JP2006500353A - キナーゼ阻害剤としての尿素誘導体 - Google Patents

キナーゼ阻害剤としての尿素誘導体 Download PDF

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Publication number
JP2006500353A
JP2006500353A JP2004527753A JP2004527753A JP2006500353A JP 2006500353 A JP2006500353 A JP 2006500353A JP 2004527753 A JP2004527753 A JP 2004527753A JP 2004527753 A JP2004527753 A JP 2004527753A JP 2006500353 A JP2006500353 A JP 2006500353A
Authority
JP
Japan
Prior art keywords
cyano
pyrazinyl
urea
phenyl
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004527753A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006500353A5 (https=
Inventor
リー，ゴアチユアン
リー，チユン
リー，トンメイ
リン，ナン−ホルン
マンテイ，ロバート・エイ
シヤム，ヒン・エル
ワン，ギヤリー・テイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of JP2006500353A publication Critical patent/JP2006500353A/ja
Publication of JP2006500353A5 publication Critical patent/JP2006500353A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2004527753A 2002-08-13 2003-08-05 キナーゼ阻害剤としての尿素誘導体 Pending JP2006500353A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/218,121 US20040034038A1 (en) 2002-08-13 2002-08-13 Urea kinase inhibitors
PCT/US2003/024474 WO2004014876A1 (en) 2002-08-13 2003-08-05 Urea derivatives as kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2006500353A true JP2006500353A (ja) 2006-01-05
JP2006500353A5 JP2006500353A5 (https=) 2006-10-26

Family

ID=31714498

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004527753A Pending JP2006500353A (ja) 2002-08-13 2003-08-05 キナーゼ阻害剤としての尿素誘導体

Country Status (6)

Country Link
US (1) US20040034038A1 (https=)
EP (1) EP1534692A1 (https=)
JP (1) JP2006500353A (https=)
CA (1) CA2494848A1 (https=)
MX (1) MXPA05001724A (https=)
WO (1) WO2004014876A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005072733A1 (en) * 2004-01-20 2005-08-11 Millennium Pharmaceuticals, Inc. Dyarylurea compounds as chk-1 inhibitors
GB0512324D0 (en) * 2005-06-16 2005-07-27 Novartis Ag Organic compounds
MX2007000265A (es) * 2004-07-02 2007-07-20 Icos Corp Compuestos utiles para inhibir chk1.
HRP20100678T1 (hr) 2005-03-29 2011-02-28 Icos Corporation Derivati heteroariluree korisni kao inhibitori chk1
GEP20105074B (en) * 2005-12-21 2010-09-10 Novartis Ag Pyrimidinyl aryl urea derivatives being fgf inhibitors
HU227696B1 (en) * 2006-04-13 2011-12-28 Egyt Gyogyszervegyeszeti Gyar Zinc salt of rosuvastatin, process for its preparation and pharmaceutical compositions containing it
JP2010510222A (ja) * 2006-11-17 2010-04-02 シェーリング コーポレイション 増殖性障害に対する併用療法
US8314108B2 (en) 2008-12-17 2012-11-20 Eli Lilly And Company 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile, pharmaceutically acceptable salts thereof, or solvate of salts
PA8850801A1 (es) 2008-12-17 2010-07-27 Lilly Co Eli Compuestos útiles para inhibir chk1
GB201008005D0 (en) 2010-05-13 2010-06-30 Sentinel Oncology Ltd Pharmaceutical compounds
EP2970114B1 (en) * 2013-03-15 2019-05-15 Bristol-Myers Squibb Company Ido inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004523568A (ja) * 2001-03-02 2004-08-05 アイコス コーポレイション 放射線増感剤および化学増感剤としてのアリールおよびヘテロアリール尿素Ｃｈｋ１阻害剤の使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1213022C (zh) * 1997-12-22 2005-08-03 拜尔有限公司 用对称和不对称的取代二苯脲抑制raf激酶
EP1140840B1 (en) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
KR20020084116A (ko) * 2000-02-07 2002-11-04 애보트 게엠베하 운트 콤파니 카게 2-벤조티아졸릴 우레아 유도체 및 이의 단백질 키나제억제제로서의 용도

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004523568A (ja) * 2001-03-02 2004-08-05 アイコス コーポレイション 放射線増感剤および化学増感剤としてのアリールおよびヘテロアリール尿素Ｃｈｋ１阻害剤の使用

Also Published As

Publication number Publication date
WO2004014876A1 (en) 2004-02-19
US20040034038A1 (en) 2004-02-19
CA2494848A1 (en) 2004-02-19
EP1534692A1 (en) 2005-06-01
MXPA05001724A (es) 2005-05-27

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