JP2006513261A5 - - Google Patents
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- Publication number
- JP2006513261A5 JP2006513261A5 JP2005506687A JP2005506687A JP2006513261A5 JP 2006513261 A5 JP2006513261 A5 JP 2006513261A5 JP 2005506687 A JP2005506687 A JP 2005506687A JP 2005506687 A JP2005506687 A JP 2005506687A JP 2006513261 A5 JP2006513261 A5 JP 2006513261A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- oxo
- trifluoromethyl
- dihydropyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0203348A SE0203348D0 (sv) | 2002-11-12 | 2002-11-12 | Novel compounds |
| SE0300388A SE0300388D0 (sv) | 2003-02-12 | 2003-02-12 | Novel compounds |
| SE0302120A SE0302120D0 (sv) | 2003-07-22 | 2003-07-22 | Novel compounds |
| PCT/SE2003/001739 WO2004043924A1 (en) | 2002-11-12 | 2003-11-11 | 2-pyridone derivatives as inhibitors of neutrophile elastase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006513261A JP2006513261A (ja) | 2006-04-20 |
| JP2006513261A5 true JP2006513261A5 (https=) | 2006-12-28 |
Family
ID=32314809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005506687A Pending JP2006513261A (ja) | 2002-11-12 | 2003-11-11 | 好中球エラスターゼの阻害剤としての２−ピリドン誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20060035938A1 (https=) |
| EP (1) | EP1562902B1 (https=) |
| JP (1) | JP2006513261A (https=) |
| KR (1) | KR20050086516A (https=) |
| AR (1) | AR042024A1 (https=) |
| AT (1) | ATE325096T1 (https=) |
| AU (1) | AU2003276802B2 (https=) |
| BR (1) | BR0316081A (https=) |
| CA (1) | CA2504766A1 (https=) |
| CY (1) | CY1106130T1 (https=) |
| DE (1) | DE60305061T2 (https=) |
| DK (1) | DK1562902T3 (https=) |
| ES (1) | ES2262029T3 (https=) |
| IS (1) | IS2478B (https=) |
| MX (1) | MXPA05004818A (https=) |
| MY (1) | MY137133A (https=) |
| NO (1) | NO20052818L (https=) |
| NZ (1) | NZ539787A (https=) |
| PL (1) | PL376957A1 (https=) |
| PT (1) | PT1562902E (https=) |
| RU (1) | RU2328486C2 (https=) |
| SI (1) | SI1562902T1 (https=) |
| TW (1) | TW200500341A (https=) |
| WO (1) | WO2004043924A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| TW200640881A (en) * | 2005-02-15 | 2006-12-01 | Du Pont | Fungicidal pyrazine derivatives |
| TW200700392A (en) * | 2005-03-16 | 2007-01-01 | Astrazeneca Ab | Novel compounds |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| GB0605469D0 (en) * | 2006-03-17 | 2006-04-26 | Argenta Discovery Ltd | Multimers of heterocyclic compounds and their use |
| TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| TW200808771A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| JP2009537632A (ja) * | 2006-05-19 | 2009-10-29 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 過剰増殖性障害および血管新生障害の処置に有用なピリドンカルボキサミド誘導体 |
| JP2009541321A (ja) * | 2006-06-21 | 2009-11-26 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 細胞増殖阻害剤としてのピラジノン |
| WO2008053199A1 (en) * | 2006-10-30 | 2008-05-08 | Astrazeneca Ab | Combination therapy for the treatment of respiratory diseases |
| WO2008107398A2 (en) * | 2007-03-02 | 2008-09-12 | Basf Se | Pyrazine compounds |
| EP2217591A4 (en) | 2007-11-06 | 2011-10-26 | Astrazeneca Ab | CERTAIN 2-PYRAZINONE DERIVATIVES AND THEIR USE AS NEUTROPHILES ELASTASE INHIBITORS |
| CA2722923C (en) | 2008-04-29 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Indazole compounds as ccr1 receptor antagonists |
| CA2722811C (en) | 2008-05-06 | 2016-07-05 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as ccr1 antagonists |
| NZ591115A (en) | 2008-09-26 | 2012-10-26 | Boehringer Ingelheim Int | Azaindazole compounds as ccr1 receptor antagonists |
| TW201036957A (en) * | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| AU2010302420B2 (en) * | 2009-10-02 | 2013-07-04 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
| PH12012500775A1 (en) | 2009-10-21 | 2012-11-26 | Boehringer Ingelheim Int | Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists |
| US8927550B2 (en) | 2009-10-27 | 2015-01-06 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as CCR1 receptor antagonists |
| WO2011058766A1 (en) * | 2009-11-16 | 2011-05-19 | Raqualia Pharma Inc. | Aryl carboxamide derivatives as ttx-s blockers |
| WO2011071730A1 (en) * | 2009-12-08 | 2011-06-16 | Boehringer Ingelheim International Gmbh | Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds |
| US8871786B2 (en) | 2010-04-30 | 2014-10-28 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as CCR1 receptor antagonists |
| WO2012087782A1 (en) | 2010-12-23 | 2012-06-28 | Boehringer Ingelheim International Gmbh | Pyrazolopiperidine compounds as ccr1 receptor antagonists |
| TWI549943B (zh) * | 2011-03-09 | 2016-09-21 | 杜邦股份有限公司 | 除草之含側氧與磺酸基(sulfono)雙氮雜環 |
| CN104024241B (zh) * | 2011-08-01 | 2016-01-20 | 大日本住友制药株式会社 | 尿嘧啶衍生物和其用于医学目的的用途 |
| EP2562174A1 (de) * | 2011-08-24 | 2013-02-27 | Bayer Cropscience AG | Herbizid wirksame 6-Oxo-1,6-dihydropyrimidin-5-carboxamide und 2-Oxo-1,2-dihydropyridin-3-carboxamide |
| EP2780014A4 (en) | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF |
| US9051269B2 (en) | 2011-11-18 | 2015-06-09 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| JP5989805B2 (ja) | 2012-02-10 | 2016-09-07 | コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | メチル基変更酵素の調節物質、組成物及びその使用 |
| US9102624B2 (en) * | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057920A1 (en) * | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057926A1 (en) * | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| JP5799117B2 (ja) * | 2013-02-05 | 2015-10-21 | 大日本住友製薬株式会社 | ウラシル誘導体からなる医薬 |
| US9745305B2 (en) | 2013-03-15 | 2017-08-29 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| US9969716B2 (en) | 2013-08-15 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
| US9221807B2 (en) * | 2014-02-21 | 2015-12-29 | Boehringer Ingelheim International Gmbh | Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity |
| PT3174852T (pt) * | 2014-07-30 | 2018-10-23 | Abac Therapeutics S L | Aril-hidrazidas contendo uma unidade 2-piridona como agentes antibacterianos seletivos |
| US10577350B2 (en) | 2015-08-28 | 2020-03-03 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide |
| CN109843870A (zh) | 2016-10-19 | 2019-06-04 | 星座制药公司 | Ezh2抑制剂的合成 |
| WO2018200571A1 (en) | 2017-04-25 | 2018-11-01 | Arbutus Biopharma Corporation | Substituted 2,3-dihydro-1h-indene analogs and methods using same |
| AU2019215799B2 (en) | 2018-02-01 | 2022-04-14 | The University Of Sydney | Anti-cancer compounds |
| EP3749697A4 (en) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE |
| US12083118B2 (en) | 2018-03-29 | 2024-09-10 | Arbutus Biopharma Corporation | Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same |
| JP7672641B2 (ja) | 2019-09-17 | 2025-05-08 | メレオ バイオファーマ ４ リミテッド | 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット |
| IL297211B2 (en) | 2020-04-16 | 2025-12-01 | Mereo Biopharma 4 Ltd | Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency |
| KR20240090272A (ko) | 2021-10-20 | 2024-06-21 | 메레오 바이오파마 4 리미티드 | 섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US541960A (en) * | 1895-07-02 | Nose-piece for eyeglasses | ||
| DE2706977A1 (de) * | 1977-02-18 | 1978-08-24 | Hoechst Ag | Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung |
| US4816658A (en) * | 1983-01-10 | 1989-03-28 | Casi-Rusco, Inc. | Card reader for security system |
| US5420297A (en) * | 1990-10-24 | 1995-05-30 | Fujisawa Pharmaceutical Co., Ltd. | Peptides having substance P antagonistic activity |
| GB9207145D0 (en) * | 1991-04-18 | 1992-05-13 | Ici Plc | Heterocyclic amides |
| GB9216272D0 (en) * | 1991-08-15 | 1992-09-09 | Ici Plc | Substituted heterocycles |
| US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| RU2140917C1 (ru) * | 1993-11-19 | 1999-11-10 | Парк, Дэвис энд Компани | Производные 5,6-дигидропирона и фармацевтическая композиция на их основе |
| KR20030027119A (ko) * | 2000-09-08 | 2003-04-03 | 오노 야꾸힝 고교 가부시키가이샤 | 1,3,4-옥사디아졸 유도체의 신규 결정, 그 제조 방법 및그것을 유효 성분으로서 함유하는 약제 |
| KR100828982B1 (ko) * | 2000-12-28 | 2008-05-14 | 시오노기세이야쿠가부시키가이샤 | 칸나비노이드 2형 수용체 친화 작용을 갖는 피리돈 유도체 |
| GB0129260D0 (en) * | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| AU2002348856A1 (en) * | 2001-12-21 | 2003-07-09 | Milton Lawrence Weinbren | Gas scrubber |
| SE0302324D0 (sv) * | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| SE0302323D0 (sv) * | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
-
2003
- 2003-11-06 TW TW092131093A patent/TW200500341A/zh unknown
- 2003-11-10 MY MYPI20034290A patent/MY137133A/en unknown
- 2003-11-11 SI SI200330314T patent/SI1562902T1/sl unknown
- 2003-11-11 KR KR1020057008383A patent/KR20050086516A/ko not_active Ceased
- 2003-11-11 US US10/534,720 patent/US20060035938A1/en not_active Abandoned
- 2003-11-11 RU RU2005113168/04A patent/RU2328486C2/ru not_active IP Right Cessation
- 2003-11-11 CA CA002504766A patent/CA2504766A1/en not_active Abandoned
- 2003-11-11 MX MXPA05004818A patent/MXPA05004818A/es active IP Right Grant
- 2003-11-11 AT AT03811170T patent/ATE325096T1/de not_active IP Right Cessation
- 2003-11-11 DE DE60305061T patent/DE60305061T2/de not_active Expired - Fee Related
- 2003-11-11 AU AU2003276802A patent/AU2003276802B2/en not_active Ceased
- 2003-11-11 BR BR0316081-5A patent/BR0316081A/pt not_active IP Right Cessation
- 2003-11-11 ES ES03811170T patent/ES2262029T3/es not_active Expired - Lifetime
- 2003-11-11 PT PT03811170T patent/PT1562902E/pt unknown
- 2003-11-11 PL PL376957A patent/PL376957A1/pl not_active Application Discontinuation
- 2003-11-11 NZ NZ539787A patent/NZ539787A/en unknown
- 2003-11-11 DK DK03811170T patent/DK1562902T3/da active
- 2003-11-11 JP JP2005506687A patent/JP2006513261A/ja active Pending
- 2003-11-11 WO PCT/SE2003/001739 patent/WO2004043924A1/en not_active Ceased
- 2003-11-11 EP EP03811170A patent/EP1562902B1/en not_active Expired - Lifetime
- 2003-11-12 AR ARP030104153A patent/AR042024A1/es unknown
-
2005
- 2005-05-26 IS IS7867A patent/IS2478B/is unknown
- 2005-06-10 NO NO20052818A patent/NO20052818L/no not_active Application Discontinuation
-
2006
- 2006-07-27 CY CY20061101039T patent/CY1106130T1/el unknown
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