JP2006514003A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006514003A5 JP2006514003A5 JP2004550126A JP2004550126A JP2006514003A5 JP 2006514003 A5 JP2006514003 A5 JP 2006514003A5 JP 2004550126 A JP2004550126 A JP 2004550126A JP 2004550126 A JP2004550126 A JP 2004550126A JP 2006514003 A5 JP2006514003 A5 JP 2006514003A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituents
- hydrogen
- hydroxy
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 135
- 125000001424 substituent group Chemical group 0.000 claims description 52
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 44
- 239000001257 hydrogen Substances 0.000 claims description 39
- 229910052739 hydrogen Inorganic materials 0.000 claims description 39
- 125000001153 fluoro group Chemical group F* 0.000 claims description 36
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 28
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 28
- 125000005843 halogen group Chemical group 0.000 claims description 22
- 125000003545 alkoxy group Chemical group 0.000 claims description 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 12
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 12
- 125000001246 bromo group Chemical group Br* 0.000 claims description 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 8
- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- -1 -pyridyl Chemical group 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 55
- 150000002431 hydrogen Chemical class 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 10
- 238000000034 method Methods 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102000009410 Chemokine receptor Human genes 0.000 claims 2
- 108050000299 Chemokine receptor Proteins 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000004957 immunoregulator effect Effects 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 0 *C1CC*CC1 Chemical compound *C1CC*CC1 0.000 description 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42245102P | 2002-10-30 | 2002-10-30 | |
| PCT/US2003/033972 WO2004041161A2 (en) | 2002-10-30 | 2003-10-24 | Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006514003A JP2006514003A (ja) | 2006-04-27 |
| JP2006514003A5 true JP2006514003A5 (https=) | 2006-07-27 |
Family
ID=32312509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004550126A Pending JP2006514003A (ja) | 2002-10-30 | 2003-10-24 | ケモカイン受容体活性のテトラヒドロピラニルシクロペンチルベンジルアミド調節剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7390803B2 (https=) |
| EP (1) | EP1558243A4 (https=) |
| JP (1) | JP2006514003A (https=) |
| AU (1) | AU2003286701B2 (https=) |
| CA (1) | CA2502174A1 (https=) |
| WO (1) | WO2004041161A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060030582A1 (en) * | 2002-04-29 | 2006-02-09 | Demartino Julie | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| MY129850A (en) | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| AU2003284165B2 (en) * | 2002-10-30 | 2008-12-11 | Merck Sharp & Dohme Corp. | Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity |
| WO2004041777A2 (en) * | 2002-10-30 | 2004-05-21 | Merck & Co., Inc. | Heteroarylpiperidine modulators of chemokine receptor activity |
| US7514431B2 (en) * | 2002-10-30 | 2009-04-07 | Merck & Co., Inc. | Piperidinyl cyclopentyl aryl benzylamide modulators of chemokine receptor activity |
| MXPA05005660A (es) | 2002-11-27 | 2005-10-18 | Incyte Corp | Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina. |
| US7393844B2 (en) * | 2003-03-18 | 2008-07-01 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity |
| US20060205761A1 (en) * | 2003-06-06 | 2006-09-14 | Catherine Abbadie | Ccr-2 antagonists for treatment of neuropathic pain |
| EP1654256A4 (en) * | 2003-08-08 | 2009-03-11 | Merck & Co Inc | HETEROCYCLIC TETRAHYDROPYRANCYCLOPENTYL HETEROARYL MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY |
| BRPI0417605B8 (pt) | 2003-12-18 | 2021-05-25 | Incyte Corp | n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende. |
| EP1701724A4 (en) * | 2004-01-02 | 2007-11-14 | Merck & Co Inc | ALKYLAMINO, ARYLAMINO AND SULFONAMIDOCYCLOPENTYLAMIDE MODULATORS OF THE ACTIVITY OF CHEMOKIN RECEPTORS |
| CN1972913A (zh) * | 2004-04-26 | 2007-05-30 | 默克公司 | 四氢吡喃基环戊基四氢吡啶并吡啶趋化因子受体活性调节剂 |
| JP2007537264A (ja) | 2004-05-11 | 2007-12-20 | インサイト コーポレイション | ケモカインレセプタのモジュレータとしての３−（４−ヘテロアリールシクロヘキシルアミノ）シクロペンタンカルボキサミド |
| WO2006001958A2 (en) * | 2004-05-21 | 2006-01-05 | Merck & Co., Inc. | Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity |
| JP4116670B2 (ja) | 2004-06-28 | 2008-07-09 | インサイト コーポレイション | ケモカイン受容体の調節剤としての３−アミノシクロペンタンカルボキサミド |
| WO2006004741A2 (en) | 2004-06-28 | 2006-01-12 | Incyte Corporation | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| WO2007053499A2 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| WO2007053498A1 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| WO2008124092A2 (en) | 2007-04-03 | 2008-10-16 | E. I. Du Pont De Nemours And Company | Substituted benzene fungicides |
| CN101565369B (zh) * | 2009-05-22 | 2012-10-03 | 江苏开元医药化工有限公司 | 一种3-溴-5-三氟甲基苯甲酸的制备方法 |
| WO2012125663A2 (en) * | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists |
| AU2012340519B2 (en) | 2011-11-22 | 2017-09-14 | Fondazione Istituto Italiano Di Tecnologia | Disubstituted beta-lactones as inhibitors of N-acylethanolamine acid amidase (NAAA) |
| TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| US11053189B2 (en) | 2019-03-25 | 2021-07-06 | National Tsing Hua University | Method and mixture to form functionalized cyclic compounds |
| WO2024075825A1 (ja) * | 2022-10-07 | 2024-04-11 | キッセイ薬品工業株式会社 | シクロペンタン化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2737409B1 (fr) * | 1995-08-03 | 1997-10-24 | Neovacs | Nouvelles utilisations de diamines alticycliques |
| US6632836B1 (en) * | 1998-10-30 | 2003-10-14 | Merck & Co., Inc. | Carbocyclic potassium channel inhibitors |
| GB0012214D0 (en) * | 2000-05-19 | 2000-07-12 | Merck Sharp & Dohme | Therapeutic agents |
| WO2002060859A2 (en) | 2000-12-20 | 2002-08-08 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| JP4459807B2 (ja) * | 2002-04-29 | 2010-04-28 | メルク エンド カムパニー インコーポレーテッド | テトラヒドロピラニルシクロペンチルテトラヒドロイソキノリン系のケモカイン受容体活性調節剤 |
-
2003
- 2003-10-24 WO PCT/US2003/033972 patent/WO2004041161A2/en not_active Ceased
- 2003-10-24 AU AU2003286701A patent/AU2003286701B2/en not_active Ceased
- 2003-10-24 EP EP03777911A patent/EP1558243A4/en not_active Withdrawn
- 2003-10-24 JP JP2004550126A patent/JP2006514003A/ja active Pending
- 2003-10-24 US US10/533,326 patent/US7390803B2/en not_active Expired - Fee Related
- 2003-10-24 CA CA002502174A patent/CA2502174A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006514003A5 (https=) | ||
| JP2004511518A5 (https=) | ||
| JP2004516314A5 (https=) | ||
| JP2009521483A5 (https=) | ||
| RU2003134544A (ru) | Амиды антраниловой кислоты, способы их получения, их применение в качестве антиаритмических средств, а также содержащие их фармацевтические композиции | |
| RU2012110246A (ru) | Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора | |
| JP2005526691A5 (https=) | ||
| RU2003135482A (ru) | Геропротектор на основе гидрированных пиридо(4,3-b) индолов (варианты), фармакологическое средство на его основе и способ его применения | |
| JP2007531740A5 (https=) | ||
| RU2004120781A (ru) | Ацетиленовые производные, обладающие антагонистической активностью в отношении метаботропных глутаматных рецепторов (mgiur5) | |
| JPH09505809A (ja) | ヒドロキシカルバゾール化合物類による平滑筋移動および増殖の阻害 | |
| RU2005135432A (ru) | Бензоксазинил*амидоциклопентил-гетероциклические модуляторы хемокиновых рецепторов | |
| JP2007519633A5 (https=) | ||
| JP2005539049A5 (https=) | ||
| RU2008109914A (ru) | Применение производных тиенопиридона в качестве активаторов амфк и фармацевтические композиции, которые их содержат | |
| JP2007534755A5 (https=) | ||
| CN1274281A (zh) | 单独的或与抗血小板聚集药物联合的Xa因子抑制剂 | |
| JP2006523704A5 (https=) | ||
| JP2005533007A5 (https=) | ||
| RU2006124863A (ru) | Трициклические производные индолгидроксиэтиламина и их применение при лечении болезни альцгеймера | |
| JP2007518799A5 (https=) | ||
| RU98111742A (ru) | 2,7-замещенные производные октагидропиролло 1,2-а пиразина | |
| US20070141174A1 (en) | Enantiomeric compositions of cicletanine, in combination with other agents, for the treatment of hypertension | |
| RU2004102398A (ru) | Производные бензо[g]хинолина для лечения глаукомы и близорукости | |
| CN105163760B (zh) | 肝纤维化的预防或治疗试剂 |