JP2006503044A5 - - Google Patents

Info

Publication number

JP2006503044A5

JP2006503044A5 JP2004536558A JP2004536558A JP2006503044A5 JP 2006503044 A5 JP2006503044 A5 JP 2006503044A5 JP 2004536558 A JP2004536558 A JP 2004536558A JP 2004536558 A JP2004536558 A JP 2004536558A JP 2006503044 A5 JP2006503044 A5 JP 2006503044A5

Authority

JP

Japan

Prior art keywords

lactoferrin

composition

wound

use according

polymers

Prior art date

2003-09-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 102000010445 Lactoferrin Human genes 0.000 claims 28
• 108010063045 Lactoferrin Proteins 0.000 claims 28
• CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 28
• 229940078795 lactoferrin Drugs 0.000 claims 28
• 235000021242 lactoferrin Nutrition 0.000 claims 28
• 206010052428 Wound Diseases 0.000 claims 18
• 208000027418 Wounds and injury Diseases 0.000 claims 18
• 229920000642 polymer Polymers 0.000 claims 16
• 239000000203 mixture Substances 0.000 claims 14
• 239000008194 pharmaceutical composition Substances 0.000 claims 10
• 238000004519 manufacturing process Methods 0.000 claims 5
• 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims 4
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 3
• 229940069428 antacid Drugs 0.000 claims 3
• 239000003159 antacid agent Substances 0.000 claims 3
• 230000001458 anti-acid effect Effects 0.000 claims 3
• 229940042129 topical gel Drugs 0.000 claims 3
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
• 229920002683 Glycosaminoglycan Polymers 0.000 claims 2
• 230000001154 acute effect Effects 0.000 claims 2
• 239000002738 chelating agent Substances 0.000 claims 2
• 230000001684 chronic effect Effects 0.000 claims 2
• DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 claims 2
• 150000004676 glycans Chemical class 0.000 claims 2
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
• 210000000987 immune system Anatomy 0.000 claims 2
• 239000002184 metal Substances 0.000 claims 2
• 229920002401 polyacrylamide Polymers 0.000 claims 2
• 229920001282 polysaccharide Polymers 0.000 claims 2
• 239000005017 polysaccharide Substances 0.000 claims 2
• 235000018102 proteins Nutrition 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 238000005728 strengthening Methods 0.000 claims 2
• 230000001502 supplementing effect Effects 0.000 claims 2
• 229920002554 vinyl polymer Polymers 0.000 claims 2
• FYIHPNCKLYPALH-UHFFFAOYSA-N 2-[2-(2-aminophenoxy)ethenoxy]aniline Chemical compound NC1=CC=CC=C1OC=COC1=CC=CC=C1N FYIHPNCKLYPALH-UHFFFAOYSA-N 0.000 claims 1
• BDDLHHRCDSJVKV-UHFFFAOYSA-N 7028-40-2 Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O BDDLHHRCDSJVKV-UHFFFAOYSA-N 0.000 claims 1
• FTEDXVNDVHYDQW-UHFFFAOYSA-N BAPTA Chemical compound OC(=O)CN(CC(O)=O)C1=CC=CC=C1OCCOC1=CC=CC=C1N(CC(O)=O)CC(O)=O FTEDXVNDVHYDQW-UHFFFAOYSA-N 0.000 claims 1
• 206010011985 Decubitus ulcer Diseases 0.000 claims 1
• 206010056340 Diabetic ulcer Diseases 0.000 claims 1
• 208000034693 Laceration Diseases 0.000 claims 1
• 208000004210 Pressure Ulcer Diseases 0.000 claims 1
• 206010040943 Skin Ulcer Diseases 0.000 claims 1
• 206010072170 Skin wound Diseases 0.000 claims 1
• 208000002847 Surgical Wound Diseases 0.000 claims 1
• 208000025865 Ulcer Diseases 0.000 claims 1
• 208000000558 Varicose Ulcer Diseases 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 229920001400 block copolymer Polymers 0.000 claims 1
• 210000000988 bone and bone Anatomy 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 230000002496 gastric effect Effects 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 230000009885 systemic effect Effects 0.000 claims 1
• 231100000397 ulcer Toxicity 0.000 claims 1
• 230000029663 wound healing Effects 0.000 claims 1