JP2005536455A5 - - Google Patents
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- JP2005536455A5 JP2005536455A5 JP2003583337A JP2003583337A JP2005536455A5 JP 2005536455 A5 JP2005536455 A5 JP 2005536455A5 JP 2003583337 A JP2003583337 A JP 2003583337A JP 2003583337 A JP2003583337 A JP 2003583337A JP 2005536455 A5 JP2005536455 A5 JP 2005536455A5
- Authority
- JP
- Japan
- Prior art keywords
- tweak
- use according
- antibody
- cells
- antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100024584 Tumor necrosis factor ligand superfamily member 12 Human genes 0.000 claims 38
- 101710097155 Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 claims 38
- 239000002243 precursor Substances 0.000 claims 25
- 210000004027 cell Anatomy 0.000 claims 23
- 238000000034 method Methods 0.000 claims 21
- 239000005557 antagonist Substances 0.000 claims 18
- 239000000556 agonist Substances 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 10
- 102000005962 receptors Human genes 0.000 claims 9
- 108020003175 receptors Proteins 0.000 claims 9
- 108010014401 TWEAK Receptor Proteins 0.000 claims 8
- 102100028786 Tumor necrosis factor receptor superfamily member 12A Human genes 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 230000002757 inflammatory effect Effects 0.000 claims 6
- 210000003734 kidney Anatomy 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- 206010061218 Inflammation Diseases 0.000 claims 3
- 230000024245 cell differentiation Effects 0.000 claims 3
- 206010020718 hyperplasia Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 210000004185 liver Anatomy 0.000 claims 3
- 210000005229 liver cell Anatomy 0.000 claims 3
- 210000005265 lung cell Anatomy 0.000 claims 3
- 208000031229 Cardiomyopathies Diseases 0.000 claims 2
- 210000001789 adipocyte Anatomy 0.000 claims 2
- 210000004413 cardiac myocyte Anatomy 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 230000008929 regeneration Effects 0.000 claims 2
- 238000011069 regeneration method Methods 0.000 claims 2
- 210000004927 skin cell Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 208000024985 Alport syndrome Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010056370 Congestive cardiomyopathy Diseases 0.000 claims 1
- 206010011732 Cyst Diseases 0.000 claims 1
- 201000010046 Dilated cardiomyopathy Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010067125 Liver injury Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 210000000013 bile duct Anatomy 0.000 claims 1
- 210000002449 bone cell Anatomy 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 210000001612 chondrocyte Anatomy 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 210000001608 connective tissue cell Anatomy 0.000 claims 1
- 208000031513 cyst Diseases 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 210000002308 embryonic cell Anatomy 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000001434 glomerular Effects 0.000 claims 1
- 208000010758 granulomatous inflammation Diseases 0.000 claims 1
- 231100000753 hepatic injury Toxicity 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 208000003215 hereditary nephritis Diseases 0.000 claims 1
- 210000004276 hyalin Anatomy 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 210000002894 multi-fate stem cell Anatomy 0.000 claims 1
- 230000001114 myogenic effect Effects 0.000 claims 1
- 210000001178 neural stem cell Anatomy 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 210000000229 preadipocyte Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
- 210000002363 skeletal muscle cell Anatomy 0.000 claims 1
- 230000002477 vacuolizing effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37161102P | 2002-04-09 | 2002-04-09 | |
| PCT/US2003/011350 WO2003086311A2 (en) | 2002-04-09 | 2003-04-09 | Methods for treating tweak-related conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009202035A Division JP5603040B2 (ja) | 2002-04-09 | 2009-09-01 | Ｔｗｅａｋ関連状態を治療するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005536455A JP2005536455A (ja) | 2005-12-02 |
| JP2005536455A5 true JP2005536455A5 (enExample) | 2006-01-26 |
Family
ID=29250708
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003583337A Pending JP2005536455A (ja) | 2002-04-09 | 2003-04-09 | Ｔｗｅａｋ関連状態を治療するための方法 |
| JP2009202035A Expired - Fee Related JP5603040B2 (ja) | 2002-04-09 | 2009-09-01 | Ｔｗｅａｋ関連状態を治療するための方法 |
| JP2011196571A Withdrawn JP2012021014A (ja) | 2002-04-09 | 2011-09-08 | Ｔｗｅａｋ関連状態を治療するための方法 |
| JP2014016608A Expired - Fee Related JP5916776B2 (ja) | 2002-04-09 | 2014-01-31 | Ｔｗｅａｋ関連状態を治療するための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009202035A Expired - Fee Related JP5603040B2 (ja) | 2002-04-09 | 2009-09-01 | Ｔｗｅａｋ関連状態を治療するための方法 |
| JP2011196571A Withdrawn JP2012021014A (ja) | 2002-04-09 | 2011-09-08 | Ｔｗｅａｋ関連状態を治療するための方法 |
| JP2014016608A Expired - Fee Related JP5916776B2 (ja) | 2002-04-09 | 2014-01-31 | Ｔｗｅａｋ関連状態を治療するための方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US20060240004A1 (enExample) |
| EP (4) | EP2301578A3 (enExample) |
| JP (4) | JP2005536455A (enExample) |
| KR (2) | KR101000842B1 (enExample) |
| CN (5) | CN106421778A (enExample) |
| AU (1) | AU2003224950B2 (enExample) |
| BR (1) | BRPI0309126A8 (enExample) |
| CA (2) | CA2480745A1 (enExample) |
| DK (1) | DK1997512T3 (enExample) |
| EA (1) | EA011607B1 (enExample) |
| ES (1) | ES2444121T3 (enExample) |
| IL (3) | IL164352A0 (enExample) |
| MX (2) | MXPA04009683A (enExample) |
| NO (2) | NO334266B1 (enExample) |
| NZ (2) | NZ548701A (enExample) |
| PT (1) | PT1997512E (enExample) |
| SI (1) | SI1997512T1 (enExample) |
| WO (1) | WO2003086311A2 (enExample) |
| ZA (1) | ZA200408073B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129061B1 (en) * | 1996-08-07 | 2006-10-31 | Biogen Idec Ma Inc. | Tumor necrosis factor related ligand |
| AU2507700A (en) | 1999-01-15 | 2000-08-01 | Biogen, Inc. | Antagonists of tweak and of tweak receptor and their use to treat immunological disorders |
| US6943146B2 (en) | 2000-05-08 | 2005-09-13 | Biogen Idec Ma Inc. | Method for promoting neovascularization |
| US7208151B2 (en) | 2001-09-12 | 2007-04-24 | Biogen Idec Ma Inc. | Tweak receptor agonists as anti-angiogenic agents |
| SI1997512T1 (sl) | 2002-04-09 | 2014-03-31 | Biogen Idec Ma Inc. | Postopki za zdravljenje stanj, povezanih s TWEAK-om |
| WO2005053728A2 (de) * | 2003-12-01 | 2005-06-16 | Xantos Biomedicine Ag | Mit adipositas assoziierte proteine und deren verwendung in therapie und diagnostik |
| US7939490B2 (en) * | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| DK2529619T3 (en) * | 2005-02-17 | 2016-01-11 | Biogen Ma Inc | Treatment of neurological disorders |
| WO2006088890A2 (en) * | 2005-02-17 | 2006-08-24 | Biogen Idec Ma Inc. | Treating stroke |
| AU2011239311B2 (en) * | 2005-02-17 | 2014-05-22 | Biogen Ma Inc. | Treating Neurological Disorders |
| CA2607697C (en) * | 2005-05-10 | 2015-01-06 | Biogen Idec Ma Inc. | Treating and evaluating inflammatory disorders |
| WO2006125632A2 (en) * | 2005-05-24 | 2006-11-30 | Rechtsanwalt Dr. Martin Prager Als Insolvenzverwalter Über Das Vermögen Der Xantos Biomedicine Ag, Pluta Rechtsanwalts Gmbh | Agonistic antibodies that bind to the tweak receptor fn14 and thereby modulate adiposity-associated phenotypes as well as their use in therapy |
| EP1764109A1 (de) * | 2005-05-24 | 2007-03-21 | Xantos Biomedicine AG | Agonistische Antikörper, welche an den Tweak Rezeptor Fn14 binden und dadurch Adipositas assoziierte Phänotypen modulieren, und deren Verwendung in der Therapie |
| WO2006130429A2 (en) * | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Treatment of cancer |
| EP2460832A3 (en) * | 2005-05-27 | 2012-10-31 | Biogen Idec MA Inc. | TWEAK binding antibodies |
| WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| WO2010005519A1 (en) * | 2008-06-30 | 2010-01-14 | University Of Pennsylvania | Fn14/trail fusion proteins |
| WO2010019234A1 (en) * | 2008-08-12 | 2010-02-18 | Ihc Intellectual Asset Management, Llc | Analysis of genetic markers for peripartum cardiomyopathy |
| JP5161718B2 (ja) * | 2008-09-25 | 2013-03-13 | 株式会社ゲノム創薬研究所 | 肝障害モデル動物、及びそれを用いた肝障害を改善又は予防する、薬剤若しくは食品素材のスクリーニング方法 |
| BRPI1007529A2 (pt) * | 2009-01-30 | 2016-10-18 | Biogen Idec Inc | métodos para regeneração de tecido pancreático |
| US8093006B2 (en) | 2009-04-02 | 2012-01-10 | Hoffmann-La Roche Inc. | Antibodies against human tweak and uses thereof |
| US9096879B2 (en) * | 2009-11-24 | 2015-08-04 | Biogen Ma Inc. | Method of supplementing culture media to prevent undesirable amino acid substitutions |
| WO2011097500A2 (en) | 2010-02-04 | 2011-08-11 | University Of Louisville Research Foundation, Inc. | The tweak/fn14 system regulates skeletal muscle atrophy and regeneration |
| AU2011309689B2 (en) | 2010-09-28 | 2015-01-15 | Hadasit Medical Research Services & Development Ltd. | Compositions and methods for treatment of hematological malignancies |
| SG188605A1 (en) | 2010-10-05 | 2013-04-30 | Hoffmann La Roche | Antibodies against human tweak and uses thereof |
| RU2462222C1 (ru) * | 2011-07-11 | 2012-09-27 | Наталья Николаевна Молчанова | Способ лечения больных артериальной гипертонией с метаболическими нарушениями |
| WO2013026099A1 (en) | 2011-08-23 | 2013-02-28 | Transbio Ltd | Fn14 binding proteins and uses thereof |
| PE20142422A1 (es) | 2012-04-05 | 2015-01-21 | Hoffmann La Roche | Anticuerpos biespecificos contra tweak humana e il 17 humana y usos de los mismos |
| GB201317929D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
| EP3182989B1 (en) * | 2014-08-21 | 2021-04-14 | Stealth Biotherapeutics Corp | Peptide d-arg-2',6'-dmt-lys-phe-nh2 for treating alport syndrome |
| WO2016061632A1 (en) * | 2014-10-23 | 2016-04-28 | La Trobe University | Fn14-binding proteins and uses thereof |
| KR101881531B1 (ko) * | 2016-11-25 | 2018-07-25 | 고려대학교 산학협력단 | 폴리-2-하이드록시에틸 메타아크릴레이트를 이용한 사이토카인의 발현능이 증가된 줄기세포의 제조방법 |
| CA3192646A1 (en) * | 2020-08-28 | 2022-03-03 | Carisma Therapeutics Inc. | Modified immune cells for fibrosis and inflammation |
| CN113616777A (zh) * | 2021-08-18 | 2021-11-09 | 中山大学附属第三医院（中山大学肝脏病医院） | 基于主要尿蛋白改善内质网应激的转化应用 |
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| ATE364050T1 (de) | 2003-07-24 | 2007-06-15 | Amgen Inc | Zusammensetzungen und verfahren, die multimere und oligomere lösliche fragmente des tweak- rezeptors betreffen |
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