CN101103027A - 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂 - Google Patents

3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂 Download PDF

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Publication number
CN101103027A
CN101103027A CNA2005800135915A CN200580013591A CN101103027A CN 101103027 A CN101103027 A CN 101103027A CN A2005800135915 A CNA2005800135915 A CN A2005800135915A CN 200580013591 A CN200580013591 A CN 200580013591A CN 101103027 A CN101103027 A CN 101103027A
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China
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alkyl
unsubstituted
hydroxyl
cor
fluorine
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CNA2005800135915A
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Chinese (zh)
Inventor
杨立虎
S·G·米尔斯
K·尚卡兰
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Merck and Co Inc
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Merck and Co Inc
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Publication of CN101103027A publication Critical patent/CN101103027A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
CNA2005800135915A 2004-04-28 2005-04-22 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂 Pending CN101103027A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56601204P 2004-04-28 2004-04-28
US60/566,012 2004-04-28

Publications (1)

Publication Number Publication Date
CN101103027A true CN101103027A (zh) 2008-01-09

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CNA2005800135915A Pending CN101103027A (zh) 2004-04-28 2005-04-22 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂

Country Status (7)

Country Link
US (1) US7566726B2 (https=)
EP (1) EP1755603A4 (https=)
JP (1) JP2007534755A (https=)
CN (1) CN101103027A (https=)
AU (1) AU2005237500A1 (https=)
CA (1) CA2564561A1 (https=)
WO (1) WO2005105092A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110028469A (zh) * 2019-04-28 2019-07-19 南京药石科技股份有限公司 一种非阿片类镇痛药的关键中间体的制备方法及应用

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
US20060030582A1 (en) * 2002-04-29 2006-02-09 Demartino Julie Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
US20060205761A1 (en) * 2003-06-06 2006-09-14 Catherine Abbadie Ccr-2 antagonists for treatment of neuropathic pain
WO2007053499A2 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
WO2007053498A1 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
PT2370442E (pt) 2008-11-26 2013-06-27 Pfizer 3-aminociclopentanocarboxamidas como moduladores de receptor de quimiocina
US9040526B2 (en) 2010-02-09 2015-05-26 Bristol-Myers Squibb Company Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
WO2012125663A2 (en) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
IN2014MN02512A (https=) 2012-06-14 2015-07-17 Daiichi Sankyo Co Ltd
CN109790116B (zh) 2016-09-20 2022-10-28 葛兰素史密斯克莱知识产权（第2 号）有限公司 Trpv4拮抗剂
US10590077B2 (en) 2016-09-20 2020-03-17 Glaxosmithkline Intellectual Property Development Limited TRPV4 antagonists
TW201825458A (zh) 2016-09-20 2018-07-16 英商葛蘭素史克智慧財產（第二）有限公司 Ｔｒｐｖ４拮抗劑

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3850920B2 (ja) * 1995-08-09 2006-11-29 壽製薬株式会社 アズレン誘導体およびその製造方法ならびにタキキニン受容体拮抗剤
MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
EP1501507B1 (en) 2002-04-29 2008-05-28 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
JP4459807B2 (ja) * 2002-04-29 2010-04-28 メルク エンド カムパニー インコーポレーテッド テトラヒドロピラニルシクロペンチルテトラヒドロイソキノリン系のケモカイン受容体活性調節剤
US20060205761A1 (en) * 2003-06-06 2006-09-14 Catherine Abbadie Ccr-2 antagonists for treatment of neuropathic pain

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110028469A (zh) * 2019-04-28 2019-07-19 南京药石科技股份有限公司 一种非阿片类镇痛药的关键中间体的制备方法及应用
CN110028469B (zh) * 2019-04-28 2022-08-09 南京药石科技股份有限公司 一种非阿片类镇痛药的关键中间体的制备方法及应用

Also Published As

Publication number Publication date
JP2007534755A (ja) 2007-11-29
WO2005105092A3 (en) 2007-07-26
CA2564561A1 (en) 2005-11-10
US20080021057A1 (en) 2008-01-24
EP1755603A2 (en) 2007-02-28
US7566726B2 (en) 2009-07-28
AU2005237500A1 (en) 2005-11-10
EP1755603A4 (en) 2009-03-11
WO2005105092A2 (en) 2005-11-10

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