JP2005537282A5 - - Google Patents

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Publication number
JP2005537282A5
JP2005537282A5 JP2004523305A JP2004523305A JP2005537282A5 JP 2005537282 A5 JP2005537282 A5 JP 2005537282A5 JP 2004523305 A JP2004523305 A JP 2004523305A JP 2004523305 A JP2004523305 A JP 2004523305A JP 2005537282 A5 JP2005537282 A5 JP 2005537282A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
composition according
cephalotaxin
disease
angiogenic disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004523305A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005537282A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/022926 external-priority patent/WO2004009030A2/en
Publication of JP2005537282A publication Critical patent/JP2005537282A/ja
Publication of JP2005537282A5 publication Critical patent/JP2005537282A5/ja
Pending legal-status Critical Current

Links

JP2004523305A 2002-07-22 2003-07-22 セファロタキシンアルカロイドによる血管新生抑制、並びにその誘導体、組成物、および使用方法 Pending JP2005537282A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39765702P 2002-07-22 2002-07-22
PCT/US2003/022926 WO2004009030A2 (en) 2002-07-22 2003-07-22 Angiogenesis inhibition by cephalotaxine alkaloids, derivatives, compositions and uses thereof

Publications (2)

Publication Number Publication Date
JP2005537282A JP2005537282A (ja) 2005-12-08
JP2005537282A5 true JP2005537282A5 (https=) 2006-09-07

Family

ID=30771096

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004523305A Pending JP2005537282A (ja) 2002-07-22 2003-07-22 セファロタキシンアルカロイドによる血管新生抑制、並びにその誘導体、組成物、および使用方法

Country Status (7)

Country Link
US (2) US7642252B2 (https=)
EP (1) EP1539179B1 (https=)
JP (1) JP2005537282A (https=)
AU (1) AU2003254120B2 (https=)
CA (1) CA2493544A1 (https=)
ES (1) ES2572145T3 (https=)
WO (1) WO2004009030A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060211648A1 (en) * 2000-04-12 2006-09-21 Chemgenex Pharmaceuticals, Inc. Naphthalimide compositions and uses thereof
US7135481B2 (en) * 2000-04-12 2006-11-14 Chemgenex Pharmaceuticals, Inc. Naphthalimide compositions and uses thereof
US20050170015A1 (en) * 2000-10-31 2005-08-04 Brown Dennis M. Antiproliferative colchicine compositions and uses thereof
WO2005087221A1 (en) * 2004-03-15 2005-09-22 Christine Allen Biodegradable biocompatible implant and method of manufacturing same
WO2005117893A2 (en) * 2004-06-04 2005-12-15 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and parp-1 inhibitors
CA2597323A1 (en) * 2005-02-10 2006-08-17 Chemgenex Pharmaceuticals, Inc. Medical devices
JP5550546B2 (ja) * 2007-04-13 2014-07-16 ケムジェネックス・ファーマシューティカルズ・インコーポレイテッド 経口セファロタキシン剤形
EP2260041A4 (en) 2008-03-03 2012-04-25 Sloan Kettering Inst Cancer CEPHALOTAXUS ESTERS, METHOD FOR THEIR SYNTHESIS AND USES THEREOF
US20120283306A1 (en) * 2011-04-27 2012-11-08 Georgia Health Sciences University Mouse model for avm
KR102066684B1 (ko) * 2018-02-19 2020-01-15 가천대학교 산학협력단 개비자나무 추출물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 자가면역질환의 예방 또는 치료용 조성물
KR102174166B1 (ko) * 2018-12-13 2020-11-04 영남대학교 산학협력단 호모해링토닌을 유효성분으로 함유하는 세포노화 관련 질환 예방 또는 치료용 조성물
KR102066683B1 (ko) * 2019-09-16 2020-01-15 가천대학교 산학협력단 개비자나무 추출물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 자가면역질환의 예방 또는 치료용 조성물
KR102209386B1 (ko) * 2020-01-09 2021-02-01 영남대학교 산학협력단 호모해링토닌을 유효성분으로 함유하는 대사질환 예방 또는 치료용 약학조성물

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3793454A (en) * 1971-11-12 1974-02-19 Us Agriculture Harringtonine and isopharringtonine for treating l1210 or p388 leukemic tumors in mice
US4152214A (en) * 1977-10-07 1979-05-01 The United States Of America As Represented By The Secretary Of Agriculture Production of homodeoxyharringtonine and other cephalotaxine esters by tissue culture
JPS5835146A (ja) * 1981-08-28 1983-03-01 Isukura Sangyo Kk 2−ケト−6−メチル−5−ヘプテン酸エチルエステルの製造方法
US5380747A (en) * 1992-10-30 1995-01-10 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
ATE355379T1 (de) 1994-04-26 2006-03-15 Childrens Medical Center Angiostatin und verfahren zu seiner nutzung zur vermeidung der angiogenese
WO1999001118A2 (en) * 1997-07-01 1999-01-14 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
US6025353A (en) * 1997-11-19 2000-02-15 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
DE69919179T2 (de) * 1998-09-09 2005-07-28 Inflazyme Pharmaceuticals, Ltd., Richmond Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen
US6465424B1 (en) * 1999-02-17 2002-10-15 Bristol-Myers Squibb Company Anti-angiogenic agent and method for inhibiting angiogenesis
JP2003527337A (ja) * 1999-11-12 2003-09-16 エントレメッド インコーポレイテッド 抗血管新生スケジュールに基づく治療薬の投与方法
DK1263440T3 (da) 2000-03-15 2006-10-23 Chemgenex Pharmaceuticals Inc Cephalotaxinalkaloidkombinationspræparater og anvendelser deraf
EP1274458B1 (en) * 2000-04-12 2005-09-28 ChemGenex Pharmaceuticals, Inc. Compositions containing a naphthalmide and an antiproliferative agent
WO2002003904A1 (en) 2000-06-21 2002-01-17 Shigeo Takizawa Lift device capable of performing activating motion
AU7940500A (en) * 2000-10-17 2002-04-29 Oncopharm Corp New cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including thus resistant to usual chemotherapeutic agents and as reversal agents
ATE369894T1 (de) * 2000-11-22 2007-09-15 Novartis Pharma Gmbh Kombination enthaltend ein mittel zur verminderung von vegf-aktivität und ein mittel zur verminderung von egf-aktivität
CN100396286C (zh) * 2002-12-30 2008-06-25 北京大学第一医院 高三尖杉酯碱和三尖杉酯碱在制备抑制血管生成药物中的应用

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