ATE362939T1 - Dimere von thrombinpeptidderivaten - Google Patents
Dimere von thrombinpeptidderivatenInfo
- Publication number
- ATE362939T1 ATE362939T1 AT03763062T AT03763062T ATE362939T1 AT E362939 T1 ATE362939 T1 AT E362939T1 AT 03763062 T AT03763062 T AT 03763062T AT 03763062 T AT03763062 T AT 03763062T AT E362939 T1 ATE362939 T1 AT E362939T1
- Authority
- AT
- Austria
- Prior art keywords
- gly
- polypeptide
- thrombin peptide
- dimers
- asp
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 108090000190 Thrombin Proteins 0.000 title abstract 3
- 229960004072 thrombin Drugs 0.000 title abstract 3
- 239000000539 dimer Substances 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 150000001413 amino acids Chemical group 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 2
- 229940117028 Thrombin receptor agonist Drugs 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- OXHYRVSBKWIFES-WWSDOYNLSA-N trap-14 peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=CC=C1 OXHYRVSBKWIFES-WWSDOYNLSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39357902P | 2002-07-02 | 2002-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE362939T1 true ATE362939T1 (de) | 2007-06-15 |
Family
ID=30115603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03763062T ATE362939T1 (de) | 2002-07-02 | 2003-07-01 | Dimere von thrombinpeptidderivaten |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7456250B2 (https=) |
| EP (1) | EP1539800B1 (https=) |
| JP (1) | JP4668612B2 (https=) |
| AT (1) | ATE362939T1 (https=) |
| AU (1) | AU2003247848B2 (https=) |
| CA (1) | CA2491135A1 (https=) |
| DE (1) | DE60313982T2 (https=) |
| WO (1) | WO2004005317A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1913917B (zh) * | 2003-12-31 | 2012-02-01 | 正统逻辑公司 | 凝血酶肽衍生物的药物组合物 |
| JP2010504336A (ja) * | 2006-09-22 | 2010-02-12 | オーソロジック コーポレイション | 血管内皮機能不全を治療する方法 |
| WO2008100567A2 (en) * | 2007-02-15 | 2008-08-21 | Orthologic Corp. | Thrombin peptide derivatives for treating fractures in osteopenic patients |
| EP2155234A1 (en) * | 2007-04-10 | 2010-02-24 | The Board of Regents,The University of Texas System | Combination therapy for chronic dermal ulcers |
| WO2008124173A1 (en) * | 2007-04-10 | 2008-10-16 | The Board Of Regents, The University Of Texas System | Combination therapy for cardiac revascularization and cardiac repair |
| CA2722621A1 (en) * | 2008-03-26 | 2009-10-01 | Orthologic Corp. | Thrombin derived peptides for smooth muscle relaxation |
| EP2280722A2 (en) * | 2008-03-26 | 2011-02-09 | Orthologic Corp. | Method of treating degenerative diseases |
| US20110105400A1 (en) * | 2008-03-26 | 2011-05-05 | Orthologic Corp. | Methods for treating acute myocardial infarction |
| WO2009120307A2 (en) * | 2008-03-26 | 2009-10-01 | Orthologic Corp. | Method of treating peripheral arterial disease |
| CU23716A1 (es) * | 2008-09-30 | 2011-10-05 | Ct Ingenieria Genetica Biotech | Péptido antagonista de la actividad de la interleucina-15 |
| JP2013529600A (ja) | 2010-06-11 | 2013-07-22 | ザ ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 放射の影響を軽減し、及び全身性感染症のリスクを減少させる方法 |
| US10220078B2 (en) | 2014-06-11 | 2019-03-05 | The Board Of Regents Of The University Of Texas System | Methods of using thrombin derivatives to treat medulloblastoma |
| EP3952991A4 (en) * | 2019-04-12 | 2023-08-09 | Affirmed Pharma, LLC | RUSALATIDE ACETATE COMPOSITIONS |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5352664A (en) | 1986-10-31 | 1994-10-04 | Board Of Regents, The University Of Texas System | Thrombin derived polypeptides; compositions and methods for use |
| US6500934B1 (en) * | 1996-07-24 | 2002-12-31 | Michael Rush Lerner | Bivalent agonists for G-protein coupled receptors |
| TWI257307B (en) | 2000-07-12 | 2006-07-01 | Orthologic Corp | Pharmaceutical composition for cardiac tissue repair |
| ATE254925T1 (de) | 2000-07-19 | 2003-12-15 | Univ Texas | Stimulierung des knochenwachstums mit peptidderivaten von thrombin |
| AU7356101A (en) | 2000-07-20 | 2002-02-05 | Univ Texas | Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor |
| ES2271216T3 (es) | 2001-07-27 | 2007-04-16 | Orthologic Corp. | Uso de los peptidos derivados de la trombina para la terapia de las ulceras dermicas cronicas. |
| TW200407905A (en) * | 2002-11-06 | 2004-05-16 | Leadtek Research Inc | Data write-in and read-out method of flash memory and circuit thereof |
| CN1913917B (zh) | 2003-12-31 | 2012-02-01 | 正统逻辑公司 | 凝血酶肽衍生物的药物组合物 |
-
2003
- 2003-07-01 DE DE60313982T patent/DE60313982T2/de not_active Expired - Lifetime
- 2003-07-01 AT AT03763062T patent/ATE362939T1/de not_active IP Right Cessation
- 2003-07-01 JP JP2004519705A patent/JP4668612B2/ja not_active Expired - Fee Related
- 2003-07-01 WO PCT/US2003/020626 patent/WO2004005317A2/en not_active Ceased
- 2003-07-01 CA CA002491135A patent/CA2491135A1/en not_active Abandoned
- 2003-07-01 AU AU2003247848A patent/AU2003247848B2/en not_active Ceased
- 2003-07-01 EP EP03763062A patent/EP1539800B1/en not_active Expired - Lifetime
-
2004
- 2004-12-30 US US11/027,795 patent/US7456250B2/en not_active Expired - Lifetime
-
2008
- 2008-10-10 US US12/287,703 patent/US7919457B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60313982T2 (de) | 2008-01-17 |
| EP1539800B1 (en) | 2007-05-23 |
| JP2006507229A (ja) | 2006-03-02 |
| JP4668612B2 (ja) | 2011-04-13 |
| AU2003247848C1 (en) | 2004-01-23 |
| US7919457B2 (en) | 2011-04-05 |
| US20050153893A1 (en) | 2005-07-14 |
| DE60313982D1 (de) | 2007-07-05 |
| WO2004005317A2 (en) | 2004-01-15 |
| EP1539800A2 (en) | 2005-06-15 |
| AU2003247848B2 (en) | 2006-12-21 |
| US20090124550A1 (en) | 2009-05-14 |
| US7456250B2 (en) | 2008-11-25 |
| CA2491135A1 (en) | 2004-01-15 |
| EP1539800A4 (en) | 2005-11-16 |
| WO2004005317A3 (en) | 2004-09-30 |
| AU2003247848A1 (en) | 2004-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |