JP2005506987A5 - - Google Patents
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- Publication number
- JP2005506987A5 JP2005506987A5 JP2003530331A JP2003530331A JP2005506987A5 JP 2005506987 A5 JP2005506987 A5 JP 2005506987A5 JP 2003530331 A JP2003530331 A JP 2003530331A JP 2003530331 A JP2003530331 A JP 2003530331A JP 2005506987 A5 JP2005506987 A5 JP 2005506987A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- pharmaceutically acceptable
- drug
- dissolution
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000203 mixture Substances 0.000 claims 31
- 238000004090 dissolution Methods 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 13
- 229940079593 drug Drugs 0.000 claims 13
- 150000001720 carbohydrates Chemical class 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 230000001747 exhibiting effect Effects 0.000 claims 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims 8
- 210000000214 mouth Anatomy 0.000 claims 6
- 238000001035 drying Methods 0.000 claims 5
- 238000005550 wet granulation Methods 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 3
- 229920003134 Eudragit® polymer Polymers 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- 238000007908 dry granulation Methods 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 229920000193 polymethacrylate Polymers 0.000 claims 2
- 230000001953 sensory effect Effects 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000009477 fluid bed granulation Methods 0.000 claims 1
- 238000009478 high shear granulation Methods 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000000845 maltitol Substances 0.000 claims 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 1
- 235000010449 maltitol Nutrition 0.000 claims 1
- 229940035436 maltitol Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 238000009490 roller compaction Methods 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32535601P | 2001-09-26 | 2001-09-26 | |
| PCT/US2002/030048 WO2003026697A2 (en) | 2001-09-26 | 2002-09-23 | Organoleptically acceptable intraorally disintegrating compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005506987A JP2005506987A (ja) | 2005-03-10 |
| JP2005506987A5 true JP2005506987A5 (https=) | 2005-12-08 |
Family
ID=23267542
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530331A Withdrawn JP2005506987A (ja) | 2001-09-26 | 2002-09-23 | 感覚的に許容される口内崩壊性組成物 |
| JP2003530260A Withdrawn JP2005512964A (ja) | 2001-09-26 | 2002-09-23 | 口内崩壊性バルデコキシブ組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530260A Withdrawn JP2005512964A (ja) | 2001-09-26 | 2002-09-23 | 口内崩壊性バルデコキシブ組成物 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20030181501A1 (https=) |
| EP (2) | EP1490035A1 (https=) |
| JP (2) | JP2005506987A (https=) |
| KR (2) | KR20040044990A (https=) |
| CN (2) | CN1633281A (https=) |
| AP (2) | AP2004002999A0 (https=) |
| AR (1) | AR037239A1 (https=) |
| BR (2) | BR0212861A (https=) |
| CA (2) | CA2461044A1 (https=) |
| CO (2) | CO5570684A2 (https=) |
| EA (2) | EA200400352A1 (https=) |
| EC (1) | ECSP045029A (https=) |
| GE (1) | GEP20063856B (https=) |
| HK (1) | HK1079988A1 (https=) |
| IL (2) | IL160855A0 (https=) |
| IS (2) | IS7178A (https=) |
| MA (2) | MA27682A1 (https=) |
| MX (2) | MXPA04002798A (https=) |
| NO (2) | NO20041258L (https=) |
| OA (2) | OA12707A (https=) |
| PL (2) | PL369298A1 (https=) |
| TN (2) | TNSN04045A1 (https=) |
| WO (2) | WO2003026623A1 (https=) |
| YU (1) | YU34804A (https=) |
| ZA (2) | ZA200401953B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005002557A1 (en) * | 2003-07-03 | 2005-01-13 | Warner-Lambert Company Llc | Pharmaceutical compositions including an ether and selective cox-2 inhibitor and uses thereof |
| US20050186271A1 (en) * | 2004-02-24 | 2005-08-25 | Sheskey Paul J. | Process for dispersing a fluid in a mass of solid particles |
| WO2006016602A1 (ja) * | 2004-08-10 | 2006-02-16 | Ajinomoto Co., Inc. | 苦味の低減したナテグリニド含有製剤 |
| US20080063710A1 (en) * | 2004-12-28 | 2008-03-13 | Eisai R&D Management Co., Ltd. | Rapidly Disintegrating Tablet and Production Method Thereof |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| EP1964549A1 (en) * | 2005-12-20 | 2008-09-03 | Eisai R&D Management Co., Ltd. | Orally disintegrating tablet comprising fat-soluble substance |
| US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
| US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| WO2007087188A2 (en) * | 2006-01-20 | 2007-08-02 | Merck & Co., Inc. | Taste-masked tablets and granules |
| US20070196494A1 (en) * | 2006-02-17 | 2007-08-23 | Arnaud Grenier | Low-friability, patient-friendly orally disintegrating formulations |
| JP2009537554A (ja) * | 2006-05-19 | 2009-10-29 | ソマクソン ファーマシューティカルズ インコーポレイテッド | 不眠症を治療するための、口腔内、舌下および急速融解製剤を含む、低用量ドキセピン製剤、ならびにその使用 |
| US8685457B2 (en) * | 2007-06-06 | 2014-04-01 | Basf Se | Pharmaceutical formulation for the production of rapidly disintegrating tablets |
| CN102083410B (zh) * | 2007-06-06 | 2013-04-17 | 巴斯夫欧洲公司 | 用于制备迅速崩解的片剂的药物制剂 |
| JP2010529073A (ja) * | 2007-06-06 | 2010-08-26 | ビーエーエスエフ ソシエタス・ヨーロピア | チュアブル錠及びトローチ剤製造のための医薬製剤 |
| KR20160083132A (ko) * | 2007-06-06 | 2016-07-11 | 바스프 에스이 | 급속 붕해 정제의 제조를 위한 제약 제제 |
| CN101820838B (zh) * | 2007-08-07 | 2013-06-05 | 阿塞尔Rx制药有限公司 | 采用口腔经粘膜剂型的用于程序镇静和镇痛的组合物和方法 |
| EP2268268A2 (en) * | 2008-03-24 | 2011-01-05 | Wockhardt Research Centre | Orally disintegrating compositions of rhein or diacerein |
| US8945592B2 (en) * | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
| CN102223880B (zh) * | 2008-11-25 | 2017-04-26 | 田边三菱制药株式会社 | 口腔速崩片及其制备方法 |
| US20110097401A1 (en) | 2009-06-12 | 2011-04-28 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
| US20110091544A1 (en) * | 2009-10-16 | 2011-04-21 | Acelrx Pharmaceuticals, Inc. | Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting |
| FR2968995B1 (fr) * | 2010-12-16 | 2013-03-22 | Sanofi Aventis | Composition pharmaceutioue pour une administration par voie orale destinee a eviter le mesusage |
| CN106822007B (zh) | 2015-09-11 | 2021-12-31 | 西姆莱斯股份公司 | 口服制剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5576014A (en) * | 1994-01-31 | 1996-11-19 | Yamanouchi Pharmaceutical Co., Ltd | Intrabuccally dissolving compressed moldings and production process thereof |
| US5633272A (en) * | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| SK74396A3 (en) * | 1995-06-13 | 1997-04-09 | American Home Prod | Organoleptically acceptable oral pharmaceutical compositions |
| JPH11513641A (ja) * | 1995-10-20 | 1999-11-24 | ファルマシア・アンド・アップジョン・カンパニー | ブリスターパッケージ |
| CN1140267C (zh) * | 1996-05-17 | 2004-03-03 | 麦克公司 | 治疗环加氧酶-2介导的疾病的每天一次的组合物 |
| EP0863134A1 (en) * | 1997-03-07 | 1998-09-09 | Merck Frosst Canada Inc. | 2-(3,5-difluorophenyl)-3-(4-(methyl-sulfonyl)phenyl)-2-cyclopenten-1-one useful as an inhibitor of cyclooxygenase-2 |
| US6465009B1 (en) * | 1998-03-18 | 2002-10-15 | Yamanouchi Pharmaceutical Co., Ltd. | Water soluble polymer-based rapidly dissolving tablets and production processes thereof |
| JP2003516353A (ja) * | 1999-12-08 | 2003-05-13 | ファルマシア コーポレイション | ヴァルデコキシブ組成物 |
| US6316029B1 (en) * | 2000-05-18 | 2001-11-13 | Flak Pharma International, Ltd. | Rapidly disintegrating solid oral dosage form |
| US6800297B2 (en) * | 2000-06-15 | 2004-10-05 | Acusphere, Inc. | Porous COX-2 inhibitor matrices and methods of manufacture thereof |
| CN1638739A (zh) * | 2000-08-18 | 2005-07-13 | 法玛西雅厄普约翰美国公司 | 治疗成瘾性障碍的化合物 |
| JP2004506680A (ja) * | 2000-08-18 | 2004-03-04 | ファルマシア・コーポレーション | シクロオキシゲナーゼ−２阻害剤の迅速崩壊経口製剤 |
-
2002
- 2002-09-23 MX MXPA04002798A patent/MXPA04002798A/es unknown
- 2002-09-23 HK HK06100055.6A patent/HK1079988A1/zh unknown
- 2002-09-23 OA OA1200400083A patent/OA12707A/en unknown
- 2002-09-23 IL IL16085502A patent/IL160855A0/xx unknown
- 2002-09-23 BR BR0212861-6A patent/BR0212861A/pt not_active IP Right Cessation
- 2002-09-23 EA EA200400352A patent/EA200400352A1/ru unknown
- 2002-09-23 AP APAP/P/2004/002999A patent/AP2004002999A0/en unknown
- 2002-09-23 PL PL02369298A patent/PL369298A1/xx not_active Application Discontinuation
- 2002-09-23 OA OA1200400082A patent/OA13060A/en unknown
- 2002-09-23 CN CNA028211413A patent/CN1633281A/zh active Pending
- 2002-09-23 KR KR10-2004-7004373A patent/KR20040044990A/ko not_active Ceased
- 2002-09-23 BR BR0212778-4A patent/BR0212778A/pt not_active IP Right Cessation
- 2002-09-23 WO PCT/US2002/030161 patent/WO2003026623A1/en not_active Ceased
- 2002-09-23 CA CA002461044A patent/CA2461044A1/en not_active Abandoned
- 2002-09-23 AP APAP/P/2004/002998A patent/AP2004002998A0/en unknown
- 2002-09-23 CA CA002461630A patent/CA2461630A1/en not_active Abandoned
- 2002-09-23 PL PL02369297A patent/PL369297A1/xx not_active Application Discontinuation
- 2002-09-23 WO PCT/US2002/030048 patent/WO2003026697A2/en not_active Ceased
- 2002-09-23 EP EP02775948A patent/EP1490035A1/en not_active Withdrawn
- 2002-09-23 KR KR10-2004-7004334A patent/KR20040058189A/ko not_active Ceased
- 2002-09-23 YU YU34804A patent/YU34804A/sh unknown
- 2002-09-23 GE GE5525A patent/GEP20063856B/en unknown
- 2002-09-23 MX MXPA04002652A patent/MXPA04002652A/es unknown
- 2002-09-23 CN CNA028189078A patent/CN1703203A/zh active Pending
- 2002-09-23 JP JP2003530331A patent/JP2005506987A/ja not_active Withdrawn
- 2002-09-23 IL IL16084802A patent/IL160848A0/xx unknown
- 2002-09-23 EA EA200400357A patent/EA200400357A1/ru unknown
- 2002-09-23 JP JP2003530260A patent/JP2005512964A/ja not_active Withdrawn
- 2002-09-23 US US10/252,222 patent/US20030181501A1/en not_active Abandoned
- 2002-09-23 EP EP02773522A patent/EP1429736A2/en not_active Withdrawn
- 2002-09-26 AR ARP020103627A patent/AR037239A1/es unknown
-
2004
- 2004-03-10 ZA ZA200401953A patent/ZA200401953B/en unknown
- 2004-03-11 IS IS7178A patent/IS7178A/is unknown
- 2004-03-11 IS IS7177A patent/IS7177A/is unknown
- 2004-03-23 TN TNP2004000045A patent/TNSN04045A1/fr unknown
- 2004-03-23 EC EC2004005029A patent/ECSP045029A/es unknown
- 2004-03-24 MA MA27586A patent/MA27682A1/fr unknown
- 2004-03-24 TN TNP2004000047A patent/TNSN04047A1/fr unknown
- 2004-03-24 MA MA27587A patent/MA27542A1/fr unknown
- 2004-03-25 NO NO20041258A patent/NO20041258L/no not_active Application Discontinuation
- 2004-03-25 ZA ZA200402364A patent/ZA200402364B/xx unknown
- 2004-03-26 CO CO04028409A patent/CO5570684A2/es not_active Application Discontinuation
- 2004-03-26 CO CO04028410A patent/CO5570659A2/es not_active Application Discontinuation
- 2004-04-15 NO NO20041532A patent/NO20041532L/no not_active Application Discontinuation
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