JP2005537282A - セファロタキシンアルカロイドによる血管新生抑制、並びにその誘導体、組成物、および使用方法 - Google Patents
セファロタキシンアルカロイドによる血管新生抑制、並びにその誘導体、組成物、および使用方法 Download PDFInfo
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- JP2005537282A JP2005537282A JP2004523305A JP2004523305A JP2005537282A JP 2005537282 A JP2005537282 A JP 2005537282A JP 2004523305 A JP2004523305 A JP 2004523305A JP 2004523305 A JP2004523305 A JP 2004523305A JP 2005537282 A JP2005537282 A JP 2005537282A
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- cephalotaxin
- host
- vascular disease
- angiogenesis
- homoharringtonine
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Abstract
Description
本発明は、血管疾患を処置しまたは予防するのに有用な組成物および方法に関する。本発明は、血管疾患を有する宿主の処置のため、または血管疾患の発症もしくは進行を抑制するために宿主の予防学的処置のための、抗血管新生薬としてのセファロタキシンアルカロイドを含有する組成物を提供する。
血管新生は、新規な血管の形成および分化として定義される。そのものは、多数の疾患および病気、特に癌、炎症およびある網膜の障害と関連する。血管疾患としては例えば、固形腫瘍、糖尿病網膜症、炎症性疾患(例えば、関節リウマチ、骨関節炎、喘息、および肺線維症)、黄斑変性症、血管線維腫、血管新生緑内症(neovascular glaucoma)、動静脈奇形(arteriovenous malformations)、骨癒合不全(nonunion fracture)、ループスおよび他の結合組織疾患、オースラー−ウェーバー症候群、アテローム硬化型プラーク、乾癬、角膜移植片血管新生、化膿性肉芽腫、水晶体後線維増殖症、強皮症、肉芽形成、血管腫、トラコーマ、血友病性関節、並びに血管接着を含むが、これらに限定されない。
上記の目的によれば、本発明は、望まない血管新生を抑制する際に有効である、組成物および方法を提供する。本発明の1態様は、血管疾患を有する宿主の処置方法を提供することであって、該方法は、該宿主を、血管新生を抑制するのに十分な量のセファロタキシンと接触させることを含む。本発明の1実施態様において、該血管疾患は、固形腫瘍以外の疾患である。本発明の更なる実施態様において、該血管疾患は、炎症性疾患(例えば、関節リウマチ、骨関節炎、喘息、および肺線維症を含む);糖尿病性網膜症;および、黄斑変性症からなる群から選ばれる。
(1)血管疾患を有する宿主の処置;および(2)血管疾患の発症または進行を予防するための宿主の予防学的処置、のための方法および組成物を提供する。好ましい実施態様において、該セファロタキシンは、抗血管新生効果を与える。
(実施例1)
CAMアッセイにおけるホモハリングトニンの影響
(プロトコール)
鶏の受精卵(HiChick Breeding Co, Kapunda, South Australia)を、38℃で3日間インキュベートした。3日後に、胚を該卵から砕いてとり出し、このものをプラスチック製菅から構成されるカップ(このものは、頂上部でプラスチック製フィルムを伸張して、懸濁させる卵のためにハンモックを形成する)中に入れた。ペニシリンおよびストレプトマイシンを含有するDMEM(2mL)を、該卵を加える前に各カップに加えた。頂上のペトリ皿は、無菌を保った。インキュベートは、加湿の37℃のインキュベーター中で続けた。
Claims (14)
- 血管疾患を有する宿主の処置方法であって、該宿主を、血管新生を抑制するのに十分な量のセファロタキシンと接触させることを含み、ここで、該血管疾患は固形腫瘍ではない、該方法。
- 血管疾患は、炎症性疾患、糖尿病性網膜症、または黄斑変性症からなる群から選ばれる、請求項1記載の方法。
- 炎症性疾患は、関節リウマチ、骨関節炎、喘息、および肺線維症からなる群から選ばれる、請求2記載の方法。
- セファロタキシンは、ホモハリングトニン(セファロタキシン、4−メチル−2−ヒドロキシ−2−(4−ヒドロキシ−4−メチルペンチル)ブタン二酸エステルを含む、請求項1記載の方法。
- セファロタキシンは、ホモハリングトニンアナログを含む、請求項1記載の方法。
- セファロタキシンは、該宿主に、経口、静脈内、局所、血管内、腹腔内、筋肉内、皮内、皮下、または動脈内で投与する、請求項1記載の方法。
- 宿主の予防学的処置方法であって、該宿主を、血管疾患の発症または進行を抑制するのに十分な量のセファロタキシンと接触させることを含む、該方法。
- 血管疾患は癌である、請求項7記載の方法。
- 癌は、微小腫瘍性または微小転移性の癌細胞であることを特徴とする、請求項8記載の方法。
- 血管疾患は癌以外の血管疾患である、請求項7記載の方法。
- 血管疾患は、炎症性疾患、糖尿病性網膜症、または黄斑変性症からなる群から選ばれる、請求項7記載の方法。
- 炎症性疾患は、関節リウマチ、骨関節炎、喘息、および肺線維症からなる群から選ばれる、請求項11記載の方法。
- セファロタキシンは、ホモハリングトニン(セファロタキシン、4−メチル−2−ヒドロキシ−2−(4−ヒドロキシ−4−メチルペンチル)ブタン二酸エステル)を含む、請求項7記載の方法。
- セファロタキシンは、ホモハリングトニンアナログを含む、請求項7記載の方法。
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KR102209386B1 (ko) * | 2020-01-09 | 2021-02-01 | 영남대학교 산학협력단 | 호모해링토닌을 유효성분으로 함유하는 대사질환 예방 또는 치료용 약학조성물 |
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US7135481B2 (en) * | 2000-04-12 | 2006-11-14 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide compositions and uses thereof |
US20060211648A1 (en) * | 2000-04-12 | 2006-09-21 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide compositions and uses thereof |
US20050170015A1 (en) * | 2000-10-31 | 2005-08-04 | Brown Dennis M. | Antiproliferative colchicine compositions and uses thereof |
US7901707B2 (en) * | 2004-03-15 | 2011-03-08 | Christine Allen | Biodegradable biocompatible implant and method of manufacturing same |
CA2569279A1 (en) * | 2004-06-04 | 2005-12-15 | Chemgenex Pharmaceuticals, Inc. | Methods of treating cellular proliferative disease using naphthalimide and parp-1 inhibitors |
JP2008529667A (ja) * | 2005-02-10 | 2008-08-07 | ケムジェネックス・ファーマシューティカルズ・インコーポレイテッド | 医療デバイス |
CA2684219C (en) * | 2007-04-13 | 2017-05-23 | Chemgenex Pharmaceuticals, Inc. | Oral cephalotaxine dosage forms |
WO2009148654A2 (en) * | 2008-03-03 | 2009-12-10 | Sloan-Kettering Institute For Cancer Research | Cephalotaxus esters, methods of synthesis, and uses thereof |
US20120283306A1 (en) * | 2011-04-27 | 2012-11-08 | Georgia Health Sciences University | Mouse model for avm |
KR102066684B1 (ko) * | 2018-02-19 | 2020-01-15 | 가천대학교 산학협력단 | 개비자나무 추출물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 자가면역질환의 예방 또는 치료용 조성물 |
KR102174166B1 (ko) * | 2018-12-13 | 2020-11-04 | 영남대학교 산학협력단 | 호모해링토닌을 유효성분으로 함유하는 세포노화 관련 질환 예방 또는 치료용 조성물 |
KR102066683B1 (ko) * | 2019-09-16 | 2020-01-15 | 가천대학교 산학협력단 | 개비자나무 추출물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 자가면역질환의 예방 또는 치료용 조성물 |
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KR102209386B1 (ko) * | 2020-01-09 | 2021-02-01 | 영남대학교 산학협력단 | 호모해링토닌을 유효성분으로 함유하는 대사질환 예방 또는 치료용 약학조성물 |
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EP1539179A4 (en) | 2007-01-31 |
US7642252B2 (en) | 2010-01-05 |
EP1539179B1 (en) | 2016-03-02 |
CA2493544A1 (en) | 2004-01-29 |
WO2004009030A3 (en) | 2004-09-10 |
ES2572145T3 (es) | 2016-05-30 |
AU2003254120A1 (en) | 2004-02-09 |
WO2004009030A2 (en) | 2004-01-29 |
US20090270368A1 (en) | 2009-10-29 |
EP1539179A2 (en) | 2005-06-15 |
US20040077629A1 (en) | 2004-04-22 |
AU2003254120B2 (en) | 2009-09-10 |
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