JP2007518799A5 - - Google Patents
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- Publication number
- JP2007518799A5 JP2007518799A5 JP2006551125A JP2006551125A JP2007518799A5 JP 2007518799 A5 JP2007518799 A5 JP 2007518799A5 JP 2006551125 A JP2006551125 A JP 2006551125A JP 2006551125 A JP2006551125 A JP 2006551125A JP 2007518799 A5 JP2007518799 A5 JP 2007518799A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydroxy
- substituted
- unsubstituted
- cor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000217 alkyl group Chemical group 0.000 claims 98
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 31
- 150000003839 salts Chemical class 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 29
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 29
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 26
- 125000001424 substituent group Chemical group 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 25
- 239000001257 hydrogen Substances 0.000 claims 25
- 125000001153 fluoro group Chemical group F* 0.000 claims 24
- 125000005843 halogen group Chemical group 0.000 claims 23
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 23
- 229910005965 SO 2 Inorganic materials 0.000 claims 22
- 150000002431 hydrogen Chemical class 0.000 claims 16
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000001309 chloro group Chemical group Cl* 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 125000005189 alkyl hydroxy group Chemical group 0.000 claims 4
- 125000001246 bromo group Chemical group Br* 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- -1 hydroxy, chloro, fluoro, bromo, phenyl Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims 2
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical compound C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 2
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- KVRZARWOKBNZMM-UHFFFAOYSA-N 1,3-dihydro-2-benzothiophene Chemical compound C1=CC=C2CSCC2=C1 KVRZARWOKBNZMM-UHFFFAOYSA-N 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- SIBFFZUQMOJJOI-UHFFFAOYSA-N 6h-cyclopenta[d][1,2]oxazol-3-one Chemical compound C1C=CC2=C1ON=C2O SIBFFZUQMOJJOI-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 102000009410 Chemokine receptor Human genes 0.000 claims 1
- 108050000299 Chemokine receptor Proteins 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical group 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims 1
- 230000004957 immunoregulator effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- SFLGSKRGOWRGBR-UHFFFAOYSA-N phthalane Chemical compound C1=CC=C2COCC2=C1 SFLGSKRGOWRGBR-UHFFFAOYSA-N 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 0 *C1CC(*)N(C(CC2)CC2(*)C(N(CC2)Cc3c2*(*)cc(*)c3)=O)C(*)C1 Chemical compound *C1CC(*)N(C(CC2)CC2(*)C(N(CC2)Cc3c2*(*)cc(*)c3)=O)C(*)C1 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53773204P | 2004-01-20 | 2004-01-20 | |
| PCT/US2005/000770 WO2005070133A2 (en) | 2004-01-20 | 2005-01-14 | 2,6-disubstituted piperidines as modulators of chemokine receptor activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007518799A JP2007518799A (ja) | 2007-07-12 |
| JP2007518799A5 true JP2007518799A5 (https=) | 2008-02-14 |
Family
ID=34807118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551125A Withdrawn JP2007518799A (ja) | 2004-01-20 | 2005-01-14 | ケモカイン受容体活性モジュレーターとしての２，６−二置換ピペリジン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7410961B2 (https=) |
| EP (1) | EP1732552A4 (https=) |
| JP (1) | JP2007518799A (https=) |
| CN (1) | CN1909906A (https=) |
| AU (1) | AU2005206791A1 (https=) |
| CA (1) | CA2553242A1 (https=) |
| WO (1) | WO2005070133A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05005660A (es) | 2002-11-27 | 2005-10-18 | Incyte Corp | Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina. |
| BRPI0417605B8 (pt) | 2003-12-18 | 2021-05-25 | Incyte Corp | n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende. |
| JP2007537264A (ja) | 2004-05-11 | 2007-12-20 | インサイト コーポレイション | ケモカインレセプタのモジュレータとしての３−（４−ヘテロアリールシクロヘキシルアミノ）シクロペンタンカルボキサミド |
| JP4116670B2 (ja) | 2004-06-28 | 2008-07-09 | インサイト コーポレイション | ケモカイン受容体の調節剤としての３−アミノシクロペンタンカルボキサミド |
| WO2006004741A2 (en) | 2004-06-28 | 2006-01-12 | Incyte Corporation | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| WO2007053498A1 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| WO2007053499A2 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| JP5571387B2 (ja) | 2007-01-11 | 2014-08-13 | クリティカル・アウトカム・テクノロジーズ・インコーポレイテッド | 癌の治療のための化合物および方法 |
| CA2710039C (en) | 2007-12-26 | 2018-07-03 | Critical Outcome Technologies, Inc. | Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer |
| EP2318406B1 (en) | 2008-07-17 | 2016-01-27 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
| AR080374A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida |
| CA2999435A1 (en) | 2010-04-01 | 2011-10-06 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
| WO2022094668A1 (en) * | 2020-11-06 | 2022-05-12 | Actinogen Medical Limited | Process for preparing heterocyclic methanone compounds and aza-bicyclo intermediates thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3647804A (en) * | 1970-02-27 | 1972-03-07 | Upjohn Co | Cycloalkanecarboxamides |
| EP1318811B1 (en) * | 2000-08-17 | 2006-08-30 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| JP4459807B2 (ja) * | 2002-04-29 | 2010-04-28 | メルク エンド カムパニー インコーポレーテッド | テトラヒドロピラニルシクロペンチルテトラヒドロイソキノリン系のケモカイン受容体活性調節剤 |
| WO2004082682A1 (en) * | 2003-03-18 | 2004-09-30 | Merck & Co. Inc. | Amino cyclobutylamide modulators of chemokine receptor activity |
| WO2004094971A1 (en) * | 2003-03-27 | 2004-11-04 | Dresser, Inc. | Temperature measurement device |
| KR20060003353A (ko) * | 2003-04-15 | 2006-01-10 | 머크 앤드 캄파니 인코포레이티드 | 케모킨 수용체의벤족사지닐-아미도사이클로펜틸-헤테로사이클릭 조절제 |
| US20060205761A1 (en) * | 2003-06-06 | 2006-09-14 | Catherine Abbadie | Ccr-2 antagonists for treatment of neuropathic pain |
| EP1654256A4 (en) * | 2003-08-08 | 2009-03-11 | Merck & Co Inc | HETEROCYCLIC TETRAHYDROPYRANCYCLOPENTYL HETEROARYL MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY |
-
2005
- 2005-01-14 CN CNA200580002715XA patent/CN1909906A/zh active Pending
- 2005-01-14 AU AU2005206791A patent/AU2005206791A1/en not_active Abandoned
- 2005-01-14 WO PCT/US2005/000770 patent/WO2005070133A2/en not_active Ceased
- 2005-01-14 CA CA002553242A patent/CA2553242A1/en not_active Abandoned
- 2005-01-14 EP EP05711338A patent/EP1732552A4/en not_active Withdrawn
- 2005-01-14 US US10/586,765 patent/US7410961B2/en not_active Expired - Fee Related
- 2005-01-14 JP JP2006551125A patent/JP2007518799A/ja not_active Withdrawn
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