DE69620474T2 - Mikrobielle 11alpha-hydroxylierung von steroiden - Google Patents

Mikrobielle 11alpha-hydroxylierung von steroiden

Info

Publication number
DE69620474T2
DE69620474T2 DE69620474T DE69620474T DE69620474T2 DE 69620474 T2 DE69620474 T2 DE 69620474T2 DE 69620474 T DE69620474 T DE 69620474T DE 69620474 T DE69620474 T DE 69620474T DE 69620474 T2 DE69620474 T2 DE 69620474T2
Authority
DE
Germany
Prior art keywords
11alpha
hydroxylation
steroids
microbial
microbial 11alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69620474T
Other languages
English (en)
Other versions
DE69620474D1 (de
Inventor
Marten Wiersma
Der Meijden Pieter Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of DE69620474D1 publication Critical patent/DE69620474D1/de
Application granted granted Critical
Publication of DE69620474T2 publication Critical patent/DE69620474T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DE69620474T 1995-12-12 1996-12-10 Mikrobielle 11alpha-hydroxylierung von steroiden Expired - Fee Related DE69620474T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95203451 1995-12-12
PCT/EP1996/005729 WO1997021830A1 (en) 1995-12-12 1996-12-10 MICROBIAL 11α-HYDROXYLATION OF STEROIDS

Publications (2)

Publication Number Publication Date
DE69620474D1 DE69620474D1 (de) 2002-05-08
DE69620474T2 true DE69620474T2 (de) 2002-11-14

Family

ID=8220937

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69620474T Expired - Fee Related DE69620474T2 (de) 1995-12-12 1996-12-10 Mikrobielle 11alpha-hydroxylierung von steroiden

Country Status (21)

Country Link
US (1) US6046023A (de)
EP (1) EP0900283B1 (de)
JP (1) JP2000501940A (de)
KR (1) KR19990072066A (de)
CN (1) CN1138861C (de)
AR (1) AR005043A1 (de)
AT (1) ATE215606T1 (de)
AU (1) AU713685B2 (de)
CA (1) CA2240315A1 (de)
CZ (1) CZ289764B6 (de)
DE (1) DE69620474T2 (de)
DK (1) DK0900283T3 (de)
ES (1) ES2175175T3 (de)
IL (1) IL119818A (de)
NO (1) NO982700D0 (de)
NZ (1) NZ325276A (de)
PL (1) PL185223B1 (de)
PT (1) PT900283E (de)
RU (1) RU2213143C2 (de)
WO (1) WO1997021830A1 (de)
ZA (1) ZA9610485B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2427615A1 (en) * 2000-10-30 2002-06-13 Pharmacia Corporation Aspergillus ochraceus 11 alpha hydroxylase and oxidoreductase
NZ525726A (en) * 2000-11-09 2004-10-29 Astrazeneca Ab Oral pharmaceutical composition containing a block copolymer
FR2817284B1 (fr) 2000-11-27 2003-02-14 Alstom Power Nv Piece, notamment composant hydraulique, en matiere composite et procede de fabrication d'une telle piece
DE10233723A1 (de) 2002-07-24 2004-02-12 Schering Ag Mikrobiologische Verfahren zur Herstellung von 7α-substituierten 11α-Hydroxysteroiden, daraus herstellbare 7α,17α-substituierte 11β-Halogensteroide, deren Herstellungsverfahren und Verwendung sowie pharmazeutische Präparate, die diese Verbindungen enthalten, sowie daraus herstellbare 7α-substituierte Estra-1,3,5(10)-triene
CN100339486C (zh) * 2002-07-24 2007-09-26 舍林股份公司 制备7α－被取代的11α－羟基甾族化合物的微生物方法
ATE339437T1 (de) * 2002-08-16 2006-10-15 Pharmacia & Upjohn Co Llc 5-androsten-3-olsteroidzwischenprodukte und verfahren zu deren herstellung
US20070066579A1 (en) * 2002-08-16 2007-03-22 White Michael J 5-androsten-3beta-ol steroid intermediates and processs for their preparation
CN100338226C (zh) * 2005-07-29 2007-09-19 天津科技大学 微生物分批发酵转化法制备11α羟基坎利酮的方法
US20070212751A1 (en) * 2006-01-18 2007-09-13 Solvay Pharmaceuticals Gmbh Microbial method for the 11beta hydroxylation of 9beta, 10alpha-steriods
RU2731712C2 (ru) * 2018-12-07 2020-09-08 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) МИКРОБИОЛОГИЧЕСКИЙ СПОСОБ ПОЛУЧЕНИЯ 11α-АЦЕТОКСИПРОГЕСТЕРОНА
CN111593086B (zh) * 2020-05-27 2023-05-05 湖北葛店人福药业有限责任公司 一种利用混合溶剂减少乙基双酮11a羟化过程中杂质的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1162915A (fr) * 1950-08-19 1958-09-18 Upjohn Co Procédé d'oxydation de stéroïdes et produits préparables par ce procédé
US2602769A (en) * 1952-02-23 1952-07-08 Upjohn Co Oxygenation of steroids by mucorales fungi
US2721163A (en) * 1952-09-24 1955-10-18 Pfizer & Co C Oxygenation of steroids in the 11-position
FR1261181A (fr) * 1958-02-21 1961-05-19 Merck & Co Inc Production par fermentation de dérivés 11 alpha-hydroxyles de stéroïdes de la série de la 16 alpha-alkyl-4-prégnène-3, 20-dione
FR1406102A (fr) * 1963-06-17 1965-07-16 Upjohn Co Procédé d'oxygénation de progestérone par voie microbiologique
US3294646A (en) * 1963-10-23 1966-12-27 American Home Prod Microbiological hydroxylation of norsteroids using aspergillus ochraceus
NL6409039A (de) * 1964-08-06 1966-02-07
NL6801762A (de) * 1967-02-20 1968-08-21

Also Published As

Publication number Publication date
JP2000501940A (ja) 2000-02-22
CN1207136A (zh) 1999-02-03
AR005043A1 (es) 1999-04-07
ZA9610485B (en) 1997-06-24
CA2240315A1 (en) 1997-06-19
IL119818A (en) 2000-02-29
WO1997021830A1 (en) 1997-06-19
KR19990072066A (ko) 1999-09-27
DE69620474D1 (de) 2002-05-08
AU713685B2 (en) 1999-12-09
RU2213143C2 (ru) 2003-09-27
IL119818A0 (en) 1997-03-18
US6046023A (en) 2000-04-04
PL185223B1 (pl) 2003-04-30
EP0900283B1 (de) 2002-04-03
EP0900283A1 (de) 1999-03-10
CZ183498A3 (cs) 1998-10-14
CZ289764B6 (cs) 2002-04-17
DK0900283T3 (da) 2002-07-15
NO982700L (no) 1998-06-11
NZ325276A (en) 1999-11-29
ATE215606T1 (de) 2002-04-15
AU1375897A (en) 1997-07-03
CN1138861C (zh) 2004-02-18
PL327439A1 (en) 1998-12-07
PT900283E (pt) 2002-09-30
ES2175175T3 (es) 2002-11-16
NO982700D0 (no) 1998-06-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee