JP2007518799A5 - - Google Patents
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- Publication number
- JP2007518799A5 JP2007518799A5 JP2006551125A JP2006551125A JP2007518799A5 JP 2007518799 A5 JP2007518799 A5 JP 2007518799A5 JP 2006551125 A JP2006551125 A JP 2006551125A JP 2006551125 A JP2006551125 A JP 2006551125A JP 2007518799 A5 JP2007518799 A5 JP 2007518799A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydroxy
- substituted
- unsubstituted
- cor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000217 alkyl group Chemical group 0.000 claims 98
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 31
- 150000003839 salts Chemical class 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 29
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 29
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 26
- 125000001424 substituent group Chemical group 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 25
- 239000001257 hydrogen Substances 0.000 claims 25
- 125000001153 fluoro group Chemical group F* 0.000 claims 24
- 125000005843 halogen group Chemical group 0.000 claims 23
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 23
- 229910005965 SO 2 Inorganic materials 0.000 claims 22
- 150000002431 hydrogen Chemical class 0.000 claims 16
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000001309 chloro group Chemical group Cl* 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 125000005189 alkyl hydroxy group Chemical group 0.000 claims 4
- 125000001246 bromo group Chemical group Br* 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- -1 hydroxy, chloro, fluoro, bromo, phenyl Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims 2
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical compound C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 2
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- KVRZARWOKBNZMM-UHFFFAOYSA-N 1,3-dihydro-2-benzothiophene Chemical compound C1=CC=C2CSCC2=C1 KVRZARWOKBNZMM-UHFFFAOYSA-N 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- SIBFFZUQMOJJOI-UHFFFAOYSA-N 6h-cyclopenta[d][1,2]oxazol-3-one Chemical compound C1C=CC2=C1ON=C2O SIBFFZUQMOJJOI-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 102000009410 Chemokine receptor Human genes 0.000 claims 1
- 108050000299 Chemokine receptor Proteins 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical group 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims 1
- 230000004957 immunoregulator effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- SFLGSKRGOWRGBR-UHFFFAOYSA-N phthalane Chemical compound C1=CC=C2COCC2=C1 SFLGSKRGOWRGBR-UHFFFAOYSA-N 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 0 *C1CC(*)N(C(CC2)CC2(*)C(N(CC2)Cc3c2*(*)cc(*)c3)=O)C(*)C1 Chemical compound *C1CC(*)N(C(CC2)CC2(*)C(N(CC2)Cc3c2*(*)cc(*)c3)=O)C(*)C1 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53773204P | 2004-01-20 | 2004-01-20 | |
| PCT/US2005/000770 WO2005070133A2 (en) | 2004-01-20 | 2005-01-14 | 2,6-disubstituted piperidines as modulators of chemokine receptor activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007518799A JP2007518799A (ja) | 2007-07-12 |
| JP2007518799A5 true JP2007518799A5 (https=) | 2008-02-14 |
Family
ID=34807118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551125A Withdrawn JP2007518799A (ja) | 2004-01-20 | 2005-01-14 | ケモカイン受容体活性モジュレーターとしての２，６−二置換ピペリジン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7410961B2 (https=) |
| EP (1) | EP1732552A4 (https=) |
| JP (1) | JP2007518799A (https=) |
| CN (1) | CN1909906A (https=) |
| AU (1) | AU2005206791A1 (https=) |
| CA (1) | CA2553242A1 (https=) |
| WO (1) | WO2005070133A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1565436B1 (en) | 2002-11-27 | 2012-04-25 | Incyte Corporation | 3-aminopyrrolidine derivatives as modulators of chemokine receptors |
| KR20080052683A (ko) | 2003-12-18 | 2008-06-11 | 인사이트 코포레이션 | 케모킨 수용체의 조절제로서의3-사이클로알킬아미노피롤리딘 유도체 |
| BRPI0510665A (pt) | 2004-05-11 | 2007-12-04 | Incyte Corp | 3-(4-heteroarilcicloexilamino) ciclopentano-carboxiamidas como moduladores de receptores de quimiocinas |
| WO2006004741A2 (en) | 2004-06-28 | 2006-01-12 | Incyte Corporation | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| MXPA06014672A (es) | 2004-06-28 | 2007-03-26 | Incyte Corp | 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas. |
| WO2007053499A2 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| US8067457B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| EP2121681B1 (en) | 2007-01-11 | 2015-04-15 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
| CA2710039C (en) | 2007-12-26 | 2018-07-03 | Critical Outcome Technologies, Inc. | Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer |
| EP2318406B1 (en) | 2008-07-17 | 2016-01-27 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
| AR080375A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida |
| EP2552915B1 (en) | 2010-04-01 | 2017-07-19 | Critical Outcome Technologies Inc. | Compounds for the treatment of hiv |
| KR20230154789A (ko) * | 2020-11-06 | 2023-11-09 | 액티노젠 메디컬 리미티드 | 헤테로고리 메탄온 화합물 및 그의 아자-비시클로 중간체의 제조 공정 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3647804A (en) * | 1970-02-27 | 1972-03-07 | Upjohn Co | Cycloalkanecarboxamides |
| EP1318811B1 (en) * | 2000-08-17 | 2006-08-30 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| DE60322877D1 (de) * | 2002-04-29 | 2008-09-25 | Merck Sharp & Dohme | Tetrahydropyranylcyclopentyltetrahydroisochino-linmodulatoren der chemokinrezeptoraktivität |
| AU2004222336B2 (en) * | 2003-03-18 | 2010-06-03 | Merck Sharp & Dohme Corp. | Amino cyclobutylamide modulators of chemokine receptor activity |
| WO2004094971A1 (en) * | 2003-03-27 | 2004-11-04 | Dresser, Inc. | Temperature measurement device |
| AU2004231087B2 (en) * | 2003-04-15 | 2007-01-04 | Merck Sharp & Dohme Corp. | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
| WO2004110376A2 (en) * | 2003-06-06 | 2004-12-23 | Merck & Co., Inc. | Ccr-2 antagonists for treatment of neuropathic pain |
| CN1832943A (zh) * | 2003-08-08 | 2006-09-13 | 默克公司 | 趋化因子受体活性的四氢吡喃杂环环戊基杂芳基调制剂 |
-
2005
- 2005-01-14 US US10/586,765 patent/US7410961B2/en not_active Expired - Fee Related
- 2005-01-14 AU AU2005206791A patent/AU2005206791A1/en not_active Abandoned
- 2005-01-14 WO PCT/US2005/000770 patent/WO2005070133A2/en not_active Ceased
- 2005-01-14 CA CA002553242A patent/CA2553242A1/en not_active Abandoned
- 2005-01-14 JP JP2006551125A patent/JP2007518799A/ja not_active Withdrawn
- 2005-01-14 EP EP05711338A patent/EP1732552A4/en not_active Withdrawn
- 2005-01-14 CN CNA200580002715XA patent/CN1909906A/zh active Pending
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