DK1263440T3 - Cephalotaxinalkaloidkombinationspræparater og anvendelser deraf - Google Patents

Cephalotaxinalkaloidkombinationspræparater og anvendelser deraf

Info

Publication number
DK1263440T3
DK1263440T3 DK01918763T DK01918763T DK1263440T3 DK 1263440 T3 DK1263440 T3 DK 1263440T3 DK 01918763 T DK01918763 T DK 01918763T DK 01918763 T DK01918763 T DK 01918763T DK 1263440 T3 DK1263440 T3 DK 1263440T3
Authority
DK
Denmark
Prior art keywords
agents
cephalotaxine
cephalotaxin
applications
hydroxy
Prior art date
Application number
DK01918763T
Other languages
English (en)
Inventor
Dennis M Brown
Original Assignee
Chemgenex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemgenex Pharmaceuticals Inc filed Critical Chemgenex Pharmaceuticals Inc
Application granted granted Critical
Publication of DK1263440T3 publication Critical patent/DK1263440T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK01918763T 2000-03-15 2001-03-15 Cephalotaxinalkaloidkombinationspræparater og anvendelser deraf DK1263440T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18969900P 2000-03-15 2000-03-15

Publications (1)

Publication Number Publication Date
DK1263440T3 true DK1263440T3 (da) 2006-10-23

Family

ID=22698410

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01918763T DK1263440T3 (da) 2000-03-15 2001-03-15 Cephalotaxinalkaloidkombinationspræparater og anvendelser deraf

Country Status (12)

Country Link
US (4) US6734178B2 (da)
EP (1) EP1263440B1 (da)
JP (1) JP4929436B2 (da)
AT (1) ATE330611T1 (da)
AU (2) AU4580301A (da)
CA (1) CA2402710A1 (da)
DE (1) DE60120928T2 (da)
DK (1) DK1263440T3 (da)
ES (1) ES2267741T3 (da)
HK (1) HK1052138A1 (da)
PT (1) PT1263440E (da)
WO (1) WO2001068098A2 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2402710A1 (en) * 2000-03-15 2001-09-20 Chemgenex Therapeutics, Inc. Use of a cephalotaxine and an antiproliferative agent in treating cellular proliferative disease
US7135481B2 (en) 2000-04-12 2006-11-14 Chemgenex Pharmaceuticals, Inc. Naphthalimide compositions and uses thereof
US20060211648A1 (en) * 2000-04-12 2006-09-21 Chemgenex Pharmaceuticals, Inc. Naphthalimide compositions and uses thereof
ES2248312T3 (es) 2000-04-12 2006-03-16 Chemgenex Pharmaceuticals, Inc. Composiciones que contienen una naftalmida y un agente aniproliferativo.
US20050170015A1 (en) * 2000-10-31 2005-08-04 Brown Dennis M. Antiproliferative colchicine compositions and uses thereof
EP1330242A2 (en) * 2000-10-31 2003-07-30 Chemgenex Therapeutics Inc. Antiproliferative colchicine compositions and uses thereof
ATE361746T1 (de) * 2002-03-06 2007-06-15 Medical Res And Education Trus Botanischer extrakt mit antikrebs-aktivität enthaltend isoliquiritigenin
JP2006501199A (ja) 2002-07-17 2006-01-12 ケムジェネックス・ファーマシューティカルズ・リミテッド ホモハリングトニンを含むセファロタキシンの製剤および投与方法
EP1539179B1 (en) * 2002-07-22 2016-03-02 Teva Pharmaceuticals International GmbH Angiogenesis inhibition by cephalotaxine alkaloids, derivatives, compositions and uses thereof
CN100396286C (zh) * 2002-12-30 2008-06-25 北京大学第一医院 高三尖杉酯碱和三尖杉酯碱在制备抑制血管生成药物中的应用
US20050288310A1 (en) * 2004-06-04 2005-12-29 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and PARP-1 inhibitors
EP1848391A2 (en) * 2005-02-10 2007-10-31 ChemGenex Pharmaceuticals, Inc. Medical devices
CN101677951A (zh) * 2007-04-13 2010-03-24 化学基因制药公司 三尖杉碱口服剂型
EP2260041A4 (en) * 2008-03-03 2012-04-25 Sloan Kettering Inst Cancer CEPHALOTAXUS ESTERS, SYNTHESIS METHODS AND USES THEREOF

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US4675318A (en) * 1985-05-28 1987-06-23 Yaguang Liu Safe antileukemia drug, SAL
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
CA2402710A1 (en) * 2000-03-15 2001-09-20 Chemgenex Therapeutics, Inc. Use of a cephalotaxine and an antiproliferative agent in treating cellular proliferative disease
ES2248312T3 (es) * 2000-04-12 2006-03-16 Chemgenex Pharmaceuticals, Inc. Composiciones que contienen una naftalmida y un agente aniproliferativo.

Also Published As

Publication number Publication date
US20020032190A1 (en) 2002-03-14
JP4929436B2 (ja) 2012-05-09
HK1052138A1 (en) 2003-09-05
ATE330611T1 (de) 2006-07-15
AU2001245803B2 (en) 2005-12-15
AU2001245803B8 (en) 2006-02-02
US20040185117A1 (en) 2004-09-23
PT1263440E (pt) 2006-11-30
EP1263440A2 (en) 2002-12-11
US20110008307A1 (en) 2011-01-13
WO2001068098A2 (en) 2001-09-20
CA2402710A1 (en) 2001-09-20
DE60120928D1 (de) 2006-08-03
AU4580301A (en) 2001-09-24
US20120207855A1 (en) 2012-08-16
ES2267741T3 (es) 2007-03-16
EP1263440B1 (en) 2006-06-21
DE60120928T2 (de) 2007-02-08
US6734178B2 (en) 2004-05-11
WO2001068098A3 (en) 2002-06-06
JP2003526667A (ja) 2003-09-09

Similar Documents

Publication Publication Date Title
DK1263440T3 (da) Cephalotaxinalkaloidkombinationspræparater og anvendelser deraf
NO20020662L (no) Pyrimidin-2,4,6-trion metalloproteinase inhibitorer
NO20031852L (no) Pyrimidin-2,4,6-trion metalloproteinase inhibitorer
WO2000072799A3 (en) Method and compositions for treating the inflammatory response
EP0876387A4 (en) PROCESS FOR IMPROVING THE BIOLOGICAL AND ANTIVIRAL ACTIVITY OF PROTEASE INHIBITORS
AU5348301A (en) Naphthalimide compositions and uses thereof
DK1319003T3 (da) Xanthin-phosphodiesterase V-inhibitorer
TR200201058T2 (tr) P38 protein kinaz inhibitörleri olarak, alkilaminoyla ornatılmış bisiklik, azotlu heterosikller
BR0108480A (pt) Método e sistema para otimizar o reestabelecimento das conexões no sistema de rádio celular suportando comunicações em tempo real e em tempo não-real
BR0114576A (pt) Composto, composição farmacêutica, uso de um composto, método de tratar um estado doentio e processo para preparar um composto
AR030741A1 (es) Derivados de los acidos 2-amino-2-alquil-5-heptenoico y - heptinoico utiles como inhibidores de oxido nitrico sintetasa
BR0117198A (pt) Método de indução de ovulação usando um modulador do nìvel de camp de não-polipeptìdeo
EP1498101A4 (en) COMPOSITION FOR CELL PROLIFERATION
WO2001087288A8 (en) Method of treating vaginal dryness with nicotinic acetylcholine receptor agonists
TR199802649A2 (xx) Sikline ba�l� kinazlar�n inhibit�rleri i�in ba�lama e�leri.
BR0108454A (pt) Métodos para identificação e uso de antagonistas de receptor de adenosina a(2b) papa mediar a proliferação celular em mamìferos
NO20015659L (no) Purinderivater, fremstillingsmetode og farmasöytiske preparater inneholdende disse
EP1201765A3 (en) Cellular kinases involved in cytomegalovirus infection and their inhibition
EA200000798A1 (ru) Лечение фолликулярных лимфом с использованием ингибиторов каскада реакций лимфотоксина (lt)
ID27933A (id) Gabungan protein farnesiltransferase dan inhibitor hmg-coa reduktase serta penggunaannya untuk mengobati kanker
WO2001091740A3 (en) Compositions containing naphthaquinone and an antiproliferative agent
NO20021380D0 (no) Nye pyrimidin-2,4,6-trion-derivater, fremgangsmåter for deres fremstilling og farmasöytiske midler inneholdende dem
TR200201252T2 (tr) 15-Hidroksieikosatetraenoik asit ile ilişkili bileşikler ve bunların kullanım yöntemleri
BR0110205A (pt) Inibidores de peptìdeo deformilase
WO2007095639A3 (en) Napht alimide compositions and uses thereof