DE60308388D1 - 5-androsten-3-olsteroidzwischenprodukte und verfahren zu deren herstellung - Google Patents

5-androsten-3-olsteroidzwischenprodukte und verfahren zu deren herstellung

Info

Publication number
DE60308388D1
DE60308388D1 DE60308388T DE60308388T DE60308388D1 DE 60308388 D1 DE60308388 D1 DE 60308388D1 DE 60308388 T DE60308388 T DE 60308388T DE 60308388 T DE60308388 T DE 60308388T DE 60308388 D1 DE60308388 D1 DE 60308388D1
Authority
DE
Germany
Prior art keywords
androsten
olsteroid
production
intermediate products
3beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60308388T
Other languages
English (en)
Other versions
DE60308388T2 (de
Inventor
J White
G Wuts
Doris Beck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Application granted granted Critical
Publication of DE60308388D1 publication Critical patent/DE60308388D1/de
Publication of DE60308388T2 publication Critical patent/DE60308388T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
DE60308388T 2002-08-16 2003-03-21 5-Androsten-3beta-ol-Steroide und Verfahren für ihre Herstellung Expired - Fee Related DE60308388T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40399002P 2002-08-16 2002-08-16
US403990P 2002-08-16
US41529302P 2002-10-01 2002-10-01
US415293P 2002-10-01
PCT/US2003/007791 WO2004016640A2 (en) 2002-08-16 2003-03-21 5 ANDROSTEN-3β-OL STEROID INTERMEDIATES AND PROCESSES FOR THEIR PREPARATION

Publications (2)

Publication Number Publication Date
DE60308388D1 true DE60308388D1 (de) 2006-10-26
DE60308388T2 DE60308388T2 (de) 2007-09-20

Family

ID=31891414

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60308388T Expired - Fee Related DE60308388T2 (de) 2002-08-16 2003-03-21 5-Androsten-3beta-ol-Steroide und Verfahren für ihre Herstellung

Country Status (12)

Country Link
US (2) US20040034215A1 (de)
EP (1) EP1534732B1 (de)
JP (1) JP2006507369A (de)
AT (1) ATE339437T1 (de)
AU (1) AU2003285485A1 (de)
BR (1) BR0313523A (de)
CA (1) CA2495412A1 (de)
DE (1) DE60308388T2 (de)
ES (1) ES2271636T3 (de)
MX (1) MXPA05001857A (de)
TW (1) TW200406419A (de)
WO (1) WO2004016640A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20042338A1 (it) * 2004-12-06 2005-03-06 Ind Chimica Srl Processo per la preparazione di drospirenone
US8084446B2 (en) 2005-04-26 2011-12-27 Eric Marchewitz Use of DHEA derivatives for enhancing physical performance
DK1746101T4 (da) * 2005-07-21 2014-08-11 Bayer Pharma AG Fremgangsmåde til fremstilling af 3-oxo-pregn-4-en-21,17-carbolactoner ved metalfri oxidation af 17-(3-hydroxypropyl)-3,17-dihydroxyandrostaner
PT2527356T (pt) * 2005-07-21 2018-03-26 Bayer Ip Gmbh Processo para a produção de 3-oxo-pregn-4-eno-21,17-carbolactonas através da oxidação isenta de metais de 17-(3-hidroxipropil)-3,17-diidroxiandrostanos
US7319154B2 (en) * 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
CN110331182A (zh) * 2019-08-06 2019-10-15 江苏远大仙乐药业有限公司 一种甾体中间体的生物转化制备方法
CN111057734A (zh) * 2019-12-24 2020-04-24 天津科技大学 一种甲基睾丸素高效转化生产11α-羟基-甲基睾丸素的方法
CN110885869A (zh) * 2019-12-24 2020-03-17 天津科技大学 一种利用微生物转化生产7α-羟基-脱氢表雄酮的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3294646A (en) * 1963-10-23 1966-12-27 American Home Prod Microbiological hydroxylation of norsteroids using aspergillus ochraceus
DE2349022A1 (de) * 1973-09-26 1975-04-10 Schering Ag Neue d-homo-steroide
DK134348C (da) * 1973-11-30 1977-03-21 Schering Ag Analogifremgangsmade til fremstilling af d-homo-20-ketopregnaner
US4031074A (en) * 1974-09-02 1977-06-21 Akzona Incorporated Process for the preparation of 11β-hydroxy-18-alkyl-estrane compounds
IL48628A0 (en) * 1974-12-23 1976-02-29 Schering Ag D-homo-20-keto-pregnanes and process for their manufactur
US4054563A (en) * 1975-04-25 1977-10-18 Ciba-Geigy Corporation Process for the manufacture of spiro compounds of the steroid series
IE46010B1 (en) * 1976-12-10 1983-01-26 Schering Ag New corticoids
US4336332A (en) * 1979-02-20 1982-06-22 Hoffmann-La Roche, Inc. Process for the manufacture of hydroxylated steroids
DE3042136A1 (de) * 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
FI77669C (fi) * 1983-04-13 1989-04-10 Ciba Geigy Ag 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat.
AU7978794A (en) * 1993-10-13 1995-05-04 Neurocrine Biosciences, Inc. 3,17-dihydroxy-3,7,16 and/or 17-methyl-androst-5-ene compounds, derivatives thereof, and their use
PT973791E (pt) * 1995-12-11 2007-09-26 Searle Llc Processo para a preparação de um composto epoxi
NZ325276A (en) * 1995-12-12 1999-11-29 Akzo Nobel Nv Microbial method of in vitro transformation of a steroid into the 11a-hydroxy analogue using oxygen and a micro-organism
FR2771105A1 (fr) 1997-11-20 1999-05-21 Vitasterol Utilisation du fusarium monoliforme pour la preparation des derives 7alpha-hydroxyles de la dehydroepiandrosterone et de la pregnenolone

Also Published As

Publication number Publication date
ATE339437T1 (de) 2006-10-15
WO2004016640A3 (en) 2004-07-08
US7002028B2 (en) 2006-02-21
US20040034215A1 (en) 2004-02-19
ES2271636T3 (es) 2007-04-16
DE60308388T2 (de) 2007-09-20
TW200406419A (en) 2004-05-01
JP2006507369A (ja) 2006-03-02
CA2495412A1 (en) 2004-02-26
EP1534732B1 (de) 2006-09-13
AU2003285485A1 (en) 2004-03-03
US20040220158A1 (en) 2004-11-04
EP1534732A2 (de) 2005-06-01
BR0313523A (pt) 2005-06-28
WO2004016640A2 (en) 2004-02-26
MXPA05001857A (es) 2005-06-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee