JP2006117634A - 吐出用液体、吐出方法、液滴化方法、液体吐出カートリッジ及び吐出装置 - Google Patents
吐出用液体、吐出方法、液滴化方法、液体吐出カートリッジ及び吐出装置 Download PDFInfo
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- JP2006117634A JP2006117634A JP2005252270A JP2005252270A JP2006117634A JP 2006117634 A JP2006117634 A JP 2006117634A JP 2005252270 A JP2005252270 A JP 2005252270A JP 2005252270 A JP2005252270 A JP 2005252270A JP 2006117634 A JP2006117634 A JP 2006117634A
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Abstract
【解決手段】蛋白質及びペプチドの少なくとも1種の水溶液にアミノ酸及びその塩の少なくとも1種と、界面活性剤の少なくとも1種を添加して、熱エネルギーを利用するインクジェット方式での吐出に対する適性を向上させる。
【選択図】 なし
Description
実施例に入る前に、蛋白質溶液の吐出が困難であることの、より一層の理解のため、蛋白質のみをサーマルインクジェット方式で吐出させた場合の吐出量を示す。蛋白質溶液はアルブミンをPBSに溶解させたものを用い、各濃度にてバブルジェットプリンター(商品名PIXUS950i;キヤノン(株)社製)を溶液が回収できるよう改造した液体吐出装置を用いて吐出した。純水を同様に吐出したときの吐出量(1液滴量)を100%として、各アルブミン溶液の吐出量(1液滴量)を表した。結果を図6に示す。
(バブルジェット方式の原理に基づいた蛋白質溶液の液滴化)
吐出用液体の作製手順は、予め適切な濃度のインスリンを0.1M HCl水溶液に溶解させ、さらに攪拌しながらアミノ酸及びそれらの塩類と界面活性剤を添加し、0.1M NaOHでpH7.4に調製した後、pH7.4の緩衝液にて所定のインスリン濃度となるように定溶した。
(薬理活性の確認)
実施例10で示した組成において、吐出前後の薬理活性について検討を行った。実験は、1日間絶食させたウィスターラット(雄性、8週齢、体重約250g)に、ネンブタール麻酔を施した後、尾静脈より採血し、この状態をベースラインとした。その後、実施例10の組成の溶液をサーマルインクジェット方式で吐出して回収し、1.6U/kgとなるよう皮下投与し、投与後15、30、60、120分後に尾静脈より採血を行った。採血した血液を遠心分離し、得られた血清について血糖値の測定を行った(1群6匹)。サーマルインクジェット方式で吐出ていない添加物なしのインスリン溶液について同様に実験を行い、比較例とした。サーマルインクジェット方式で吐出した実施例10溶液投与群について、血糖値の変化より薬理活性の変化の有無を検討した。その結果を図7に示す。
(吐出の効率について)
1.0mg/mLの濃度でインスリンを含む溶液について、サーマルインクジェット方式で吐出を行い、添加物を加えた場合と加えない場合の吐出量の評価とその再現性を確認した。
(実施例27〜58及び比較例12〜25)
(各種蛋白質への効果と添加物の濃度)
続いて、より効果の高かったプロリン−Tween80、プロリン−アルギニンヤシ油脂肪酸塩、を選択し、各種蛋白質に所定の濃度にて添加した。吐出用液体は、予め適切な濃度の蛋白質又はペプチドをpH7.4の緩衝液に溶解させ、さらに攪拌しながらアミノ酸及びそれらの塩類と界面活性剤を添加した後、pH7.4の緩衝液にて所定の蛋白質又はペプチド濃度となるように定溶して作製した。これら吐出用液体を実施例1と同様に吐出実験を行い、評価を行った。なお、本実施例で検討した処方、及び結果を下記表2に列挙した。
(実施例59)
(インクジェットプリンターを用いた抗体チップの作製及びセンシング)
図9に本実施例のモデル図を示す。Human IL2モノクローナル抗体、Human IL4モノクローナル抗体及びHuman IL6モノクローナル抗体をそれぞれ0.1〜500μg/mLの濃度に調製した。ここに0.1%プロリン(w/w)、0.1%Tween80(w/w)となるように添加して吐出用液体とした。各液体を、インクジェットプリンター(商品名PIXUS950i;キヤノン(株)社製)のヘッドに充填し、Poly−L−Lysinコートスライドガラス板上に個々に吐出して、各抗体のスポットを所定の配置パターンで形成した。
2 液流路
3 ヘッド
4 液滴
5 基板
6 駆動コントローラ
10 筐体
11 タンク
12 液流路
13 ヘッド部
14 配線
15 電気接続部
16 アクセスカバー
17 空気取り入れ口
18 マウスピース
19 電源ボタン
20 吸入器本体
21 ヘッドカートリッジユニット
30 基板
31 マスキング剤
32 被検物質と特異的な反応をする物質、蛋白質、ペプチド等
33 被検物質
34 被検物質と特異的な物質
35 標識
Claims (12)
- 熱エネルギーを利用して吐出口から吐出させるための吐出用液体であって、蛋白質及びペプチドから選択された少なくとも1種と、アミノ酸及びその塩類から選択された少なくとも1種と、界面活性剤と、水を主体とする液媒体と、を含有することを特徴とする吐出用液体。
- アミノ酸がアルギニン、プロリン、グリシン、グルタミン酸、アスパラギン酸、バリン、トレオニン、アラニンから選択された少なくとも1種であることを特徴とする請求項1に記載の吐出用液体。
- アミノ酸がアルギニン、プロリン、グリシンから選択された少なくとも1種であることを特徴とする請求項1に記載の吐出用液体。
- 界面活性剤がポリオキシエチレンソルビタン脂肪酸エステル、アルキルアミドアルキルベタイン、N-アシルサルコシン、N-アシルグルタミン酸、N-アシルグリシン、アルギニン脂肪酸塩から選択された少なくとも1種であることを特徴とする請求項1に記載の吐出用液体。
- 前記蛋白質及びペプチドの少なくとも1種が、カルシトニン、インスリン類、グルカゴン類、インターフェロン類、プロテアーゼ阻害剤、サイトカイン類、成長ホルモン類、造血因子蛋白質、抗体、及びこれらのアナログ、及びこれらの誘導体、及びこれらの化学修飾体から選ばれる物質の少なくとも1種である請求項1に記載の吐出用液体。
- 蛋白質及びペプチドの少なくとも一種の1重量部に対して、アミノ酸およびその塩の少なくとも一種を0.1から20重量部、界面活性剤を0.1から10重量部添加することを特徴とする請求項1に記載の吐出用液体。
- 請求項1から請求項6のいずれかに記載の吐出用液体をサーマルインクジェット方式の原理に基づいて吐出することを特徴とする吐出方法。
- 請求項1から請求項6のいずれかに記載の吐出用液体が収納されるタンクと、吐出用ヘッドと、を有することを特徴とする液体吐出用カートリッジ。
- 前記吐出用ヘッドが、サーマルインクジェット方式により液体を吐出する請求項8に記載の液体吐出用カートリッジ。
- 請求項8または請求項9に記載のカートリッジと、該カートリッジの有するヘッドの液体吐出部から吐出する液体を利用者の吸入部位へ誘導するための流路及び開口部と、を有することを特徴とする吐出装置。
- 利用者の口からの吸入目的のものである請求項10に記載の吐出装置。
- 蛋白質及びペプチドの少なくとも1種を含む液体に吐出用熱エネルギーを付与して該液体を液滴化する方法であって、流路中に充填された液体に吐出用エネルギーを付与して該流路に連通する吐出口から液滴として吐出する工程を有し、前記液体が、請求項1から請求項6のいずれかに記載の吐出用液体であることを特徴とする液滴化方法。
Priority Applications (7)
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JP2005252270A JP4147235B2 (ja) | 2004-09-27 | 2005-08-31 | 吐出用液体、吐出方法、液滴化方法、液体吐出カートリッジ及び吐出装置 |
US11/628,452 US20070248571A1 (en) | 2004-09-27 | 2005-09-22 | Ejection Liquid, Ejection Method, Method for Forming Liquid Droplets, Liquid Ejection Cartridge and Ejection Apparatus |
EP05787530A EP1784202A4 (en) | 2004-09-27 | 2005-09-22 | EJECTION FLUID, EJECTION METHOD, LIQUID DROPLET FORMING METHOD, LIQUID EJECTION CARTRIDGE, AND EJECTOR APPARATUS |
CN200580032497.4A CN101027076B (zh) | 2004-09-27 | 2005-09-22 | 喷射液、喷射方法、形成液滴的方法、液体喷射盒和喷射装置 |
PCT/JP2005/018070 WO2006035923A1 (en) | 2004-09-27 | 2005-09-22 | Ejection liquid, ejection method, method for forming liquid droplets, liquid ejection cartridge and ejection apparatus |
RU2007115916/28A RU2342948C1 (ru) | 2004-09-27 | 2005-09-22 | Эжектируемая жидкость, способ эжекции, способ формирования капелек жидкости, кассета для эжекции жидкости и эжекционное устройство |
US12/968,088 US8833363B2 (en) | 2004-09-27 | 2010-12-14 | Ejection liquid, ejection method, method for forming liquid droplets, liquid ejection cartridge and ejection apparatus |
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JP2005252270A JP4147235B2 (ja) | 2004-09-27 | 2005-08-31 | 吐出用液体、吐出方法、液滴化方法、液体吐出カートリッジ及び吐出装置 |
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EP (1) | EP1784202A4 (ja) |
JP (1) | JP4147235B2 (ja) |
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JP2008137967A (ja) * | 2006-12-04 | 2008-06-19 | Canon Inc | 吐出用液体及び吐出方法 |
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- 2005-09-22 CN CN200580032497.4A patent/CN101027076B/zh not_active Expired - Fee Related
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Also Published As
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US20110079223A1 (en) | 2011-04-07 |
CN101027076A (zh) | 2007-08-29 |
US8833363B2 (en) | 2014-09-16 |
JP4147235B2 (ja) | 2008-09-10 |
EP1784202A4 (en) | 2012-11-28 |
EP1784202A1 (en) | 2007-05-16 |
CN101027076B (zh) | 2011-06-15 |
US20070248571A1 (en) | 2007-10-25 |
WO2006035923A1 (en) | 2006-04-06 |
RU2342948C1 (ru) | 2009-01-10 |
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