutz |
US4816570A (en) | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
CA2083386C (en) | 1990-06-13 | 1999-02-16 | Arnold Glazier | Phosphorous prodrugs |
DE69129650T2 (de) | 1990-09-14 | 1999-03-25 | Acad Of Science Czech Republic | Wirkstoffvorläufer von Phosphonaten |
EP0498722B1 (fr) | 1991-02-07 | 1997-07-30 | Roussel Uclaf | Dérivés bicycliques azotés, leur procédé de préparation, les intermédiaires obtenus, leur application comme médicaments et les compositions pharmaceutiques les renfermant |
EP0520573A1 (en) | 1991-06-27 | 1992-12-30 | Glaxo Inc. | Cyclic imide derivatives |
US5639881A (en) * | 1991-11-08 | 1997-06-17 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Synthesis and elucidation of pyrimido (4,5-Q) quinazoline derivatives |
TW304945B (pl) | 1992-06-27 | 1997-05-11 | Hoechst Ag | |
US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
US5538988A (en) | 1994-04-26 | 1996-07-23 | Martinez; Gregory R. | Benzocycloalkylazolethione derivatives |
US5854275A (en) | 1996-05-16 | 1998-12-29 | Pfizer Inc. | Cyclic imide derivatives |
CA2262786A1 (en) | 1996-09-10 | 1998-03-19 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
US6329375B1 (en) * | 1997-08-05 | 2001-12-11 | Sugen, Inc. | Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors |
US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
CA2333707A1 (en) | 1998-06-03 | 1999-12-09 | Melissa Egbertson | Hiv integrase inhibitors |
CA2329134A1 (en) | 1998-06-03 | 1999-12-09 | David L. Clark | Hiv integrase inhibitors |
US6218402B1 (en) * | 1998-06-10 | 2001-04-17 | Arena Pharmaceuticals, Inc. | Acetylcholine enhancers |
US6187907B1 (en) | 1998-08-31 | 2001-02-13 | James Chen | Triple helix coil template having a biologically active ligand |
AU3118200A (en) | 1998-12-14 | 2000-07-03 | Merck & Co., Inc. | Hiv integrase inhibitors |
HUP0201472A3 (en) | 1998-12-25 | 2006-03-28 | Shionogi & Co | Aromatic heterocycle compounds having hiv integrase inhibiting activities |
TR200103801T2 (tr) | 1999-06-02 | 2002-04-22 | Shonogi & Co., Ltd. | Yeni ikameli propenon türevlerinin hazırlanması için prosesler |
WO2001000578A1 (en) | 1999-06-25 | 2001-01-04 | Merck & Co., Inc. | 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof |
US6245806B1 (en) | 1999-08-03 | 2001-06-12 | Merck & Co., Inc. | HIV integrase inhibitors |
WO2001027309A1 (en) | 1999-10-13 | 2001-04-19 | Merck & Co., Inc. | Hiv integrase inhibitors |
DE60124577T2 (de) | 2000-10-12 | 2007-09-27 | Merck & Co., Inc. | Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer |
MXPA03003263A (es) | 2000-10-12 | 2003-06-06 | Merck & Co Inc | Aza y poliaza naftalenil carboxamidas utiles como inhibidores de la integrasa del virus de inmunodeficiencia humana. |
WO2002030426A1 (en) * | 2000-10-12 | 2002-04-18 | Merck & Co., Inc. | Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors |
EP1333831A2 (en) | 2000-10-12 | 2003-08-13 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl ketones useful as hiv integrase inhibitors |
WO2002030970A2 (en) * | 2000-10-13 | 2002-04-18 | Bayer Aktiengesellschaft | Human histone deacetylase gene |
US6518767B1 (en) * | 2000-10-19 | 2003-02-11 | Schweitzer Engineering Laboratories, Inc. | Line differential protection system for a power transmission line |
DK1742642T3 (da) * | 2004-04-14 | 2009-02-16 | Gilead Sciences Inc | Phosphonatanaloge af HIV-integraseinhibitorforbindelser |
-
2003
- 2003-10-15 WO PCT/US2003/032866 patent/WO2004035577A2/en not_active Application Discontinuation
- 2003-10-15 AU AU2003301439A patent/AU2003301439A1/en not_active Abandoned
- 2003-10-15 US US10/687,374 patent/US20040157804A1/en not_active Abandoned
- 2003-10-16 MX MXPA05003950A patent/MXPA05003950A/es active IP Right Grant
- 2003-10-16 WO PCT/US2003/032666 patent/WO2004035576A2/en active Application Filing
- 2003-10-16 AP AP2005003279A patent/AP1858A/xx active
- 2003-10-16 CN CNB2003801061816A patent/CN100374438C/zh not_active Expired - Fee Related
- 2003-10-16 BR BR0315405-0A patent/BR0315405A/pt not_active IP Right Cessation
- 2003-10-16 EP EP03809030A patent/EP1558613A2/en not_active Withdrawn
- 2003-10-16 NZ NZ539264A patent/NZ539264A/en not_active IP Right Cessation
- 2003-10-16 CA CA002501881A patent/CA2501881A1/en not_active Abandoned
- 2003-10-16 US US10/687,373 patent/US7253180B2/en not_active Expired - Fee Related
- 2003-10-16 JP JP2005501423A patent/JP2006514099A/ja active Pending
- 2003-10-16 KR KR1020057006668A patent/KR20050087787A/ko not_active Application Discontinuation
- 2003-10-16 AU AU2003301306A patent/AU2003301306A1/en not_active Abandoned
- 2003-10-16 OA OA1200500108A patent/OA13079A/en unknown
- 2003-10-16 EA EA200500660A patent/EA011399B1/ru not_active IP Right Cessation
- 2003-10-16 PL PL377966A patent/PL377966A1/pl not_active Application Discontinuation
- 2003-10-16 UA UAA200504480A patent/UA79830C2/uk unknown
-
2005
- 2005-05-13 IS IS7845A patent/IS7845A/is unknown
- 2005-05-13 HR HR20050431A patent/HRP20050431A2/hr not_active Application Discontinuation
- 2005-05-13 NO NO20052378A patent/NO20052378L/no not_active Application Discontinuation
-
2007
- 2007-05-25 US US11/807,303 patent/US20090029939A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA05003950A (es) | 2005-06-17 |
WO2004035576A3 (en) | 2004-06-24 |
EA200500660A1 (ru) | 2005-10-27 |
CA2501881A1 (en) | 2004-04-29 |
KR20050087787A (ko) | 2005-08-31 |
WO2004035577A2 (en) | 2004-04-29 |
AU2003301439A1 (en) | 2004-05-04 |
CN100374438C (zh) | 2008-03-12 |
EA011399B1 (ru) | 2009-02-27 |
OA13079A (en) | 2006-11-10 |
IS7845A (is) | 2005-05-13 |
JP2006514099A (ja) | 2006-04-27 |
NZ539264A (en) | 2007-08-31 |
WO2004035576A2 (en) | 2004-04-29 |
AP2005003279A0 (en) | 2005-06-30 |
CN1726212A (zh) | 2006-01-25 |
NO20052378L (no) | 2005-07-18 |
AU2003301306A1 (en) | 2004-05-04 |
UA79830C2 (en) | 2007-07-25 |
WO2004035577A3 (en) | 2004-07-29 |
US20090029939A1 (en) | 2009-01-29 |
US7253180B2 (en) | 2007-08-07 |
US20040167124A1 (en) | 2004-08-26 |
AP1858A (en) | 2008-06-30 |
EP1558613A2 (en) | 2005-08-03 |
NO20052378D0 (no) | 2005-05-13 |
BR0315405A (pt) | 2005-08-09 |
US20040157804A1 (en) | 2004-08-12 |
HRP20050431A2 (en) | 2005-10-31 |
AU2003301439A8 (en) | 2004-05-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |