JP2006513261A5 - - Google Patents
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- Publication number
- JP2006513261A5 JP2006513261A5 JP2005506687A JP2005506687A JP2006513261A5 JP 2006513261 A5 JP2006513261 A5 JP 2006513261A5 JP 2005506687 A JP2005506687 A JP 2005506687A JP 2005506687 A JP2005506687 A JP 2005506687A JP 2006513261 A5 JP2006513261 A5 JP 2006513261A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- oxo
- trifluoromethyl
- dihydropyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0203348A SE0203348D0 (sv) | 2002-11-12 | 2002-11-12 | Novel compounds |
| SE0300388A SE0300388D0 (sv) | 2003-02-12 | 2003-02-12 | Novel compounds |
| SE0302120A SE0302120D0 (sv) | 2003-07-22 | 2003-07-22 | Novel compounds |
| PCT/SE2003/001739 WO2004043924A1 (en) | 2002-11-12 | 2003-11-11 | 2-pyridone derivatives as inhibitors of neutrophile elastase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006513261A JP2006513261A (ja) | 2006-04-20 |
| JP2006513261A5 true JP2006513261A5 (https=) | 2006-12-28 |
Family
ID=32314809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005506687A Pending JP2006513261A (ja) | 2002-11-12 | 2003-11-11 | 好中球エラスターゼの阻害剤としての２−ピリドン誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20060035938A1 (https=) |
| EP (1) | EP1562902B1 (https=) |
| JP (1) | JP2006513261A (https=) |
| KR (1) | KR20050086516A (https=) |
| AR (1) | AR042024A1 (https=) |
| AT (1) | ATE325096T1 (https=) |
| AU (1) | AU2003276802B2 (https=) |
| BR (1) | BR0316081A (https=) |
| CA (1) | CA2504766A1 (https=) |
| CY (1) | CY1106130T1 (https=) |
| DE (1) | DE60305061T2 (https=) |
| DK (1) | DK1562902T3 (https=) |
| ES (1) | ES2262029T3 (https=) |
| IS (1) | IS2478B (https=) |
| MX (1) | MXPA05004818A (https=) |
| MY (1) | MY137133A (https=) |
| NO (1) | NO20052818L (https=) |
| NZ (1) | NZ539787A (https=) |
| PL (1) | PL376957A1 (https=) |
| PT (1) | PT1562902E (https=) |
| RU (1) | RU2328486C2 (https=) |
| SI (1) | SI1562902T1 (https=) |
| TW (1) | TW200500341A (https=) |
| WO (1) | WO2004043924A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| TW200640881A (en) * | 2005-02-15 | 2006-12-01 | Du Pont | Fungicidal pyrazine derivatives |
| TW200700392A (en) * | 2005-03-16 | 2007-01-01 | Astrazeneca Ab | Novel compounds |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| GB0605469D0 (en) * | 2006-03-17 | 2006-04-26 | Argenta Discovery Ltd | Multimers of heterocyclic compounds and their use |
| TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| TW200808771A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| ATE528002T1 (de) * | 2006-05-19 | 2011-10-15 | Bayer Pharma AG | Pyridoncarboxamidderivate zur behandlung hyperproliferativer und angiogenese-vermittelter leiden |
| MX2008015648A (es) * | 2006-06-21 | 2009-01-09 | Du Pont | Pirazinonas como inhibidores de proliferacion celular. |
| WO2008053199A1 (en) * | 2006-10-30 | 2008-05-08 | Astrazeneca Ab | Combination therapy for the treatment of respiratory diseases |
| WO2008107398A2 (en) * | 2007-03-02 | 2008-09-12 | Basf Se | Pyrazine compounds |
| WO2009061271A1 (en) * | 2007-11-06 | 2009-05-14 | Astrazeneca Ab | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| CA2722923C (en) | 2008-04-29 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Indazole compounds as ccr1 receptor antagonists |
| JP5411927B2 (ja) | 2008-05-06 | 2014-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１アンタゴニストとしてのピラゾール化合物 |
| EP2346868B1 (en) | 2008-09-26 | 2016-01-27 | Boehringer Ingelheim International Gmbh | Azaindazole compounds as ccr1 receptor antagonists |
| TW201036957A (en) * | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| CA2773618A1 (en) * | 2009-10-02 | 2011-04-07 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
| EP2491028B1 (en) | 2009-10-21 | 2013-12-11 | Boehringer Ingelheim International GmbH | Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists |
| EP2493875B1 (en) | 2009-10-27 | 2014-08-06 | Boehringer Ingelheim International GmbH | Heterocyclic compounds as ccr1 receptor antagonists |
| US9051296B2 (en) | 2009-11-16 | 2015-06-09 | Raqualia Pharma Inc. | Aryl carboxamide derivatives as TTX-S blockers |
| CA2782384A1 (en) * | 2009-12-08 | 2011-06-16 | Boehringer Ingelheim International Gmbh | Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds |
| WO2011137109A1 (en) | 2010-04-30 | 2011-11-03 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as ccr1 receptor antagonists |
| EP2655371B1 (en) | 2010-12-23 | 2015-02-25 | Boehringer Ingelheim International GmbH | Pyrazolopiperidine compounds as ccr1 receptor antagonists |
| TWI549943B (zh) * | 2011-03-09 | 2016-09-21 | 杜邦股份有限公司 | 除草之含側氧與磺酸基(sulfono)雙氮雜環 |
| CN104024241B (zh) * | 2011-08-01 | 2016-01-20 | 大日本住友制药株式会社 | 尿嘧啶衍生物和其用于医学目的的用途 |
| EP2562174A1 (de) * | 2011-08-24 | 2013-02-27 | Bayer Cropscience AG | Herbizid wirksame 6-Oxo-1,6-dihydropyrimidin-5-carboxamide und 2-Oxo-1,2-dihydropyridin-3-carboxamide |
| EP2780013A4 (en) | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF |
| EP2780014A4 (en) | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF |
| NZ628762A (en) | 2012-02-10 | 2016-07-29 | Constellation Pharmaceuticals Inc | Modulators of methyl modifying enzymes, compositions and uses thereof |
| US20140057920A1 (en) * | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US9102624B2 (en) | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057926A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| JP5799117B2 (ja) * | 2013-02-05 | 2015-10-21 | 大日本住友製薬株式会社 | ウラシル誘導体からなる医薬 |
| WO2014151142A1 (en) | 2013-03-15 | 2014-09-25 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP3033334A1 (en) | 2013-08-15 | 2016-06-22 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
| US9221807B2 (en) * | 2014-02-21 | 2015-12-29 | Boehringer Ingelheim International Gmbh | Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity |
| CN106660962A (zh) * | 2014-07-30 | 2017-05-10 | Abac治疗法有限公司 | 用作选择性抗菌剂的含2‑吡啶酮部分的芳基酰肼 |
| US10577350B2 (en) | 2015-08-28 | 2020-03-03 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide |
| US10457640B2 (en) | 2016-10-19 | 2019-10-29 | Constellation Pharmaceuticals, Inc. | Synthesis of inhibitors of EZH2 |
| US11130740B2 (en) | 2017-04-25 | 2021-09-28 | Arbutus Biopharma Corporation | Substituted 2,3-dihydro-1H-indene analogs and methods using same |
| WO2019148244A1 (en) | 2018-02-01 | 2019-08-08 | The University Of Sydney | Anti-cancer compounds |
| EP3749697A4 (en) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE |
| US12083118B2 (en) | 2018-03-29 | 2024-09-10 | Arbutus Biopharma Corporation | Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same |
| CN114650819A (zh) | 2019-09-17 | 2022-06-21 | 美莱奥生物制药第四有限公司 | 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他 |
| WO2021209740A1 (en) | 2020-04-16 | 2021-10-21 | Mereo Biopharma 4 Limited | Methods involving neutrophil elastase inhibitor alvelestat for treating coronavirus infection |
| EP4419102A1 (en) | 2021-10-20 | 2024-08-28 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US541960A (en) * | 1895-07-02 | Nose-piece for eyeglasses | ||
| DE2706977A1 (de) * | 1977-02-18 | 1978-08-24 | Hoechst Ag | Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung |
| US4816658A (en) * | 1983-01-10 | 1989-03-28 | Casi-Rusco, Inc. | Card reader for security system |
| US5420297A (en) * | 1990-10-24 | 1995-05-30 | Fujisawa Pharmaceutical Co., Ltd. | Peptides having substance P antagonistic activity |
| GB9207145D0 (en) * | 1991-04-18 | 1992-05-13 | Ici Plc | Heterocyclic amides |
| GB9216272D0 (en) * | 1991-08-15 | 1992-09-09 | Ici Plc | Substituted heterocycles |
| US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| DE69433705T2 (de) * | 1993-11-19 | 2005-03-10 | Parke, Davis & Company | 5,6-Dihydropyronderivate als Proteaseinhibitoren und Antiviralmittel |
| US20040023998A1 (en) * | 2000-09-08 | 2004-02-05 | Tsutomu Kojima | Novel crystals of 1,3,4-oxadiazole derivatives, process for producing the crystals and medicines containing the same as the active ingredient |
| ES2330719T3 (es) * | 2000-12-28 | 2009-12-15 | SHIONOGI & CO., LTD. | Derivados de 2-piridona con afinidad para el receptor cannabinoide de tipo 2. |
| GB0129260D0 (en) * | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| WO2003053543A1 (en) * | 2001-12-21 | 2003-07-03 | Milton Lawrence Weinbren | Gas scrubber |
| SE0302323D0 (sv) * | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| SE0302324D0 (sv) * | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
-
2003
- 2003-11-06 TW TW092131093A patent/TW200500341A/zh unknown
- 2003-11-10 MY MYPI20034290A patent/MY137133A/en unknown
- 2003-11-11 ES ES03811170T patent/ES2262029T3/es not_active Expired - Lifetime
- 2003-11-11 NZ NZ539787A patent/NZ539787A/en unknown
- 2003-11-11 JP JP2005506687A patent/JP2006513261A/ja active Pending
- 2003-11-11 AU AU2003276802A patent/AU2003276802B2/en not_active Ceased
- 2003-11-11 PL PL376957A patent/PL376957A1/pl not_active Application Discontinuation
- 2003-11-11 SI SI200330314T patent/SI1562902T1/sl unknown
- 2003-11-11 MX MXPA05004818A patent/MXPA05004818A/es active IP Right Grant
- 2003-11-11 CA CA002504766A patent/CA2504766A1/en not_active Abandoned
- 2003-11-11 AT AT03811170T patent/ATE325096T1/de not_active IP Right Cessation
- 2003-11-11 KR KR1020057008383A patent/KR20050086516A/ko not_active Ceased
- 2003-11-11 US US10/534,720 patent/US20060035938A1/en not_active Abandoned
- 2003-11-11 RU RU2005113168/04A patent/RU2328486C2/ru not_active IP Right Cessation
- 2003-11-11 EP EP03811170A patent/EP1562902B1/en not_active Expired - Lifetime
- 2003-11-11 WO PCT/SE2003/001739 patent/WO2004043924A1/en not_active Ceased
- 2003-11-11 PT PT03811170T patent/PT1562902E/pt unknown
- 2003-11-11 BR BR0316081-5A patent/BR0316081A/pt not_active IP Right Cessation
- 2003-11-11 DK DK03811170T patent/DK1562902T3/da active
- 2003-11-11 DE DE60305061T patent/DE60305061T2/de not_active Expired - Fee Related
- 2003-11-12 AR ARP030104153A patent/AR042024A1/es unknown
-
2005
- 2005-05-26 IS IS7867A patent/IS2478B/is unknown
- 2005-06-10 NO NO20052818A patent/NO20052818L/no not_active Application Discontinuation
-
2006
- 2006-07-27 CY CY20061101039T patent/CY1106130T1/el unknown
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