JP2007534755A5 - - Google Patents
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- Publication number
- JP2007534755A5 JP2007534755A5 JP2007510818A JP2007510818A JP2007534755A5 JP 2007534755 A5 JP2007534755 A5 JP 2007534755A5 JP 2007510818 A JP2007510818 A JP 2007510818A JP 2007510818 A JP2007510818 A JP 2007510818A JP 2007534755 A5 JP2007534755 A5 JP 2007534755A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- fluoro
- unsubstituted
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 88
- 125000001153 fluoro group Chemical group F* 0.000 claims 40
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 31
- 125000001424 substituent group Chemical group 0.000 claims 18
- 125000005843 halogen group Chemical group 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 150000002431 hydrogen Chemical class 0.000 claims 13
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- -1 when C is C Chemical class 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 229920001577 copolymer Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004957 immunoregulator effect Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56601204P | 2004-04-28 | 2004-04-28 | |
| PCT/US2005/013752 WO2005105092A2 (en) | 2004-04-28 | 2005-04-22 | 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007534755A JP2007534755A (ja) | 2007-11-29 |
| JP2007534755A5 true JP2007534755A5 (https=) | 2008-06-05 |
Family
ID=35242218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007510818A Withdrawn JP2007534755A (ja) | 2004-04-28 | 2005-04-22 | ケモカイン受容体活性のモジュレーターとなる３，３−ジ置換テトラヒドロピラニルシクロペンチルアミド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7566726B2 (https=) |
| EP (1) | EP1755603A4 (https=) |
| JP (1) | JP2007534755A (https=) |
| CN (1) | CN101103027A (https=) |
| AU (1) | AU2005237500A1 (https=) |
| CA (1) | CA2564561A1 (https=) |
| WO (1) | WO2005105092A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY129850A (en) | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| US20060030582A1 (en) * | 2002-04-29 | 2006-02-09 | Demartino Julie | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| US20060205761A1 (en) * | 2003-06-06 | 2006-09-14 | Catherine Abbadie | Ccr-2 antagonists for treatment of neuropathic pain |
| WO2007053499A2 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| WO2007053498A1 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| PT2370442E (pt) | 2008-11-26 | 2013-06-27 | Pfizer | 3-aminociclopentanocarboxamidas como moduladores de receptor de quimiocina |
| US9040526B2 (en) | 2010-02-09 | 2015-05-26 | Bristol-Myers Squibb Company | Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity |
| WO2012125663A2 (en) * | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists |
| US8822460B2 (en) * | 2012-04-06 | 2014-09-02 | Janssen Pharmaceutica Nv | Fused cyclopentyl antagonists of CCR2 |
| IN2014MN02512A (https=) | 2012-06-14 | 2015-07-17 | Daiichi Sankyo Co Ltd | |
| CN109790116B (zh) | 2016-09-20 | 2022-10-28 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | Trpv4拮抗剂 |
| US10590077B2 (en) | 2016-09-20 | 2020-03-17 | Glaxosmithkline Intellectual Property Development Limited | TRPV4 antagonists |
| TW201825458A (zh) | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產（第二）有限公司 | Ｔｒｐｖ４拮抗劑 |
| CN110028469B (zh) * | 2019-04-28 | 2022-08-09 | 南京药石科技股份有限公司 | 一种非阿片类镇痛药的关键中间体的制备方法及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3850920B2 (ja) * | 1995-08-09 | 2006-11-29 | 壽製薬株式会社 | アズレン誘導体およびその製造方法ならびにタキキニン受容体拮抗剤 |
| MY129850A (en) | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| EP1501507B1 (en) | 2002-04-29 | 2008-05-28 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| JP4459807B2 (ja) * | 2002-04-29 | 2010-04-28 | メルク エンド カムパニー インコーポレーテッド | テトラヒドロピラニルシクロペンチルテトラヒドロイソキノリン系のケモカイン受容体活性調節剤 |
| US20060205761A1 (en) * | 2003-06-06 | 2006-09-14 | Catherine Abbadie | Ccr-2 antagonists for treatment of neuropathic pain |
-
2005
- 2005-04-22 WO PCT/US2005/013752 patent/WO2005105092A2/en not_active Ceased
- 2005-04-22 CN CNA2005800135915A patent/CN101103027A/zh active Pending
- 2005-04-22 US US11/587,448 patent/US7566726B2/en not_active Expired - Fee Related
- 2005-04-22 JP JP2007510818A patent/JP2007534755A/ja not_active Withdrawn
- 2005-04-22 EP EP05741852A patent/EP1755603A4/en not_active Withdrawn
- 2005-04-22 CA CA002564561A patent/CA2564561A1/en not_active Abandoned
- 2005-04-22 AU AU2005237500A patent/AU2005237500A1/en not_active Abandoned
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