JP2006508107A5 - - Google Patents
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- JP2006508107A5 JP2006508107A5 JP2004550489A JP2004550489A JP2006508107A5 JP 2006508107 A5 JP2006508107 A5 JP 2006508107A5 JP 2004550489 A JP2004550489 A JP 2004550489A JP 2004550489 A JP2004550489 A JP 2004550489A JP 2006508107 A5 JP2006508107 A5 JP 2006508107A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- composition
- optionally substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 **=*C(c1c(*)*n*(N*)*1)=*[*+] Chemical compound **=*C(c1c(*)*n*(N*)*1)=*[*+] 0.000 description 10
- QEITZRMTXOMJER-UHFFFAOYSA-N C1C2C(CC3)C3CCC12 Chemical compound C1C2C(CC3)C3CCC12 QEITZRMTXOMJER-UHFFFAOYSA-N 0.000 description 1
- LXNRLNDZSUGVIZ-UHFFFAOYSA-N CC1C(C)(CC2)C2CC1 Chemical compound CC1C(C)(CC2)C2CC1 LXNRLNDZSUGVIZ-UHFFFAOYSA-N 0.000 description 1
- XGOJEEATRXFBJN-UHFFFAOYSA-N CCC(C1)=CC=C(C(C=C2N)C=C=C2OC)N=C1Nc1cccc(OC2C=CC=CC2)c1 Chemical compound CCC(C1)=CC=C(C(C=C2N)C=C=C2OC)N=C1Nc1cccc(OC2C=CC=CC2)c1 XGOJEEATRXFBJN-UHFFFAOYSA-N 0.000 description 1
- FLLVWQWXWWJBLW-UHFFFAOYSA-N CCC(C1)=CC=C(c(cc2N)ccc2OC)N=C1Nc(cc1)ccc1S(=C)=O Chemical compound CCC(C1)=CC=C(c(cc2N)ccc2OC)N=C1Nc(cc1)ccc1S(=C)=O FLLVWQWXWWJBLW-UHFFFAOYSA-N 0.000 description 1
- CXUIMSIUZAGXBG-UHFFFAOYSA-O CCC(C1)=CCC(C(CC2N)=CC=C2OC)N=C1[NH2+]c1cc(C)cc(C)c1 Chemical compound CCC(C1)=CCC(C(CC2N)=CC=C2OC)N=C1[NH2+]c1cc(C)cc(C)c1 CXUIMSIUZAGXBG-UHFFFAOYSA-O 0.000 description 1
- CBEGTFNCNBGGFY-UHFFFAOYSA-O CCC(C1)=CCC(c(cc2N)ccc2OC)N=C1[NH2+]c1cccc(-c2ccccc2)c1 Chemical compound CCC(C1)=CCC(c(cc2N)ccc2OC)N=C1[NH2+]c1cccc(-c2ccccc2)c1 CBEGTFNCNBGGFY-UHFFFAOYSA-O 0.000 description 1
- SJYXRQQGBIFRBO-UHFFFAOYSA-O CCC(CC(C)[NH2+]C(C1)C=CC=C1C(OCC)=O)=CC=C(C(C=C1N)=CCC1OC)N Chemical compound CCC(CC(C)[NH2+]C(C1)C=CC=C1C(OCC)=O)=CC=C(C(C=C1N)=CCC1OC)N SJYXRQQGBIFRBO-UHFFFAOYSA-O 0.000 description 1
- QJTBHYFTQAEADC-UHFFFAOYSA-O COC(C(N)=C1)=CCC1C(N)=CC1C(CC([NH2+]c2ccccc2)=C)C1 Chemical compound COC(C(N)=C1)=CCC1C(N)=CC1C(CC([NH2+]c2ccccc2)=C)C1 QJTBHYFTQAEADC-UHFFFAOYSA-O 0.000 description 1
- WAGDBAZSJRNKMB-UHFFFAOYSA-O COc(c(N)c1)ccc1-c1cccc([NH2+]C(C2)C=CC=C2F)n1 Chemical compound COc(c(N)c1)ccc1-c1cccc([NH2+]C(C2)C=CC=C2F)n1 WAGDBAZSJRNKMB-UHFFFAOYSA-O 0.000 description 1
- WSXBWBYDNIVHHN-UHFFFAOYSA-O COc1cc([NH2+]c2nc(-c(cc3N)ccc3OC)ccn2)ccc1 Chemical compound COc1cc([NH2+]c2nc(-c(cc3N)ccc3OC)ccn2)ccc1 WSXBWBYDNIVHHN-UHFFFAOYSA-O 0.000 description 1
- VORBWXREWDZPFB-MKMHIBQSSA-N C[C@H](CC1)C2(C)C1C1C2CC1 Chemical compound C[C@H](CC1)C2(C)C1C1C2CC1 VORBWXREWDZPFB-MKMHIBQSSA-N 0.000 description 1
- IQZDIBKPVOENRY-UHFFFAOYSA-N C[OH+][NH+](c(cc(cc1)-c2ccnc(NC3(C4)C=CC=C4C3)n2)c1O)[O-] Chemical compound C[OH+][NH+](c(cc(cc1)-c2ccnc(NC3(C4)C=CC=C4C3)n2)c1O)[O-] IQZDIBKPVOENRY-UHFFFAOYSA-N 0.000 description 1
- NDJURPXFXIUTPX-UHFFFAOYSA-N Cc1cc(Nc2nc(-c(cc3N)ccc3OC)ccn2)ccc1 Chemical compound Cc1cc(Nc2nc(-c(cc3N)ccc3OC)ccn2)ccc1 NDJURPXFXIUTPX-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42404302P | 2002-11-05 | 2002-11-05 | |
| PCT/US2003/035188 WO2004041810A1 (en) | 2002-11-05 | 2003-11-05 | Compounds useful as inhibitors of jak and other protein kinases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010139840A Division JP2010195838A (ja) | 2002-11-05 | 2010-06-18 | Ｊａｋおよび他のプロテインキナーゼのインヒビターとして有用な化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006508107A JP2006508107A (ja) | 2006-03-09 |
| JP2006508107A5 true JP2006508107A5 (enExample) | 2006-08-31 |
Family
ID=32312743
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004550489A Pending JP2006508107A (ja) | 2002-11-05 | 2003-11-05 | Ｊａｋおよび他のプロテインキナーゼのインヒビターとして有用な化合物 |
| JP2010139840A Pending JP2010195838A (ja) | 2002-11-05 | 2010-06-18 | Ｊａｋおよび他のプロテインキナーゼのインヒビターとして有用な化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010139840A Pending JP2010195838A (ja) | 2002-11-05 | 2010-06-18 | Ｊａｋおよび他のプロテインキナーゼのインヒビターとして有用な化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7348335B2 (enExample) |
| EP (1) | EP1560824A1 (enExample) |
| JP (2) | JP2006508107A (enExample) |
| AU (2) | AU2003286895A1 (enExample) |
| CA (1) | CA2507406A1 (enExample) |
| WO (1) | WO2004041810A1 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| IL166241A0 (en) | 2002-07-29 | 2006-01-15 | Rigel Pharmaceuticals Inc | Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds |
| AU2003262642B2 (en) * | 2002-08-14 | 2010-06-17 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors and uses thereof |
| EP1562911B1 (en) * | 2002-11-01 | 2010-01-06 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of jak and other protein kinases |
| US20050014753A1 (en) * | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
| ES2421139T3 (es) | 2003-07-30 | 2013-08-29 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias |
| EP1648875A1 (en) | 2003-07-30 | 2006-04-26 | Cyclacel Limited | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors |
| PT1689715E (pt) * | 2003-12-03 | 2011-05-16 | Ym Biosciences Australia Pty | Inibidores da tubulina |
| CA2579007A1 (en) * | 2004-09-10 | 2006-03-16 | Altana Pharma Ag | Ciclesonide and syk inhibitor combination and methods of use thereof |
| US7799915B2 (en) * | 2004-10-13 | 2010-09-21 | Wyeth Llc | Anilino-pyrimidine analogs |
| US7449458B2 (en) | 2005-01-19 | 2008-11-11 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| BRPI0607062A2 (pt) | 2005-02-28 | 2009-08-04 | Japan Tobacco Inc | composto de aminopiridina com atividade inibidora de syk, composição farmacêutica e agente terapêutico compreendendo os mesmos |
| WO2006133426A2 (en) | 2005-06-08 | 2006-12-14 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| EA200870217A1 (ru) | 2006-01-30 | 2009-02-27 | Экселиксис, Инк. | 4-арил-2-аминопиримидины или 4-арил-2-аминоалкилпиримидины в качестве модуляторов jak-2 и содержащие их фармацевтические композиции |
| WO2007098507A2 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| PT2402319T (pt) | 2006-03-31 | 2017-12-11 | Novartis Ag | Inibidores de dgat |
| CA2649302A1 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | Anilino-pyrimidine phenyl and benzothiophene analogs |
| WO2008009458A1 (en) * | 2006-07-21 | 2008-01-24 | Novartis Ag | 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors |
| DK2089369T3 (da) | 2006-10-19 | 2011-05-09 | Rigel Pharmaceuticals Inc | 2,4-pyrimidindiaminderivater som hæmmere af JAK-kinaser til behandling af autoimmune sygdomme |
| US20080153822A1 (en) * | 2006-11-30 | 2008-06-26 | Martin Augustin | Methods of treating pain |
| JP2010512410A (ja) * | 2006-12-11 | 2010-04-22 | ノバルティス アーゲー | 心筋虚血を予防または処置するための方法 |
| AU2016200866B2 (en) * | 2007-03-12 | 2017-06-22 | Glaxosmithkline Llc | Phenyl amino pyrimidine compounds and uses thereof |
| AU2013201306B2 (en) * | 2007-03-12 | 2015-11-12 | Glaxosmithkline Llc | Phenyl Amino Pyrimidine Compounds and Uses Thereof |
| HUE029188T2 (en) * | 2007-03-12 | 2017-03-28 | Ym Biosciences Australia Pty | Phenylamino-pyrimidine compounds and their use |
| EP2200436B1 (en) * | 2007-09-04 | 2015-01-21 | The Scripps Research Institute | Substituted pyrimidinyl-amines as protein kinase inhibitors |
| HRP20170317T1 (hr) | 2008-02-15 | 2017-04-21 | Rigel Pharmaceuticals, Inc. | Spojevi pirimidin-2-amina i njihova uporaba kao inhibitora jak kinaza |
| JPWO2009107391A1 (ja) * | 2008-02-27 | 2011-06-30 | 武田薬品工業株式会社 | ６員芳香環含有化合物 |
| GB0805477D0 (en) * | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| US8063058B2 (en) | 2008-04-16 | 2011-11-22 | Portola Pharmaceuticals, Inc. | Inhibitors of syk and JAK protein kinases |
| BRPI0910668A2 (pt) | 2008-04-22 | 2019-09-24 | Portola Pharmaceutiacals Inc | inibidores de proteína quinases |
| EP2285989B1 (en) | 2008-05-15 | 2016-11-16 | The University of North Carolina At Chapel Hill | Novel targets for regulation of angiogenesis |
| KR20120114224A (ko) * | 2009-10-12 | 2012-10-16 | 마이렉시스 인코포레이티드 | Ｉｋｋ 엡실론 및/또는 ｔｂｋ１의 억제제로서의 아미노-피리미딘 화합물 |
| EP2512246B1 (en) * | 2009-12-17 | 2015-09-30 | Merck Sharp & Dohme Corp. | Aminopyrimidines as syk inhibitors |
| EP2516434B1 (en) | 2009-12-23 | 2015-05-27 | Takeda Pharmaceutical Company Limited | Fused heteroaromatic pyrrolidinones as syk inhibitors |
| EP2975027A1 (en) | 2010-11-01 | 2016-01-20 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
| CA2816679A1 (en) * | 2010-11-17 | 2012-05-24 | Novartis Ag | 3-(aminoaryl)-pyridine compounds |
| WO2012066065A1 (en) * | 2010-11-17 | 2012-05-24 | Novartis Ag | Phenyl-heteroaryl amine compounds and their uses |
| EP2668177B1 (en) * | 2011-01-28 | 2014-10-22 | Boehringer Ingelheim International GmbH | Substituted pyridinyl-pyrimidines and their use as medicaments |
| WO2012154518A1 (en) * | 2011-05-10 | 2012-11-15 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as syk inhibitors |
| WO2012177714A1 (en) | 2011-06-22 | 2012-12-27 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
| EP2782579B1 (en) | 2011-11-23 | 2019-01-02 | Portola Pharmaceuticals, Inc. | Pyrazine kinase inhibitors |
| EP2807166B1 (en) | 2012-01-23 | 2016-04-06 | Boehringer Ingelheim International GmbH | 5,8-dihydro-6h-pyrazolo[3,4-h]quinazolines as igf-1r/ir inhibitors |
| WO2013175415A1 (en) * | 2012-05-23 | 2013-11-28 | Piramal Enterprises Limited | Substituted pyrimidine compounds and uses thereof |
| US8809359B2 (en) | 2012-06-29 | 2014-08-19 | Ym Biosciences Australia Pty Ltd | Phenyl amino pyrimidine bicyclic compounds and uses thereof |
| WO2014013014A1 (en) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
| EP2884982B1 (en) * | 2012-08-20 | 2017-09-20 | Merck Sharp & Dohme Corp. | SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
| WO2014058921A2 (en) | 2012-10-08 | 2014-04-17 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
| CA2944466C (en) * | 2014-04-02 | 2020-06-09 | Bristol-Myers Squibb Company | Biaryl kinase inhibitors |
| TWI681954B (zh) | 2014-06-12 | 2020-01-11 | 美商西爾拉癌症醫學公司 | Ｎ-（氰基甲基）-４-（２-（４-𠰌啉基苯基胺基）嘧啶-４-基）苯甲醯胺 |
| ES2767776T3 (es) | 2015-10-01 | 2020-06-18 | Bristol Myers Squibb Co | Inhibidores de biaril cinasa |
| CN112142655A (zh) * | 2015-10-01 | 2020-12-29 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
| WO2018041989A1 (en) | 2016-09-02 | 2018-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating refractory celiac disease type 2 |
| CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| WO2020201362A2 (en) | 2019-04-02 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| WO2020212395A1 (en) | 2019-04-16 | 2020-10-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN113549018B (zh) * | 2020-04-24 | 2024-02-27 | 中国药科大学 | 蛋白激酶抑制剂及其衍生物，制备方法、药物组合物和应用 |
| CN115403516B (zh) * | 2021-08-03 | 2024-01-26 | 河南省儿童医院郑州儿童医院 | 含3,4,5-三取代基苯环的芳杂环化合物、药物组合物及其制备方法和应用 |
| CN115703760B (zh) * | 2021-08-11 | 2024-05-31 | 山东大学 | 2,4-二取代嘧啶类细胞周期蛋白依赖性激酶酶抑制剂及其制备方法和应用 |
| CA3251183A1 (en) * | 2022-02-03 | 2023-08-10 | Nexys Therapeutics, Inc. | ARYL HYDROCARBONE RECEPTOR AGONISTS AND THEIR USES |
| US20250283174A1 (en) | 2022-05-16 | 2025-09-11 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stem cells induced by chronic inflammation |
| KR20250054814A (ko) * | 2022-09-05 | 2025-04-23 | 티와이케이 메디슨즈, 인코포레이티드 | Cdk4 키나아제 억제제로 사용되는 화합물 및 이의 용도 |
| CN117886801B (zh) * | 2024-03-14 | 2024-05-17 | 中国药科大学 | 吡啶酮嘧啶类cdk抑制剂及其制备方法和应用 |
| WO2026093435A1 (en) | 2024-10-31 | 2026-05-07 | Institut National de la Santé et de la Recherche Médicale | Use of jak inhibitors for enhancing the potency of immunotherapy in the treament of cancer |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4218458A (en) * | 1978-06-23 | 1980-08-19 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| GB8412184D0 (en) * | 1984-05-12 | 1984-06-20 | Fisons Plc | Biologically active nitrogen heterocycles |
| DE69429078T2 (de) | 1993-10-01 | 2002-07-11 | Novartis Ag, Basel | Pharmacologisch wirksame pyridinderivate und verfahren zu deren herstellung |
| AU693475B2 (en) | 1993-10-01 | 1998-07-02 | Novartis Ag | Pyrimidineamine derivatives and processes for the preparation thereof |
| PT672042E (pt) | 1993-10-01 | 2006-08-31 | Novartis Ag | Derivados de pirimidinoamina farmacologicamente activos e processos para a sua preparacao |
| GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| DE69919707T2 (de) | 1998-06-19 | 2005-09-01 | Chiron Corp., Emeryville | Glycogen synthase kinase 3 inhibitoren |
| GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
| WO2002020495A2 (en) * | 2000-09-06 | 2002-03-14 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| AU2001290912A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US7122544B2 (en) * | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| US7129242B2 (en) * | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| GB0107901D0 (en) * | 2001-03-29 | 2001-05-23 | Cyclacel Ltd | Anti-cancer compounds |
| MXPA03008888A (es) | 2001-03-29 | 2005-03-07 | Vertex Pharma | Inhibidores de n-terminal c-jun cinasas (jnk) y otras proteinas cinasas. |
| WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| EP1562911B1 (en) * | 2002-11-01 | 2010-01-06 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of jak and other protein kinases |
-
2003
- 2003-11-05 US US10/702,113 patent/US7348335B2/en not_active Expired - Fee Related
- 2003-11-05 EP EP03778111A patent/EP1560824A1/en not_active Withdrawn
- 2003-11-05 WO PCT/US2003/035188 patent/WO2004041810A1/en not_active Ceased
- 2003-11-05 AU AU2003286895A patent/AU2003286895A1/en not_active Abandoned
- 2003-11-05 CA CA002507406A patent/CA2507406A1/en not_active Abandoned
- 2003-11-05 JP JP2004550489A patent/JP2006508107A/ja active Pending
-
2010
- 2010-06-18 JP JP2010139840A patent/JP2010195838A/ja active Pending
- 2010-11-19 AU AU2010246324A patent/AU2010246324B2/en not_active Ceased
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