JP2006504624A5 - - Google Patents
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- Publication number
- JP2006504624A5 JP2006504624A5 JP2003579751A JP2003579751A JP2006504624A5 JP 2006504624 A5 JP2006504624 A5 JP 2006504624A5 JP 2003579751 A JP2003579751 A JP 2003579751A JP 2003579751 A JP2003579751 A JP 2003579751A JP 2006504624 A5 JP2006504624 A5 JP 2006504624A5
- Authority
- JP
- Japan
- Prior art keywords
- heterocyclo
- group
- alkyl
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36824902P | 2002-03-28 | 2002-03-28 | |
| US40211802P | 2002-08-08 | 2002-08-08 | |
| PCT/US2003/009550 WO2003082208A2 (en) | 2002-03-28 | 2003-03-26 | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006504624A JP2006504624A (ja) | 2006-02-09 |
| JP2006504624A5 true JP2006504624A5 (https=) | 2006-04-20 |
| JP4589005B2 JP4589005B2 (ja) | 2010-12-01 |
Family
ID=28678223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003579751A Expired - Fee Related JP4589005B2 (ja) | 2002-03-28 | 2003-03-26 | ピロロピリダジン化合物および増殖性疾患治療におけるその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6900208B2 (https=) |
| EP (1) | EP1578351B1 (https=) |
| JP (1) | JP4589005B2 (https=) |
| AR (1) | AR039189A1 (https=) |
| AT (1) | ATE490964T1 (https=) |
| AU (1) | AU2003223380A1 (https=) |
| CL (1) | CL2008003391A1 (https=) |
| DE (1) | DE60335293D1 (https=) |
| PE (1) | PE20040168A1 (https=) |
| PL (1) | PL374759A1 (https=) |
| TW (1) | TW200403245A (https=) |
| WO (1) | WO2003082208A2 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999001124A1 (en) * | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| DE60330407D1 (de) * | 2002-08-23 | 2010-01-14 | Sloan Kettering Inst Cancer | Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung |
| RU2328499C2 (ru) | 2003-01-09 | 2008-07-10 | Астеллас Фарма Инк. | Производные пирролопиридазина, фармацевтическая композиция, способ профилактики или лечения заболеваний, применение в качестве ингибитора фосфодиэстеразы iv, и/или продуцирования tnf |
| US7030112B2 (en) * | 2003-03-25 | 2006-04-18 | Bristol-Myers Squibb Company | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
| US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
| TW200538453A (en) * | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
| US7432373B2 (en) * | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
| US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| WO2006004191A1 (en) * | 2004-07-05 | 2006-01-12 | Astellas Pharma Inc. | Pyrrolopyridazine derivatives which inhibit pde iv and tnf alfa |
| WO2007035428A1 (en) * | 2005-09-15 | 2007-03-29 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| US7547782B2 (en) | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| EP1953147A1 (en) * | 2005-11-21 | 2008-08-06 | Japan Tobacco, Inc. | Heterocyclic compound and medicinal application thereof |
| CN101679409B (zh) | 2006-12-22 | 2014-11-26 | Astex治疗学有限公司 | 双环杂环衍生化合物、其医药组合物和其用途 |
| WO2008078091A1 (en) * | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| ES2413806T3 (es) | 2008-03-20 | 2013-07-17 | Amgen Inc. | Moduladores de la aurora cinasa y método de uso |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| US9126935B2 (en) | 2008-08-14 | 2015-09-08 | Amgen Inc. | Aurora kinase modulators and methods of use |
| EP2340244A4 (en) * | 2008-10-14 | 2012-07-25 | Ning Xi | COMPOUNDS AND APPLICATION PROCEDURES |
| ES2578990T3 (es) * | 2009-03-21 | 2016-08-03 | Sunshine Lake Pharma Co., Ltd. | Derivados de amino éster, sales de los mismos y métodos de uso |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| AR077428A1 (es) * | 2009-07-29 | 2011-08-24 | Sanofi Aventis | (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos |
| RU2012107101A (ru) * | 2009-07-31 | 2013-09-10 | Байокрист Фармасьютикалз, Инк. | Производные пирроло[1,2-в] пиридазина как ингибиторы янус-киназы |
| JP6386527B2 (ja) * | 2013-03-11 | 2018-09-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | カリウムイオンチャネル阻害剤としてのピロロピリダジン |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| WO2019071147A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD |
| US11066412B2 (en) | 2017-11-17 | 2021-07-20 | Academia Sinica | Substituted pyrrolo[2,1-a]phthalazines and benzo[g]pyrrolo[2,1-a]phthalazines for the treatment of cancer |
| AU2019301510B2 (en) | 2018-07-09 | 2024-06-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelminthic heterocyclic compounds |
| TWI842978B (zh) | 2018-07-13 | 2024-05-21 | 美商基利科學股份有限公司 | 衍生物 |
| CA3133100A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
| UY39995A (es) | 2021-11-01 | 2023-05-15 | Boehringer Ingelheim Vetmedica GmbH | Compuestos de pirrolopiridazina como antihelmínticos |
| WO2026019977A1 (en) * | 2024-07-19 | 2026-01-22 | Merck Sharp & Dohme Llc | Pyrrolopyridazine vegfr inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999059999A1 (en) * | 1998-05-21 | 1999-11-25 | Shionogi & Co., Ltd. | PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES HAVING sPLA2 INHIBITORY EFFECT |
| CA2342251A1 (en) | 1998-08-28 | 2000-03-09 | Scios Inc. | Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
| DE60026297T2 (de) | 1999-05-21 | 2006-11-02 | Bristol-Myers Squibb Co. | Pyrrolotriazin kinasehemmer |
| US6982265B1 (en) | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| WO2002000621A1 (en) * | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Compounds exhibiting x-type spla2 inhibiting effect |
| US6670357B2 (en) | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
| YU37903A (sh) | 2000-11-17 | 2006-05-25 | Bristol-Myers Squibb Company | POSTUPCI LEČENJA STANJA POVEZANIH SA p38 KINAZOM I JEDINJENJA PIROLOTRIAZINA KOJA SE KORISTE KAO INHIBITORI KINAZE |
-
2003
- 2003-03-25 US US10/396,197 patent/US6900208B2/en not_active Expired - Lifetime
- 2003-03-26 DE DE60335293T patent/DE60335293D1/de not_active Expired - Lifetime
- 2003-03-26 AU AU2003223380A patent/AU2003223380A1/en not_active Abandoned
- 2003-03-26 AT AT03719500T patent/ATE490964T1/de not_active IP Right Cessation
- 2003-03-26 PL PL03374759A patent/PL374759A1/xx not_active Application Discontinuation
- 2003-03-26 EP EP03719500A patent/EP1578351B1/en not_active Expired - Lifetime
- 2003-03-26 JP JP2003579751A patent/JP4589005B2/ja not_active Expired - Fee Related
- 2003-03-26 WO PCT/US2003/009550 patent/WO2003082208A2/en not_active Ceased
- 2003-03-28 PE PE2003000316A patent/PE20040168A1/es not_active Application Discontinuation
- 2003-03-28 TW TW092107144A patent/TW200403245A/zh unknown
- 2003-03-28 AR ARP030101102A patent/AR039189A1/es not_active Application Discontinuation
-
2005
- 2005-01-05 US US11/029,547 patent/US20050159420A1/en not_active Abandoned
-
2008
- 2008-11-14 CL CL2008003391A patent/CL2008003391A1/es unknown
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