JP2006507229A5 - - Google Patents
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- Publication number
- JP2006507229A5 JP2006507229A5 JP2004519705A JP2004519705A JP2006507229A5 JP 2006507229 A5 JP2006507229 A5 JP 2006507229A5 JP 2004519705 A JP2004519705 A JP 2004519705A JP 2004519705 A JP2004519705 A JP 2004519705A JP 2006507229 A5 JP2006507229 A5 JP 2006507229A5
- Authority
- JP
- Japan
- Prior art keywords
- gly
- asp
- dimer
- pro
- glu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 25
- 239000000539 dimer Substances 0.000 claims 19
- 108090000190 Thrombin Proteins 0.000 claims 18
- 229960004072 thrombin Drugs 0.000 claims 18
- 150000001413 amino acids Chemical class 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 5
- 150000001408 amides Chemical group 0.000 claims 3
- 210000000988 bone and bone Anatomy 0.000 claims 3
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 229940117028 Thrombin receptor agonist Drugs 0.000 claims 1
- 230000008468 bone growth Effects 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000003869 thrombin derivative Substances 0.000 claims 1
- OXHYRVSBKWIFES-WWSDOYNLSA-N trap-14 peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=CC=C1 OXHYRVSBKWIFES-WWSDOYNLSA-N 0.000 claims 1
- 239000011800 void material Substances 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39357902P | 2002-07-02 | 2002-07-02 | |
| PCT/US2003/020626 WO2004005317A2 (en) | 2002-07-02 | 2003-07-01 | Thrombin peptide derivative dimers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006507229A JP2006507229A (ja) | 2006-03-02 |
| JP2006507229A5 true JP2006507229A5 (https=) | 2006-08-17 |
| JP4668612B2 JP4668612B2 (ja) | 2011-04-13 |
Family
ID=30115603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004519705A Expired - Fee Related JP4668612B2 (ja) | 2002-07-02 | 2003-07-01 | トロンビンペプチド誘導体ダイマー |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7456250B2 (https=) |
| EP (1) | EP1539800B1 (https=) |
| JP (1) | JP4668612B2 (https=) |
| AT (1) | ATE362939T1 (https=) |
| AU (1) | AU2003247848B2 (https=) |
| CA (1) | CA2491135A1 (https=) |
| DE (1) | DE60313982T2 (https=) |
| WO (1) | WO2004005317A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1913917B (zh) * | 2003-12-31 | 2012-02-01 | 正统逻辑公司 | 凝血酶肽衍生物的药物组合物 |
| JP2010504336A (ja) * | 2006-09-22 | 2010-02-12 | オーソロジック コーポレイション | 血管内皮機能不全を治療する方法 |
| WO2008100567A2 (en) * | 2007-02-15 | 2008-08-21 | Orthologic Corp. | Thrombin peptide derivatives for treating fractures in osteopenic patients |
| EP2155234A1 (en) * | 2007-04-10 | 2010-02-24 | The Board of Regents,The University of Texas System | Combination therapy for chronic dermal ulcers |
| WO2008124173A1 (en) * | 2007-04-10 | 2008-10-16 | The Board Of Regents, The University Of Texas System | Combination therapy for cardiac revascularization and cardiac repair |
| CA2722621A1 (en) * | 2008-03-26 | 2009-10-01 | Orthologic Corp. | Thrombin derived peptides for smooth muscle relaxation |
| EP2280722A2 (en) * | 2008-03-26 | 2011-02-09 | Orthologic Corp. | Method of treating degenerative diseases |
| US20110105400A1 (en) * | 2008-03-26 | 2011-05-05 | Orthologic Corp. | Methods for treating acute myocardial infarction |
| WO2009120307A2 (en) * | 2008-03-26 | 2009-10-01 | Orthologic Corp. | Method of treating peripheral arterial disease |
| CU23716A1 (es) * | 2008-09-30 | 2011-10-05 | Ct Ingenieria Genetica Biotech | Péptido antagonista de la actividad de la interleucina-15 |
| JP2013529600A (ja) | 2010-06-11 | 2013-07-22 | ザ ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 放射の影響を軽減し、及び全身性感染症のリスクを減少させる方法 |
| US10220078B2 (en) | 2014-06-11 | 2019-03-05 | The Board Of Regents Of The University Of Texas System | Methods of using thrombin derivatives to treat medulloblastoma |
| EP3952991A4 (en) * | 2019-04-12 | 2023-08-09 | Affirmed Pharma, LLC | RUSALATIDE ACETATE COMPOSITIONS |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5352664A (en) | 1986-10-31 | 1994-10-04 | Board Of Regents, The University Of Texas System | Thrombin derived polypeptides; compositions and methods for use |
| US6500934B1 (en) * | 1996-07-24 | 2002-12-31 | Michael Rush Lerner | Bivalent agonists for G-protein coupled receptors |
| TWI257307B (en) | 2000-07-12 | 2006-07-01 | Orthologic Corp | Pharmaceutical composition for cardiac tissue repair |
| ATE254925T1 (de) | 2000-07-19 | 2003-12-15 | Univ Texas | Stimulierung des knochenwachstums mit peptidderivaten von thrombin |
| AU7356101A (en) | 2000-07-20 | 2002-02-05 | Univ Texas | Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor |
| ES2271216T3 (es) | 2001-07-27 | 2007-04-16 | Orthologic Corp. | Uso de los peptidos derivados de la trombina para la terapia de las ulceras dermicas cronicas. |
| TW200407905A (en) * | 2002-11-06 | 2004-05-16 | Leadtek Research Inc | Data write-in and read-out method of flash memory and circuit thereof |
| CN1913917B (zh) | 2003-12-31 | 2012-02-01 | 正统逻辑公司 | 凝血酶肽衍生物的药物组合物 |
-
2003
- 2003-07-01 DE DE60313982T patent/DE60313982T2/de not_active Expired - Lifetime
- 2003-07-01 AT AT03763062T patent/ATE362939T1/de not_active IP Right Cessation
- 2003-07-01 JP JP2004519705A patent/JP4668612B2/ja not_active Expired - Fee Related
- 2003-07-01 WO PCT/US2003/020626 patent/WO2004005317A2/en not_active Ceased
- 2003-07-01 CA CA002491135A patent/CA2491135A1/en not_active Abandoned
- 2003-07-01 AU AU2003247848A patent/AU2003247848B2/en not_active Ceased
- 2003-07-01 EP EP03763062A patent/EP1539800B1/en not_active Expired - Lifetime
-
2004
- 2004-12-30 US US11/027,795 patent/US7456250B2/en not_active Expired - Lifetime
-
2008
- 2008-10-10 US US12/287,703 patent/US7919457B2/en not_active Expired - Lifetime
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