JP2006509524A5 - - Google Patents
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- Publication number
- JP2006509524A5 JP2006509524A5 JP2004560855A JP2004560855A JP2006509524A5 JP 2006509524 A5 JP2006509524 A5 JP 2006509524A5 JP 2004560855 A JP2004560855 A JP 2004560855A JP 2004560855 A JP2004560855 A JP 2004560855A JP 2006509524 A5 JP2006509524 A5 JP 2006509524A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- alphavirus
- helper
- host cell
- arps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000710929 Alphavirus Species 0.000 claims 28
- 238000000034 method Methods 0.000 claims 28
- 210000004027 cell Anatomy 0.000 claims 26
- 150000007523 nucleic acids Chemical class 0.000 claims 23
- 108020004707 nucleic acids Proteins 0.000 claims 22
- 102000039446 nucleic acids Human genes 0.000 claims 22
- 238000004520 electroporation Methods 0.000 claims 9
- 239000000243 solution Substances 0.000 claims 5
- 239000007864 aqueous solution Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 238000004806 packaging method and process Methods 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 3
- 229960002897 heparin Drugs 0.000 claims 3
- 229920000669 heparin Polymers 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 108090000565 Capsid Proteins Proteins 0.000 claims 2
- 102100023321 Ceruloplasmin Human genes 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 2
- 208000000832 Equine Encephalomyelitis Diseases 0.000 claims 2
- 102000003886 Glycoproteins Human genes 0.000 claims 2
- 108090000288 Glycoproteins Proteins 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 claims 1
- 239000005695 Ammonium acetate Substances 0.000 claims 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims 1
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 101710172711 Structural protein Proteins 0.000 claims 1
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 229940043376 ammonium acetate Drugs 0.000 claims 1
- 235000019257 ammonium acetate Nutrition 0.000 claims 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 claims 1
- 239000001099 ammonium carbonate Substances 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 238000011210 chromatographic step Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 238000005342 ion exchange Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 210000003501 vero cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43305802P | 2002-12-13 | 2002-12-13 | |
| US60/433,058 | 2002-12-13 | ||
| PCT/US2003/039725 WO2004055167A2 (en) | 2002-12-13 | 2003-12-12 | Alphavirus particles and methods for preparation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012152561A Division JP5727420B2 (ja) | 2002-12-13 | 2012-07-06 | アルファウイルス粒子及び調製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006509524A JP2006509524A (ja) | 2006-03-23 |
| JP2006509524A5 true JP2006509524A5 (https=) | 2007-02-01 |
| JP5079981B2 JP5079981B2 (ja) | 2012-11-21 |
Family
ID=32595112
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004560855A Expired - Lifetime JP5079981B2 (ja) | 2002-12-13 | 2003-12-12 | アルファウイルス粒子及び調製方法 |
| JP2012152561A Expired - Lifetime JP5727420B2 (ja) | 2002-12-13 | 2012-07-06 | アルファウイルス粒子及び調製方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012152561A Expired - Lifetime JP5727420B2 (ja) | 2002-12-13 | 2012-07-06 | アルファウイルス粒子及び調製方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7078218B2 (https=) |
| EP (3) | EP3246399B1 (https=) |
| JP (2) | JP5079981B2 (https=) |
| AU (1) | AU2003297041B2 (https=) |
| BR (2) | BR122019005271B1 (https=) |
| CA (2) | CA2807515C (https=) |
| DK (3) | DK3246399T3 (https=) |
| ES (3) | ES2630222T3 (https=) |
| IL (1) | IL169076A (https=) |
| NZ (1) | NZ540657A (https=) |
| WO (1) | WO2004055167A2 (https=) |
| ZA (1) | ZA200505517B (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6783939B2 (en) * | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
| ES2330202T5 (es) | 2001-09-06 | 2014-01-20 | Alphavax, Inc. | Sistemas vectores basados en replicones de alfavirus |
| US7078218B2 (en) | 2002-12-13 | 2006-07-18 | Alphavax, Inc. | Alphavirus particles and methods for preparation |
| US20040208848A1 (en) * | 2002-12-13 | 2004-10-21 | Smith Jonathan F. | Multi-antigenic alphavirus replicon particles and methods |
| US7442381B2 (en) * | 2003-03-20 | 2008-10-28 | Alphavax, Inc. | Alphavirus replicons and helper constructs |
| DE602004021260D1 (de) | 2003-07-11 | 2009-07-09 | Alphavax Inc | Cytomegalovirusimpfstoffe, die auf dem alphavirus basieren |
| CN1989250B (zh) | 2004-05-18 | 2013-11-20 | 阿尔法瓦克斯公司 | Tc-83衍生的甲病毒属载体、颗粒和方法 |
| EP1773403B1 (en) * | 2004-07-09 | 2018-04-25 | The University of North Carolina At Chapel Hill | Alphavirus-based adjuvants |
| EP1812564A2 (en) * | 2004-11-11 | 2007-08-01 | Solvay Pharmaceuticals B.V. | Defective influenza virus particles |
| EP1856250B1 (en) * | 2005-02-15 | 2013-07-24 | The University of North Carolina At Chapel Hill | New live virus vaccines |
| US7759104B2 (en) * | 2005-07-14 | 2010-07-20 | Mayo Foundation For Medical Education And Research | Paramyxoviridae virus preparations |
| US20100233209A1 (en) * | 2005-08-11 | 2010-09-16 | Higgs Stephen T | Chikungunya virus infectious clones and uses therefor |
| US9066847B2 (en) | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
| US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
| US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8252329B2 (en) * | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
| US20070299687A1 (en) * | 2006-06-23 | 2007-12-27 | Pamela Palmer | Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed |
| CA2663295C (en) | 2006-09-12 | 2020-03-10 | Alphavax, Inc. | Alphavirus replicon particles matched to protein antigens as immunological adjuvants |
| ES2746960T3 (es) | 2006-09-12 | 2020-03-09 | Alphavax Inc | Partículas de replicón de alfavirus que codifican IL-12 como adyuvantes inmunológicos |
| DK2099485T3 (en) * | 2006-11-03 | 2018-05-22 | Alphavax Inc | Alphavirus and alphavirus replica particle formulations and associated methods |
| US20080294361A1 (en) * | 2007-05-24 | 2008-11-27 | Popp Shane M | Intelligent execution system for the monitoring and execution of vaccine manufacturing |
| US8460913B2 (en) | 2007-06-21 | 2013-06-11 | Alpha Vax, Inc. | Promoterless cassettes for expression of alpha virus structural proteins |
| CA2704153A1 (en) * | 2007-09-26 | 2009-04-02 | Vanderbilt University | Vaccine for rsv and mpv |
| CA2720166A1 (en) * | 2008-04-04 | 2009-10-08 | David B. Weiner | Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same |
| US20100040650A1 (en) * | 2008-05-30 | 2010-02-18 | Crowe Jr James E | Virus-Like paramyxovirus particles and vaccines |
| US8945592B2 (en) | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
| US8680258B2 (en) | 2008-12-01 | 2014-03-25 | Alphavax, Inc. | Use of microRNAs to control virus helper nucleic acids |
| AU2010234362B2 (en) | 2009-04-08 | 2015-11-26 | Alphavax, Inc. | Alphavirus replicon particles expressing TRP2 |
| WO2012001196A2 (es) | 2010-06-28 | 2012-01-05 | Proyecto De Biomedicina Cima, S.L. | Vectores alfavirales y usos de los mismos para la expresión de genes heterólogos |
| PL2852671T3 (pl) | 2012-05-21 | 2019-06-28 | The Regents Of The University Of California | Wytwarzanie ludzkich komórek ips z użyciem syntetycznego samoreplikującego się rna |
| TWI676636B (zh) | 2013-07-12 | 2019-11-11 | Ｖｌｐ醫療股份有限公司 | 包含ｐｄ－１抗原或ｐｄ－１配體抗原的類病毒粒子 |
| EP3634449A4 (en) | 2017-05-08 | 2021-03-17 | Gritstone Oncology, Inc. | ALPHAVIRUS NEOANTIGEN VECTORS |
| SG11202005792RA (en) | 2017-12-20 | 2020-07-29 | Vlp Therapeutics Llc | Alphavirus replicon particle |
| NL2022538B1 (en) | 2019-02-08 | 2020-08-19 | Academisch Ziekenhuis Groningen | Methods for providing purified viral particles of Semliki Forest Virus (SFV), preparations obtainable thereby, and uses thereof. |
| MX2021014525A (es) | 2019-05-30 | 2022-03-17 | Gritstone Bio Inc | Adenovirus modificados. |
| MX2022007905A (es) | 2019-12-31 | 2022-08-25 | Elixirgen Therapeutics Inc | Administracion transitoria basada en temperatura de acidos nucleicos y proteinas a celulas y tejidos. |
| TWI891771B (zh) | 2020-04-17 | 2025-08-01 | 美商Ｖｌｐ醫療股份有限公司 | 冠狀病毒疫苗 |
| AU2021264216A1 (en) | 2020-04-30 | 2022-11-10 | Vlp Therapeutics, Inc. | Cytokine immunotherapy |
| US20220010286A1 (en) * | 2020-07-10 | 2022-01-13 | Boehringer Ingelheim International Gmbh | Process for producing a purified rhabdovirus from cell culture |
| CN116438308A (zh) | 2020-08-06 | 2023-07-14 | 磨石生物公司 | 多表位疫苗盒 |
| CN119563028A (zh) | 2022-05-12 | 2025-03-04 | 尚威天成信使核糖核酸治疗公司 | 具有分泌抗原和免疫调节物的合成自扩增mRNA分子 |
| EP4541899A1 (en) * | 2022-06-17 | 2025-04-23 | Nippon Medical School Foundation | Method for producing high-titer viral vector |
| CN115948351B (zh) * | 2022-12-01 | 2023-11-14 | 杭州养生堂生物医药有限公司 | 一种分离纯化cvb1的方法 |
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| CA1247080A (en) * | 1983-03-08 | 1988-12-20 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| US4650764A (en) * | 1983-04-12 | 1987-03-17 | Wisconsin Alumni Research Foundation | Helper cell |
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| US6783939B2 (en) * | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
| US6982087B2 (en) | 2000-09-07 | 2006-01-03 | The University Of North Carolina At Chapel Hill | Vectors derived from South African Arbovirus No. 86 |
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| ES2330202T5 (es) | 2001-09-06 | 2014-01-20 | Alphavax, Inc. | Sistemas vectores basados en replicones de alfavirus |
| WO2004055161A2 (en) * | 2002-12-12 | 2004-07-01 | The Board Of Regents Of The University Of Texas System | Large scale production of packaged alphavirus replicons |
| US7078218B2 (en) | 2002-12-13 | 2006-07-18 | Alphavax, Inc. | Alphavirus particles and methods for preparation |
| US7442381B2 (en) | 2003-03-20 | 2008-10-28 | Alphavax, Inc. | Alphavirus replicons and helper constructs |
| DE602004021260D1 (de) * | 2003-07-11 | 2009-07-09 | Alphavax Inc | Cytomegalovirusimpfstoffe, die auf dem alphavirus basieren |
-
2003
- 2003-12-12 US US10/734,609 patent/US7078218B2/en not_active Expired - Lifetime
- 2003-12-12 ES ES10011537.7T patent/ES2630222T3/es not_active Expired - Lifetime
- 2003-12-12 DK DK17163152.6T patent/DK3246399T3/da active
- 2003-12-12 EP EP17163152.6A patent/EP3246399B1/en not_active Expired - Lifetime
- 2003-12-12 ES ES03813433.4T patent/ES2552687T3/es not_active Expired - Lifetime
- 2003-12-12 CA CA2807515A patent/CA2807515C/en not_active Expired - Lifetime
- 2003-12-12 BR BR122019005271-9A patent/BR122019005271B1/pt active IP Right Grant
- 2003-12-12 AU AU2003297041A patent/AU2003297041B2/en not_active Expired
- 2003-12-12 WO PCT/US2003/039725 patent/WO2004055167A2/en not_active Ceased
- 2003-12-12 BR BRPI0317276A patent/BRPI0317276B8/pt active IP Right Grant
- 2003-12-12 DK DK10011537.7T patent/DK2290054T3/en active
- 2003-12-12 JP JP2004560855A patent/JP5079981B2/ja not_active Expired - Lifetime
- 2003-12-12 NZ NZ540657A patent/NZ540657A/en not_active IP Right Cessation
- 2003-12-12 DK DK03813433.4T patent/DK1590451T3/en active
- 2003-12-12 CA CA2509979A patent/CA2509979C/en not_active Expired - Lifetime
- 2003-12-12 EP EP03813433.4A patent/EP1590451B1/en not_active Expired - Lifetime
- 2003-12-12 ES ES17163152T patent/ES2890023T3/es not_active Expired - Lifetime
- 2003-12-12 EP EP10011537.7A patent/EP2290054B1/en not_active Expired - Lifetime
-
2005
- 2005-06-08 IL IL169076A patent/IL169076A/en active IP Right Grant
-
2006
- 2006-01-24 ZA ZA200505517A patent/ZA200505517B/en unknown
-
2012
- 2012-07-06 JP JP2012152561A patent/JP5727420B2/ja not_active Expired - Lifetime
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