JP2003514770A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003514770A5 JP2003514770A5 JP2001522958A JP2001522958A JP2003514770A5 JP 2003514770 A5 JP2003514770 A5 JP 2003514770A5 JP 2001522958 A JP2001522958 A JP 2001522958A JP 2001522958 A JP2001522958 A JP 2001522958A JP 2003514770 A5 JP2003514770 A5 JP 2003514770A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- disease
- composition according
- compound
- glycero
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL131887 | 1999-09-14 | ||
| IL13188799A IL131887A0 (en) | 1999-09-14 | 1999-09-14 | Phospholipid prodrugs of anti-proliferative drugs |
| PCT/IL2000/000562 WO2001019320A2 (en) | 1999-09-14 | 2000-09-13 | Phospholipid prodrugs of anti-proliferative drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003514770A JP2003514770A (ja) | 2003-04-22 |
| JP2003514770A5 true JP2003514770A5 (enExample) | 2007-10-11 |
Family
ID=11073248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522958A Pending JP2003514770A (ja) | 1999-09-14 | 2000-09-13 | 抗増殖性医薬の燐脂質プロドラッグ |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6774121B1 (enExample) |
| EP (1) | EP1218013A4 (enExample) |
| JP (1) | JP2003514770A (enExample) |
| AU (1) | AU781507B2 (enExample) |
| CA (1) | CA2382633A1 (enExample) |
| IL (2) | IL131887A0 (enExample) |
| NZ (1) | NZ517522A (enExample) |
| WO (1) | WO2001019320A2 (enExample) |
| ZA (1) | ZA200201081B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7135584B2 (en) | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
| AU3216695A (en) | 1994-08-29 | 1996-03-22 | University Of North Carolina At Chapel Hill, The | Lipid analogs for treating viral infections |
| US6670341B1 (en) | 1999-10-28 | 2003-12-30 | Wake Forest University Health Sciences | Compositions and methods for double-targeting virus infections and targeting cancer cells |
| US7026469B2 (en) * | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
| US7309696B2 (en) | 2000-10-19 | 2007-12-18 | Wake Forest University | Compositions and methods for targeting cancer cells |
| IL158532A0 (en) | 2001-05-02 | 2004-05-12 | Purdue Research Foundation | Treatment and diagnosis of macrophage mediated disease |
| US8043603B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| EP1485107A1 (en) * | 2002-02-11 | 2004-12-15 | Vertex Pharmaceuticals Incorporated | Phospholipids as caspase inhibitor prodrugs |
| TW200408645A (en) | 2002-04-26 | 2004-06-01 | Gilead Sciences Inc | Non nucleoside reverse transcriptase inhibitors |
| SG182849A1 (en) | 2003-04-25 | 2012-08-30 | Gilead Sciences Inc | Antiviral phosphonate analogs |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| WO2004096285A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
| EP1620109A2 (en) | 2003-04-25 | 2006-02-01 | Gilead Sciences, Inc. | Kinase inhibitor phosphonate conjugates |
| US7427636B2 (en) | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| JP4680185B2 (ja) | 2003-05-30 | 2011-05-11 | パーデュー・リサーチ・ファウンデーション | アテローム性動脈硬化症の診断法 |
| WO2005044279A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Purine nucleoside phosphonate conjugates |
| WO2005042773A1 (en) | 2003-10-24 | 2005-05-12 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds |
| US7432273B2 (en) | 2003-10-24 | 2008-10-07 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| BRPI0417988A (pt) | 2003-12-22 | 2007-04-27 | Gilead Sciences Inc | análogos de fosfonato antivirais |
| PT2258376T (pt) | 2004-07-27 | 2019-05-31 | Gilead Sciences Inc | Análogos fosfonatados de compostos inibidores do vih |
| JP5175723B2 (ja) | 2005-07-05 | 2013-04-03 | パーデュー・リサーチ・ファウンデーション | 単球介在性疾患を治療するための組成物の調製 |
| DE102006019907A1 (de) * | 2006-04-28 | 2007-10-31 | Müller-Enoch, Dieter, Prof. Dr. | Verwendung von substituierten Glycerinderivaten zur Herstellung einer pharmazeutischen Zubereitung |
| JP2010509570A (ja) | 2006-11-03 | 2010-03-25 | パーデュー・リサーチ・ファウンデーション | エクスビボフローサイトメトリーの方法および装置 |
| US8586595B2 (en) | 2007-02-07 | 2013-11-19 | Purdue Research Foundation | Positron emission tomography imaging method |
| WO2008148001A2 (en) | 2007-05-25 | 2008-12-04 | Purdue Research Foundation | Method of imaging localized infections |
| BRPI0915878A2 (pt) | 2008-07-08 | 2015-11-03 | Gilead Sciences Inc | sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende |
| WO2010088924A1 (en) | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
| EP2563404B1 (en) * | 2010-04-30 | 2016-09-21 | Urogen Pharma Ltd. | Phospholipid drug analogs |
| WO2011134669A1 (en) * | 2010-04-30 | 2011-11-03 | Telormedix Sa | Methods for inducing an immune response |
| US20130244982A1 (en) | 2010-12-02 | 2013-09-19 | Bengurion University Of The Negev Research And Development Authority | Conjugates of a phospholipid and a drug for the treatment of inflammatory bowel disease |
| US9499800B2 (en) | 2013-12-26 | 2016-11-22 | Regents Of The University Of Minnesota | Methods of making and using chemically self assembled-nanorings |
| CN107708702A (zh) * | 2014-11-17 | 2018-02-16 | 塞勒克塔生物科学有限公司 | 磷脂醚类似物作为靶向癌症的药物载体 |
| PT3661937T (pt) | 2017-08-01 | 2021-09-24 | Gilead Sciences Inc | Formas cristalinas de ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-il)-4-fluoro-2,5-dihidrofurano-2-il)oxi)metil)(fenoxi)fosforil)-l-alaninato de etil (gs-9131) para tratamento de infeções virais |
| WO2019200043A1 (en) * | 2018-04-11 | 2019-10-17 | New Mexico Tech University Research Park Coporation | Lipid prodrugs for use in drug delivery |
| WO2025202629A1 (en) | 2024-03-26 | 2025-10-02 | Coopervision International Limited | Contact lens loaded with a glycerophospholipid |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61152694A (ja) * | 1984-12-27 | 1986-07-11 | Toyama Chem Co Ltd | 新規な５−フルオロ−２′−デオキシウリジン−５′−ホスフエ−ト誘導体およびその塩 |
| US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| DE3769676D1 (de) * | 1986-03-14 | 1991-06-06 | Fujisawa Pharmaceutical Co | Prodrugverbindungen, verfahren zu deren herstellung und diese enthaltende zubereitungen mit verzoegerter freisetzung. |
| JPS6383093A (ja) * | 1986-09-27 | 1988-04-13 | Toyo Jozo Co Ltd | ヌクレオシド−リン脂質複合体 |
| US5411947A (en) * | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
| AU7872491A (en) | 1990-05-07 | 1991-11-27 | Vical, Inc. | Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs |
| US5149794A (en) | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
| US5543389A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization | Covalent polar lipid-peptide conjugates for use in salves |
| CA2112803A1 (en) | 1991-07-12 | 1993-01-21 | Karl Y. Hostetler | Antiviral liponucleosides: treatment of hepatitis b |
| IL105244A (en) | 1993-03-31 | 2003-07-31 | Dpharm Ltd | Prodrugs with enhanced penetration into cells |
| US6413949B1 (en) * | 1995-06-07 | 2002-07-02 | D-Pharm, Ltd. | Prodrugs with enhanced penetration into cells |
| US7517858B1 (en) * | 1995-06-07 | 2009-04-14 | The Regents Of The University Of California | Prodrugs of pharmaceuticals with improved bioavailability |
| JP2001500847A (ja) * | 1996-08-02 | 2001-01-23 | スミスクライン・ビーチャム・コーポレイション | 癌の検出および処置の新規方法 |
| US6090800A (en) * | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| WO1999042830A1 (en) * | 1998-02-23 | 1999-08-26 | Diadexus Llc | Methods using pla2 as a marker of metastases and for the diagnosis of selected cancers |
-
1999
- 1999-09-14 IL IL13188799A patent/IL131887A0/xx unknown
-
2000
- 2000-09-13 JP JP2001522958A patent/JP2003514770A/ja active Pending
- 2000-09-13 EP EP00960946A patent/EP1218013A4/en not_active Withdrawn
- 2000-09-13 WO PCT/IL2000/000562 patent/WO2001019320A2/en not_active Ceased
- 2000-09-13 AU AU73093/00A patent/AU781507B2/en not_active Ceased
- 2000-09-13 NZ NZ517522A patent/NZ517522A/en not_active IP Right Cessation
- 2000-09-13 CA CA002382633A patent/CA2382633A1/en not_active Abandoned
- 2000-09-13 US US10/088,160 patent/US6774121B1/en not_active Expired - Fee Related
-
2002
- 2002-02-07 ZA ZA200201081A patent/ZA200201081B/en unknown
- 2002-03-07 IL IL148554A patent/IL148554A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10570123B2 (en) | Pharmacokinetically improved compounds | |
| US6774121B1 (en) | Phospholipid prodrugs of anti-proliferative drugs | |
| US9255106B2 (en) | Substituted [1,2,4]triazolo[4,3-a]pyrazines as PARP-1 inhibitors | |
| US9096627B2 (en) | Hydroxamic acid derivatives | |
| TWI508725B (zh) | 脂肪酸富馬酸酯衍生物及其用途 | |
| ES2249884T3 (es) | Derivados del acido indolil-3-glioxilico con efecto antitumoral. | |
| JP2006523202A (ja) | 生体還元により活性化されるプロドラッグ | |
| US20120202793A1 (en) | Rho kinase inhibitors | |
| TWI736578B (zh) | 6-5元稠合唑環衍生物及其藥物組合物，以及作為藥物的應用 | |
| CN102131812A (zh) | 吡咯并[2，3-d]嘧啶化合物 | |
| CN1938307A (zh) | 9－取代的8－氧化腺嘌呤 | |
| BR122023027277A2 (pt) | Derivados deuterados de ruxolitinib e composição farmacêutica | |
| JP2021519297A (ja) | Ｔｒｋキナーゼ阻害剤としての大環状化合物 | |
| US7902359B2 (en) | Decahydronaphthalene compounds | |
| KR20020065341A (ko) | 포스포디에스트라스(phosphodiesterase, PDE) Ⅳ 억제작용을 가진 푸린 유도체 | |
| TW201805290A (zh) | 一類蛋白激酶抑制劑 | |
| US20210380626A1 (en) | Novel small molecule drug conjugates of gemcitabine derivatives | |
| CN113372366A (zh) | 一种吡咯并嘧啶类化合物的盐、其晶型及其应用 | |
| US20020198218A1 (en) | Synthesis and methods of use of tetrahydroindolone analogues and derivatives | |
| ES2914355T3 (es) | Inhibidores bicíclicos de la histona desacetilasa | |
| US12275738B2 (en) | CDK9 inhibitors | |
| US20260022120A1 (en) | Inhibitors of MENIN-MLL Interaction | |
| TW202019887A (zh) | 酚系trpv1促效劑之聚乙二醇化前藥 | |
| EP1480984B9 (en) | Hexacyclic compounds | |
| US11129899B1 (en) | Methotrexate derivatives and uses thereof |