JP2006022033A - 血管新生抑制剤 - Google Patents
血管新生抑制剤 Download PDFInfo
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- JP2006022033A JP2006022033A JP2004200790A JP2004200790A JP2006022033A JP 2006022033 A JP2006022033 A JP 2006022033A JP 2004200790 A JP2004200790 A JP 2004200790A JP 2004200790 A JP2004200790 A JP 2004200790A JP 2006022033 A JP2006022033 A JP 2006022033A
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- extract
- seaweed
- alcohol
- angiogenesis
- angiogenesis inhibitor
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004200790A JP2006022033A (ja) | 2004-07-07 | 2004-07-07 | 血管新生抑制剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004200790A JP2006022033A (ja) | 2004-07-07 | 2004-07-07 | 血管新生抑制剤 |
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| JP2006022033A true JP2006022033A (ja) | 2006-01-26 |
| JP2006022033A5 JP2006022033A5 (enrdf_load_stackoverflow) | 2007-08-02 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007217339A (ja) * | 2006-02-16 | 2007-08-30 | Kanehatsu Foods Co Ltd | 抗アレルギー物質 |
| JP2008214245A (ja) * | 2007-03-02 | 2008-09-18 | Nagase & Co Ltd | アルドース還元酵素阻害剤およびその製造方法 |
| US8722098B2 (en) * | 2007-09-06 | 2014-05-13 | Pukyong National University Industry-Academic Cooperation | Ecklonia cava extracts for alleviating or preventing asthmatic reactions |
| US20140377305A1 (en) * | 2012-04-02 | 2014-12-25 | Maruhachi Muramatsu, Inc. | Method for treating disease associated with transcription activation by nf-kb |
| KR101516317B1 (ko) * | 2012-09-27 | 2015-04-30 | 재단법인 제주테크노파크 | 넓미역 추출물을 이용한 항염증용 조성물 |
| JP2019081734A (ja) * | 2017-10-31 | 2019-05-30 | 日本メナード化粧品株式会社 | Ｗｎｔ発現抑制剤 |
-
2004
- 2004-07-07 JP JP2004200790A patent/JP2006022033A/ja active Pending
Non-Patent Citations (1)
| Title |
|---|
| JPN6010058469, Ｋｏｙａｎａｇｉ，Ｓａｔｏｒｕ ｅｔ ａｌ, "Ｏｖｅｒｓｕｌｆａｔｉｏｎ ｏｆ ｆｕｃｏｉｄａｎ ｅｎｈａｎｃｅｓ ｉｔｓ ａｎｔｉ−ａｎｇｉｏｇｅｎｉｃ ａｎｄ ａｎｔｉｔｕｍｏｒ ａｃｔｉｖｉｔｉｅｓ", Ｂｉｏｃｈｅｍｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ, 2003, ６５（２）, ｐｐ．１７３−１７９ * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007217339A (ja) * | 2006-02-16 | 2007-08-30 | Kanehatsu Foods Co Ltd | 抗アレルギー物質 |
| JP2008214245A (ja) * | 2007-03-02 | 2008-09-18 | Nagase & Co Ltd | アルドース還元酵素阻害剤およびその製造方法 |
| US8722098B2 (en) * | 2007-09-06 | 2014-05-13 | Pukyong National University Industry-Academic Cooperation | Ecklonia cava extracts for alleviating or preventing asthmatic reactions |
| US20140377305A1 (en) * | 2012-04-02 | 2014-12-25 | Maruhachi Muramatsu, Inc. | Method for treating disease associated with transcription activation by nf-kb |
| US10463705B2 (en) * | 2012-04-02 | 2019-11-05 | Maruhachi Muramatsu, Inc. | Method for treating disease associated with transcription activation by NF-κB |
| KR101516317B1 (ko) * | 2012-09-27 | 2015-04-30 | 재단법인 제주테크노파크 | 넓미역 추출물을 이용한 항염증용 조성물 |
| JP2019081734A (ja) * | 2017-10-31 | 2019-05-30 | 日本メナード化粧品株式会社 | Ｗｎｔ発現抑制剤 |
| JP7152737B2 (ja) | 2017-10-31 | 2022-10-13 | 日本メナード化粧品株式会社 | Ｗｎｔ発現抑制剤 |
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