JP2006514822A5 - - Google Patents
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- Publication number
- JP2006514822A5 JP2006514822A5 JP2004527586A JP2004527586A JP2006514822A5 JP 2006514822 A5 JP2006514822 A5 JP 2006514822A5 JP 2004527586 A JP2004527586 A JP 2004527586A JP 2004527586 A JP2004527586 A JP 2004527586A JP 2006514822 A5 JP2006514822 A5 JP 2006514822A5
- Authority
- JP
- Japan
- Prior art keywords
- gly
- asp
- peptide derivative
- thrombin peptide
- glu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 30
- 108090000190 Thrombin Proteins 0.000 claims 23
- 229960004072 thrombin Drugs 0.000 claims 23
- 150000001413 amino acids Chemical group 0.000 claims 18
- 235000001014 amino acid Nutrition 0.000 claims 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 6
- 235000004279 alanine Nutrition 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 150000001408 amides Chemical group 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 239000004471 Glycine Substances 0.000 claims 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- 210000000988 bone and bone Anatomy 0.000 claims 3
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- HZKLCOYAVAAQRD-VGMNWLOBSA-N (3s)-3-[[2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1r)-1-carboxyethyl]amino]-4-oxobutanoic acid Chemical compound OC(=O)[C@@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCN=C(N)N HZKLCOYAVAAQRD-VGMNWLOBSA-N 0.000 claims 1
- 229940117028 Thrombin receptor agonist Drugs 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 108010086780 arginyl-glycyl-aspartyl-alanine Proteins 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 230000008468 bone growth Effects 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- OXHYRVSBKWIFES-WWSDOYNLSA-N trap-14 peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=CC=C1 OXHYRVSBKWIFES-WWSDOYNLSA-N 0.000 claims 1
- 239000011800 void material Substances 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39358002P | 2002-07-02 | 2002-07-02 | |
| PCT/US2003/020635 WO2004014937A2 (en) | 2002-07-02 | 2003-07-01 | Thrombin peptide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006514822A JP2006514822A (ja) | 2006-05-18 |
| JP2006514822A5 true JP2006514822A5 (https=) | 2006-08-17 |
Family
ID=31715655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004527586A Pending JP2006514822A (ja) | 2002-07-02 | 2003-07-01 | トロンビンペプチド誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7713934B2 (https=) |
| EP (1) | EP1539214A4 (https=) |
| JP (1) | JP2006514822A (https=) |
| AU (1) | AU2003256343B2 (https=) |
| CA (1) | CA2491052A1 (https=) |
| WO (1) | WO2004014937A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1913917B (zh) * | 2003-12-31 | 2012-02-01 | 正统逻辑公司 | 凝血酶肽衍生物的药物组合物 |
| EP1934262A1 (en) | 2005-09-16 | 2008-06-25 | The Board Of Regents, The University Of Texas System | Antibodies to complementary peptides of thrombin or portions thereof |
| JP2010504336A (ja) | 2006-09-22 | 2010-02-12 | オーソロジック コーポレイション | 血管内皮機能不全を治療する方法 |
| WO2008100567A2 (en) * | 2007-02-15 | 2008-08-21 | Orthologic Corp. | Thrombin peptide derivatives for treating fractures in osteopenic patients |
| US8227412B2 (en) * | 2007-03-29 | 2012-07-24 | Tsopanoglou Nikos E | Bioactive parstatin peptides and methods of use |
| WO2008124173A1 (en) * | 2007-04-10 | 2008-10-16 | The Board Of Regents, The University Of Texas System | Combination therapy for cardiac revascularization and cardiac repair |
| EP2155234A1 (en) * | 2007-04-10 | 2010-02-24 | The Board of Regents,The University of Texas System | Combination therapy for chronic dermal ulcers |
| EP2280722A2 (en) | 2008-03-26 | 2011-02-09 | Orthologic Corp. | Method of treating degenerative diseases |
| US20110105400A1 (en) * | 2008-03-26 | 2011-05-05 | Orthologic Corp. | Methods for treating acute myocardial infarction |
| WO2009120307A2 (en) * | 2008-03-26 | 2009-10-01 | Orthologic Corp. | Method of treating peripheral arterial disease |
| JP2013529600A (ja) | 2010-06-11 | 2013-07-22 | ザ ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 放射の影響を軽減し、及び全身性感染症のリスクを減少させる方法 |
| EP3129040A4 (en) * | 2014-04-07 | 2018-03-21 | La Jolla Pharmaceutical Company | Hepdicin mimetic peptides and uses thereof |
| US10220078B2 (en) | 2014-06-11 | 2019-03-05 | The Board Of Regents Of The University Of Texas System | Methods of using thrombin derivatives to treat medulloblastoma |
| EP4565227A2 (en) * | 2022-08-05 | 2025-06-11 | Emory University | Compositions and methods for improving cartilage formation |
| CN117659119B (zh) * | 2022-10-31 | 2024-11-19 | 珠海市藤栢医药有限公司 | 一种rgd片段、利用其制备多肽的方法及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6630572B1 (en) * | 1986-10-31 | 2003-10-07 | The Board Of Regents, University Of Texas Syatems | Thrombin derived polypeptides: compositions and methods for use |
| US5352664A (en) | 1986-10-31 | 1994-10-04 | Board Of Regents, The University Of Texas System | Thrombin derived polypeptides; compositions and methods for use |
| US5688768A (en) * | 1991-02-19 | 1997-11-18 | Cor Therapeutics, Inc. | Recombinant thrombin receptor and related pharmaceuticals |
| US5716789A (en) * | 1993-07-26 | 1998-02-10 | Cor Therapeutics, Inc. | Method to determine ligands, agonist and antagonist of C140 receptor |
| US6184342B1 (en) * | 1994-10-28 | 2001-02-06 | Chrysalis Biotechnology, Inc. | Synthetic peptide neutrophil cell chemotactic agents |
| WO1996040033A1 (en) * | 1995-06-07 | 1996-12-19 | Clarion Pharmaceuticals Inc. | Non-biological patch for hemostasis |
| AU719366B2 (en) * | 1995-10-24 | 2000-05-04 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Novel peptide |
| US5912229A (en) * | 1996-03-01 | 1999-06-15 | Novo Nordisk Als | Use of a pharmaceutical composition comprising an appetite-suppressing peptide |
| CA2329010A1 (en) | 1998-04-17 | 1999-10-28 | Angiogenix Incorporated | Therapeutic angiogenic factors and methods for their use |
| GB9930768D0 (en) | 1999-12-29 | 2000-02-16 | Pfizer Ltd | Composition |
| TWI257307B (en) * | 2000-07-12 | 2006-07-01 | Orthologic Corp | Pharmaceutical composition for cardiac tissue repair |
| ATE254925T1 (de) * | 2000-07-19 | 2003-12-15 | Univ Texas | Stimulierung des knochenwachstums mit peptidderivaten von thrombin |
| AU7356101A (en) * | 2000-07-20 | 2002-02-05 | Univ Texas | Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor |
| ES2271216T3 (es) * | 2001-07-27 | 2007-04-16 | Orthologic Corp. | Uso de los peptidos derivados de la trombina para la terapia de las ulceras dermicas cronicas. |
-
2003
- 2003-07-01 AU AU2003256343A patent/AU2003256343B2/en not_active Ceased
- 2003-07-01 WO PCT/US2003/020635 patent/WO2004014937A2/en not_active Ceased
- 2003-07-01 EP EP03784751A patent/EP1539214A4/en active Pending
- 2003-07-01 JP JP2004527586A patent/JP2006514822A/ja active Pending
- 2003-07-01 CA CA002491052A patent/CA2491052A1/en not_active Abandoned
-
2004
- 2004-12-30 US US11/026,521 patent/US7713934B2/en not_active Expired - Lifetime
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