JP2006507369A - ５−アンドロステン−３β−オールステロイド中間体およびそれらの製法 - Google Patents
５−アンドロステン−３β−オールステロイド中間体およびそれらの製法 Download PDFInfo
- Publication number
- JP2006507369A JP2006507369A JP2005502036A JP2005502036A JP2006507369A JP 2006507369 A JP2006507369 A JP 2006507369A JP 2005502036 A JP2005502036 A JP 2005502036A JP 2005502036 A JP2005502036 A JP 2005502036A JP 2006507369 A JP2006507369 A JP 2006507369A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- steroid
- producing
- hydroxysteroid
- dihydroxysteroid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000000543 intermediate Substances 0.000 title abstract description 11
- -1 5-Androsten-3β-ol steroid Chemical class 0.000 title abstract description 10
- LYFPAZBMEUSVNA-UHFFFAOYSA-N (10R)-3c-Hydroxy-10r.13c-dimethyl-(8cH.9tH.14tH)-Delta5-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCCC1(C)CC2 LYFPAZBMEUSVNA-UHFFFAOYSA-N 0.000 title abstract description 3
- 150000003431 steroids Chemical group 0.000 claims description 111
- 229910052799 carbon Inorganic materials 0.000 claims description 60
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- VWFCWHWCCOZKJZ-CAMMJAKZSA-N (8s,10s,13s,14s)-10,13-dimethyl-2,3,4,7,8,12,14,15,16,17-decahydro-1h-cyclopenta[a]phenanthrene Chemical compound C([C@H]12)C=C3CCCC[C@]3(C)C1=CC[C@@]1(C)[C@H]2CCC1 VWFCWHWCCOZKJZ-CAMMJAKZSA-N 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
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- 230000036983 biotransformation Effects 0.000 description 23
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40399002P | 2002-08-16 | 2002-08-16 | |
| US41529302P | 2002-10-01 | 2002-10-01 | |
| PCT/US2003/007791 WO2004016640A2 (en) | 2002-08-16 | 2003-03-21 | 5 ANDROSTEN-3β-OL STEROID INTERMEDIATES AND PROCESSES FOR THEIR PREPARATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006507369A true JP2006507369A (ja) | 2006-03-02 |
| JP2006507369A5 JP2006507369A5 (enExample) | 2006-05-11 |
Family
ID=31891414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005502036A Abandoned JP2006507369A (ja) | 2002-08-16 | 2003-03-21 | ５−アンドロステン−３β−オールステロイド中間体およびそれらの製法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20040034215A1 (enExample) |
| EP (1) | EP1534732B1 (enExample) |
| JP (1) | JP2006507369A (enExample) |
| AT (1) | ATE339437T1 (enExample) |
| AU (1) | AU2003285485A1 (enExample) |
| BR (1) | BR0313523A (enExample) |
| CA (1) | CA2495412A1 (enExample) |
| DE (1) | DE60308388T2 (enExample) |
| ES (1) | ES2271636T3 (enExample) |
| MX (1) | MXPA05001857A (enExample) |
| TW (1) | TW200406419A (enExample) |
| WO (1) | WO2004016640A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008522962A (ja) * | 2004-12-06 | 2008-07-03 | インダストリアレ チミカ ソシエタ ア レスポンサビリタ リミタータ | ドロスピレノンの調製方法 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8084446B2 (en) * | 2005-04-26 | 2011-12-27 | Eric Marchewitz | Use of DHEA derivatives for enhancing physical performance |
| PL2527356T3 (pl) * | 2005-07-21 | 2018-06-29 | Bayer Intellectual Property Gmbh | Sposób wytwarzania 3-okso-pregn-4-eno-21,17-karbolaktonów za pomocą wolnego od metali utleniania 17-(3-hydroksypropylo)-3,17- dihydroksyandrostanów |
| ATE403668T1 (de) | 2005-07-21 | 2008-08-15 | Bayer Schering Pharma Ag | Verfahren zur herstellung von 3-oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie oxidation von 17-(3-hydroxypropyl)-3,17- dihydroxyandrostanen |
| US7319154B2 (en) | 2005-07-21 | 2008-01-15 | Bayer Schering Pharma Ag | Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes |
| CN110331182A (zh) * | 2019-08-06 | 2019-10-15 | 江苏远大仙乐药业有限公司 | 一种甾体中间体的生物转化制备方法 |
| CN110885869A (zh) * | 2019-12-24 | 2020-03-17 | 天津科技大学 | 一种利用微生物转化生产7α-羟基-脱氢表雄酮的方法 |
| CN111057734A (zh) * | 2019-12-24 | 2020-04-24 | 天津科技大学 | 一种甲基睾丸素高效转化生产11α-羟基-甲基睾丸素的方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3294646A (en) * | 1963-10-23 | 1966-12-27 | American Home Prod | Microbiological hydroxylation of norsteroids using aspergillus ochraceus |
| DE2349022A1 (de) * | 1973-09-26 | 1975-04-10 | Schering Ag | Neue d-homo-steroide |
| DK134348C (da) * | 1973-11-30 | 1977-03-21 | Schering Ag | Analogifremgangsmade til fremstilling af d-homo-20-ketopregnaner |
| US4031074A (en) * | 1974-09-02 | 1977-06-21 | Akzona Incorporated | Process for the preparation of 11β-hydroxy-18-alkyl-estrane compounds |
| IL48628A0 (en) * | 1974-12-23 | 1976-02-29 | Schering Ag | D-homo-20-keto-pregnanes and process for their manufactur |
| US4054563A (en) * | 1975-04-25 | 1977-10-18 | Ciba-Geigy Corporation | Process for the manufacture of spiro compounds of the steroid series |
| CH633562A5 (de) * | 1976-12-10 | 1982-12-15 | Schering Ag | Verfahren zur herstellung neuer kortikoide. |
| US4336332A (en) * | 1979-02-20 | 1982-06-22 | Hoffmann-La Roche, Inc. | Process for the manufacture of hydroxylated steroids |
| DE3042136A1 (de) * | 1980-11-03 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden |
| US4559332A (en) * | 1983-04-13 | 1985-12-17 | Ciba Geigy Corporation | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof |
| AU7978794A (en) * | 1993-10-13 | 1995-05-04 | Neurocrine Biosciences, Inc. | 3,17-dihydroxy-3,7,16 and/or 17-methyl-androst-5-ene compounds, derivatives thereof, and their use |
| PT973791E (pt) * | 1995-12-11 | 2007-09-26 | Searle Llc | Processo para a preparação de um composto epoxi |
| DE69620474T2 (de) * | 1995-12-12 | 2002-11-14 | Akzo Nobel N.V., Arnhem | Mikrobielle 11alpha-hydroxylierung von steroiden |
| FR2771105A1 (fr) | 1997-11-20 | 1999-05-21 | Vitasterol | Utilisation du fusarium monoliforme pour la preparation des derives 7alpha-hydroxyles de la dehydroepiandrosterone et de la pregnenolone |
-
2003
- 2003-03-21 DE DE60308388T patent/DE60308388T2/de not_active Expired - Fee Related
- 2003-03-21 CA CA002495412A patent/CA2495412A1/en not_active Abandoned
- 2003-03-21 TW TW092106331A patent/TW200406419A/zh unknown
- 2003-03-21 MX MXPA05001857A patent/MXPA05001857A/es unknown
- 2003-03-21 WO PCT/US2003/007791 patent/WO2004016640A2/en not_active Ceased
- 2003-03-21 AU AU2003285485A patent/AU2003285485A1/en not_active Abandoned
- 2003-03-21 US US10/392,955 patent/US20040034215A1/en not_active Abandoned
- 2003-03-21 AT AT03756776T patent/ATE339437T1/de not_active IP Right Cessation
- 2003-03-21 ES ES03756776T patent/ES2271636T3/es not_active Expired - Lifetime
- 2003-03-21 JP JP2005502036A patent/JP2006507369A/ja not_active Abandoned
- 2003-03-21 EP EP03756776A patent/EP1534732B1/en not_active Expired - Lifetime
- 2003-03-21 BR BR0313523-3A patent/BR0313523A/pt not_active IP Right Cessation
-
2004
- 2004-06-01 US US10/858,177 patent/US7002028B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008522962A (ja) * | 2004-12-06 | 2008-07-03 | インダストリアレ チミカ ソシエタ ア レスポンサビリタ リミタータ | ドロスピレノンの調製方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05001857A (es) | 2005-06-03 |
| WO2004016640A3 (en) | 2004-07-08 |
| BR0313523A (pt) | 2005-06-28 |
| CA2495412A1 (en) | 2004-02-26 |
| DE60308388T2 (de) | 2007-09-20 |
| US20040034215A1 (en) | 2004-02-19 |
| EP1534732A2 (en) | 2005-06-01 |
| US7002028B2 (en) | 2006-02-21 |
| ES2271636T3 (es) | 2007-04-16 |
| WO2004016640A2 (en) | 2004-02-26 |
| AU2003285485A1 (en) | 2004-03-03 |
| US20040220158A1 (en) | 2004-11-04 |
| ATE339437T1 (de) | 2006-10-15 |
| DE60308388D1 (de) | 2006-10-26 |
| TW200406419A (en) | 2004-05-01 |
| EP1534732B1 (en) | 2006-09-13 |
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